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Segment and Geographic Information (Details) (USD $)
In Thousands, unless otherwise specified
3 Months Ended 6 Months Ended
Jun. 30, 2011
Jun. 30, 2010
Jun. 30, 2011
years
segment
productcandidate
product
workforcereduction
Jun. 30, 2010
Dec. 31, 2010
Revenues from External Customers and Long-Lived Assets [Line Items]          
Number of operating segment     1    
Net revenue $ 119,591 $ 110,135 $ 231,728 $ 212,223  
Long-lived assets 116,005   116,005   118,528
United States
         
Revenues from External Customers and Long-Lived Assets [Line Items]          
Net revenue 112,298 104,375 217,288 200,831  
Percentage of revenue by geographic segments 93.90% 94.80% 93.80% 94.60%  
Long-lived assets 114,675   114,675   117,095
Percentage of long-lived assets by geographic segments 98.90%   98.90%   98.80%
Europe [Member]
         
Revenues from External Customers and Long-Lived Assets [Line Items]          
Net revenue 6,494 4,727 12,369 9,595  
Percentage of revenue by geographic segments 5.40% 4.30% 5.30% 4.50%  
Long-lived assets 1,230   1,230   1,213
Percentage of long-lived assets by geographic segments 1.10%   1.10%   1.00%
Rest of world [Member]
         
Revenues from External Customers and Long-Lived Assets [Line Items]          
Net revenue 799 1,033 2,071 1,797  
Percentage of revenue by geographic segments 0.70% 0.90% 0.90% 0.90%  
Long-lived assets $ 100   $ 100   $ 220
Percentage of long-lived assets by geographic segments 0.10%   0.10%   0.20%