Significant Accounting Policies (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017	Jan. 01, 2018	Dec. 31, 2017
Debt Instrument [Line Items]
Accumulated deficit	$ (1,282,614)		$ (1,282,614)			$ (1,257,356)
Net revenues	1,667	$ 10,861	9,438	$ 28,326
Variable consideration			7,600
Restricted cash	5,433	5,033	$ 5,433	5,033		$ 5,541
ICS
Debt Instrument [Line Items]
Distribution agreement, renewal term			1 year
Distribution agreement, notice period for renewal			90 days
Distribution agreement, notice period for termination			180 days
Bivalirudin | Sandoz
Debt Instrument [Line Items]
Net revenues	1,400	8,500	$ 8,800	22,600
Accounting Standards Update 2014-09 | Difference between Revenue Guidance in Effect before and after Topic 606
Debt Instrument [Line Items]
Accumulated deficit					$ (200)
Accounting Standards Update 2016-18
Debt Instrument [Line Items]
Restricted cash		5,000		5,000
U.S. government agencies
Debt Instrument [Line Items]
Reimbursement revenue	$ 300	$ 300	$ 700	$ 600
Minimum
Debt Instrument [Line Items]
Payment term			45 days
Maximum
Debt Instrument [Line Items]
Payment term			120 days