X0508 4 2025-02-27 0001116463 ORASURE TECHNOLOGIES INC OSUR 0001942342 McGrath Kenneth J C/O ORASURE TECHNOLOGIES, INC. 220 EAST FIRST STREET BETHLEHEM PA 18015 0 1 0 0 Chief Financial Officer 0 Common Stock 2025-02-27 4 P 0 64000 3.1513 A 371013 D Represents shares of common stock purchased in the open market on February 27, 2025. The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.08 to $3.275, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. /s/ Michele Anthony, Attorney-in-Fact 2025-02-27