X0306 4 2016-12-06 0 0001113481 MEDICINES CO /DE MDCO 0001033409 ESHELMAN FREDRIC N 8 SYLVAN WAY PARSIPPANY NJ 07054 1 0 0 0 Common Stock 2016-12-06 4 P 0 337680 34.15 A 641106 D Common Stock 2016-12-07 4 P 0 172764 33.61 A 813870 D Common Stock 2016-12-07 4 P 0 86587 32.90 A 900457 D Common Stock 2016-12-08 4 P 0 19188 32.51 A 919645 D Common Stock 2016-12-08 4 P 0 5501 33.19 A 925146 D Common Stock 944537 I See footnote Represents the weighted average purchase price of the shares purchased ranging from a low of $33.83 to a high of $34.80 per share. The reporting person undertakes, upon request by the Commission staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares sold at each separate price for these transactions and the other transactions reported on this Form 4 and described in notes 2 through 5. Represents the weighted average purchase price of the shares purchased ranging from a low of $33.29 to a high of $34.27 per share. Represents the weighted average purchase price of the shares purchased ranging from a low of $32.29 to a high of $33.28 per share. Represents the weighted average purchase price of the shares purchased ranging from a low of $32.07 to a high of $33.06 per share. Represents the weighted average purchase price of the shares purchased ranging from a low of $33.07 to a high of $33.25 per share. These shares of the issuer's common stock are owned by Eshelman Ventures, LLC, an entity wholly owned by the reporting person. /s/ Stephen M. Rodin, Attorney-in-Fact for Fredric N. Eshelman 2016-12-08