X0202 4 2005-10-03 0 0001113481 MEDICINES CO /DE MDCO 0001204790 RICHARDS JOHN D THE MEDICINES COMPANY 8 CAMPUS DRIVE PARSIPPANY NJ 07054 0 1 0 0 Vice President Common Stock 2005-10-03 4 M 0 2000 15.50 A 9100 D Common Stock 2005-10-03 4 S 0 2000 22.85 D 7100 D Option (right to buy) 15.50 2005-10-03 4 M 0 2000 0 D 2005-10-03 2012-12-10 Common Stock 2000 12280 D The common stock reported on this Form 4 were affected pursuant to a Rule 10b5-1 program adopted by Mr. Richards on April 29, 2005. As of October 3, 2005, the original grant (25,000 shares granted on 12/10/02) was vested with respect to 17,188 of the shares covered thereby and the remaining 7,812 vest in equal monthly installments ending on 12/10/06. After the exercise of the options reported hereby, as of October 3, 2005, 12,280 of the shares covered by the option were vested but not exercised. /s/ John D. Richards 2005-10-04