X0306 4 2016-07-29 0 0001114220 KERYX BIOPHARMACEUTICALS INC KERX 0001537670 Holmes Scott A C/O KERYX BIOPHARMACEUTICALS, INC. ONE MARINA PARK DRIVE, 12TH FLOOR BOSTON MA 02210 0 1 0 0 Chief Financial Officer Common Stock 2016-07-29 4 S 0 4935 7.36 D 108557 D Sale of a total of 4,935 shares of common stock was made in order to satisfy Mr. Holmes' income tax withholding obligation upon the vesting of 15,001 shares of restricted stock on July 27, 2016. Mr. Holmes had no discretion with respect to such sale, which was transacted automatically in accordance with the Issuer's corporate policies regarding the vesting of restricted stock. Includes 83,749 shares of restricted stock. /s/ Brian Adams, Attorney-in-Fact 2016-08-01