X0306 4 2022-02-28 0001111711 NISOURCE INC. NI 0001646748 Sistovaris Violet NISOURCE INC. 801 E. 86TH AVENUE MERRILLVILLE IN 46410 1 EVP & Chief Experience Officer Common Stock 2022-02-28 4 A 0 16940 28.93 A 172549 D Common Stock 2022-02-28 4 F 0 4927 28.93 D 167622 D Common Stock 2022-02-28 4 F 0 2243 28.93 D 165379 D Common Stock 22668.3192 I 401(k) Vesting of non-derivative performance stock units granted in 2019, which are exempt from liability under Section 16(b) of the Securities Exchange Act pursuant to rule 16b-3(d). Number of shares reported represent shares withheld to satisfy tax withholding obligations in connection with the vesting of the performance stock units above. Number of shares reported represent shares withheld to satisfy tax withholding obligations in connection with the vesting of the 2019 Restricted Stock Unit awards. Constitutes shares acquired through the NiSource Retirement Savings Plan through February 28, 2022. /s/ Kimberly V. Loies, Attorney-in-Fact 2022-03-01