<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001114357</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001717115</issuerCik>
      <issuerName>Tempus AI, Inc.</issuerName>
      <secFileNumber>001-42130</secFileNumber>
      <issuerAddress>
        <com:street1>600 W. Chicago Ave., Suite 510</com:street1>
        <com:city>Chicago</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60654</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>800-976-5448</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Eric Lefkofsky</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
        <relationshipToIssuer>10% Stockholder</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Class A Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>J.P. Morgan Securities LLC</name>
        <address>
          <com:street1>270 Park Avenue - 10th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10017</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>166250</noOfUnitsSold>
      <aggregateMarketValue>9336600</aggregateMarketValue>
      <noOfUnitsOutstanding>172863470</noOfUnitsOutstanding>
      <approxSaleDate>02/19/2026</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Class A Common</securitiesClassTitle>
      <acquiredDate>02/06/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>63258</amountOfSecuritiesAcquired>
      <paymentDate>02/06/2025</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Class A Common</securitiesClassTitle>
      <acquiredDate>02/07/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>69742</amountOfSecuritiesAcquired>
      <paymentDate>02/07/2025</paymentDate>
      <natureOfPayment>Compensation</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Class A Common</securitiesClassTitle>
      <acquiredDate>09/14/2017</acquiredDate>
      <natureOfAcquisitionTransaction>Direct Investment</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>33250</amountOfSecuritiesAcquired>
      <paymentDate>09/14/2017</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Blue Media, LLC</name>
        <address>
          <com:street1>Care of Tempus AI, Inc</com:street1>
          <com:street2>600 West Chicago Avenue, Suite 510</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60654</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common</securitiesClassTitle>
      <saleDate>11/20/2025</saleDate>
      <amountOfSecuritiesSold>133000</amountOfSecuritiesSold>
      <grossProceeds>9172714</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Blue Media, LLC</name>
        <address>
          <com:street1>Care of Tempus AI, Inc</com:street1>
          <com:street2>600 West Chicago Avenue, Suite 510</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60654</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common</securitiesClassTitle>
      <saleDate>12/18/2025</saleDate>
      <amountOfSecuritiesSold>133000</amountOfSecuritiesSold>
      <grossProceeds>8510855</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Blue Media, LLC</name>
        <address>
          <com:street1>Care of Tempus AI, Inc</com:street1>
          <com:street2>600 West Chicago Avenue, Suite 510</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60654</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common</securitiesClassTitle>
      <saleDate>01/28/2026</saleDate>
      <amountOfSecuritiesSold>133000</amountOfSecuritiesSold>
      <grossProceeds>8719055</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Gray Media, LLC</name>
        <address>
          <com:street1>Care of Tempus AI, Inc</com:street1>
          <com:street2>600 West Chicago Avenue, Suite 510</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60654</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common</securitiesClassTitle>
      <saleDate>11/20/2025</saleDate>
      <amountOfSecuritiesSold>33250</amountOfSecuritiesSold>
      <grossProceeds>2293179</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Gray Media, LLC</name>
        <address>
          <com:street1>Care of Tempus AI, Inc</com:street1>
          <com:street2>600 West Chicago Avenue, Suite 510</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60654</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common</securitiesClassTitle>
      <saleDate>12/18/2025</saleDate>
      <amountOfSecuritiesSold>33250</amountOfSecuritiesSold>
      <grossProceeds>2127714</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Gray Media, LLC</name>
        <address>
          <com:street1>Care of Tempus AI, Inc</com:street1>
          <com:street2>600 West Chicago Avenue, Suite 510</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60654</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Class A Common</securitiesClassTitle>
      <saleDate>01/28/2026</saleDate>
      <amountOfSecuritiesSold>33250</amountOfSecuritiesSold>
      <grossProceeds>2179764</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>This form relates to sales by Blue Media, LLC (133,000 shares) and Gray Media, LLC (33,250 shares), of which Mr. Lefkofsky is the sole manager.</remarks>
    <noticeSignature>
      <noticeDate>02/19/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>03/04/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Eric Lefkofsky</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
