X0306 4 2016-08-09 0 0001114220 KERYX BIOPHARMACEUTICALS INC KERX 0001564955 Madison Greg C/O KERYX BIOPHARMACEUTICALS, INC. ONE MARINA PARK DRIVE, 12TH FLOOR BOSTON MA 02210 1 1 0 0 President and CEO Common Stock 2016-08-09 4 S 0 1622 4.22 D 257123 D Sale of a total of 1,622 shares of common stock was made in order to satisfy Mr. Madison's income tax withholding obligation upon the vesting of 5,000 shares of restricted stock on August 8, 2016. Mr. Madison had no discretion with respect to such sale, which was transacted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock. Includes 180,687 shares of restricted stock. /s/ Brian Adams, Attorney-in-Fact 2016-08-11