Income Taxes	6 Months Ended
Jun. 30, 2017
Income Tax Disclosure [Abstract]
Income Taxes	Income Taxes For the three months ended June 30, 2017, the Company recorded a benefit for income taxes of $23.0 million for income taxes based upon its estimated federal, state and foreign (loss)/income for the year. For the three months ended June 30, 2016, the Company recorded a provision for income taxes of $0.01 million for income taxes based upon its estimated federal, state and foreign (loss)/income for the year. The worldwide effective income tax rates for the Company for the three months ended June 30, 2017 and 2016 was 5.5% and 0.01%, respectively. For the six months ended June 30, 2017, the Company recorded a benefit for income taxes of $23.0 million for income taxes based upon its estimated federal, state and foreign (loss)/income for the year. For the six months ended June 30, 2016, the Company recorded a provision for income taxes of $0.1 million for income taxes based upon its estimated federal, state and foreign (loss)/income for the year. The worldwide effective income tax rates for the Company for the six months ended June 30, 2017 and 2016 was 4.4% and 0.1%, respectively. For the three and six months ended June 30, 2017, the Company’s benefit for income taxes is the result of the Company’s impairment of its investment in MDCO-700, which was a discrete item of $23.0 million, partially offset by a provision for state tax minimums and estimated taxes due by profitable foreign subsidiaries. See Note 9, “Intangible Assets and Goodwill,” for further details of this impairment. The Company considers all available evidence, both positive and negative, to determine whether, based on the weight of that evidence, a valuation allowance is needed to reduce its deferred tax assets to the amount that is more likely than not to be realized. The Company placed significant weight on the fact that the Company expects to be in a cumulative net book loss for the three-year period ending December 31, 2017 in recording valuation allowances on substantial portions of its deferred tax assets as of June 30, 2017. The Company will continue to evaluate its ability to realize its deferred tax assets on a periodic basis and will adjust such amounts in light of changing facts and circumstances including, but not limited to, future projections of taxable income, tax legislation, rulings by relevant tax authorities, the progress of ongoing tax audits and the regulatory approval of products currently under development. Any additional changes to the valuation allowance recorded on deferred tax assets in the future would impact the Company’s income taxes.

Income Taxes

For the three months ended June 30, 2017, the Company recorded a benefit for income taxes of $23.0 million for income taxes based upon its estimated federal, state and foreign (loss)/income for the year. For the three months ended June 30, 2016, the Company recorded a provision for income taxes of $0.01 million for income taxes based upon its estimated federal, state and foreign (loss)/income for the year. The worldwide effective income tax rates for the Company for the three months ended June 30, 2017 and 2016 was 5.5% and 0.01%, respectively.

For the six months ended June 30, 2017, the Company recorded a benefit for income taxes of $23.0 million for income taxes based upon its estimated federal, state and foreign (loss)/income for the year. For the six months ended June 30, 2016, the Company recorded a provision for income taxes of $0.1 million for income taxes based upon its estimated federal, state and foreign (loss)/income for the year. The worldwide effective income tax rates for the Company for the six months ended June 30, 2017 and 2016 was 4.4% and 0.1%, respectively. For the three and six months ended June 30, 2017, the Company’s benefit for income taxes is the result of the Company’s impairment of its investment in MDCO-700, which was a discrete item of $23.0 million, partially offset by a provision for state tax minimums and estimated taxes due by profitable foreign subsidiaries. See Note 9, “Intangible Assets and Goodwill,” for further details of this impairment.

The Company considers all available evidence, both positive and negative, to determine whether, based on the weight of that evidence, a valuation allowance is needed to reduce its deferred tax assets to the amount that is more likely than not to be realized. The Company placed significant weight on the fact that the Company expects to be in a cumulative net book loss for the three-year period ending December 31, 2017 in recording valuation allowances on substantial portions of its deferred tax assets as of June 30, 2017.

The Company will continue to evaluate its ability to realize its deferred tax assets on a periodic basis and will adjust such amounts in light of changing facts and circumstances including, but not limited to, future projections of taxable income, tax legislation, rulings by relevant tax authorities, the progress of ongoing tax audits and the regulatory approval of products currently under development. Any additional changes to the valuation allowance recorded on deferred tax assets in the future would impact the Company’s income taxes.