<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-03-30</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001113148</issuerCik>
        <issuerName>INFINITY PHARMACEUTICALS, INC.</issuerName>
        <issuerTradingSymbol>INFI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001336503</rptOwnerCik>
            <rptOwnerName>KANGO SUJAY</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O INFINITY PHARMACEUTICALS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1100 MASSACHUSETTS AVENUE, 4TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02138</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>No securities of the issuer were beneficially owned by Mr. Kango prior to becoming a reporting person.
EXHIBIT LIST: EX-24 Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Seth A. Tasker, attorney-in-fact</signatureName>
        <signatureDate>2022-03-31</signatureDate>
    </ownerSignature>
</ownershipDocument>
