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Restructuring (Details)
$ in Thousands
3 Months Ended 9 Months Ended
Jun. 19, 2017
USD ($)
position
Sep. 30, 2018
USD ($)
Sep. 30, 2017
USD ($)
Sep. 30, 2018
USD ($)
position
Sep. 30, 2017
USD ($)
Restructuring Reserve [Roll Forward]          
Balance as of January 1, 2018       $ 0  
Expenses, Net       12,753  
Cash       (8,223)  
Noncash       (1,956)  
Balance as of June 30, 2018   $ 2,574   2,574  
Asset impairment charges   $ 5,073 $ 0 5,073 $ 329,097
Cost of goods sold          
Restructuring Reserve [Roll Forward]          
Expenses, Net       600  
Research and development          
Restructuring Reserve [Roll Forward]          
Expenses, Net       3,600  
Selling, general and administrative          
Restructuring Reserve [Roll Forward]          
Expenses, Net       $ 8,600  
Workforce Reductions          
Restructuring Cost and Reserve [Line Items]          
Number of positions expected to be eliminated | position       60  
Workforce Reductions | Minimum          
Restructuring Cost and Reserve [Line Items]          
Period of coverage       6 months  
Workforce Reductions | Maximum          
Restructuring Cost and Reserve [Line Items]          
Period of coverage       1 year  
Ionsys | Not discontinued operations, discontinuation and market withdrawal          
Restructuring Cost and Reserve [Line Items]          
Number of positions expected to be eliminated | position 57        
Restructuring Reserve [Roll Forward]          
Number of positions eliminated in restructuring, percentage of workforce 15.00%        
Pre-tax restructuring charge $ 276,900        
Asset impairment charges 268,100        
Severance costs 5,800        
Other exit costs $ 3,000