X0306 4 2017-05-25 0 0001113148 INFINITY PHARMACEUTICALS, INC. INFI 0001197032 SMITH IAN F C/O INFINITY PHARMACEUTICALS, INC. 784 MEMORIAL DRIVE CAMBRIDGE MA 02139 1 0 0 0 Common Stock 2017-05-25 4 A 0 22988 1.74 A 22988 D Stock Option (right to buy) 1.74 2017-05-25 4 A 0 20000 0.00 A 2027-05-25 Common Stock 20000 20000 D Stock Option (right to buy) 1.74 2017-05-25 4 A 0 4000 0.00 A 2027-05-25 Common Stock 4000 4000 D Pursuant to the issuer's non-employee director compensation program, the reporting person has elected to receive this grant of shares in lieu of cash as payment of such person's $40,000 annual retainer for service as a director. The option vests over a period of one year in equal quarterly installments beginning at the end of the first quarter after the date of grant, provided that the holder continues to serve as a director of the issuer. The option vests over a period of one year in equal quarterly installments beginning at the end of the first quarter after the date of grant, provided that the holder continues to serve as Chair of the Audit Committee of the issuer's Board of Directors. /s/ Ian F. Smith 2017-05-25