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   &lt;div align="left" style="font-size: 10pt; margin-top: 12pt"&gt;&lt;b&gt;1. Nature of Business&lt;/b&gt;
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   &lt;div align="left" style="font-size: 10pt; margin-top: 6pt"&gt;&amp;#160;&amp;#160;&amp;#160;&amp;#160;&amp;#160;The Medicines Company (the Company) is a global pharmaceutical company focused on advancing
   the treatment of intensive and critical care patients through the delivery of innovative,
   cost-effective medicines to the worldwide hospital marketplace. The Company has two marketed
   products, Angiomax&lt;sup style="font-size: 85%; vertical-align: text-top"&gt;&amp;#174;&lt;/sup&gt; (bivalirudin)&amp;#160;and Cleviprex&lt;sup style="font-size: 85%; vertical-align: text-top"&gt;&amp;#174;&lt;/sup&gt;
   (clevidipine butyrate) injectable emulsion, and a pipeline of critical care hospital products in
   development, including two late-stage development product candidates, cangrelor and oritavancin,
   two early stage development product candidates, CU2010 (which the Company has re-designated
   MDCO-2010) and ApoA-I Milano (which the Company has re-designated MDCO-216), and marketing rights
   in the United States and Canada to a ready-to-use formulation of Argatroban for which a new drug
   application (NDA)&amp;#160;has been submitted to the U.S. Food and Drug Administration (FDA). The Company
   believes that Angiomax, Cleviprex and its products in development possess favorable attributes that
   competitive products do not provide, can satisfy unmet medical needs in the critical care hospital
   product market and offer, or, in the case of the Company&amp;#8217;s products in development, have the
   potential to offer, improved performance to patients and hospital businesses.
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 -Publisher AICPA
 -Name Statement of Position (SOP)
 -Number 94-6
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