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Nature of Business (Details) - USD ($)
1 Months Ended 9 Months Ended
Oct. 02, 2018
Jan. 05, 2018
Oct. 31, 2018
Aug. 31, 2018
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]              
Short-term investment         $ 13,089,000   $ 0
Proceeds from sale of business         166,383,000 $ 0  
Disposal Group, Disposed of by Sale, Not Discontinued Operations | Infectious Disease Business              
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]              
Total sale price   $ 166,400,000          
Consideration received (in shares)   3,313,702          
Consideration received, market value   $ 54,500,000          
Receivable due in 12 months   25,000,000          
Receivable due in 18 months   $ 25,000,000          
Proceeds from sale of business         166,383,000 $ 0  
Disposal Group, Disposed of by Sale, Not Discontinued Operations | Infectious Disease Business | Minimum              
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]              
Tiered royalty payments, percent of net sales   5.00%          
Disposal Group, Disposed of by Sale, Not Discontinued Operations | Infectious Disease Business | Maximum              
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]              
Tiered royalty payments, percent of net sales   25.00%          
Sandoz Inc | Disposal Group, Disposed of by Sale, Not Discontinued Operations | Angiomax              
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]              
Proceeds from sale of business       $ 9,900,000      
Subsequent Event | Opex Biopharma, Inc. | Disposal Group, Disposed of by Sale, Not Discontinued Operations | Infectious Disease Business              
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]              
Upfront consideration received $ 2,700,000   $ 2,700,000        
Contingent consideration $ 29,000,000   $ 29,000,000        
Melinta              
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]              
Short-term investment         $ 13,100,000