Collaborative Arrangement, Additional Payments

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- Definition

Collaborative Arrangement, Payment for Milestone Met1

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No definition available.

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- Definition

Disposal Group, Including Discontinued Operation, Contingent Liability

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- Definition

Operating Leases, Percent

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No definition available.

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- Definition

Recorded Unconditional Purchase Obligation Due in Fifth and Sixth Years

+ References

No definition available.

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- Definition

Recorded Unconditional Purchase Obligation Due in Second Through Fourth Year

+ References

No definition available.

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- Definition

Area of a real estate property.

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No definition available.

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- Definition

Amount of rent expense incurred for leased assets, including but not limited to, furniture and equipment, that is not directly or indirectly associated with the manufacture, sale or creation of a product or product line.

+ References

No definition available.

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- Definition

Term of lessee's operating lease, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 842
-SubTopic 20
-Section 50
-Paragraph 3
-Subparagraph (a)(3)
-URI http://asc.fasb.org/extlink&oid=77888426&loc=SL77918673-209980

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- Definition

Amount of required minimum rental payments for leases having an initial or remaining non-cancelable letter-terms in excess of one year.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 840
-SubTopic 10
-Section 55
-Paragraph 40
-Subparagraph (Note 3)
-URI http://asc.fasb.org/extlink&oid=82846649&loc=d3e38371-112697

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-Topic 840
-SubTopic 20
-Section 50
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-URI http://asc.fasb.org/extlink&oid=77902758&loc=d3e41502-112717

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- Definition

Amount of the recorded obligation to transfer funds in the future for fixed or minimum amounts or quantities of goods or services at fixed or minimum prices (for example, as in take-or-pay contracts or throughput contracts).

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 440
-SubTopic 10
-Section 50
-Paragraph 6
-URI http://asc.fasb.org/extlink&oid=77896938&loc=d3e25383-109308

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- Definition

Amount of the recorded unconditional purchase obligation maturing after the fifth fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.

+ References

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- Definition

Amount of the recorded unconditional purchase obligation maturing in the next fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.

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- References

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- Definition

Amount of expense related to royalty payments under a contractual arrangement such as payment for mineral and drilling rights and use of technology or intellectual property.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 225
-SubTopic 10
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03.3)
-URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688

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Commitments and Contingencies (Details) $ in Thousands	12 Months Ended
Commitments and Contingencies (Details) $ in Thousands	Dec. 31, 2017 USD ($) ft²	Dec. 31, 2016 USD ($)	Dec. 31, 2015 USD ($)	Oct. 01, 2014 ft²
Future Estimated Contract Obligations
Less Than 1 Year	$ 134,335
1-3 Years	100,962
3-5 Years	49,936
More Than 5 Years	58,337
Total	$ 343,570
Leased area (sqft) \| ft²	173,146
Operating leases, percent	99.70%
Aggregate rent expense under property leases	$ 9,600	$ 7,600	$ 7,300
Targanta [Member]
Future Estimated Contract Obligations
Payment for milestone met	49,400
Additional payments	25,000
Alnylam [Member]
Future Estimated Contract Obligations
Payment for milestone met	170,000
Other [Member]
Future Estimated Contract Obligations
Payment for milestone met	2,200
Biogen Idec and HRI [Member]
Future Estimated Contract Obligations
Royalties	800	800	1,800
Cleviprex [Member]
Future Estimated Contract Obligations
Royalties	$ 0	$ 600	$ 1,300
Building [Member]
Future Estimated Contract Obligations
Leased area (sqft) \| ft²				63,000
Lease term	144 months
Expected total obligation for lease	$ 36,600
Inventory related commitments [Member]
Future Estimated Contract Obligations
Less Than 1 Year	52,111
1-3 Years	16,167
3-5 Years	0
More Than 5 Years	0
Total	68,278
Inventory related commitments [Member] \| Angiomax [Member]
Future Estimated Contract Obligations
Less Than 1 Year	66,900
Inventory related commitments [Member] \| Minocin [Member]
Future Estimated Contract Obligations
Less Than 1 Year	1,200
Inventory related commitments [Member] \| Orbactiv [Member]
Future Estimated Contract Obligations
Less Than 1 Year	200
Research and development [Member]
Future Estimated Contract Obligations
Less Than 1 Year	71,115
1-3 Years	68,387
3-5 Years	34,508
More Than 5 Years	30,409
Total	204,419
Operating leases [Member]
Future Estimated Contract Obligations
Less Than 1 Year	7,185
1-3 Years	15,029
3-5 Years	15,428
More Than 5 Years	27,928
Total	65,570
Selling, general and administrative [Member]
Future Estimated Contract Obligations
Less Than 1 Year	3,924
1-3 Years	1,379
3-5 Years	0
More Than 5 Years	0
Total	5,303
Research and development, and selling, general and administrative [Member]
Future Estimated Contract Obligations
Total	5,300
Infectious Disease Business [Member] \| Inventory related commitments [Member]
Future Estimated Contract Obligations
Total	68,300
Infectious Disease Business [Member] \| Research and development [Member]
Future Estimated Contract Obligations
Total	7,300
Infectious Disease Business [Member] \| Selling, general and administrative [Member]
Future Estimated Contract Obligations
Total	1,800
Infectious Disease Business [Member] \| Not discontinued operations, disposed of by sale [Member]
Future Estimated Contract Obligations
Contingent purchase price	229,400
Ionsys and MDCO-700 [Member] \| Disposal Group, Disposed of by Means Other than Sale, Not Discontinued Operations, Abandonment [Member]
Future Estimated Contract Obligations
Contingent purchase price	$ 175,800