144 0001114357 XXXXXXXX LIVE 0001717115 Tempus AI, Inc. 001-42130 600 West Chicago Avenue, Suite 510 Chicago IL 60654 800-976-5448 Eric Lefkofsky Officer Director 10% Stockholder Class A Common Stock J.P. Morgan Securities LLC 270 Park Avenue, 10th Floor New York NY 10017 200000 13994000 175390967 09/17/2026 NASDAQ Class A Common Stock 12/02/2016 Direct Investment Issuer N 135000 12/02/2016 Cash Class A Common Stock 09/24/2015 Direct Investment Issuer N 57500 09/24/2015 Cash Class A Common Stock 03/05/2020 Direct Investment Issuer N 7500 03/05/2020 Cash N Blue Media, LLC C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 06/29/2026 133000 7645208.81 Blue Media, LLC C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 07/28/2026 135000 5678417 Blue Media, LLC C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 08/25/2026 135000 9241867 Gray Media, LLC C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 06/29/2026 33250 1911302.2 Gray Media, LLC C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 07/28/2026 57500 2418585 Gray Media, LLC C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 08/25/2026 57500 3936351 Lefkofsky Family Foundation C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 07/28/2026 7500 315468 Lefkofsky Family Foundation C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 08/25/2026 7500 513437 Vas.org Foundation C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 07/28/2026 50000 2103118 This form relates to sales by Blue Media, LLC (135,000 shares), Gray Media, LLC (57,500 shares), Lefkofsky Family Foundation (7,500 shares) of which Mr. Lefkofsky is the authorized signatory. 09/17/2026 03/08/2026 /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Eric Lefkofsky