Cash and Cash Equivalents and Investments - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017	Dec. 31, 2017
Cash and Cash Equivalents [Line Items]
Cash and cash equivalents	$ 215,962	$ 436,715	$ 151,359
Cash	203,800		139,300
Cash equivalents	12,100
Short-term investment	24,521		0
Loss on short-term investments	29,989	0
Restricted Cash
Restricted cash	5,543	$ 5,037	5,541
Restricted cash, letter of credit - foreign taxes	4,100		4,100
Restricted cash, letter of credit - lease agreement			1,000
Restricted cash, guaranteed investment certificate for collateralizing an available credit facility	200		200
Restricted cash, foreign tender requirements	300		300
Melinta
Cash and Cash Equivalents [Line Items]
Short-term investment	24,500
Money market funds
Cash and Cash Equivalents [Line Items]
Cash equivalents	$ 12,100		$ 12,100