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Fair Value Measurements - Level 3 Contingent Purchase Price (Details) - Fair Value, Measurements, Recurring [Member] - Level 3 [Member] - Contingent Purchase Price Liability [Member] - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]    
Balance at beginning of period $ 123,757 $ 351,134
Fair value of contingent purchase price with respect to Annovation as of February 2, 2015 0 18,000
Payments (10,449) (236,418)
Allocation to Hemostasis Business 0 (28,600)
Fair value adjustments to contingent purchase prices included in net loss 23,981 19,641
Balance at end of period $ 137,289 $ 123,757