X0304 4 2012-01-03 0 0001113481 MEDICINES CO /DE MDCO 0001204787 MEANWELL CLIVE 8 SYLVAN WAY PARSIPPANY NJ 07054 1 1 0 0 Chairman & CEO Common Stock 2012-01-03 4 S 0 2500 18.99 D 306497 D The common stock sales reported on the Form 4 were effected pursuant to a Rule 10b5-1 program adopted by Dr. Meanwell on March 18, 2011. The range of prices for the transactions reported on this line is between $18.87 and $19.14 per share. The price reported above reflects the weighted average sales price. The undersigned undertakes, upon request by the Commission staff, the issuer or a security holder of the issuer, to provide full informaton regarding the number of shares sold at each separate price. /s/ Paul M. Antinori as Attorney-In-Fact for Clive Meanwell 2012-01-05