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   &lt;div align="left" style="font-size: 10pt; margin-top: 6pt"&gt;&amp;#160;&amp;#160;&amp;#160;&amp;#160;&amp;#160;For the three months ended June&amp;#160;30, 2010 and 2009, the Company recorded a provision for income
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   the year. The Company&amp;#8217;s effective tax rate for the three months ended June&amp;#160;30, 2010 and 2009 was
   approximately 6% and 44%, respectively. For the six months ended June&amp;#160;30, 2010 and 2009, the
   Company recorded a provision for income taxes of $1.6&amp;#160;million and $0.5&amp;#160;million, respectively, based
   upon its estimated tax liability for the year. The Company&amp;#8217;s effective tax rate for the six months
   ended June&amp;#160;30, 2010 and 2009 was approximately 6% and 50%, respectively. The provision for income
   taxes is based on federal, state and foreign income taxes.
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   &lt;div align="left" style="font-size: 10pt; margin-top: 6pt"&gt;&amp;#160;&amp;#160;&amp;#160;&amp;#160;&amp;#160;In the fourth quarter of 2009, the Company established a full valuation allowance against its
   deferred tax assets. It continues to evaluate their future realizability on a periodic basis in
   light of changing facts and circumstances, including but not limited to projections of future
   taxable income, tax legislation, rulings by relevant tax authorities, the progress of ongoing tax
   audits, the regulatory approval of products currently under development, extension of the patent
   rights relating to Angiomax and the ability to achieve future anticipated revenues. If the Company
   reduces the valuation allowance on deferred tax assets in future periods, the Company would
   recognize an income tax benefit.
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      <ElementReferences>Reference 1: http://www.xbrl.org/2003/role/presentationRef
 -Publisher SEC
 -Name Regulation S-X (SX)
 -Number 210
 -Section 08
 -Paragraph h
 -Article 4

Reference 2: http://www.xbrl.org/2003/role/presentationRef
 -Publisher FASB
 -Name Statement of Financial Accounting Standard (FAS)
 -Number 109
 -Paragraph 136, 172

Reference 3: http://www.xbrl.org/2003/role/presentationRef
 -Publisher FASB
 -Name Statement of Financial Accounting Standard (FAS)
 -Number 109
 -Paragraph 43, 44, 45, 46, 47, 48, 49

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