X0306 4 2017-04-05 0 0001114220 KERYX BIOPHARMACEUTICALS INC KERX 0001564955 Madison Greg C/O KERYX BIOPHARMACEUTICALS, INC. ONE MARINA PARK DRIVE, 12TH FLOOR BOSTON MA 02210 1 1 0 0 President and CEO Common Stock 2017-04-05 4 S 0 911 5.80 D 382800 D Sale of a total of 911 shares of common stock was made in order to satisfy Mr. Madison's income tax withholding obligation upon the vesting of 2,823 shares of restricted stock on April 4, 2017. Mr. Madison had no discretion with respect to such sale, which was transacted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock. Includes 260,967 shares of restricted stock. /s/ Brian Adams, Attorney-in-Fact 2017-04-06