Commitments and Contingencies (Tables)

12 Months Ended

Dec. 31, 2017

Commitments and Contingencies Disclosure [Abstract]

Future Estimated Contractual Obligations

Future estimated contractual obligations as of December 31, 2017 are:

Contractual Obligations (1) (2)	Less Than 1 Year		1-3 Years		3-5 Years		More Than 5 Years		Total
	(In thousands)
Inventory related commitments	$	52,111	$	16,167	$	—	$	—	$	68,278
Research and development	71,115		68,387		34,508		30,409		204,419
Operating leases	7,185		15,029		15,428		27,928		65,570
Selling, general and administrative	3,924		1,379		—		—		5,303
Total contractual obligations	$	134,335	$	100,962	$	49,936	$	58,337	$	343,570

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(1) This table does not include any milestone and royalty payments which may become payable to third parties for which the timing and likelihood of such payments are not known, as discussed below. It also does not include the long-term debt obligations. See Note 9 “Convertible Senior Notes” for further details.