X0202 4 2007-02-16 0 0001113481 MEDICINES CO /DE MDCO 0001204787 MEANWELL CLIVE THE MEDICINES COMPANY 8 CAMPUS DRIVE PARSIPPANY NJ 07054 1 1 0 0 Chief Executive Officer Common Stock 2007-02-16 4 A 0 50000 0 A 277174 D Common Stock 2007-02-20 4 J 0 85403 D 191771 D Common Stock 2007-02-20 4 J 0 15520 A 191771 D Option (right to buy) 28.60 2007-02-16 4 A 0 100000 0 A 2017-02-16 Common Stock 100000 100000 D End of period holdings includes 100,923 shares subject to a prepaid variable forward sales contract (the "Contract"), pursuant to which Dr. Meanwell pledged and agreed to deliver to Bear Stearns Bank plc ("Bear") in February 2007 up to 100,923 shares of common stock of The Medicines Company (the "Company"). On February 20, 2007 (the "Pricing Date"), Clive A. Meanwell settled his obligation to deliver shares of common stock of the Company under the Contract entered into with Bear on August 19, 2004 by delivering 85,403 shares of common stock to Bear. Pursuant to the Contract, Dr. Meanwell received a cash payment in August 2004 of $2,091,401.59. In exchange for the cash payment, Dr. Meanwell pledged and agreed to deliver to Bear on the Pricing Date up to 100,923 shares of common stock of the Company. Under the Contract, the number of shares delivered by Dr. Meanwell at settlement was determined based on the closing price (the "Settlement Price") of the Company's common stock on the Pricing Date. The Settlement Price was $28.81 per share. Dr. Meanwell was obligated to deliver a number of shares equal to the product of (a) 100,923 and (continued in Footnote 3 below) (continued from Footnote 2 above) (b) the ratio obtained by dividing the Floor Price of $24.38 per share by the Settlement Price. As a result, Dr. Meanwell was obligated to deliver 85,403 shares to Bear and was not required to deliver 15,520 shares which were subject to the Contract. Consists of the 15,520 shares of common stock that Dr. Meanwell retained and was not required to deliver to Bear under the Contract, as described in Footnotes 2 and 3 above. The option vests in 48 equal monthly installments beginning on March 16, 2007. /s/ Clive A. Meanwell 2007-02-21