Exhibit

We consent to the incorporation by reference in this Registration Statement on Form S-8 pertaining to the 2010 Employee Stock Purchase Plan, as amended, and the 2013 Stock Incentive Plan, as amended, of The Medicines Company of our reports dated February 29, 2016, with respect to the consolidated financial statements and schedule of The Medicines Company and the effectiveness of internal control over financial reporting of The Medicines Company included in its Annual Report (Form 10-K) for the year ended December 31, 2015, filed with the Securities and Exchange Commission.