Intangible Assets and Goodwill - Additional Information (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016	Dec. 31, 2016
Goodwill and Intangible Assets Disclosure [Abstract]
Amortization of intangible assets	$ 2,000,000	$ 6,600,000	$ 8,500,000	$ 12,900,000
Future amortization expense, remainder of fiscal year	4,000,000		4,000,000
Future amortization expense, 2018	7,900,000		7,900,000
Future amortization expense, 2019	7,900,000		7,900,000
Future amortization expense, 2020	7,900,000		7,900,000
Future amortization expense, 2021	7,900,000		7,900,000
Future amortization expense, 2022	7,900,000		7,900,000
Future amortization expense, thereafter	56,800,000		56,800,000
Finite-Lived Intangible Assets [Line Items]
Finite-lived intangible assets, net	100,451,000		100,451,000		$ 361,601,000
Indefinite-lived intangible assets	188,620,000		188,620,000		253,620,000
Increase (decrease) in carrying amount of goodwill			0
In-process research & development
Finite-Lived Intangible Assets [Line Items]
Indefinite-lived intangible assets	188,620,000		188,620,000		253,620,000
Product licenses, net
Finite-Lived Intangible Assets [Line Items]
Finite-lived intangible assets, net	0		0		26,987,000
Developed product rights, net
Finite-Lived Intangible Assets [Line Items]
Finite-lived intangible assets, net	100,451,000		100,451,000		$ 334,614,000
Not discontinued operations, discontinuation and market withdrawal | Ionsys | Product licenses, net
Finite-Lived Intangible Assets [Line Items]
Impairment of finite-lived intangible assets	226,500,000
Not discontinued operations, discontinuation and market withdrawal | Ionsys | Developed product rights, net
Finite-Lived Intangible Assets [Line Items]
Impairment of finite-lived intangible assets	26,200,000
Finite-lived intangible assets, net	0		0
Not discontinued operations, discontinuation and market withdrawal | MDCO-700
Finite-Lived Intangible Assets [Line Items]
Impairment of indefinite-lived intangible assets	65,000,000
Not discontinued operations, discontinuation and market withdrawal | MDCO-700 | In-process research & development
Finite-Lived Intangible Assets [Line Items]
Impairment of indefinite-lived intangible assets			65,000,000
Indefinite-lived intangible assets	0		0
Not discontinued operations, discontinuation and market withdrawal | MDCO-700 | Product licenses, net
Finite-Lived Intangible Assets [Line Items]
Finite-lived intangible assets, net	$ 0		$ 0