Significant Accounting Policies (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017	Jan. 01, 2018	Dec. 31, 2017
Debt Instrument [Line Items]
Accumulated deficit	$ (1,338,248)		$ (1,338,248)			$ (1,257,356)
Cash, cash equivalents and short-term investments	131,800		131,800
Charge to revenue	(3,300)	$ 7,868	6,138	$ 36,194
Restricted cash	5,410	5,048	5,410	5,048		$ 5,541
Accounting Standards Update 2014-09 | Difference between Revenue Guidance in Effect before and after Topic 606
Debt Instrument [Line Items]
Accumulated deficit					$ (200)
Accounting Standards Update 2016-18
Debt Instrument [Line Items]
Restricted cash		5,000		5,000
U.S. government agencies
Debt Instrument [Line Items]
Reduction of research and development expenses	200	$ 500	$ 900	$ 1,100
Minimum
Debt Instrument [Line Items]
Payment term			45 days
Maximum
Debt Instrument [Line Items]
Payment term			120 days
Integrated Commercialization Solutions, Inc
Debt Instrument [Line Items]
Distribution agreement, renewal term			1 year
Distribution agreement, notice period for renewal			90 days
Distribution agreement, notice period for termination			180 days
Angiomax
Debt Instrument [Line Items]
Charge to revenue	$ (3,300)		$ (3,300)