Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Cash flows from operating activities:
Net loss	$ (119,172)	$ (352,746)	$ (32,348)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
Depreciation and amortization	31,042	34,837	34,398
Asset impairment charges	0	29,413	31,133
Impairment on divestiture	0	133,273	0
Amortization of debt discount	26,182	23,676	11,920
Unrealized foreign currency transaction gains, net	(941)	(173)	(833)
Stock compensation expense	30,987	30,605	34,311
Loss on disposal of fixed assets	521	543	35
Deferred tax benefit	(23)	(53,292)	(5,565)
Excess tax benefit from share-based compensation arrangements	0	0	(1,443)
Extinguishment of debt	5,380	0	0
Gain on sale of businesses	(289,305)	0	0
Gain on sale of investment	0	(19,773)	0
Gain on remeasurement of equity investment	0	(22,597)	0
Reserve for excess or obsolete inventory	8,533	42,599	0
Changes in contingent consideration obligations	23,981	20,278	20,823
Loss in equity investment	0	0	1,711
Changes in operating assets and liabilities:
Accounts receivable	30,144	103,100	(54,739)
Inventory, net	(15,653)	(69,318)	5,627
Prepaid expenses and other current assets	569	(5,286)	(3,559)
Accounts payable	(7,398)	16,362	(6,866)
Accrued expenses	(37,233)	(39,501)	24,058
Deferred revenue	1,568	8,386	5,257
Payments on contingent purchase price	(1,045)	(78,900)	0
Other liabilities	(11,446)	549	3,394
Net cash (used in) provided by operating activities	(323,309)	(197,965)	67,314
Cash flows from investing activities:
Proceeds from sale of fixed assets	0	250	0
Proceeds from sale of investment	0	19,773	0
Purchases of fixed assets	(2,176)	(2,555)	(7,289)
Payments for intangible assets	(10,000)	(112,617)	(15,000)
Other investments	0	0	(3,625)
Acquisition of business, net of cash acquired	0	(28,397)	(58,934)
Proceeds from sale of businesses	437,875	0	0
Change in restricted cash	(3,656)	35	92
Net cash provided by (used in) investing activities	422,043	(123,511)	(84,756)
Cash flows from financing activities:
Proceeds from issuances of common stock, net	33,776	95,198	17,343
Milestone payments	(9,404)	(157,601)	(9,953)
Proceeds from the issuance of convertible senior notes	402,500	400,000	0
Repayments of convertible senior notes	(323,225)	0	0
Purchase of capped call transactions related to convertible senior notes	(33,931)	0	0
Proceeds from settlement of bond hedges related to convertible senior notes	100,459	0	0
Settlement of warrants	(87,874)	0	0
Debt and equity issuance costs	(11,725)	(12,769)	0
Excess tax benefit from share-based compensation arrangements	0	0	1,443
Net cash provided by financing activities	70,576	324,828	8,833
Effect of exchange rate changes on cash	(648)	(920)	2,623
Increase (decrease) in cash and cash equivalents	168,662	2,432	(5,986)
Cash and cash equivalents at beginning of period	373,173	370,741	376,727
Cash and cash equivalents at end of period	541,835	373,173	370,741
Supplemental disclosure of cash flow information:
Interest paid	12,269	8,837	3,782
Taxes paid	$ 36	$ 114	$ 1,371