X0206 3 2014-03-03 0 0001113481 MEDICINES CO /DE MDCO 0001600752 Furse Brent 8 SYLVAN WAY PARSIPPANY NJ 07054 0 1 0 0 EVP, Chief Customer Officer Common Stock 40629 D Stock Option (right-to-buy) 28.6 2017-02-16 Common Stock 13000 D Stock Option (right-to-buy) 7.31 2020-02-19 Common Stock 1458 D Stock Option (right-to-buy) 17.45 2021-02-18 Common Stock 11111 D Stock Option (right-to-buy) 22.04 2022-02-24 Common Stock 17500 D Stock Option (right-to-buy) 31.49 2023-03-01 Common Stock 15373 D Stock Option (right-to-buy) 30.55 2024-03-01 Common Stock 25072 D Includes 32,501 shares of restricted stock that vest in 25% increments on each anniversary of the date of grant, until fully vested. The reporting person was appointed Executive Vice President, Chief Customer Officer and Regional Engagement Leader - Americas of the Issuer effective March 3, 2014. Represents a grant made to the reporting person on February 16, 2007. The option vested in forty-eight equal installments beginning March 16, 2007. Represents the remainder of a grant of 17,500 stock options made to the reporting person on February 19, 2010. The remaining option vests in equal monthly installments ending on March 19, 2014. Represents the remainder of a grant of 33,333 stock options made to the reporting person on February 18, 2011. The remaining option vests in equal monthly installments ending on March 18, 2015. Represents the remainder of a grant of 30,000 stock options made to the reporting person on February 24, 2012. The remaining option vests in equal monthly installments ending on March 24, 2016. Represents a grant made to the reporting person on March 1, 2013. The option vests in forty-eight equal installments ending April 1, 2017. presents a grant made to the reporting person on March 1, 2013. The option vests in forty-eight equal installments ending April 1, 2018. /s/ Stephen M. Rodin, Attorney-in-Fact for Brent Furse 2014-03-04