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SEGMENT INFORMATION (Tables)
 6 Months Ended
Jun. 29, 2025
Segment Reporting [Abstract]  
Schedule of Operating Performance and Assets by Segment
The following tables present selected financial information with respect to segments for the periods presented:
In millionsQ2 2025Q2 2024YTD 2025YTD 2024
Core Illumina:
Revenue (1)
$1,059 $1,092 $2,100 $2,148 
Less:
Cost of revenue364 349 722 712 
Research and development247 241 499 479 
Selling and marketing146 165 311 318 
General and administrative88 (105)190 78 
Goodwill and intangible impairment
— — — 3 
Core Illumina income from operations214 442 378 558 
GRAIL:
Revenue
— 29 — 55 
Total operating expenses (2)
— 2,107 — 2,360 
Consolidated other income (expense), net
92 (339)110 (337)
Consolidated provision for income taxes
71 12 122 28 
Intersegment eliminations
— (1)— (2)
Consolidated net income (loss)
$235 $(1,988)$366 $(2,114)
_____________
(1)Core Illumina revenue included intercompany revenue of $9 million and $15 million in Q2 2024 and YTD 2024.
(2)GRAIL operating expenses are inclusive of cost of revenue, research and development, selling and marketing, general and administrative, and goodwill and intangible impairment for the comparative period prior to the Spin-Off on June 24, 2024.
 In millionsQ2 2025Q2 2024YTD 2025YTD 2024
Depreciation and amortization:
Core Illumina$68 $69 $137 $137 
GRAIL— 36 — 76 
Consolidated depreciation and amortization$68 $105 $137 $213