144 0001575229 XXXXXXXX LIVE 0001110803 ILLUMINA INC 001-35406 5200 Illumina Way San Diego CA 92122 8582024500 CHARLES E. DADSWELL TRUST U/A/D 02/12/2021 Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

4948 720131.92 159300000 10/14/2024 NASDAQ Common 08/01/2022 Employee Stock Purchase Plan Issuer N 53 08/01/2022 Cash Common 11/05/2021 Restricted Stock Units Issuer N 4895 11/05/2021 N/A N 10b5-1 Sales for CHARLES E DADSWELL TTEECHARLES DADSWELL TRUST U/A DTD02/12/2021

5200 Illumina Way San Diego CA 92122

Common 09/13/2024 989 125553.55 10b5-1 Sales for CHARLES E DADSWELL TTEECHARLES DADSWELL TRUST U/A DTD02/12/2021

5200 Illumina Way San Diego CA 92122

Common 08/15/2024 989 122200.84 Sales that were executed on October 14, 2024 are being reported on this Form 144 filed on October 15, 2024 given the EDGAR system was not accepting filings on October 14, 2024 in observance of the federal holiday. The securities to be sold were acquired upon the vesting of restricted stock units and performance stock units during the period of 11/05/2021 through 11/05/2023. 10/14/2024 05/16/2024 /s/ Charles E. Dadswell