EXHIBIT 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in the Registration Statements on Form S-3 (file Nos. 333-66460 and 333-82762) and Form S-8 (Nos. 333-41374, 333-49978 and 333-102741) of Network Engines, Inc. of our reports dated December 14, 2005, relating to the consolidated financial statements, financial statement schedule, management’s assessment of the effectiveness of internal control over financial reporting and the effectiveness of internal control over financial reporting which appears in this Form 10-K.

/s/ PricewaterhouseCoopers LLP

Boston, Massachusetts

December 14, 2005