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   &lt;div align="left" style="font-size: 10pt; margin-top: 12pt"&gt;&lt;b&gt;1. Nature of Business&lt;/b&gt;
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   &lt;div align="left" style="font-size: 10pt; margin-top: 6pt"&gt;&amp;#160;&amp;#160;&amp;#160;&amp;#160;&amp;#160;The Medicines Company (the Company) is a global pharmaceutical company focused on advancing
   the treatment of intensive and critical care patients through the delivery of innovative,
   cost-effective medicines to the worldwide hospital marketplace. The Company has two marketed
   products, Angiomax&lt;sup style="font-size: 85%; vertical-align: text-top"&gt;&amp;#174;&lt;/sup&gt; (bivalirudin)&amp;#160;and Cleviprex&lt;sup style="font-size: 85%; vertical-align: text-top"&gt;&amp;#174;&lt;/sup&gt; (clevidipine butyrate) injectable emulsion, and a
   pipeline of critical care hospital products in development, including two late-stage development
   product candidates, cangrelor and oritavancin, two early stage development product candidates,
   MDCO-2010 (formerly known as CU2010) and MDCO-216 (formerly known as ApoA-I Milano), and marketing
   rights in the United States and Canada to a ready-to-use formulation of Argatroban for which a new
   drug application (NDA)&amp;#160;has been submitted to the U.S. Food and Drug Administration (FDA). The
   Company believes that Angiomax, Cleviprex and its products in development possess favorable
   attributes that competitive products do not provide, can satisfy unmet medical needs in the
   critical care hospital product market and offer, or, in the case of the Company&amp;#8217;s products in
   development, have the potential to offer, improved performance to patients and hospital businesses.
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 -Publisher AICPA
 -Name Statement of Position (SOP)
 -Number 94-6
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