144 0001114357 XXXXXXXX LIVE 0001717115 Tempus AI, Inc. 001-42130 600 West Chicago Avenue, Suite 510 Chicago IL 60654 800-976-5448 Eric Lefkofsky Officer Director 10% Stockholder Class A Common Stock J.P. Morgan Securities LLC 270 Park Avenue, 10th Floor New York NY 10017 250000 10727500 174520978 07/28/2026 NASDAQ Class A Common Stock 01/22/2025 Stock Compensation Issuer N 135000 01/22/2025 Compensation Class A Common Stock 09/14/2017 Direct Investment Issuer N 57500 09/14/2017 Cash Class A Common Stock 03/05/2020 Direct Investment Issuer N 7500 03/05/2020 Cash Class A Common Stock 12/04/2025 Donation Blue Media LLC who acquired the shares on 09/24/2015 N 50000 12/04/2025 Donation N Eric Lefkofsky C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 05/19/2026 22335 984303.45 Blue Media, LLC C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 05/27/2026 133000 6210943 Blue Media, LLC C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 06/29/2026 133000 7645208.81 Gray Media, LLC C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 05/27/2026 33250 1552736 Gray Media, LLC C/o Tempus AI, Inc. 600 West Chicago Avenue, Suite 510 Chicago IL 60654 Class A Common Stock 06/29/2026 33250 1911302.2 This form relates to sales by Blue Media, LLC (135,000 shares), Gray Media, LLC (57,500 shares), Lefkofsky Family Foundation (7,500 shares) and Vas.org Foundation (50,000 shares) of which Mr. Lefkofsky is the authorized signatory. 07/28/2026 03/08/2026 /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Eric Lefkofsky