X0202 4 2006-08-15 0 0001113481 MEDICINES CO /DE MDCO 0001204787 MEANWELL CLIVE THE MEDICINES COMPANY 8 CAMPUS DRIVE PARSIPPANY NJ 07054 1 1 0 0 Chief Executive Officer Common Stock 2006-08-15 4 J 0 100000 D 226568 D On August 15, 2006 (the "Pricing Date"), Clive A. Meanwell settled his obligation to deliver shares of common stock of The Medicines Company (the "Company") under a prepaid variable forward sales contract (the "Contract") entered into with Bear Stearns Bank plc ("Bear") on June 13, 2003. Pursuant to the Contract, Dr. Meanwell received a cash payment in June 2003 of $1,618,091. In exchange for the cash payment, Dr. Meanwell pledged and agreed to deliver to Bear on the Pricing Date up to 100,000 shares of common stock of the Company. Under the Contract, the number of shares to be delivered by Dr. Meanwell at settlement was determined based on the arithmetic average of the closing offer price of the Company's common stock on the date one week prior to the Pricing Date and on the Pricing Date (the "Settlement Price"); if the Settlement Price was at or below $22.726 per share, Dr. Meanwell was obligated to deliver (continued in Footnote 2) (continued from Footnote 1 above) 100,000 shares to Bear. The Settlement Price was $20.795 per share. As a result, upon settlement, Dr. Meanwell transferred 100,000 shares to Bear. End of period holdings includes 100,923 shares subject to a prepaid variable forward sales contract, pursuant to which Dr. Meanwell pledged and agreed to deliver to Bear in February 2007 up to 100,923 shares of common stock of the Company. /s/ Clive A. Meanwell 2006-08-16