X0508 4 2023-09-08 0 0001113148 INFINITY PHARMACEUTICALS, INC. INFI 0001375124 Perkins Adelene Q C/O INFINITY PHARMACEUTICALS, INC. 1100 MASSACHUSETTS AVENUE, FLOOR 4 CAMBRIDGE MA 02138 1 0 0 0 1 Common Stock 2023-09-09 4 M 0 768133 A 1585487 D Common Stock 2023-09-12 4 S 0 410196 0.07 D 1175291 D Common Stock 16446.7945 I 401(K) Restricted Stock Unit 2023-09-09 4 M 0 768133 0.00 D Common Stock 768133 0 D Restricted stock units ("RSUs") convert into Common Stock of the issuer on a one-for-one basis. This transaction represents the settlement of RSUs in shares of Common Stock on their vesting date. Pursuant to a binding contract entered into between the issuer and the reporting person on August 15, 2022, this represents the shares automatically sold by the reporting person to satisfy tax withholding obligations in connection with the vesting of the RSUs listed in Table II. Such binding contract is intended to be consistent with the affirmative action defense to liability under Section 10(b) of the Securities Exchange Act of 1934 under Rule 10b5-1(c) promulgated under such Act. This sale does not represent a discretionary trade by the reporting person. On August 11, 2022, the reporting person was granted RSUs, of which all 768,133 vested as of September 9, 2023. /s/ Adelene Q. Perkins 2023-09-12