X0306 4 2012-10-25 0 0001113481 MEDICINES CO /DE MDCO 0001204787 MEANWELL CLIVE 8 SYLVAN WAY PARSIPPANY NJ 07054 1 1 0 0 Chairman & CEO Common Stock 2012-10-25 4 M 0 13600 15.50 A 369476 D Common Stock 2012-10-25 4 S 0 13600 23.09 D 355876 D Option (right to buy) 15.50 2012-10-25 4 M 0 13600 0 D 2012-12-10 Common Stock 13600 13593 D The common stock sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 program adopted by Dr. Meanwell in July 2012. The range of prices for the transactions reported on this line is between $23.03 and $23.19 per share. The price reported above reflects the weighted average sales price. The undersigned undertakes, upon request by the Commission staff, the issuer or a security holder of the issuer, to provide full informaton regarding the number of shares sold at each separate price. As of 10/25/2012, the original grant (123,000 shares granted on 12/10/2002) was fully vested. The remaining 13,593 shares covered by this option are vested but not exercised. /s/ Paul M. Antinori as Attorney-In-Fact for Clive Meanwell 2012-10-29