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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2020
Jun. 30, 2019
Cash flows from operating activities:    
Net loss $ (20,436) $ (35,343)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation of property and equipment 216 306
Amortization of discount/premium on investments (277) (1,205)
Share-based compensation 2,717 6,440
Unrealized loss on equity investment 0 30
Lease-related amortization (43) (36)
Changes in operating assets and liabilities:    
Accounts receivable 866 (444)
Prepaid expenses and other assets 809 399
Accounts payable and accrued liabilities (2,546) 302
Net cash used in operating activities (18,694) (29,551)
Cash flows from investing activities:    
Purchases of property and equipment (11) (150)
Purchases of short-term investments (27,652) (107,149)
Proceeds from sales of short-term investments 1,498 0
Proceeds from maturities of short-term investments 80,652 77,210
Net cash provided by (used in) investing activities 54,487 (30,089)
Cash flows from financing activities:    
Proceeds from exercise of stock options 578 30
Proceeds from employee stock purchase plan 229 171
Payments of deferred offering costs 0 (23)
Net cash provided by financing activities 807 178
Net increase (decrease) in cash and cash equivalents 36,600 (59,462)
Cash and cash equivalents:    
Beginning of period 16,901 81,106
End of period $ 53,501 $ 21,644