X0206 3 2019-10-16 0 0001113148 INFINITY PHARMACEUTICALS, INC. INFI 0001748961 Agresta Samuel C/O INFINITY PHARMACEUTICALS, INC. 1100 MASSACHUSETTS AVENUE CAMBRIDGE MA 02138 1 0 0 0 Common Stock 10593 D Stock Option (right to buy) 1.80 Common Stock 81250 D Stock Option (right to buy) 1.24 Common Stock 10433 D These 10,593 shares of common stock were acquired by Dr. Agresta on June 14, 2019 during his tenure as the Issuer's Chief Medical Officer and through participation in the issuer's Employee Stock Purchase Plan. This option became exercisable as to 12/48th of the 300,000 shares originally subject to the award on August 6, 2019 and as to 1/48th of such shares at the end of each calendar month thereafter until it ceased vesting upon Dr. Agresta's resignation as the Issuer's Chief Medical Officer on September 13, 2019. This option became exercisable as to 1/48th of the 62,596 shares originally subject to the award on January 31, 2019 and as to 1/48th of such shares at the end of each calendar month thereafter until it ceased vesting upon Dr. Agresta's resignation as the Issuer's Chief Medical Officer on September 13, 2019. Pursuant to a resolution approved by the Issuer's Board of Directors on October 16, 2019, the last date this option may be exercised is the earlier of August 6, 2022, or three months following cessation of Dr. Agresta's service as a member of the Board of Directors. /s/ Samuel Agresta 2019-10-16