REVENUE - Disaggregation of Revenue (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 29, 2025	Jun. 30, 2024	Jun. 29, 2025	Jun. 30, 2024
Disaggregation of Revenue [Line Items]
Total revenue	$ 1,059	$ 1,112	$ 2,100	$ 2,188
Americas
Disaggregation of Revenue [Line Items]
Total revenue	586	640	1,156	1,243
Europe
Disaggregation of Revenue [Line Items]
Total revenue	310	289	603	568
Greater China
Disaggregation of Revenue [Line Items]
Total revenue	63	75	135	153
Asia-Pacific, Middle East, and Africa
Disaggregation of Revenue [Line Items]
Total revenue	100	108	206	224
Total product revenue
Disaggregation of Revenue [Line Items]
Total revenue	912	927	1,793	1,803
Consumables
Disaggregation of Revenue [Line Items]
Total revenue	811	807	1,580	1,569
Instruments
Disaggregation of Revenue [Line Items]
Total revenue	101	120	213	234
Service and other revenue
Disaggregation of Revenue [Line Items]
Total revenue	147	185	307	385
Sequencing
Disaggregation of Revenue [Line Items]
Total revenue	972	1,016	1,918	1,995
Sequencing | Total product revenue
Disaggregation of Revenue [Line Items]
Total revenue	836	845	1,641	1,646
Sequencing | Consumables
Disaggregation of Revenue [Line Items]
Total revenue	740	729	1,437	1,420
Sequencing | Instruments
Disaggregation of Revenue [Line Items]
Total revenue	96	116	204	226
Sequencing | Service and other revenue
Disaggregation of Revenue [Line Items]
Total revenue	136	171	277	349
Microarray
Disaggregation of Revenue [Line Items]
Total revenue	87	96	182	193
Microarray | Total product revenue
Disaggregation of Revenue [Line Items]
Total revenue	76	82	152	157
Microarray | Consumables
Disaggregation of Revenue [Line Items]
Total revenue	71	78	143	149
Microarray | Instruments
Disaggregation of Revenue [Line Items]
Total revenue	5	4	9	8
Microarray | Service and other revenue
Disaggregation of Revenue [Line Items]
Total revenue	$ 11	$ 14	$ 30	$ 36