Acquisitions (Details) (USD $)	3 Months Ended		0 Months Ended
	Mar. 31, 2015	Mar. 31, 2014	Feb. 02, 2015	Dec. 31, 2014	Feb. 01, 2015
Business Acquisition [Line Items]
Gain on remeasurement of equity investment	$ 22,741,000	$ 0
Assets Acquired and Liabilities Assumed
Goodwill	314,070,000			286,532,000
Annovation [Member]
Business Acquisition [Line Items]
Payments to acquire businesses			28,397,000
Ownership interest					35.80%
Fair value of interest			25,886,000
Gain on remeasurement of equity investment			22,700,000
Total cash consideration and fair value of existing equity interest			54,283,000
Estimated fair value of contingent cash payment			18,000,000
Total preliminary estimated purchase price			72,283,000
Assets Acquired and Liabilities Assumed
Cash and cash equivalents			1,482,000
Other current assets			692,000
IPR&D			65,000,000
Goodwill			24,530,000
Total assets			91,704,000
Accrued expenses			398,000
Contingent purchase price			18,000,000
Deferred tax liability			19,023,000
Total liabilities			37,421,000
Total cash price paid upon acquisition and fair value of existing equity interest			54,283,000
Commercial Milestones [Member] | Annovation [Member]
Business Acquisition [Line Items]
Additional Milestone Payment			$ 26,300,000