Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Cash flows from operating activities:
Net loss	$ (102,670)	$ (92,464)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	8,030	7,343
Amortization of debt discount	6,973	6,300
Unrealized foreign currency transaction losses (gains), net	352	(573)
Stock compensation expense	6,643	6,940
Gain on sale of businesses	0	(1,004)
Deferred tax benefit	0	(867)
Changes in contingent consideration obligations	8,512	(1,372)
Changes in operating assets and liabilities:
Accounts receivable	(400)	9,580
Inventory, net	(790)	(2,347)
Prepaid expenses and other current assets	3,907	635
Accounts payable	(10,972)	(20,559)
Accrued expenses	(21,395)	(31,181)
Deferred revenue	(294)	1,993
Payments on contingent purchase price	(12,343)	0
Other liabilities	(5,155)	(804)
Net cash used in operating activities	(119,602)	(118,380)
Cash flows from investing activities:
Purchases of fixed assets	(1,333)	0
Proceeds from sale of businesses	0	174,068
Change in restricted cash	(2)	(13)
Net cash (used in) provided by investing activities	(1,335)	174,055
Cash flows from financing activities:
Proceeds from issuances of common stock, net	24,694	5,104
Milestone payments	(8,723)	(2,773)
Purchase of shares of non-controlling interest	(167)	0
Net cash provided by financing activities	15,804	2,331
Effect of exchange rate changes on cash	13	(983)
(Decrease) increase in cash and cash equivalents	(105,120)	57,023
Cash and cash equivalents at beginning of period	541,835	373,173
Cash and cash equivalents at end of period	436,715	430,196
Supplemental disclosure of cash flow information:
Interest paid	11,611	5,000
Taxes paid	$ 0	$ 24