Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016
Cash flows from operating activities:
Net (loss) income	$ (499,938)	$ 89,957
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	11,727	14,586
Asset impairment charges	329,097	0
Amortization of debt discount	13,822	12,770
Unrealized foreign currency transaction losses (gains), net	523	(264)
Stock compensation expense	16,200	16,551
Gain on sale of businesses	0	(289,305)
Deferred tax benefit	(22,989)	(1,623)
Extinguishment of debt	0	5,380
Reserve for excess or obsolete inventory	2,147	0
Changes in contingent consideration obligations	(4,116)	1,336
Changes in operating assets and liabilities:
Accounts receivable	6,708	3,974
Inventory, net	(2,605)	(10,219)
Prepaid expenses and other current assets	4,595	(2,696)
Accounts payable	(12,070)	(9,320)
Accrued expenses	1,530	(38,377)
Deferred revenue	(4,960)	(3,450)
Payments on contingent purchase price	(12,437)	0
Other liabilities	(2,586)	(1,629)
Net cash used in operating activities	(175,352)	(212,329)
Cash flows from investing activities:
Purchases of fixed assets	(4,448)
Proceeds from sale of fixed assets		171
Purchases of available for sale securities	(131,560)	0
Payments for intangible assets	0	(10,000)
Proceeds from sale of businesses	0	437,875
Change in restricted cash	17	(12)
Net cash (used in) provided by investing activities	(135,991)	428,034
Cash flows from financing activities:
Proceeds from issuances of common stock, net	35,859	16,911
Milestone payments	(9,565)	(6,522)
Proceeds from the issuance of convertible senior notes	0	402,500
Repayments of convertible senior notes	(54,997)	(323,225)
Purchase of capped call transactions related to convertible senior notes	0	(33,931)
Proceeds from settlement of bond hedges related to convertible senior notes	0	100,459
Settlement of warrants	0	(87,874)
Debt and equity issuance costs	0	(11,725)
Purchase of shares of non-controlling interest	(167)	0
Net cash (used in) provided by financing activities	(28,870)	56,593
Effect of exchange rate changes on cash	800	(1,275)
(Decrease) increase in cash and cash equivalents	(339,413)	271,023
Cash and cash equivalents at beginning of period	541,835	373,173
Cash and cash equivalents at end of period	202,422	644,196
Supplemental disclosure of cash flow information:
Interest paid	11,988	6,891
Taxes paid	0	27
Non-cash investing and financing activities
Issuance of common stock upon conversion of convertible notes	32,018	0
Receipt of common stock upon settlement of 2017 Note hedge	$ 40,015	$ 0