10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

☑ Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

For the Quarterly Period Ended October 1, 2023

☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

For the transition period from             to            

Commission File Number 001-35406 

Illumina, Inc.

(Exact name of registrant as specified in its charter)

Delaware	33-0804655
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)

5200 Illumina Way, San Diego, CA 92122

(Address of principal executive offices) (Zip code)

(858) 202-4500

(Registrant’s telephone number, including area code)

N/A

(Former name, former address and former fiscal year, if changed since last report)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common Stock, $0.01 par value	ILMN	The Nasdaq Stock Market LLC

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes   ☑    No   ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).    Yes   ☑    No  ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer þ Accelerated filer ☐ Non-accelerated filer ☐ Smaller reporting company ☐ Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13a of the Exchange Act. ☐    

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).     Yes  ☐    No   þ

As of November 6, 2023, there were 158.8 million shares of the registrant’s common stock outstanding.

ILLUMINA, INC.

FORM 10-Q

FOR THE FISCAL QUARTER ENDED OCTOBER 1, 2023

TABLE OF CONTENTS

See “Form 10-Q Cross-Reference Index” within Other Key Information for a cross-reference to the parts and items requirements of the Securities and Exchange Commission Quarterly Report on Form 10-Q.

CONDENSED CONSOLIDATED FINANCIAL STATEMENTS	PAGE
Condensed Consolidated Balance Sheets	6
Condensed Consolidated Statements of Operations	7
Condensed Consolidated Statements of Comprehensive Loss	8
Condensed Consolidated Statements of Stockholders’ Equity	9
Condensed Consolidated Statements of Cash Flows	11
Notes to Condensed Consolidated Financial Statements	12
1. Organization and Significant Accounting Policies	12
2. Revenue	13
3. Investments and Fair Value Measurements	14
4. Debt	17
5. Stockholders’ Equity	19
6. Supplemental Balance Sheet Details	22
7. Legal Proceedings	25
8. Income Taxes	27
9. Segment Information	28
MANAGEMENT’S DISCUSSION & ANALYSIS
Management’s Overview and Outlook	29
Results of Operations	31
Liquidity and Capital Resources	36
Critical Accounting Policies and Estimates	38
Recent Accounting Pronouncements	39
Quantitative and Qualitative Disclosures About Market Risk	39
OTHER KEY INFORMATION
Controls and Procedures	39
Legal Proceedings	39
Risk Factors	39
Share Repurchases and Sales	42
Adoptions, Modifications or Terminations of Trading Plans	42
Exhibits	43
Form 10-Q Cross-Reference Index	44

2

Consideration Regarding Forward-Looking Statements

This Quarterly Report on Form 10-Q contains, and our officers and representatives may from time to time make, “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Words such as: “anticipate,” “intend,” “plan,” “goal,” “seek,” “believe,” “continue,” “project,” “estimate,” “expect,” “strategy,” “future,” “likely,” “may,” “potential,” “predict,” “should,” “will,” or similar words or phrases, or the negatives of these words, may identify forward-looking statements, but the absence of these words does not necessarily mean that a statement is not forward looking. Examples of forward-looking statements include, among others, statements we make regarding:

•our expectations as to our future financial performance, results of operations, or other operational results or metrics;

•the benefits that we expect will result from our business activities and certain transactions we have completed, or may complete, such as product introductions, increased revenue, decreased expenses, and avoided expenses and expenditures;

•our expectations of the effect on our financial condition of claims, litigation, contingent liabilities, and governmental investigations, proceedings, and regulations;

•our strategies or expectations for product development, market position, financial results, and reserves;

•our ability to successfully implement cost reduction plans in a timely manner and the possibility that costs associated with our cost reduction plans are greater than we anticipate;

•our expectations regarding the outcome of the legal and regulatory proceedings, including appeals, related to our acquisition of GRAIL, Inc. (GRAIL) and other actions that may be taken or pursued by the European Commission, the U.S. Federal Trade Commission (FTC) and/or other governmental or regulatory authorities in connection with such acquisition;

•the transitional measures imposed by the European Commission, the duration and impact of such measures on Illumina and GRAIL, and the appointment of a monitoring trustee to monitor our compliance with such measures;

•the prohibition decision adopted by the European Commission on September 6, 2022 (the Prohibition Decision), informing us of its decision to prohibit our acquisition of GRAIL, and the decision adopted by the European Commission on October 12, 2023 requiring us to (among other things) divest GRAIL and imposing transitional measures (the EC Divestment Decision);

•the opinion and order issued by the FTC on March 31, 2023 (the FTC Order), requiring us to divest GRAIL and to hold GRAIL separate through the completion of the divestiture;

•the Article 14(2)(b) fine imposed by the European Commission on July 12, 2023; and

•other expectations, beliefs, plans, strategies, anticipated developments, and other matters that are not historical facts.

Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations, and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy, and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks, and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following:

•our expectations and beliefs regarding prospects and growth for our business and the markets in which we operate;

•the timing and mix of customer orders among our products and services;

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•challenges inherent in developing, manufacturing, and launching new products and services, including expanding manufacturing operations and reliance on third-party suppliers for critical components;

•the impact of recently launched or pre-announced products and services on existing products and services;

•risks and uncertainties regarding the legal and regulatory proceedings, including the failure to obtain or delays in obtaining the required regulatory approvals or clearances including for any potential divestiture of GRAIL, any appeals relating to our acquisition of GRAIL and our ability to achieve the expected benefits of such acquisition and other actions that have been or may be taken or pursued by the European Commission, the FTC and/or other governmental or regulatory authorities in connection with such acquisition;

•the transitional measures and hold separate requirements imposed by the European Commission, the duration and impact of these requirements on Illumina and GRAIL (which may include material and adverse effects on benefits we expect to achieve as a result of the acquisition of GRAIL, additional costs or liabilities, loss of revenue and other adverse effects on our business, financial condition and results of operations) and the administration of these requirements by an appointed monitoring trustee;

•our compliance with burdensome transitional measures imposed by the European Commission and the risk that the European Commission could impose or seek to impose additional fines and other penalties for alleged noncompliance with these requirements;

•the EC Divestment Decision and the FTC Order, which may each adversely affect us and our business, including current plans and operations, financial condition and results of operations, each requiring us to divest GRAIL and to hold GRAIL separate through the completion of the divestiture, the terms and conditions thereof (including with respect to a divestiture of GRAIL), and the timing of and the risks, costs and business disruptions (including the diversion of management’s attention) associated with such divestiture and/or any related appeals, the implementation thereof or any associated legal or regulatory proceedings or obligations, including any related appeals, and other uncertainties related to our compliance (or ability to comply) with each of the EC Divestment Decision and the FTC Order, which may adversely affect us and our business, including current plans and operations, financial condition and results of operations;

•risks associated with contracts or other agreements containing provisions that might be implicated by any divestiture of GRAIL or the EC Divestment Decision, including our ability to fully realize the anticipated economic benefits of our commercial arrangements with GRAIL and our obligations with respect to contingent value rights (the CVRs) issued by us in connection with the GRAIL acquisition and the risk that we will be unable to fully discharge such obligations in connection with a divestiture of GRAIL, that a divestiture will result in a change in obligor on the CVRs and/or of other consequences related thereto, which may adversely affect us and our business and/or the market value of the CVRs;

•the risk of adverse effects resulting from additional potential litigation associated with the acquisition of GRAIL, such as additional legal, financial advisory, regulatory and other professional services fees;

•the risk of additional litigation arising against us in connection with the GRAIL acquisition;

•the assumptions underlying our critical accounting policies and estimates;

•our assessments and estimates that determine our effective tax rate;

•our assessments and beliefs regarding the outcome of pending legal proceedings and any liability that we may incur as a result of those proceedings as well as the cost and potential diversion of management resources associated with these proceedings;

•uncertainty, or adverse economic and business conditions, including as a result of slowing or uncertain economic growth, COVID-19 pandemic mitigation measures, or armed conflict; and

•other factors detailed in our filings with the Securities and Exchange Commission (SEC), including the risks, uncertainties, and assumptions described in “Risk Factors” within the Business & Market Information section of our Annual Report on Form 10-K for the fiscal year ended January 1, 2023, the “Other Key Information” section of our Quarterly Report on Form 10-Q for the period ended April 2, 2023

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and on Form 10-Q for the period ended July 2, 2023, the “Risk Factors” section below, or in information disclosed in public conference calls, the date and time of which are released beforehand.

Any forward-looking statement made by us in this Quarterly Report on Form 10-Q is based only on information currently available to us and speaks only as of the date on which it is made. We undertake no obligation, and do not intend, to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, or to review or confirm analysts’ expectations, or to provide interim reports or updates on the progress of any current financial quarter, in each case whether as a result of new information, future developments, or otherwise.

5

CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

ILLUMINA, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(In millions)

	October 1, 2023		January 1, 2023
	(Unaudited)
ASSETS
Current assets:
Cash and cash equivalents	$	927	$	2,011
Short-term investments	6		26
Accounts receivable, net	690		671
Inventory, net	615		568
Prepaid expenses and other current assets	268		285
Total current assets	2,506		3,561
Property and equipment, net	1,040		1,091
Operating lease right-of-use assets	581		653
Goodwill	2,527		3,239
Intangible assets, net	3,029		3,285
Other assets	439		423
Total assets	$	10,122	$	12,252
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable	$	240	$	293
Accrued liabilities	1,242		1,232
Term notes, current portion	—		500
Convertible senior notes, current portion	—		748
Total current liabilities	1,482		2,773
Operating lease liabilities	698		744
Term notes	1,489		1,487
Other long-term liabilities	555		649
Stockholders’ equity:
Common stock	2		2
Additional paid-in capital	9,487		9,207
Accumulated other comprehensive income	21		3
Retained earnings	157		1,142
Treasury stock, at cost	(3,769)		(3,755)
Total stockholders’ equity	5,898		6,599
Total liabilities and stockholders’ equity	$	10,122	$	12,252

See accompanying notes to condensed consolidated financial statements.

6

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(Unaudited)

(In millions, except per share amounts)

 

	Three Months Ended				Nine Months Ended
	October 1, 2023		October 2, 2022		October 1, 2023		October 2, 2022
Revenue:
Product revenue	$	941	$	963	$	2,864	$	3,039
Service and other revenue	178		152		518		462
Total revenue	1,119		1,115		3,382		3,501
Cost of revenue:
Cost of product revenue	293		280		884		866
Cost of service and other revenue	95		72		285		210
Amortization of acquired intangible assets	47		46		143		125
Total cost of revenue	435		398		1,312		1,201
Gross profit	684		717		2,070		2,300
Operating expense:
Research and development	315		325		1,013		975
Selling, general and administrative	303		146		1,127		865
Goodwill and intangible impairment	821		3,914		821		3,914
Legal contingency and settlement	(1)		(11)		14		598
Total operating expense	1,438		4,374		2,975		6,352
Loss from operations	(754)		(3,657)		(905)		(4,052)
Other income (expense):
Interest income	13		3		47		4
Interest expense	(19)		(6)		(59)		(17)
Other expense, net	(22)		(12)		(33)		(103)
Total other expense, net	(28)		(15)		(45)		(116)
Loss before income taxes	(782)		(3,672)		(950)		(4,168)
(Benefit) provision for income taxes	(28)		144		36		97
Net loss	$	(754)	$	(3,816)	$	(986)	$	(4,265)
Loss per share:
Basic	$	(4.77)	$	(24.26)	$	(6.23)	$	(27.13)
Diluted	$	(4.77)	$	(24.26)	$	(6.23)	$	(27.13)
Shares used in computing loss per share:
Basic	158		157		158		157
Diluted	158		157		158		157

See accompanying notes to condensed consolidated financial statements.

7

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS

(Unaudited)

(In millions)

 

	Three Months Ended				Nine Months Ended
	October 1, 2023		October 2, 2022		October 1, 2023		October 2, 2022
Net loss	$	(754)	$	(3,816)	$	(986)	$	(4,265)
Unrealized gain on cash flow hedges, net of deferred tax	9		9		18		22
Total comprehensive loss	$	(745)	$	(3,807)	$	(968)	$	(4,243)

See accompanying notes to condensed consolidated financial statements.

8

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

(Unaudited)

(In millions)

				Additional		Accumulated Other							Total
	Common Stock			Paid-In		Comprehensive		Retained		Treasury Stock			Stockholders’
	Shares	Amount		Capital		Income		Earnings		Shares	Amount		Equity
Balance as of January 2, 2022	197	$	2	$	8,938	$	17	$	5,485	(40)	$	(3,702)	$	10,740
Net income	—	—		—		—		86		—	—		86
Unrealized gain on cash flow hedges, net of deferred tax	—	—		—		1		—		—	—		1
Issuance of common stock, net of repurchases	—	—		33		—		—		—	(12)		21
Share-based compensation	—	—		79		—		—		—	—		79
Cumulative-effect adjustment from adoption of ASU 2020-06, net of deferred tax	—	—		(93)		—		61		—	—		(32)
Balance as of April 3, 2022	197	2		8,957		18		5,632		(40)	(3,714)		10,895
Net loss	—	—		—		—		(535)		—	—		(535)
Unrealized gain on cash flow hedges, net of deferred tax	—	—		—		12		—		—	—		12
Issuance of common stock, net of repurchases	—	—		—		—		—		—	(4)		(4)
Share-based compensation	—	—		76		—		—		—	—		76
Balance as of July 3, 2022	197	2		9,033		30		5,097		(40)	(3,718)		10,444
Net loss	—	—		—		—		(3,816)		—	—		(3,816)
Unrealized gain on cash flow hedges, net of deferred tax	—	—		—		9		—		—	—		9
Issuance of common stock, net of repurchases	—	—		30		—		—		—	(2)		28
Share-based compensation	—	—		66		—		—		—	—		66
Balance as of October 2, 2022	197	2		9,129		39		1,281		(40)	(3,720)		6,731
Net loss	—	—		—		—		(139)		—	—		(139)
Unrealized loss on cash flow hedges, net of deferred tax	—	—		—		(36)		—		—	—		(36)
Issuance of common stock, net of repurchases	1	—		—		—		—		—	(35)		(35)
Share-based compensation	—	—		78		—		—		—	—		78
Balance as of January 1, 2023	198	$	2	$	9,207	$	3	$	1,142	(40)	$	(3,755)	$	6,599

See accompanying notes to condensed consolidated financial statements.

9

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

(Unaudited)

(In millions)

				Additional		Accumulated Other							Total
	Common Stock			Paid-In		Comprehensive		Retained		Treasury Stock			Stockholders’
	Shares	Amount		Capital		Income (Loss)		Earnings		Shares	Amount		Equity
Balance as of January 1, 2023	198	$	2	$	9,207	$	3	$	1,142	(40)	$	(3,755)	$	6,599
Net income	—	—		—		—		3		—	—		3
Unrealized loss on cash flow hedges, net of deferred tax	—	—		—		(4)		—		—	—		(4)
Issuance of common stock, net of repurchases	—	—		37		—		—		—	(9)		28
Share-based compensation	—	—		67		—		—		—	—		67
Balance as of April 2, 2023	198	2		9,311		(1)		1,145		(40)	(3,764)		6,693
Net loss	—	—		—		—		(234)		—	—		(234)
Unrealized gain on cash flow hedges, net of deferred tax	—	—		—		13		—		—	—		13
Issuance of common stock, net of repurchases	—	—		—		—		—		—	(3)		(3)
Share-based compensation	—	—		77		—		—		—	—		77
Reclassification of liability-classified awards	—	—		9		—		—		—	—		9
Balance as of July 2, 2023	198	2		9,397		12		911		(40)	(3,767)		6,555
Net loss	—	—		—		—		(754)		—	—		(754)
Unrealized gain on cash flow hedges, net of deferred tax	—	—		—		9		—		—	—		9
Issuance of common stock, net of repurchases	—	—		30		—		—		—	(2)		28
Share-based compensation	—	—		60		—		—		—	—		60
Balance as of October 1, 2023	198	$	2	$	9,487	$	21	$	157	(40)	$	(3,769)	$	5,898

See accompanying notes to condensed consolidated financial statements.

10

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

(In millions)

	Nine Months Ended
	October 1, 2023		October 2, 2022
Cash flows from operating activities:
Net loss	$	(986)	$	(4,265)
Adjustments to reconcile net loss to net cash provided by operating activities:
Depreciation expense	175		158
Amortization of intangible assets	148		130
Share-based compensation expense	286		266
Deferred income taxes	(42)		(40)
Goodwill and intangible (IPR&D) impairment	821		3,914
Property and equipment and right-of-use asset impairment	56		—
Net losses on strategic investments	39		79
(Gain) loss on Helix contingent value right	(8)		8
Payment of accreted debt discount	(15)		—
Change in fair value of contingent consideration liabilities	(82)		(230)
Unrealized loss on foreign exchange translation	21		1
Other	9		6
Changes in operating assets and liabilities:
Accounts receivable	(31)		13
Inventory	(47)		(127)
Prepaid expenses and other current assets	(3)		10
Operating lease right-of-use assets and liabilities, net	(13)		(10)
Other assets	6		17
Accounts payable	(50)		(51)
Accrued liabilities	(25)		388
Other long-term liabilities	(5)		(22)
Net cash provided by operating activities	254		245
Cash flows from investing activities:
Purchases of property and equipment	(144)		(198)
Purchases of strategic investments	(19)		(26)
Sales of strategic investments	18		—
Net cash paid for acquisitions	—		(85)
Cash paid for intangible asset	(1)		(180)
Net cash used in investing activities	(146)		(489)
Cash flows from financing activities:
Debt issuance costs paid for credit facility	(1)		—
Payments on financing obligations	(1,235)		—
Taxes paid related to net share settlement of equity awards	(14)		(19)
Proceeds from issuance of common stock	67		63
Net cash (used in) provided by financing activities	(1,183)		44
Effect of exchange rate changes on cash and cash equivalents	(9)		(32)
Net decrease in cash and cash equivalents	(1,084)		(232)
Cash and cash equivalents at beginning of period	2,011		1,232
Cash and cash equivalents at end of period	$	927	$	1,000

    

See accompanying notes to condensed consolidated financial statements.

11

ILLUMINA, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(UNAUDITED)

Unless the context requires otherwise, references in this report to “Illumina,” the “Company,” “we,” “us,” and “our” refer to Illumina, Inc. and its consolidated subsidiaries.

1. ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES

Business Overview

We are a provider of sequencing- and array-based solutions, serving customers in the research, clinical and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture and other emerging segments. Our customers include leading genomic research centers, academic institutions, government laboratories, and hospitals, as well as pharmaceutical, biotechnology, commercial molecular diagnostic laboratories, and consumer genomics companies.

On August 18, 2021, we acquired GRAIL, a healthcare company focused on early detection of multiple cancers. The acquisition is subject to ongoing legal proceedings and, currently, GRAIL must be held and operated separately and independently from Illumina pursuant to the transitional measures ordered by the European Commission in the EC Divestment Decision, following the prohibition of our acquisition of GRAIL on September 6, 2022. Refer to note “7. Legal Proceedings” for additional details. GRAIL is a separate reportable segment.

With respect to GRAIL, we have retained advisors and are preparing for sale and capital markets transaction options in accordance with the European Commission’s divestiture order. In parallel, ongoing appeals preserve flexibility for any divestiture of GRAIL and future transactions.

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. Interim financial results are not necessarily indicative of results anticipated for the full year. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and footnotes included in the Annual Report on Form 10-K for the fiscal year ended January 1, 2023, from which the prior year balance sheet information herein was derived. The preparation of financial statements requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, and expense, and related disclosure of contingent assets and liabilities. Though the COVID-19 pandemic, the armed conflict between Russia and Ukraine, and macroeconomic factors such as inflation, exchange rates and concerns about an economic downturn present additional uncertainty, we continue to use the best information available to form our critical accounting estimates. Actual results could differ from those estimates.

The unaudited condensed consolidated financial statements include our accounts, our wholly-owned subsidiaries, and majority-owned or controlled companies. All intercompany transactions and balances have been eliminated in consolidation. Certain prior period amounts have been reclassified to conform to the current period presentation. In management’s opinion, the accompanying unaudited condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.

Fiscal Year

Our fiscal year is the 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. References to Q3 2023 and Q3 2022 refer to the three months ended October 1, 2023 and October 2, 2022, respectively, which were both 13 weeks, and references to year-to-date (YTD) 2023 and 2022 refer to the nine months ended October 1, 2023 and October 2, 2022, respectively, which were both 39 weeks.

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Significant Accounting Policies

During YTD 2023, there were no changes to our significant accounting policies as described in our Annual Report on Form 10-K for the fiscal year ended January 1, 2023, with the exception of the following for income taxes:

Historically, we calculated the provision/(benefit) for income taxes for interim periods utilizing an estimated annual effective tax rate applied to the income/(loss) for the reporting period, except in Q2 2023 when a year-to-date effective tax rate method was utilized. We determined the estimated annual effective tax rate method would provide a more reliable estimate of the provision for income taxes for Q3 2023 and YTD 2023 since minor changes in the estimated income/(loss) before income taxes would not result in significant changes in the estimated annual effective tax rate.

Loss per Share

Basic loss per share is computed based on the weighted average number of common shares outstanding during the period. Diluted loss per share is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period. In loss periods, basic and diluted loss per share are identical since the effect of potentially dilutive common shares is antidilutive and therefore excluded.

Potentially dilutive common shares consist of shares issuable under convertible senior notes and equity awards. We utilize the if-converted method to calculate the impact of convertible senior notes on diluted loss per share. Potentially dilutive common shares from equity awards are determined using the average share price for each period under the treasury stock method. In addition, proceeds from exercise of equity awards and the average amount of unrecognized compensation expense for equity awards are assumed to be used to repurchase shares.

The following table presents the weighted average shares used to calculate basic and diluted loss per share:

In millions	Q3 2023	Q3 2022	YTD 2023	YTD 2022
Weighted average shares used in calculating basic loss per share	158	157	158	157
Weighted average shares used in calculating diluted loss per share	158	157	158	157
Antidilutive shares:
Convertible senior notes	1	2	1	2
Equity awards	3	2	3	2
Potentially dilutive shares excluded from calculation due to antidilutive effect	4	4	4	4

2. REVENUE

Our revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instruments and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from genotyping and sequencing services, instrument service contracts, development and licensing agreements, and cancer detection testing services related to the GRAIL business.

Revenue by Source

	Q3 2023						Q3 2022
In millions	Sequencing		Microarray		Total		Sequencing		Microarray		Total
Consumables	$	689	$	71	$	760	$	720	$	76	$	796
Instruments	178		3		181		162		5		167
Total product revenue	867		74		941		882		81		963
Service and other revenue	162		16		178		133		19		152
Total revenue	$	1,029	$	90	$	1,119	$	1,015	$	100	$	1,115

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	YTD 2023						YTD 2022
In millions	Sequencing		Microarray		Total		Sequencing		Microarray		Total
Consumables	$	2,108	$	219	$	2,327	$	2,237	$	225	$	2,462
Instruments	524		13		537		563		14		577
Total product revenue	2,632		232		2,864		2,800		239		3,039
Service and other revenue	456		62		518		390		72		462
Total revenue	$	3,088	$	294	$	3,382	$	3,190	$	311	$	3,501

Revenue by Geographic Area

Based on region of destination (in millions)	Q3 2023		Q3 2022(1)		YTD 2023		YTD 2022(1)
Americas	$	663	$	597	$	1,920	$	1,885
Europe	260		259		825		819
Greater China(2)	98		133		302		378
Asia-Pacific, Middle East, and Africa(3)	98		126		335		419
Total revenue	$	1,119	$	1,115	$	3,382	$	3,501

_____________

(1)We implemented a new global commercial structure in Q1 2023 to improve operating efficiencies and better align with local markets. We integrated Asia-Pacific and Japan with emerging markets across the Middle East, Africa, Turkey, and Commonwealth of Independent States (CIS). Beginning in Q1 2023, and going forward, we will report regional results for the following regions: Americas, Europe, Greater China, and Asia-Pacific, Middle East and Africa (AMEA). Prior period amounts have been reclassified to conform to this new presentation.

(2)Region includes revenue from China, Taiwan, and Hong Kong.

(3)Region includes revenue from Russia and Turkey.

Performance Obligations

We regularly enter into contracts with multiple performance obligations. These contracts are believed to be firm as of the balance sheet date. However, we may allow customers to make product substitutions as we launch new products. The timing of shipments depends on several factors, including agreed upon shipping schedules, which may span multiple quarters. Most performance obligations are generally satisfied within a short time frame, approximately three to six months, after the contract execution date. As of October 1, 2023, the aggregate amount of the transaction price allocated to remaining performance obligations was $743 million, of which approximately 83% is expected to be converted to revenue in the next twelve months, approximately 10% in the following twelve months, and the remainder thereafter.

Contract Assets and Liabilities

Contract assets, which consist of revenue recognized and performance obligations satisfied or partially satisfied in advance of customer billing, were $19 million and $17 million as of October 1, 2023 and January 1, 2023, respectively, and were recorded in prepaid expenses and other current assets.

Contract liabilities, which consist of deferred revenue and customer deposits, as of October 1, 2023 and January 1, 2023 were $315 million and $308 million, respectively, of which the short-term portions of $242 million and $245 million, respectively, were recorded in accrued liabilities and the remaining long-term portions were recorded in other long-term liabilities. Revenue recorded in Q3 2023 and YTD 2023 included $43 million and $206 million, respectively, of previously deferred revenue that was included in contract liabilities as of January 1, 2023.

3. INVESTMENTS AND FAIR VALUE MEASUREMENTS

Strategic Investments

Marketable Equity Securities

Our short-term investments consist of marketable equity securities. As of October 1, 2023 and January 1, 2023, the fair value of our marketable equity securities totaled $6 million and $26 million, respectively.

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Gains and losses recognized in other expense, net on our marketable equity securities were as follows:

In millions	Q3 2023		Q3 2022		YTD 2023		YTD 2022
Net gains (losses) recognized during the period on marketable equity securities	$	—	$	3	$	(2)	$	(66)
Less: Net losses recognized during the period on marketable equity securities sold during the period	—		—		(2)		—
Net unrealized gains (losses) recognized during the period on marketable equity securities still held at the reporting date	$	—	$	3	$	—	$	(66)

Non-Marketable Equity Securities

As of October 1, 2023 and January 1, 2023, the aggregate carrying amounts of our non-marketable equity securities without readily determinable fair values, included in other assets, were $28 million.

Revenue recognized from transactions with our strategic investees was $2 million and $68 million for Q3 2023 and YTD 2023, respectively, and $27 million and $83 million for Q3 2022 and YTD 2022, respectively.

Venture Funds

We invest in two venture capital investment funds (the Funds) with capital commitments of $100 million, callable through April 2026, and up to $150 million, callable through July 2029, respectively, of which $5 million and up to $74 million, respectively, remained callable as of October 1, 2023. Our investments in the Funds are accounted for as equity-method investments. The aggregate carrying amounts of the Funds, included in other assets, were $165 million and $183 million as of October 1, 2023 and January 1, 2023, respectively. We recorded unrealized losses of $19 million and $33 million in Q3 2023 and YTD 2023, respectively, and unrealized losses of $5 million and $11 million in Q3 2022 and YTD 2022, respectively, in other expense, net.

Helix Contingent Value Right

In conjunction with the deconsolidation of Helix Holdings I, LLC (Helix) in April 2019, we received a contingent value right with a 7-year term that entitles us to consideration dependent upon the outcome of Helix’s future financing and/or liquidity events. Changes in the fair value of our contingent value right resulted in unrealized gains of $5 million

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and $8 million in Q3 2023 and YTD 2023, respectively, and unrealized losses of $5 million and $8 million in Q3 2022 and YTD 2022, respectively, which were included in other expense, net.

Fair Value Measurements

The following table presents the hierarchy for assets and liabilities measured at fair value on a recurring basis:

	October 1, 2023								January 1, 2023
In millions	Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Assets:
Money market funds (cash equivalents)	$	646	$	—	$	—	$	646	$	1,642	$	—	$	—	$	1,642
Marketable equity securities	6		—		—		6		26		—		—		26
Helix contingent value right	—		—		66		66		—		—		58		58
Deferred compensation plan assets	—		57		—		57		—		52		—		52
Total assets measured at fair value	$	652	$	57	$	66	$	775	$	1,668	$	52	$	58	$	1,778
Liabilities:
Contingent consideration liabilities	$	—	$	—	$	330	$	330	$	—	$	—	$	412	$	412
Deferred compensation plan liability	—		54		—		54		—		51		—		51
Total liabilities measured at fair value	$	—	$	54	$	330	$	384	$	—	$	51	$	412	$	463

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Our marketable equity securities are measured at fair value based on quoted trade prices in active markets. Our deferred compensation plan assets consist primarily of investments in life insurance contracts carried at cash surrender value, which reflects the net asset value of the underlying publicly traded mutual funds. We perform control procedures to corroborate the fair value of our holdings, including comparing valuations obtained from our investment service provider to valuations reported by our asset custodians, validating pricing sources and models, and reviewing key model inputs, if necessary. We elected the fair value option to measure the contingent value right received from Helix. The fair value of such contingent value right, included in other assets, is derived using a Monte Carlo simulation. Estimates and assumptions used in the Monte Carlo simulation include probabilities related to the timing and outcome of future financing and/or liquidity events, assumptions regarding collectibility and volatility, and an estimated equity value of Helix. These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value.

We reassess the fair value of contingent consideration related to acquisitions on a quarterly basis. Changes in the fair value of contingent consideration subsequent to the acquisition date are recognized in selling, general and administrative expense. The contingent value rights issued as part of the GRAIL acquisition entitle the holders to receive future cash payments on a quarterly basis (Covered Revenue Payments) representing a pro rata portion of certain GRAIL-related revenues (Covered Revenues) each year for a 12-year period. As defined in the Contingent Value Rights Agreement, this will reflect a 2.5% payment right to the first $1 billion of revenue each year for 12 years. Revenue above $1 billion each year will be subject to a 9% contingent payment right during this same period. Covered Revenues for Q4 2022, Q1 2023, and Q2 2023 were $65 million in aggregate and Covered Revenues for Q4 2021, Q1 2022, and Q2 2022 were $32 million in aggregate, driven primarily by sales of GRAIL’s Galleri test. Covered Revenue Payments relating to such periods were approximately $609,000 and $297,000 in YTD 2023 and YTD 2022, respectively. Pursuant to the Contingent Value Rights Agreement, a portion of the Covered Revenue Payments in YTD 2022 were applied to reimburse us for certain expenses. We use a Monte Carlo simulation to estimate the fair value of contingent consideration related to the GRAIL acquisition. Estimates and assumptions used in the Monte Carlo simulation include forecasted revenues for GRAIL, a revenue risk premium, a revenue volatility estimate, an operational leverage ratio and a counterparty credit spread. These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value. The fair value of our contingent consideration liability related to GRAIL was $330 million and $412 million as of October 1, 2023 and January 1, 2023, respectively, of which $329 million and $411 million, respectively, was included in other long-term liabilities, with the remaining balances included in accrued liabilities.

Changes in the estimated fair value of our contingent consideration liabilities during YTD 2023 were as follows:

In millions
Balance as of January 1, 2023	$	412
Change in estimated fair value	(82)
Balance as of October 1, 2023	$	330

4. DEBT

Summary of Term Debt Obligations

In millions	October 1, 2023		January 1, 2023
Principal amount of 2031 Term Notes outstanding	$	500	$	500
Principal amount of 2027 Term Notes outstanding	500		500
Principal amount of 2025 Term Notes outstanding	500		500
Principal amount of 2023 Term Notes outstanding	—		500
Unamortized discounts and debt issuance costs	(11)		(13)
Net carrying amount of term notes	1,489		1,987
Less: current portion	—		(500)
Term notes, non-current	$	1,489	$	1,487
Fair value of term notes outstanding (Level 2)	$	1,375	$	1,913

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Interest expense recognized on our term notes, which included amortization of debt discounts and issuance costs, was $18 million and $55 million in Q3 2023 and YTD 2023, respectively, and $4 million and $13 million in Q3 2022 and YTD 2022, respectively.

0.550% Term Notes due 2023 (2023 Term Notes) and 2.550% Term Notes due 2031 (2031 Term Notes)

In March 2021, we issued $500 million aggregate principal amount of 2023 Term Notes and $500 million aggregate principal amount of 2031 Term Notes. The 2023 Term Notes matured and were repaid in cash on March 23, 2023.

The 2031 Term Notes, which mature on March 23, 2031, accrue interest at a rate of 2.550% per annum, payable semi-annually on March 23 and September 23 of each year. We may redeem for cash all or any portion of the 2031 Term Notes, at our option, at any time prior to maturity. Prior to December 23, 2030, the 2031 Term Notes are redeemable at make-whole premium redemption prices as defined in the applicable forms of note. After December 23, 2030, the notes are redeemable at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid interest up to, but excluding, the redemption date.

5.800% Term Notes due 2025 (2025 Term Notes) and 5.750% Term Notes due 2027 (2027 Term Notes)

In December 2022, we issued $500 million aggregate principal amount of 2025 Term Notes and $500 million aggregate principal amount of 2027 Term Notes. The 2025 Term Notes, which mature on December 12, 2025, and the 2027 Term Notes, which mature on December 13, 2027, accrue interest at a rate of 5.800% and 5.750% per annum, respectively, payable semi-annually. Interest for the 2025 Term Notes is payable on June 12 and December 12 of each year, beginning on June 12, 2023. Interest for the 2027 Term Notes is payable on June 13 and December 13 of each year, beginning on June 13, 2023.

We may redeem for cash all or any portion of the 2025 or 2027 Term Notes, at our option, at any time prior to maturity. Prior to November 12, 2025 for the 2025 Term Notes and prior to November 13, 2027 for the 2027 Term Notes, the notes are redeemable at make-whole premium redemption prices as defined in the applicable forms of note. After November 12, 2025 for the 2025 Term Notes and after November 13, 2027 for the 2027 Term Notes, the notes are redeemable at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid interest up to, but excluding, the redemption date.

0% Convertible Senior Notes due 2023 (2023 Convertible Notes)

In August 2018, we issued $750 million aggregate principal amount of 2023 Convertible Notes. The notes were convertible into cash, shares of common stock, or a combination of cash and shares of common stock, at our election, based on conversion rates as defined in the indenture. The 2023 Convertible Notes matured on August 15, 2023, at which time the principal was repaid in cash. We did not issue any shares of common stock in connection with the 2023 Convertible Notes.

Credit Agreement

On January 4, 2023, we entered into a new credit agreement (the Credit Agreement), which provides us with a $750 million senior unsecured five-year revolving credit facility, including a $40 million sublimit for swingline borrowings and a $50 million sublimit for letters of credit (the Credit Facility). The proceeds of the loans under the Credit Facility may be used to finance working capital needs and for general corporate purposes. The credit agreement dated as of March 8, 2021 and the commitments thereunder were terminated as of January 4, 2023.

The Credit Facility matures, and all amounts outstanding thereunder become due and payable in full, on January 4, 2028, subject to two one-year extensions at our option, the consent of the extending lenders and certain other conditions. We may prepay amounts borrowed and terminate commitments under the Credit Facility at any time without premium or penalty. As of October 1, 2023, there were no borrowings or letters of credit outstanding under the Credit Facility and we were in compliance with all financial and operating covenants.

Any loans under the Credit Facility will have a variable interest rate based on either the term secured overnight financing rate or the alternate base rate, plus an applicable rate that varies with the Company’s debt rating and, in the case of loans bearing interest based on the term secured overnight financing rate, a credit spread adjustment equal to 0.10% per annum. The Credit Agreement includes an option for us to elect to increase the commitments

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under the Credit Facility or to enter into one or more tranches of term loans in the aggregate principal amount of up to $250 million, subject to the consent of the lenders providing the additional commitments or term loans, as applicable, and certain other conditions.

The Credit Agreement contains financial and operating covenants. Pursuant to the Credit Agreement, we are required to maintain a ratio of total debt to annual earnings before interest, taxes, depreciation and amortization (EBITDA), calculated based on the four consecutive fiscal quarters ending with the most recent fiscal quarter, of not greater than 3.50 to 1.00 as of the end of each fiscal quarter. Upon the consummation of any Qualified Acquisition (as defined in the Credit Agreement) and us providing notice to the Administrative Agent, the ratio increases to 4.00 to 1.00 for the fiscal quarter in which the acquisition is consummated and the three consecutive fiscal quarters thereafter. The operating covenants include, among other things, limitations on (i) the incurrence of indebtedness by our subsidiaries, (ii) liens on our and our subsidiaries assets, and (iii) certain fundamental changes and the disposition of assets by us and our subsidiaries. The Credit Agreement contains other customary covenants, representations and warranties, and events of default.

5. STOCKHOLDERS’ EQUITY

In Q2 2023, the Company’s stockholders approved an amended and restated version of the Company’s 2015 Stock Incentive Plan (2015 Stock Plan) and increased the maximum number of shares authorized for issuance by 8.0 million shares. As of October 1, 2023, approximately 8.2 million shares remained available for future grants under the 2015 Stock Plan.

Restricted Stock

Restricted stock activity was as follows:

	Restricted Stock Units (RSU)	Performance Stock Units (PSU)(1)	Weighted-Average Grant Date Fair Value per Share
Units in thousands			RSU		PSU
Outstanding at January 1, 2023	1,611	74	$	311.23	$	446.74
Awarded	2,000	62	$	197.09	$	245.08
Vested	(118)	—	$	296.25	$	—
Cancelled	(411)	(96)	$	255.53	$	300.09
Outstanding at October 1, 2023	3,082	40	$	245.37	$	198.25

_____________

(1)The number of units reflect the estimated number of shares to be issued at the end of the performance period. For market-based PSU, the number of units reflect the estimated number of shares to be issued based on performance as of the current reporting period. Awarded units are presented net of performance adjustments.

Liability-Classified RSU

In Q1 2023, we granted RSU that were to be settled in cash if stockholder approval to increase our share reserve under the amended and restated 2015 Stock Plan was not obtained. In Q2 2023, the Company’s stockholders approved an amended and restated version of the 2015 Stock Plan and increased the maximum number of shares authorized for issuance. Upon such approval, all RSU previously accounted for as liability-classified awards, approximately 557,000 RSU, were reclassified to stockholders’ equity and accounted for prospectively as equity awards. There were no RSU liability-classified awards outstanding as of October 1, 2023.

Market-Based PSU

During YTD 2023, we granted PSU with a market condition that vest based on the Company’s relative total shareholder return (rTSR) as compared to a peer group of companies measured over a three-fiscal year performance period. Depending on the actual performance over the measurement period, an award recipient could receive up to 175% of the granted award. The grant date fair value of such awards is estimated using a Monte Carlo simulation, which includes assumptions for expected volatility, risk-free interest rate and dividend yield. These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value. The compensation expense for the

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awards is recognized over the requisite service period regardless of whether the market conditions are achieved. As of October 1, 2023, there were approximately 119,000 PSU with a rTSR market condition granted.

Stock Options

Stock option activity was as follows:

Units in thousands	Options	Weighted-Average Exercise Price		Performance Options(1)	Weighted-Average Exercise Price
Outstanding at January 1, 2023	187	$	319.72	17	$	85.54
Exercised	(8)	$	71.09	(1)	$	16.69
Cancelled	(135)	$	330.25	—	$	—
Outstanding at October 1, 2023	44	$	330.25	16	$	87.74
Exercisable at October 1, 2023	18	$	330.25	—	$	—

_____________

(1)The number of units reflect awards that have been granted and for which it is assumed to be probable that the underlying performance goals will be achieved.

Other Liability-Classified Awards

We grant cash-based equity incentive awards to GRAIL employees. For purposes of valuation and performance measurement of the awards, GRAIL’s stand-alone valuation, as determined by GRAIL using a reasonable calculation and based on advice from independent valuation experts and analyses, is used. The awards generally have terms of four years with equal vesting annually, subject to continued employment through the vesting period.

Cash-based equity incentive award activity was as follows:

In millions
Outstanding at January 1, 2023	$	293
Granted	116
Vested and paid in cash	(65)
Cancelled	(28)
Change in fair value	(8)
Outstanding at October 1, 2023	$	308
Estimated liability as of October 1, 2023 (included in accrued liabilities)	$	42

We recognized share-based compensation expense of $26 million and $72 million in Q3 2023 and YTD 2023, respectively, and $17 million and $46 million in Q3 2022 and YTD 2022, respectively. As of October 1, 2023, approximately $266 million of total unrecognized compensation cost related to awards issued to date was expected to be recognized over a weighted-average period of approximately 2.8 years.

In connection with the acquisition of GRAIL, we assumed a performance-based award for which vesting is based on GRAIL’s future revenues. The award has an aggregate potential value of up to $78 million and expires, to the extent unvested, in August 2030. As of October 1, 2023, it was not probable that the performance conditions associated with the award will be achieved and, therefore, no share-based compensation expense, or corresponding liability, has been recognized in the condensed consolidated financial statements to-date.

Employee Stock Purchase Plan

The price at which common stock is purchased under the Employee Stock Purchase Plan (ESPP) is equal to 85% of the fair market value of the common stock on the first day of the offering period or purchase date, whichever is lower. During YTD 2023, approximately 0.4 million shares were issued under the ESPP. As of October 1, 2023, there were approximately 12.4 million shares available for issuance under the ESPP.

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The assumptions used and the resulting estimate of weighted-average fair value per share for stock purchased under the ESPP during YTD 2023 were as follows:

Risk-free interest rate	0.78% - 5.54%
Expected volatility	41% - 51%
Expected term	0.5 - 1.1 year
Expected dividends	0		%
Weighted-average grant-date fair value per share	$	49.87

Share Repurchases

We did not repurchase any shares during YTD 2023. As of October 1, 2023, authorizations to repurchase approximately $15 million of our common stock remained available under the $750 million share repurchase program authorized by our Board of Directors on February 5, 2020. The repurchases may be completed under a 10b5-1 plan or at management’s discretion.

Share-Based Compensation

Share-based compensation expense, which includes expense for both equity and liability-classified awards, reported in our condensed consolidated statements of operations was as follows:

In millions	Q3 2023		Q3 2022		YTD 2023		YTD 2022
Cost of product revenue	$	7	$	7	$	22	$	20
Cost of service and other revenue	2		2		5		4
Research and development	36		37		117		112
Selling, general and administrative	41		37		142		130
Share-based compensation expense, before taxes	86		83		286		266
Related income tax benefits	(19)		(18)		(65)		(60)
Share-based compensation expense, net of taxes	$	67	$	65	$	221	$	206

As of October 1, 2023, approximately $582 million of total unrecognized compensation cost related to restricted stock, including RSU and PSU, stock options, including performance stock options, and ESPP shares issued to date was expected to be recognized over a weighted-average period of approximately 2.4 years.

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6. SUPPLEMENTAL BALANCE SHEET DETAILS

Accounts Receivable

In millions	October 1, 2023		January 1, 2023
Trade accounts receivable, gross	$	696	$	675
Allowance for credit losses	(6)		(4)
Total accounts receivable, net	$	690	$	671

Inventory

In millions	October 1, 2023		January 1, 2023
Raw materials	$	278	$	247
Work in process	423		386
Finished goods	35		28
Inventory, gross	736		661
Inventory reserve	(121)		(93)
Total inventory, net	$	615	$	568

Accrued Liabilities

In millions	October 1, 2023		January 1, 2023
Legal contingencies(1)	$	458	$	473
Contract liabilities, current portion	242		245
Accrued compensation expenses	195		188
Accrued taxes payable	65		97
Operating lease liabilities, current portion	85		76
Liability-classified equity incentive awards	42		36
Other, including warranties(2)	155		117
Total accrued liabilities	$	1,242	$	1,232

_____________

(1)See note “7. Legal Proceedings” for additional details.

(2)See table below for changes in the reserve for product warranties.

Changes in the reserve for product warranties were as follows:

In millions	Q3 2023		Q3 2022		YTD 2023		YTD 2022
Balance at beginning of period	$	20	$	21	$	18	$	22
Additions charged to cost of product revenue	10		5		30		17
Repairs and replacements	(11)		(7)		(29)		(20)
Balance at end of period	$	19	$	19	$	19	$	19

We generally provide a one-year warranty on instruments. Additionally, we provide a warranty on consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. At the time revenue is recognized, an accrual is established for estimated warranty expenses based on historical experience as well as anticipated product performance. We periodically review the warranty reserve for adequacy and adjust the warranty accrual, if necessary, based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue.

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Restructuring

In Q2 2023, we implemented a cost reduction initiative that included workforce reductions, the consolidation of certain facilities and other actions to reduce expenses, all as part of a plan to realign operating expenses while maintaining focus on our innovation roadmap and sustainable long-term growth. In Q3 2023 and YTD 2023, we recorded restructuring charges primarily consisting of asset impairment charges and employee separation costs.

A summary of the pre-tax restructuring charges are as follows:

In millions	Q3 2023		YTD 2023
Employee separation costs	$	7	$	33
Asset impairment charges (1)	49		56
Other costs	2		2
Total restructuring charges (2)	$	58	$	91

_____________

(1)Primarily related to impairment of right-of-use assets and leasehold improvements for our i3 campus in San Diego, California.

(2)For Q3 2023, $55 million was recorded in SG&A expense, $2 million in R&D expense, with the remainder recorded in cost of revenue.

For YTD 2023 $74 million was recorded in SG&A expense, $13 million in R&D expense, with the remainder recorded in cost of revenue.

We fully exited our i3 campus in San Diego, California in Q3 2023, which resulted in a right-of-use asset impairment of $33 million in Q3 2023 and $38 million in YTD 2023, recognized in selling, general and administrative expense. The impairment was determined by comparing the fair value of the impacted right-of-use asset to the carrying value of the asset as of the impairment measurement date. The fair value of the right-of-use asset was estimated using the discounted future cash flows method, which includes estimates and assumptions for future sublease rental rates that reflect current sublease market conditions, as well as a discount rate. The estimates and assumptions used in our assessment represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value. We also recorded $14 million in Q3 2023 and $16 million in YTD 2023 of leasehold improvement impairment, recognized in selling, general and administrative expense, related to the exit of our i3 campus. We continue to evaluate our options with respect to our campus in Foster City, California. As of October 1, 2023, we had assets, consisting primarily of right-of-use assets and leasehold improvements, related to our Foster City campus of approximately $182 million.

A summary of the restructuring liability is as follows:

In millions	Employee Separation Costs (1)		Other Costs		Total
Expense recorded in YTD 2023	$	33	$	2	$	35
Cash paid during YTD 2023	(30)		(1)		(31)
Amount recorded in accrued liabilities as of October 1, 2023	$	3	$	1	$	4
Estimated total restructuring costs to still be incurred	$	2	$	—	$	2

_____________

(1)It is expected that substantially all of the employee separation related restructuring charges will be incurred and paid by the end of 2023.

Goodwill and Intangible Assets

We test goodwill for impairment annually, as of May, or more frequently if events or circumstances indicate it is more likely than not that the fair value of a reporting unit is less than its carrying amount. We performed our annual impairment test in Q2 2023, as of May 2023. We performed a quantitative assessment for our two reporting units: Core Illumina and GRAIL. No impairment was recorded for either Core Illumina or GRAIL in Q2 2023.

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In Q3 2023, we concluded the sustained decrease in the Company’s stock price and overall market capitalization during the quarter was a circumstance indicating the fair value of a reporting unit might be less than its carrying amount that required an interim goodwill and intangible impairment test be performed.

Based on our interim assessment, we concluded that our GRAIL reporting unit’s carrying value exceeded its estimated fair value. As a result, we recorded $712 million of goodwill impairment related to our GRAIL reporting unit in Q3 2023, primarily due to a decrease in the company’s consolidated market capitalization and a higher discount rate selected for the fair value calculation of the GRAIL reporting unit. No impairment was recorded for our Core Illumina reporting unit, noting its fair value exceeded its carrying value by more than $20 billion.

We performed our impairment test using a combination of an income and a market approach to determine the fair value of each reporting unit. The income approach utilized the estimated discounted cash flows for each reporting unit, while the market approach utilized comparable company information. Estimates and assumptions used in the income approach included projected cash flows and a discount rate for each reporting unit. Discount rates were determined using a weighted average cost of capital for risk factors specific to each reporting unit and other market and industry data. For GRAIL, the selected discount rate was 24.0%. The estimates and assumptions used in our assessment represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value. The assumptions used are inherently subject to uncertainty and we note that small changes in these assumptions could have a significant impact on the concluded value. An increase of 50 to 100 basis points to the discount rate used in our assessment for GRAIL would have resulted in additional goodwill impairment of approximately $200 million to $350 million for GRAIL. In order to further validate the reasonableness of the fair values concluded for our reporting units, a reconciliation to market capitalization was performed by estimating a reasonable implied control premium and other market factors.

As a result of the impairment taken in Q3 2023, the carrying value of our GRAIL reporting unit now approximates its fair value. As such, changes in our future operating results, cash flows, share price (our share price has declined approximately 18% during the period October 1, 2023 to November 6, 2023), market capitalization or discount rates, as well as future regulatory decisions related to our acquisition of GRAIL, including the decision adopted by the European Commission on October 12, 2023 requiring us to divest GRAIL (refer to note “7. Legal Proceedings”), used when conducting future goodwill impairment tests could affect the estimated fair values of our reporting units and may result in additional impairment charges in the future. We will continue to monitor events and circumstances which may suggest that interim impairment indicators are present prior to the annual impairment test. As of October 1, 2023, remaining goodwill allocated to GRAIL was $1,466 million.

In conjunction with the interim goodwill impairment test, we also evaluated the in-process research and development (IPR&D) asset assigned to the GRAIL reporting unit for potential impairment. We performed our impairment test by comparing the carrying value of the IPR&D asset to its estimated fair value, which was determined by the income approach, using a discounted cash flow model. Estimates and assumptions used in the income approach, which represent a Level 3 measurement, included projected cash flows and a selected discount rate of 19.0%. Based on our impairment test, the carrying value of the GRAIL IPR&D asset exceeded its estimated fair value and we recorded an impairment of $109 million in Q3 2023, primarily due to a decrease in projected cash flows and a higher discount rate selected for the fair value calculation of the GRAIL IPR&D asset. As of October 1, 2023, the carrying value of the GRAIL IPR&D asset was $561 million. We also performed a recoverability test for the definite-lived intangible assets assigned to the GRAIL reporting unit, which includes developed technology and trade name, noting no impairment. No impairment was noted for Core Illumina definite-lived intangible assets.

Changes to goodwill during YTD 2023 were as follows:

In millions
Balance as of January 1, 2023 (1)	$	3,239
Impairment	(712)
Balance as of October 1, 2023	$	2,527

_____________

(1)The balance as of January 1, 2023 is inclusive of a $3,914 million goodwill impairment related to our GRAIL reporting unit in Q3 2022.

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Derivative Financial Instruments

We are exposed to foreign exchange rate risks in the normal course of business and use derivative financial instruments to partially offset this exposure. We do not use derivative financial instruments for speculative or trading purposes. Foreign exchange contracts are carried at fair value in other current assets, other assets, accrued liabilities, or other long-term liabilities, as appropriate, on the condensed consolidated balance sheets.

We use foreign exchange forward contracts to manage foreign currency risks related to monetary assets and liabilities denominated in currencies other than the U.S. dollar. These derivative financial instruments have terms of one month or less and are not designated as hedging instruments. Changes in fair value of these derivatives are recognized in other expense, net, along with the re-measurement gain or loss on the foreign currency denominated assets or liabilities. As of October 1, 2023, we had foreign exchange forward contracts in place to hedge exposures in the euro, Japanese yen, Australian dollar, Canadian dollar, Singapore dollar, Chinese Yuan Renminbi, and British pound. As of October 1, 2023 and January 1, 2023, the total notional amounts of outstanding forward contracts in place for these foreign currency purchases were $912 million and $485 million, respectively. On July 25, 2023, we entered into forward contracts for a total notional amount of €432 million to hedge the foreign currency exposure for the fine imposed by the European Commission on July 12, 2023.

We also use foreign currency forward contracts to hedge portions of our foreign currency exposure associated with forecasted revenue transactions. These derivative financial instruments have terms up to 24 months and are designated as cash flow hedges. Changes in fair value of our cash flow hedges are recorded as a component of accumulated other comprehensive income and are reclassified to revenue in the same period the underlying hedged transactions are recorded. We regularly review the effectiveness of our cash flow hedges and consider them to be ineffective if it becomes probable that the forecasted transactions will not occur in the identified period. Changes in fair value of the ineffective portions of our cash flow hedges, if any, are recognized in other expense, net. As of October 1, 2023, we had foreign currency forward contracts in place to hedge exposures associated with forecasted revenue transactions denominated in the euro, Japanese yen, Australian dollar, Canadian dollar, and Chinese Yuan Renminbi. As of October 1, 2023 and January 1, 2023, the total notional amounts of outstanding cash flow hedge contracts in place for these foreign currency purchases were $663 million and $425 million, respectively. We reclassified $5 million and $9 million to revenue in Q3 2023 and YTD 2023, respectively, and $16 million and $32 million in Q3 2022 and YTD 2022, respectively. As of October 1, 2023, the fair value of the foreign currency forward contracts recorded in total assets and total liabilities was $27 million and $1 million, respectively. As of January 1, 2023, the fair value of the foreign currency forward contracts recorded in total assets and total liabilities was $8 million and $6 million, respectively. The estimated net gains reported in accumulated other comprehensive income that are expected to be reclassified into earnings within the next 12 months are $22 million as of October 1, 2023.

7. LEGAL PROCEEDINGS

We are involved in various lawsuits and claims arising in the ordinary course of business, including actions with respect to intellectual property, employment, and contractual matters. In connection with these matters, we assess, on a regular basis, the probability and range of possible loss based on the developments in these matters. A liability is recorded in the condensed consolidated financial statements if it is believed to be probable that a loss has been incurred and the amount of the loss can be reasonably estimated. Because litigation is inherently unpredictable and unfavorable resolutions could occur, assessing contingencies is highly subjective and requires judgments about future events. We regularly review outstanding legal matters to determine the adequacy of the liabilities accrued and related disclosures in consideration of many factors, which include, but are not limited to, past history, scientific and other evidence, and the specifics and status of each matter. We may change our estimates if our assessment of the various factors changes and the amount of ultimate loss may differ from our estimates, resulting in a material effect on our business, financial condition, results of operations, and/or cash flows.

Acquisition of GRAIL

Our acquisition of GRAIL remains subject to ongoing legal and regulatory proceedings in the United States and in the European Union.

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On March 30, 2021, the U.S. Federal Trade Commission (the FTC) filed an administrative complaint and a motion for a preliminary injunction in the United States District Court for the District of Columbia. In both actions, the FTC alleged that our acquisition of GRAIL would violate Section 7 of the Clayton Act, as amended, 15 U.S.C. § 18. We filed an answer to the FTC’s complaint in federal district court on April 6, 2021, and in the administrative court on April 13, 2021. On April 20, 2021, the United States District Court for the District of Columbia granted our motion to transfer venue to the United States District Court for the Southern District of California. On May 28, 2021, the district court granted the FTC’s motion to dismiss the complaint without prejudice. The administrative trial commenced on August 24, 2021. On September 1, 2022, the administrative law judge (the ALJ) ruled in favor of Illumina and found that the acquisition of GRAIL did not violate Section 7 of the Clayton Act. In the decision, the ALJ found that the FTC’s complaint counsel had failed to prove its prima facie case that Illumina’s acquisition of GRAIL would result in harm to competition in a putative market for multi-cancer early detection (MCED) tests. The FTC’s complaint counsel appealed the ALJ’s decision to the full FTC on September 2, 2022. The appeal was fully briefed as of November 10, 2022 and oral argument occurred on December 13, 2022. On March 31, 2023, the FTC issued an opinion and order (the FTC Order) requiring Illumina to divest GRAIL, reversing the ALJ’s ruling. On April 5, 2023, Illumina filed a petition for review of the FTC Order in the U.S. Court of Appeals for the Fifth Circuit. On April 24, 2023, the FTC granted a motion staying in its entirety the FTC Order pending resolution of Illumina’s Fifth Circuit appeal. The appeal was fully briefed as of August 16, 2023 and oral argument occurred on September 12, 2023. We intend to continue to vigorously defend against the FTC action.

On April 19, 2021, the European Commission accepted a request for a referral of the GRAIL acquisition for European Union merger review, submitted by a Member State of the European Union (France), and joined by several other Member States (Belgium, Greece, Iceland, the Netherlands and Norway), under Article 22(1) of Council Regulation (EC) No 139/2004 (the EU Merger Regulation). The European Commission had never solicited referrals to take jurisdiction over an acquisition of a U.S. company that had no revenue in Europe. On April 29, 2021, we filed an action in the General Court of the European Union (the EU General Court) asking for annulment of the European Commission’s assertion of jurisdiction to review the acquisition under Article 22 of the EU Merger Regulation, as the acquisition does not meet the jurisdictional criteria under the EU Merger Regulation or under the national merger control laws of any Member State of the European Union. On December 16, 2021, the EU General Court held a hearing regarding the European Commission’s assertion of jurisdiction. On July 13, 2022, the EU General Court reached a decision in favor of the European Commission, holding that the European Commission has jurisdiction under the EU Merger Regulation to review the acquisition. On September 22, 2022, we filed an appeal in the Court of Justice of the European Union asking for annulment of the EU General Court’s decision.

On October 29, 2021, the European Commission adopted an order imposing interim measures (the Initial Interim Measures Order). As the Initial Interim Measures Order was set to expire on November 3, 2022, the European Commission adopted a new order imposing interim measures (the New Interim Measures Order) on October 28, 2022. On December 1, 2021, we filed an action with the EU General Court asking for annulment of the Initial Interim Measures Order. The hearing of that application has been stayed pending our appeal of the judgment of the EU General Court regarding the European Commission’s assertion of jurisdiction. On January 10, 2023, we filed an action with the EU General Court asking for annulment of the New Interim Measures Order. On January 20, 2023, the European Commission requested that these proceedings be stayed pending our appeal on jurisdiction. We submitted a filing indicating that we had no objections to the European Commission’s request, and the EU General Court stayed the proceedings on February 21, 2023.

On September 6, 2022, the European Commission announced that it had completed its Phase II review of the acquisition of GRAIL and adopted a final decision (the Prohibition Decision), which found that, in its view, our acquisition of GRAIL was incompatible with the internal market in Europe because it results in a significant impediment to effective competition. On November 17, 2022, we filed an action with the EU General Court asking for annulment of the Prohibition Decision.

On October 12, 2023, the European Commission adopted a decision requiring us to (among other things) divest GRAIL, and replacing the interim measures set forth in the New Interim Measures Order with substantially equivalent transitional measures (the EC Divestment Decision). We intend to appeal the EC Divestment Decision.

On July 12, 2023, the European Commission adopted a final decision finding that we breached the EU Merger Regulation by, in its view, acquiring the possibility to exert decisive influence over GRAIL and exerting such influence during the pendency of the European Commission’s review (the Article 14(2)(b) Decision). The European Commission therefore imposed a fine pursuant to Article 14(2)(b) of the EU Merger Regulation of approximately €432 million, representing the maximum fine of 10% of our consolidated annual revenues for fiscal year 2022. We provided guarantees in October 2023 to satisfy the obligation in lieu of cash payment while we appeal the European Commission’s jurisdictional decision and fine decision. The fine is accruing interest at a rate of 5.5% per annum,

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beginning in October 2023, while it is outstanding. As of October 1, 2023, we accrued $458 million, including related foreign currency gains (which were recorded in other expense, net), included in accrued liabilities. We appealed the Article 14(2)(b) Decision on September 26, 2023.

SEC Inquiry Letter

In July 2023, we were informed that the staff of the SEC was conducting an investigation relating to Illumina and was requesting documents and communications primarily related to Illumina’s acquisition of GRAIL and certain statements and disclosures concerning GRAIL, its products and its acquisition, and related to the conduct and compensation of certain members of Illumina and GRAIL management, among other things. Illumina is cooperating with the SEC in this investigation.

Derivative and Class Action Complaint

On October 17, 2023, a stockholder derivative and class action complaint captioned Icahn Partners LP, et al. v. deSouza, et al., purportedly brought on behalf of Illumina and public holders of Illumina’s common stock, was filed in the Delaware Court of Chancery against certain current and former directors (including our former Chief Executive Officer). We are named as a nominal defendant in the complaint. The lawsuit alleges the named directors breached their fiduciary duties by knowingly causing Illumina to unlawfully close the GRAIL acquisition, concealing material facts related to the GRAIL acquisition and making inadequate disclosures. Prior to the filing of the complaint, the purported stockholders did not make a demand that our Board of Directors pursue the claims asserted therein. The complaint seeks damages, costs and expenses, including attorney fees, the certification and consolidation of a putative class, the issuance of amended disclosures, the removal of conflicted directors and declaratory and other equitable relief. Since the lawsuit is brought in part on behalf of Illumina as a nominal defendant, the alleged damages were allegedly suffered by us. We deny the allegations in the complaint and intend to vigorously defend the litigation. In light of the fact that the lawsuit is in an early stage, we cannot predict the ultimate outcome of the suit.

8. INCOME TAXES

Our effective tax rate may vary from the U.S. federal statutory tax rate due to the change in the mix of earnings in tax jurisdictions with different statutory rates, benefits related to tax credits, and the tax impact of non-deductible expenses and other permanent differences between income before income taxes and taxable income.

Our effective tax rates for Q3 2023 and YTD 2023 were 3.6% and (3.8)%, respectively, compared to (4.0)% and (2.3)% in Q3 2022 and YTD 2022, respectively. The variance from the U.S. federal statutory tax rate of 21% in Q3 2023 and YTD 2023 was primarily attributable to the $149 million income tax expense impact from the impairment of goodwill, which is nondeductible for tax purposes, the $20 million and $84 million income tax expense impact of research and development expense capitalization for tax purposes, respectively, and the $38 million and $63 million income tax expense impact of GRAIL pre-acquisition net operating losses on global intangible low-taxed income (GILTI) and the utilization of U.S. foreign tax credits, respectively. This was partially offset by the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore.

Historically, we calculated the provision/(benefit) for income taxes for interim periods utilizing an estimated annual effective tax rate applied to the income/(loss) for the reporting period, except in Q2 2023 when a year-to-date effective tax rate method was utilized. We determined the estimated annual effective tax rate method would provide a more reliable estimate of the provision for income taxes for Q3 2023 and YTD 2023, since minor changes in the estimated income/(loss) before income taxes would not result in significant changes in the estimated annual effective tax rate.

As of October 1, 2023 and January 1, 2023, prepaid income taxes, included within prepaid expenses and other current assets on the condensed consolidated balance sheets, were $78 million and $116 million, respectively.

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9. SEGMENT INFORMATION

We have two reportable segments, Core Illumina and GRAIL. We report segment information based on the management approach, which designates the internal reporting used by the Chief Operating Decision Maker (CODM) for making decisions and assessing performance as the source of our reportable segments. The CODM allocates resources and assesses the performance of each operating segment using information about its revenue and income (loss) from operations. Our CODM does not evaluate our operating segments using discrete asset information. We do not allocate expenses between segments. Core Illumina sells products and provides services to GRAIL, and vice versa, in accordance with contractual agreements between the entities.

Core Illumina: Core Illumina’s products and services serve customers in the research, clinical and applied markets, and enable the adoption of a variety of genomic solutions. Core Illumina includes all of our operations, excluding the results of GRAIL.

GRAIL: GRAIL is a healthcare company focused on early detection of multiple cancers.

In millions	Q3 2023		Q3 2022		YTD 2023		YTD 2022
Revenue:
Core Illumina	$	1,106	$	1,110	$	3,341	$	3,487
GRAIL	21		10		62		32
Eliminations	(8)		(5)		(21)		(18)
Consolidated revenue	$	1,119	$	1,115	$	3,382	$	3,501
Income (loss) from operations:
Core Illumina	$	262	$	445	$	519	$	411
GRAIL	(1,015)		(4,101)		(1,424)		(4,460)
Eliminations	(1)		(1)		—		(3)
Consolidated loss from operations	$	(754)	$	(3,657)	$	(905)	$	(4,052)

Total other expense, net primarily relates to Core Illumina and we do not allocate income taxes to our segments.

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MANAGEMENT’S DISCUSSION & ANALYSIS

Our Management’s Discussion and Analysis (MD&A) will help readers understand our results of operations, financial condition, and cash flow. It is provided in addition to the accompanying condensed consolidated financial statements and notes. This MD&A is organized as follows:

•Management’s Overview and Outlook. High level discussion of our operating results and significant known trends that affect our business.

•Results of Operations. Detailed discussion of our revenues and expenses.

•Liquidity and Capital Resources. Discussion of key aspects of our condensed consolidated statements of cash flows, changes in our financial position, and our financial commitments.

•Critical Accounting Policies and Estimates. Discussion of significant changes since our most recent Annual Report on Form 10-K that we believe are important to understanding the assumptions and judgments underlying our condensed consolidated financial statements.

•Recent Accounting Pronouncements. Summary of recent accounting pronouncements applicable to our condensed consolidated financial statements.

•Quantitative and Qualitative Disclosure About Market Risk. Discussion of our financial instruments’ exposure to market risk.

Our discussion of our results of operations, financial condition, and cash flow for Q3 2022 and YTD 2022 can be found in “Management’s Discussion and Analysis of Financial Condition and Results of Operations” within our filing of Form 10-Q for the fiscal quarter ended October 2, 2022.

This MD&A discussion contains forward-looking statements that involve risks and uncertainties. See “Consideration Regarding Forward-Looking Statements” preceding the Condensed Consolidated Financial Statements section of this report for additional factors relating to such statements. This MD&A should be read in conjunction with our condensed consolidated financial statements and accompanying notes included in this report and our Annual Report on Form 10-K for the fiscal year ended January 1, 2023. Operating results are not necessarily indicative of results that may occur in future periods.

MANAGEMENT’S OVERVIEW AND OUTLOOK

This overview and outlook provide a high-level discussion of our operating results and significant known trends that affect our business. We believe that an understanding of these trends is important to understanding our financial results for the periods being reported herein as well as our future financial performance. This summary is not intended to be exhaustive, nor is it intended to be a substitute for the detailed discussion and analysis provided elsewhere in this report.

About Illumina

Our focus on innovation has established us as a global leader in DNA sequencing and array-based technologies, serving customers in the research, clinical and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture and other emerging segments. Our customers include leading genomic research centers, academic institutions, government laboratories, and hospitals, as well as pharmaceutical, biotechnology, commercial molecular diagnostic laboratories, and consumer genomics companies. Our comprehensive line of products addresses the scale of experimentation and breadth of functional analysis to advance disease research, drug development, and the development of molecular tests. This portfolio of leading-edge sequencing and array-based solutions addresses a range of genomic complexity and throughput, enabling researchers and clinical practitioners to select the best solution for their scientific challenge.

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On August 18, 2021, we acquired GRAIL, a healthcare company focused on early detection of multiple cancers. GRAIL’s Galleri blood test detects various types of cancers before they are symptomatic. We believe our acquisition of GRAIL will accelerate the adoption of next-generation sequencing based early multi-cancer detection tests, enhance our position in Clinical Genomics, and increase our directly accessible total addressable market. The acquisition is subject to ongoing legal proceedings and, currently, GRAIL must be held and operated separately and independently from Illumina pursuant to the transitional measures ordered by the European Commission in the EC Divestment Decision, following the prohibition of our acquisition of GRAIL on September 6, 2022. See note “7. Legal Proceedings” for further details.

With respect to GRAIL, we have retained advisors and are preparing for sale and capital markets transaction options in accordance with the European Commission’s divestiture order. In parallel, ongoing appeals preserve flexibility for any divestiture of GRAIL and future transactions.

We have two reportable segments, Core Illumina and GRAIL. Core Illumina relates to our core operations, excluding the results of GRAIL. See note “9. Segment Information” for additional details.

Our financial results have been, and will continue to be, impacted by several significant trends, which are described below. While these trends are important to understanding and evaluating our financial results, this discussion should be read in conjunction with our condensed consolidated financial statements and the notes thereto within the Condensed Consolidated Financial Statements section of this report, and the other transactions, events, and trends discussed in “Risk Factors” within the Other Key Information section of this report.

Financial Overview

Since 2020, the COVID-19 pandemic and international efforts to control its spread have significantly curtailed the movement of people, goods, and services worldwide, including in the regions where we sell our products and services and conduct our business operations. In addition, armed conflict between Russia and Ukraine, which began in 2022, and the sanctions imposed by the U.S. and other countries, has impacted our ability to ship products into affected regions and to designated customers. Furthermore, macroeconomic factors such as inflation, exchange rates and concerns about an economic downturn, and competitive challenges in our China region, have impacted both Illumina directly and our customers’ behavior. For example, some customers experienced supply chain pressures that delayed their lab expansions and others are managing inventory and capital more conservatively. We expect these factors to continue to impact our sales and results of operations for the remainder of 2023, the size and duration of which is significantly uncertain.

Financial highlights for YTD 2023 included the following:

•Revenue decreased 3% in YTD 2023 to $3,382 million compared to $3,501 million in YTD 2022 primarily due to decreases in sequencing consumables revenue and sequencing instruments revenue, partially offset by an increase in service and other revenue. We expect revenue to decrease 2% to 3% in 2023 compared to 2022.

•Gross profit as a percentage of revenue (gross margin) was 61.2% in YTD 2023 compared to 65.7% in YTD 2022. The decrease in gross margin was driven primarily by less fixed cost leverage on lower manufacturing volumes, lower instrument margins due to the NovaSeq X launch in Q1 2023, and unfavorable product mix. Our gross margin depends on many factors, including: market conditions that may impact our pricing; sales mix changes among consumables, instruments, services, and development and licensing revenue; product mix changes between established products and new products; excess and obsolete inventories; royalties; our cost structure for manufacturing operations relative to volume; freight costs; and product support obligations.

•Loss from operations was $905 million in YTD 2023 compared to $4,052 million in YTD 2022. The decrease was primarily due to a decrease in operating expense of $3,377 million, which included significant decreases in goodwill and intangible impairment of $3,093 million and legal contingency and settlement of $584 million, partially offset by a $230 million decrease in gross profit. We continue to focus on our cost reduction initiatives to accelerate progress toward higher margins and create flexibility for further investment in high-growth areas.

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•Our effective tax rate was (3.8)% in YTD 2023 compared to (2.3)% in YTD 2022. The variance from the U.S. federal statutory tax rate of 21% was primarily because of the income tax expense impact of the impairment of goodwill, which is nondeductible for tax purposes, the income tax expense impact of research and development expense capitalization for tax purposes, and the income tax expense impact of GRAIL pre-acquisition net operating losses on GILTI and the utilization of U.S. foreign tax credits. This was partially offset by the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore.

•We ended Q3 2023 with cash, cash equivalents, and short-term investments totaling $933 million, of which approximately $499 million was held by our foreign subsidiaries.

RESULTS OF OPERATIONS

To enhance comparability, the following table sets forth unaudited condensed consolidated statement of operations data for the specified reporting periods, stated as a percentage of total revenue.(1)

	Q3 2023		Q3 2022		YTD 2023		YTD 2022
Revenue:
Product revenue	84.1	%	86.4	%	84.7	%	86.8	%
Service and other revenue	15.9		13.6		15.3		13.2
Total revenue	100.0		100.0		100.0		100.0
Cost of revenue:
Cost of product revenue	26.2		25.1		26.1		24.7
Cost of service and other revenue	8.5		6.5		8.4		6.0
Amortization of acquired intangible assets	4.2		4.1		4.3		3.6
Total cost of revenue	38.9		35.7		38.8		34.3
Gross profit	61.1		64.3		61.2		65.7
Operating expense:
Research and development	28.1		29.1		30.0		27.8
Selling, general and administrative	27.0		13.1		33.3		24.7
Goodwill and intangible impairment	73.4		351.0		24.3		111.8
Legal contingency and settlement	(0.1)		(1.0)		0.4		17.1
Total operating expense	128.4		392.2		88.0		181.4
Loss from operations	(67.3)		(327.9)		(26.8)		(115.7)
Other income (expense):
Interest income	1.2		0.3		1.4		0.1
Interest expense	(1.7)		(0.5)		(1.7)		(0.5)
Other expense, net	(2.1)		(1.1)		(1.0)		(2.9)
Total other expense, net	(2.6)		(1.3)		(1.3)		(3.3)
Loss before income taxes	(69.9)		(329.2)		(28.1)		(119.0)
(Benefit) provision for income taxes	(2.5)		12.9		1.1		2.8
Net loss	(67.4)	%	(342.1)	%	(29.2)	%	(121.8)	%

_____________

(1)Percentages may not recalculate due to rounding.

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Revenue

Dollars in millions	Q3 2023		Q3 2022		Change		% Change		YTD 2023		YTD 2022		Change		% Change
Core Illumina:
Consumables	$	766	$	801	$	(35)	(4)	%	$	2,344	$	2,478	$	(134)	(5)	%
Instruments	182		167		15		9		539		578		(39)		(7)
Total product revenue	948		968		(20)		(2)		2,883		3,056		(173)		(6)
Service and other revenue	158		142		16		11		458		431		27		6
Total Core Illumina revenue	1,106		1,110		(4)		—		3,341		3,487		(146)		(4)
GRAIL:
Service and other revenue	21		10		11		110		62		32		30		94
Eliminations	(8)		(5)		(3)		60		(21)		(18)		(3)		17
Total consolidated revenue	$	1,119	$	1,115	$	4	—		$	3,382	$	3,501	$	(119)	(3)	%

The decrease in Core Illumina consumables revenue in Q3 2023 and YTD 2023 was primarily due to a decrease in sequencing consumables revenue of $30 million and $127 million, respectively, driven primarily by lower NovaSeq 6000 consumables pull-through as some of our high throughput customers continue to transition to NovaSeq X, as well as the impact of macroeconomic conditions on customer purchasing power and project planning. Core Illumina instruments revenue increased in Q3 2023 due to an increase in sequencing instruments revenue of $17 million, driven primarily by shipments of our NovaSeq X instrument, offset by fewer shipments of our NovaSeq 6000 and NextSeq instruments. Core Illumina instruments revenue decreased in YTD 2023 due to a decrease in sequencing instruments revenue of $38 million, driven primarily by fewer shipments of our NovaSeq 6000, NextSeq and MiSeq instruments, partially offset by shipments of NovaSeq X that launched in Q1 2023. Core Illumina service and other revenue increased in Q3 2023 and YTD 2023 primarily due to increased revenue from extended maintenance service contracts on a growing installed base. The increase in YTD 2023 was partially offset by decreases in revenues from development and licensing agreements and genotyping services. Additionally, Core Illumina revenue was favorably impacted by $9 million in Q3 2023 and adversely impacted by $26 million in YTD 2023, due to foreign exchange rate fluctuations, which included $5 million and $9 million reclassified to revenue in Q3 2023 and YTD 2023, respectively, related to our cash flow hedges.

GRAIL service and other revenue increased $11 million, or 110%, and $30 million, or 94%, in Q3 2023 and YTD 2023, respectively, primarily due to sales of Galleri.

Gross Margin

Dollars in millions	Q3 2023			Q3 2022			Change		% Change		YTD 2023			YTD 2022			Change		% Change
Gross profit (loss):
Core Illumina	$	715		$	753		$	(38)	(5)	%	$	2,161		$	2,405		$	(244)	(10)	%
GRAIL	(27)			(32)			5		(16)		(77)			(91)			14		(15)
Eliminations	(4)			(4)			—		—		(14)			(14)			—		—
Consolidated gross profit	$	684		$	717		$	(33)	(5)	%	$	2,070		$	2,300		$	(230)	(10)	%
Gross margin:
Core Illumina	64.7		%	67.9		%					64.7		%	69.0		%
GRAIL	*			*							*			*
Consolidated gross margin	61.1		%	64.3		%					61.2		%	65.7		%

________________

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*Not meaningful.

The decrease in Core Illumina gross margin in Q3 2023 and YTD 2023 was driven primarily by less fixed cost leverage on lower manufacturing volumes, lower instrument margins due to the NovaSeq X launch, which is typical with a new platform introduction until we scale manufacturing and gain operating efficiencies, and unfavorable product mix, as well as increased field services and installation costs, partially offset by lower freight costs.

GRAIL gross loss in Q3 2023 and Q3 2022 and YTD 2023 and YTD 2022 was primarily due to amortization of intangible assets of $33 million and $100 million, respectively.

Operating Expense

Dollars in millions	Q3 2023		Q3 2022		Change		% Change		YTD 2023		YTD 2022		Change		% Change
Research and development:
Core Illumina	$	238	$	253	$	(15)	(6)	%	$	771	$	740	$	31	4	%
GRAIL	79		74		5		7		254		245		9		4
Eliminations	(2)		(2)		—		—		(12)		(10)		(2)		20
Consolidated research and development	315		325		(10)		(3)		1,013		975		38		4
Selling, general and administrative:
Core Illumina	216		66		150		227		857		656		201		31
GRAIL	87		81		6		7		271		210		61		29
Eliminations	—		(1)		1		(100)		(1)		(1)		—		—
Consolidated selling, general and administrative	303		146		157		108		1,127		865		262		30
Goodwill and intangible impairment:
GRAIL	821		3,914		(3,093)		(79)		821		3,914		(3,093)		(79)
Legal contingency and settlement:
Core Illumina	(1)		(11)		10		(91)		14		598		(584)		(98)
Total consolidated operating expense	$	1,438	$	4,374	$	(2,936)	(67)	%	$	2,975	$	6,352	$	(3,377)	(53)	%

Core Illumina R&D expense decreased by $15 million, or 6%, in Q3 2023 primarily due to decreases in expenses related to lab supplies, professional services, recruiting, and travel, as we continue to focus on our cost reduction initiatives. Core Illumina R&D expense increased by $31 million, or 4%, in YTD 2023 primarily due to an increase in compensation related expenses, including performance-based compensation, as we continue to invest in the research and development of new products and enhancements to existing products and $13 million for restructuring activities that commenced in Q2 2023, primarily related to employee separation costs. The increase in YTD 2023 was partially offset by decreases in expenses related to lab supplies, professional services, recruiting, and travel.

GRAIL R&D expense increased by $5 million, or 7%, in Q3 2023 and by $9 million, or 4%, in YTD 2023 primarily due to an increase in headcount and employee related compensation costs, as well as an increase in lab and consumables spend, partially offset by a decrease in clinical trial costs.

Core Illumina SG&A expense increased by $150 million, or 227%, in Q3 2023 primarily due to a lower gain recognized on our contingent consideration liability in Q3 2023 as compared to Q3 2022 (recognized a gain of $110

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million and $219 million in Q3 2023 and Q3 2022, respectively, primarily related to the GRAIL CVRs) and $55 million for restructuring activities, primarily related to lease and other asset impairments, partially offset by decreases in professional services and travel. Core Illumina SG&A expense increased by $201 million, or 31%, in YTD 2023 primarily due to a lower gain recognized on our contingent consideration liability in YTD 2023 as compared to YTD 2022 (recognized a net gain of $82 million and $230 million in YTD 2023 and YTD 2022, respectively, primarily related to the GRAIL CVRs), $74 million for restructuring activities that commenced in Q2 2023, primarily related to lease and other asset impairments and employee separation costs, and costs related to the proxy contest of $29 million, partially offset by decreases in professional services and recruiting costs.

GRAIL SG&A expense increased by $6 million, or 7%, in Q3 2023 and by $61 million, or 29%, in YTD 2023 primarily due to an increase in headcount and employee related compensation costs. The increase in YTD 2023 was also due to increases in professional services and marketing related spend.

GRAIL goodwill and intangible impairment for Q3 2023 and YTD 2023 consisted of goodwill impairment of $712 million and IPR&D intangible asset impairment of $109 million as a result of performing an interim impairment test due to the identification of a triggering event in Q3 2023. See note “6. Supplemental Balance Sheet Details” for additional details. GRAIL goodwill and intangible impairment for Q3 2022 and YTD 2022 consisted of a goodwill impairment charge of $3,914 million as a result of performing an interim impairment test in Q3 2022.

Core Illumina legal contingency and settlement in Q3 2023 consisted of a gain on a patent litigation settlement. Core Illumina legal contingency and settlement in YTD 2023 also consisted of an adjustment to our previously recorded accrual for the fine imposed by the European Commission in July 2023 (refer to note “7. Legal Proceedings” for additional details) and a loss related to a patent litigation settlement in Q1 2023. Core Illumina legal contingency and settlement for Q3 2022 consisted of a gain of $11 million as a result of releasing $6 million of a previously recorded litigation accrual and $5 million of gain contingency recognized in Q3 2022 related to the settlement of our litigation with BGI. Core Illumina legal contingency and settlement for YTD 2022 consisted of an accrual of $453 million for the fine that the European Commission imposed and a net loss of $145 million related to the settlement of our litigation with BGI.

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Other Income (Expense)

Dollars in millions	Q3 2023		Q3 2022		Change		% Change		YTD 2023		YTD 2022		Change		% Change
Interest income	$	13	$	3	$	10	333	%	$	47	$	4	$	43	1,075	%
Interest expense	(19)		(6)		(13)		217		(59)		(17)		(42)		247
Other expense, net	(22)		(12)		(10)		83		(33)		(103)		70		(68)
Total other expense, net	$	(28)	$	(15)	$	(13)	87	%	$	(45)	$	(116)	$	71	(61)	%

Total other expense, net primarily relates to the Core Illumina segment.

Interest income consisted primarily of interest on our money market funds, which benefited from higher yields in Q3 2023 and YTD 2023 due to rising interest rates. Interest expense consisted primarily of interest on our Term Notes and increased in Q3 2023 and YTD 2023 due to the issuance of our 2025 and 2027 Term Notes in December 2022. The fluctuation in other expense, net in Q3 2023 was primarily due to higher net losses recognized on our strategic investments as compared to Q3 2022 and a net unrealized foreign currency loss related to the fine imposed by the European Commission, partially offset by a favorable impact related to our Helix contingent value right. The fluctuation in other expense, net in YTD 2023 was primarily due to lower net losses recognized on our strategic investments as compared to YTD 2022 ($39 million and $79 million in YTD 2023 and YTD 2022, respectively) and favorable impacts related to our Helix contingent value right and deferred compensation plan assets, partially offset by a net unrealized foreign currency loss related to the fine imposed by the European Commission.

(Benefit) Provision for Income Taxes

Dollars in millions	Q3 2023			Q3 2022			Change		% Change		YTD 2023			YTD 2022			Change		% Change
Loss before income taxes	$	(782)		$	(3,672)		$	2,890	(79)	%	$	(950)		$	(4,168)		$	3,218	(77)	%
(Benefit) provision for income taxes	(28)			144			(172)		(119)		36			97			(61)		(63)
Net loss	$	(754)		$	(3,816)		$	3,062	(80)	%	$	(986)		$	(4,265)		$	3,279	(77)	%
Effective tax rate	3.6		%	(4.0)		%					(3.8)		%	(2.3)		%

Our effective tax rate was 3.6% and (3.8)% in Q3 2023 and YTD 2023, respectively, compared to (4.0)% and (2.3)% in Q3 2022 and YTD 2022, respectively. The variance from the U.S. federal statutory tax rate of 21% for Q3 2023 and YTD 2023 was primarily because of the $149 million income tax expense impact from the impairment of goodwill, which is nondeductible for tax purposes, the $20 million and $84 million income tax expense impact of capitalizing research and development expenses for tax purposes, respectively, and the $38 million and $63 million income tax expense impact of GRAIL pre-acquisition net operating losses on GILTI and the utilization of U.S. foreign tax credits, respectively. The income tax expense in Q3 2023 and YTD 2023 were also favorably impacted by the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore.

The income tax benefits in Q3 2022 and YTD 2022 had an effective tax rate that was lower than the U.S. federal statutory tax rate of 21% primarily because of the $822 million income tax expense impact from the impairment of goodwill, which is nondeductible for tax purposes, the $64 million and $91 million income tax expense impact of capitalizing research and development expenses, respectively, and the $30 million and $60 million income tax expense impact of GRAIL pre-acquisition net operating losses on GILTI and the utilization of the U.S. foreign tax credits, respectively. The YTD 2022 income tax benefit was also impacted by the $95 million income tax expense impact from the European Commission fine related to the GRAIL acquisition, which was accrued in Q2 2022 and is nondeductible for tax purposes. Our effective tax rate in Q3 2022 and YTD 2022 were also favorably impacted by the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom.

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Historically, we calculated the provision/(benefit) for income taxes for interim periods utilizing an estimated annual effective tax rate applied to the income/(loss) for the reporting period, except in Q2 2023 when a year-to-date effective tax rate method was utilized. We determined the estimated annual effective tax rate method would provide a more reliable estimate of the provision for income taxes for Q3 2023 and YTD 2023, since minor changes in the estimated income/(loss) before income taxes would not result in significant changes in the estimated annual effective tax rate.

Our future effective tax rate may vary from the U.S. federal statutory tax rate due to the mix of earnings in tax jurisdictions with different statutory tax rates and the other factors discussed in the risk factor “We are subject to risks related to taxation in multiple jurisdictions” described in “Risk Factors” within the Business & Market Information section of our Annual Report on Form 10-K for the fiscal year ended January 1, 2023.

LIQUIDITY AND CAPITAL RESOURCES

As of October 1, 2023, we had approximately $927 million in cash and cash equivalents, of which approximately $499 million was held by our foreign subsidiaries. Cash and cash equivalents decreased by $1,084 million from January 1, 2023 due primarily to the repayment of our 2023 Term Notes in Q1 2023 of $500 million, the repayment of our 2023 Convertible Notes in Q3 2023 of $750 million, and other factors described in the “Cash Flow Summary” below. Our primary source of liquidity, other than our holdings of cash, cash equivalents, and investments, has been cash flows from operations and, from time to time, issuances of debt. Our ability to generate cash from operations provides us with the financial flexibility we need to meet operating, investing, and financing needs. Historically, we have liquidated our short-term investments and/or issued debt to finance our business needs as a supplement to cash provided by operating activities. As of October 1, 2023, we had $6 million in short-term investments comprised of marketable equity securities.

On July 12, 2023, as a result of our decision to proceed with the completion of our acquisition of GRAIL during the pendency of the European Commission’s review, the European Commission imposed a €432 million fine on us, representing the maximum fine of 10% of our consolidated annual revenues for fiscal year 2022. As of October 1, 2023, we accrued $458 million, including related foreign currency gains, included in accrued liabilities. We provided guarantees in October 2023 to satisfy the obligation in lieu of cash payment while we appeal the European Commission’s jurisdictional decision and fine decision. The fine is accruing interest at a rate of 5.5% per annum, beginning in October 2023, while it is outstanding. Refer to note “7. Legal Proceedings” for additional details.

In March 2021, we issued term notes due 2023 with an aggregate principal amount of $500 million and term notes due 2031 with an aggregate principal amount of $500 million. The 2023 Term Notes matured and were repaid in cash on March 23, 2023. The 2031 Term Notes, which mature on March 23, 2031, accrue interest at a rate of 2.550% per annum, payable semi-annually in March and September of each year. We may redeem for cash all or any portion of the 2031 Term Notes, at our option, at any time prior to maturity.

Our convertible senior notes, with an aggregate principal amount of $750 million, matured on August 15, 2023, at which time the principal was repaid in cash. We did not issue any shares of common stock.

In December 2022, we issued term notes due 2025 with an aggregate principal amount of $500 million and term notes due 2027 with an aggregate principal amount of $500 million. The 2025 Term Notes, which mature on December 12, 2025, and the 2027 Term Notes, which mature on December 13, 2027, accrue interest at a rate of 5.800% and 5.750% per annum, respectively, payable semi-annually in June and December of each year. We may redeem for cash all or any portion of the 2025 or 2027 Term Notes, at our option, at any time prior to maturity.

On January 4, 2023, we obtained a new Credit Facility, which provides us with a $750 million senior unsecured five year revolving credit facility, including a $40 million sublimit for swingline borrowings and a $50 million sublimit for letters of credit. The Credit Facility matures, and all amounts outstanding thereunder become due and payable in full, on January 4, 2028, subject to two one-year extensions at our option and the consent of the extending lenders and certain other conditions. As of October 1, 2023, there were no borrowings outstanding under the Credit Facility; however, we may draw upon the facility in the future to manage cash flow or for other corporate purposes, including in connection with the payment of the €432 million European Commission fine. We provided guarantees in October 2023 to satisfy the obligation in lieu of cash payment while we appeal the European Commission’s jurisdictional decision and fine decision.

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As of October 1, 2023, the fair value of our contingent consideration liability related to our acquisition of GRAIL was $330 million, of which $329 million was included in other long-term liabilities. The contingent value rights issued as part of the acquisition entitle the holders to receive future cash payments on a quarterly basis (Covered Revenue Payments) representing a pro rata portion of certain GRAIL-related revenues (Covered Revenues) each year for a 12-year period. This will reflect a 2.5% payment right to the first $1 billion of revenue each year for 12 years. Revenue above $1 billion each year will be subject to a 9% contingent payment right during this same period. We expect Covered Revenues for Q3 2023 to be approximately $21 million and for related Covered Revenue Payments to total approximately $194,000 in Q4 2023. In YTD 2023, we paid $609,000 in aggregate Covered Revenue Payments related to Covered Revenues for Q4 2022, Q1 2023, and Q2 2023 of $65 million in aggregate.

We grant cash incentive equity awards to GRAIL employees that generally have terms of four years and vest in equal annual installments. As of October 1, 2023, the aggregate cash value of awards outstanding and unvested was $308 million, and we accrued an estimated liability of $42 million, included in accrued liabilities. In addition, we have an outstanding performance-based award for which vesting is based on GRAIL’s future revenues. The award has an aggregate potential value of up to $78 million, which is expected to be settled in cash, and expires, to the extent unvested, in August 2030. As of October 1, 2023, it was not probable that the performance conditions associated with the award will be achieved.

We had $5 million and up to $74 million, respectively, remaining in our capital commitments to two venture capital investment funds as of October 1, 2023 that are callable through April 2026 and July 2029, respectively.

Authorizations to repurchase $15 million of our common stock remained available as of October 1, 2023 under the $750 million share repurchase program authorized by our Board of Directors on February 5, 2020. The repurchases may be completed under a 10b5-1 plan or at management’s discretion. We do not intend to make any share repurchases during fiscal year 2023.

We anticipate that our current cash, cash equivalents, and short-term investments, together with cash provided by operating activities and available borrowing capacity under the Credit Facility, are sufficient to fund our near-term capital and operating needs for at least the next 12 months. Operating needs include the planned costs to operate our business, including amounts required to fund working capital and capital expenditures. Our primary short-term needs for capital, which are subject to change, include:

•support of commercialization efforts related to our current and future products;

•acquisitions of equipment and other fixed assets for use in our current and future manufacturing and research and development facilities;

•the continued advancement of research and development efforts;

•the payment of the European Commission fine related to our acquisition of GRAIL;

•the requirement to ensure that GRAIL has access to sufficient funds, at the time of a divestment, to cover at least 2.5 years of operations according to its latest long-range plan per the EC Divestment Decision;

•potential strategic acquisitions and investments;

•repayment of debt obligations; and

•the expansion needs of our facilities, including costs of leasing and building out additional facilities.

We expect that our revenue and the resulting operating income, as well as the status of each of our new product development programs, will significantly impact our cash management decisions.

Our future capital requirements and the adequacy of our available funds will depend on many factors, including:

•our ability to successfully commercialize and further develop our technologies and create innovative products in our markets;

•scientific progress in our research and development programs and the magnitude of those programs;

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•competing technological and market developments; and

•the need to enter into collaborations with other companies or acquire other companies or technologies to enhance or complement our product and service offerings.

Cash Flow Summary

In millions	YTD 2023		YTD 2022
Net cash provided by operating activities	$	254	$	245
Net cash used in investing activities	(146)		(489)
Net cash (used in) provided by financing activities	(1,183)		44
Effect of exchange rate changes on cash and cash equivalents	(9)		(32)
Net decrease in cash and cash equivalents	$	(1,084)	$	(232)

Operating Activities

Net cash provided by operating activities in YTD 2023 primarily consisted of a net loss of $986 million, plus net adjustments of $1,408 million, less net changes in operating assets and liabilities of $168 million. The primary adjustments to net loss included goodwill and intangible (IPR&D) impairment of $821 million, depreciation and amortization expense of $323 million, share-based compensation expense of $286 million, property and equipment and right-of-use asset impairment of $56 million, net losses on strategic investments of $39 million and an unrealized loss on foreign exchange translation of $21 million, partially offset by change in fair value of contingent consideration liabilities of $82 million and deferred income taxes of $42 million. Cash flow impact from changes in net operating assets and liabilities were primarily driven by increases in inventory and accounts receivable and decreases in accounts payable and accrued liabilities.

Investing Activities

Net cash used in investing activities totaled $146 million in YTD 2023. We invested $144 million in capital expenditures, primarily associated with our investment in facilities, and $19 million was used for purchases of strategic investments, partially offset by sales of our strategic investments of $18 million.

Financing Activities

Net cash used in financing activities totaled $1,183 million in YTD 2023. We used $500 million to repay our 2023 Term Notes in Q1 2023, used $750 million to repay our 2023 Convertible Notes in Q3 2023, and used $14 million to pay taxes related to net share settlement of equity awards, partially offset by $67 million received in proceeds from the sale of shares under our employee stock purchase plan.

CRITICAL ACCOUNTING POLICIES AND ESTIMATES

In preparing our condensed consolidated financial statements, we make estimates, assumptions and judgments that can have a significant impact on our net revenue, operating income (loss) and net income (loss), as well as on the value of certain assets and liabilities on our balance sheet. We believe that the estimates, assumptions and judgments involved in the accounting policies described in “Critical Accounting Policies and Estimates” within the Management’s Discussion & Analysis section of our Annual Report on Form 10-K for the fiscal year ended January 1, 2023 have the greatest potential impact on our financial statements, so we consider them to be our critical accounting policies and estimates. Though the COVID-19 pandemic, the armed conflict between Russia and Ukraine, and macroeconomic factors such as inflation, exchange rates and concerns about an economic downturn present additional uncertainty, we continue to use the best information available to inform our critical accounting estimates. There were no material changes to our critical accounting policies and estimates during YTD 2023, with the exception of income taxes as disclosed in note “1. Organization and Significant Accounting Policies.”

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RECENT ACCOUNTING PRONOUNCEMENTS

For a summary of recent accounting pronouncements applicable to our condensed consolidated financial statements, see note “1. Organization and Significant Accounting Policies” within the Condensed Consolidated Financial Statements section of this report, which is incorporated herein by reference.

QUANTITATIVE AND QUALITATIVE DISCLOSURE ABOUT MARKET RISK

There were no substantial changes to our market risks in YTD 2023, when compared to the disclosures in “Quantitative and Qualitative Disclosures about Market Risk” within the Management’s Discussion & Analysis section of our Annual Report on Form 10-K for the fiscal year ended January 1, 2023.

OTHER KEY INFORMATION

CONTROLS AND PROCEDURES

We design our internal controls to provide reasonable assurance that (1) our transactions are properly authorized; (2) our assets are safeguarded against unauthorized or improper use; and (3) our transactions are properly recorded and reported in conformity with U.S. generally accepted accounting principles. We also maintain internal controls and procedures to ensure that we comply with applicable laws and our established financial policies.

During the third quarter of 2023, we continued to monitor and evaluate the design and operating effectiveness of key controls. There were no changes in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) of the Exchange Act) that materially affected or are reasonably likely to materially affect internal control over financial reporting.

Based on management’s evaluation (under the supervision and with the participation of our chief executive officer (CEO) and chief financial officer (CFO)), as of the end of the period covered by this report, our CEO and CFO concluded that our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”)), are effective to provide reasonable assurance that information required to be disclosed by us in reports that we file or submit under the Exchange Act is recorded, processed, summarized, and reported within the time periods specified in SEC rules and forms, and is accumulated and communicated to management, including our principal executive officer and principal financial officer, as appropriate, to allow timely decisions regarding required disclosure.

LEGAL PROCEEDINGS

See discussion of legal proceedings in note “7. Legal Proceedings” in the Condensed Consolidated Financial Statements section of this report, which is incorporated herein by reference.

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RISK FACTORS

Our business is subject to various risks, including those described in “Risk Factors” within the Business & Market Information section of our Annual Report on Form 10-K for the fiscal year ended January 1, 2023, the “Other Key Information” section of our Quarterly Report on Form 10-Q for the period ended April 2, 2023 and on Form 10-Q for the period ended July 2, 2023, which we strongly encourage you to review. In addition to the risk factors disclosed in our Form 10-K, Form 10-Q for Q1 2023 and Form 10-Q for Q2 2023, the issues raised in the following risk factor could adversely affect our operating results and stock price:

Our acquisition of GRAIL remains subject to ongoing legal and regulatory proceedings in the United States and in the European Union. Adverse decisions by the EU and/or U.S. courts, the European Commission, the FTC and/or other governmental or regulatory authorities, that have been issued in the past or may be issued in the future, and/or other adverse consequences resulting from our decision to proceed with the completion of the acquisition, have resulted in significant financial penalties, operational restrictions and increased costs, and could result in similar additional future consequences or further result in loss of revenues, implicate our existing contractual arrangements or require us to divest all or a portion of the assets or equity interests of GRAIL on terms that are materially worse than the terms on which we acquired GRAIL, any or all of which, individually or in the aggregate, could have a material adverse effect on our business, financial condition and results of operation.

As previously disclosed, on March 30, 2021, the FTC filed an administrative complaint alleging that our acquisition of GRAIL (the Acquisition) would violate Section 7 of the Clayton Act, as amended, 15 U.S.C. § 18. On September 1, 2022, the administrative law judge (the ALJ) ruled in favor of Illumina and found that the acquisition of GRAIL did not violate Section 7 of the Clayton Act. The FTC’s complaint counsel appealed the ALJ’s decision to the full FTC on September 2, 2022. On March 31, 2023, the FTC issued an opinion and order (the FTC Order) requiring Illumina to divest GRAIL, reversing the ALJ’s ruling. On April 5, 2023, Illumina filed a petition for review of the FTC Order in the U.S. Court of Appeals for the Fifth Circuit. On April 24, 2023, the FTC granted a motion staying in its entirety the FTC Order pending resolution of Illumina’s Fifth Circuit appeal. Illumina submitted its opening appeal brief on June 5, 2023. The appeal was fully briefed as of August 16, 2023 and oral argument occurred on September 12, 2023. We intend to continue to vigorously defend against the FTC action.

As previously disclosed, on April 19, 2021, the European Commission accepted a request for referral of the Acquisition (the Referral) for European Union merger review under Article 22(1) of Council Regulation (EC) No 139/2004 (the EU Merger Regulation), which had been submitted by a Member State of the European Union. On July 13, 2022, the EU General Court ruled that the European Commission has jurisdiction to review the Acquisition under the EU Merger Regulation. On September 22, 2022, we filed an appeal in the Court of Justice of the European Union asking for annulment of the EU General Court’s decision.

As previously disclosed, on October 29, 2021, the European Commission adopted an order imposing interim measures (the Initial Interim Measures Order), which was renewed on October 28, 2022 (subject to certain operational modifications and also expressly prohibits Illumina from selling, transferring, encumbering or otherwise disposing of GRAIL or any of GRAIL’s assets), provided that (i) we ensure that Illumina and GRAIL will continue to operate as independent legal entities that transact at arms’ length, no integration activity will take place, the day-to-day operation of GRAIL will remain the sole responsibility of GRAIL’s management and our management will have no involvement in or influence over GRAIL, (ii) we take certain supportive measures to preserve GRAIL’s viability, marketability and competitiveness, including with respect to the provision of resources to GRAIL and the retention and/or replacement of key personnel of GRAIL, (iii) subject to limited exceptions, we implement all necessary measures to ensure that Illumina does not obtain any confidential information relating to GRAIL during the hold separate period and vice versa and (iv) we appoint an independent firm as monitoring trustee to monitor our compliance with the Initial Interim Measures Order. An independent monitoring trustee has been appointed. Such hold separate arrangement, and our obligations pursuant thereto, have imposed implementation and administrative processes and additional legal, financial advisory, regulatory and other professional services costs, which have been burdensome to implement and administer, and which we expect to continue for the duration of the hold separate arrangement (in the form of transitional measures imposed on Illumina pursuant to a decision adopted by the European Commission on October 12, 2023 (the EC Divestment Decision), which replaced the New Interim Measures Order). Such burdens and additional costs, independently or together with additional burdens, costs and/or liabilities arising from such arrangement, may result in loss of revenue and other adverse effects on our business, financial condition and results of operations and have an adverse impact on our ability to achieve the anticipated benefits of the Acquisition, as further explained below. Moreover, our failure to comply with the terms of the EC

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Divestment Decision may result in the European Commission seeking to impose fines or other penalties on us. On January 10, 2023, we filed an action with the EU General Court asking for annulment of the New Interim Measures Order. On January 20, 2023, the European Commission requested that these proceedings be stayed pending our appeal on jurisdiction.

We submitted a filing indicating that we had no objections to the European Commission’s request, and the EU General Court stayed the proceedings on February 21, 2023.

On September 6, 2022, the European Commission announced that it had completed its Phase II review of the Acquisition and adopted a final decision (the Prohibition Decision), which found that, in its view, our acquisition of GRAIL was incompatible with the internal market in Europe because it results in a significant impediment to effective competition. On November 17, 2022, we filed an action with the EU General Court asking for annulment of the Prohibition Decision. On October 12, 2023, the European Commission adopted the EC Divestment Decision requiring us to (among other things) divest GRAIL and imposing the transitional measures. We intend to appeal the EC Divestment Decision.

The Prohibition Decision, the EC Divestment Decision, and any order or decision by the FTC or any other governmental or regulatory authority pursuant to which Illumina is required to divest GRAIL (an FTC Divestment Decision), if implemented once final and non-appealable or during the pendency of the applicable appeals proceedings, and our obligations pursuant thereto, have imposed in the past and may impose in the future significant costs and additional liabilities on us, including significant legal, financial advisory, regulatory and other professional services fees and additional expenses, and may result in loss of revenue and other adverse effects on our business, financial condition and results of operations. Such adverse effects could include being required to divest GRAIL on terms that are materially worse than the terms on which we acquired GRAIL. Furthermore, we may not be able to direct the timing, structure or financial terms of such divestment, which could result in negative financial or tax consequences. For example, we are unlikely to be able to, in a sale of GRAIL, effect such sale in a non-taxable transaction and so would incur significant tax liabilities attributable to the recognition of taxable gain equal to the difference between (i) the fair market value of any consideration received and (ii) our tax basis in GRAIL (which tax basis is currently estimated to be between zero and $500 million). In addition, any such divestment will likely implicate certain provisions in our third-party contracts and other agreements, including our obligations with respect to the contingent value rights (the CVRs) issued by us as part of the Acquisition. We may be unable to fully discharge our obligations with respect to the CVRs in connection with any such divestiture, and/or such divestiture may result in a change in obligor on the CVRs. Moreover, the business of GRAIL may be adversely affected by any such divestment, which could adversely affect the market value of the CVRs. The EC Divestment Decision requires us to ensure that GRAIL has access to sufficient funds to cover at least 2.5 years of operations according to its latest long-range plan.

Furthermore, even if an order or decision by the European Commission, General Court of EU, FTC or any other governmental or regulatory authority, approves the Acquisition, the delay in the approval or/and the imposition of conditions not part of the Acquisition agreement, could adversely affect the synergies and benefits we anticipate from the integration of GRAIL in our operations and may result in loss of revenue and other adverse effects on our business, financial condition and results of operations.

The Initial Interim Measures Order, the New Interim Measures Order, the Prohibition Decision, and the EC Divestment Decision, or an FTC Divestment Decision or any other order or decision by any other governmental or regulatory authority, if implemented once final and non-appealable or during the pendency of the applicable appeals proceedings, have in the past and could may also in the future divert management’s attention and company resources away from existing operations and other opportunities that may have been beneficial to us, any or all of which, individually or in the aggregate, could have a material adverse effect on our business, financial condition and results of operation. We have experienced and might continue to experience negative impacts on our stock price. We cannot predict what other adverse consequences to, among other things, our reputation, our relationships with governmental or regulatory authorities, or our ability to successfully complete future transactions, our ability to attract, retain and motivate customers, key personnel and those with whom we conduct business may result.

On July 12, 2023, the European Commission adopted a final decision finding that we breached the EU Merger Regulation by, in its view, acquiring the possibility to exert decisive influence over GRAIL and exerting such influence during the pendency of the European Commission’s review (the Article 14(2)(b) Decision). The European Commission therefore imposed a fine on us pursuant to Article 14(2)(b) of the EU Merger Regulation of

41

approximately €432 million, representing the maximum fine of 10% of our consolidated annual revenues for fiscal year 2022. We provided guarantees in October 2023 to satisfy the obligation in lieu of cash payment while we appeal the European Commission’s jurisdictional decision and fine decision. As of October 1, 2023, we accrued $458 million, including related foreign currency gains, included in accrued liabilities. In addition, the European Commission, the FTC and/or other governmental or regulatory authorities may seek to impose other fines, penalties, remedies or restrictions. We also cannot predict what other adverse consequences to, among other things, our reputation, our relationships with governmental or regulatory authorities or our ability to successfully complete future acquisitions and/or divestitures may result from our decision to proceed with the completion of the Acquisition. We expect to continue to hold the assets or equity interests of GRAIL separate until the applicable legal and regulatory proceedings are completed or, if required, a divestment of GRAIL is effected, and such inability to integrate may materially and adversely affect or prevent the synergies and other benefits we expect to achieve as a result of the Acquisition and could result in additional costs or liabilities, loss of revenue and other adverse effects on our business, financial condition and results of operations. In addition, under applicable accounting rules, we may be required from time to time to perform interim analyses of the value of GRAIL. To the extent that the value of GRAIL on a standalone basis is less than its book value, we would be required to record an impairment on our consolidated financial statements.

Furthermore, we have and may continue to become subject to stockholder inspection demands under Delaware law, investigations initiated by regulators and law firms, and derivative or other similar litigation that can be expensive, divert management attention and human and financial capital to less productive uses and result in potential reputational damage. The GRAIL acquisition and subsequent litigation resulted in (i) the announcement of an investigation by the SEC and others by law firms of possible securities law violations; (ii) stockholder inspection demands seeking to investigate possible breaches of fiduciary duties, corporate wrongdoing or a lack of independence of the members of the Board; and (iii) the filing of a stockholder derivative and class action complaint captioned Icahn Partners LP, et al. v. deSouza, et al.. The complaint, purportedly brought on behalf of Illumina and public holders of Illumina’s common stock, was filed in the Delaware Court of Chancery against certain current and former directors (including our former Chief Executive Officer). We are named as a nominal defendant in the complaint. The lawsuit alleges the named directors breached their fiduciary duties by knowingly causing Illumina to unlawfully close the GRAIL acquisition, concealing material facts related to the GRAIL acquisition and making inadequate disclosures. See note “7. Legal Proceedings” for further details. In the event that any of the matters described above result in one or more adverse judgments or settlements, we may experience an adverse impact on our financial condition, results of operations or stock price.

SHARE REPURCHASES AND SALES

Purchases of Equity Securities by the Issuer

None during the quarterly period ended October 1, 2023.

Unregistered Sales of Equity Securities

None during the quarterly period ended October 1, 2023.

ADOPTIONS, MODIFICATIONS OR TERMINATIONS OF TRADING PLANS

During the quarterly period ended October 1, 2023, the following directors and officers adopted, modified or terminated 10b5-1 plans:

•On September 26, 2023, Phil Febbo, our former Chief Medical Officer, terminated a trading arrangement he had previously adopted with respect to the sale of securities of the Company’s common stock (a “Rule 10b5-1 Trading Arrangement”) in connection with his departure from the Company. Mr. Febbo’s Rule 10b5-1 Trading Arrangement was adopted on May 30, 2023, had a termination date of December 31, 2024, and provided for the sale of up to 9,294 shares of common stock pursuant to the terms of the plan.

Other than as disclosed above, during the quarterly period ended October 1, 2023, (i) none of the Company’s directors or officers adopted or terminated any “Rule 10b5-1 trading arrangement” or any “non-Rule 10b5-1 trading arrangement,” and (ii) the Company did not adopt a “10b5-1 trading arrangement,” in each case as such term is defined in Item 408 of Regulation S-K.

42

EXHIBITS

		Incorporated by Reference
Exhibit Number	Exhibit Description	Form	File Number	Exhibit	Filing Date	Filed Herewith
+10.1	Offer Letter to Jacob Thaysen, dated August 31, 2023	8-K	001-35406	10.1	9/5/2023
+10.2	Amended and Restated Offer Letter to Jacob Thaysen, dated November 8, 2023	8-K	001-35406	10.3	11/9/2023
+10.3	Separation Agreement and Release of All Claims by and between Illumina, Inc. and Phil Febbo, dates as of September 5, 2023					X
31.1	Certification of Jacob Thaysen pursuant to Section 302 of the Sarbanes-Oxley Act of 2002					X
31.2	Certification of Joydeep Goswami pursuant to Section 302 of the Sarbanes-Oxley Act of 2002					X
32.1	Certification of Jacob Thaysen pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002					X
32.2	Certification of Joydeep Goswami pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002					X
101.INS	XBRL Instance Document - the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document					X
101.SCH	XBRL Taxonomy Extension Schema					X
101.CAL	XBRL Taxonomy Extension Calculation Linkbase					X
101.LAB	XBRL Taxonomy Extension Label Linkbase					X
101.PRE	XBRL Taxonomy Extension Presentation Linkbase					X
101.DEF	XBRL Taxonomy Extension Definition Linkbase					X
104	Cover Page Interactive Data File - formatted in Inline XBRL and included as Exhibit 101					X

__________________________________

+ Management contract or corporate plan or arrangement

* Certain schedules and exhibits have been omitted pursuant to Item 601(b)(2) of Regulation S-K. A copy of any omitted schedule or exhibit will be furnished supplementally to the SEC upon request.

43

FORM 10-Q CROSS-REFERENCE INDEX

	Page
PART I. FINANCIAL INFORMATION
Item 1. Financial Statements	6
Condensed Consolidated Balance Sheets	6
Condensed Consolidated Statements of Operations	7
Condensed Consolidated Statements of Comprehensive Loss	8
Condensed Consolidated Statement of Stockholders’ Equity	9
Condensed Consolidated Statements of Cash Flows	11
Notes to Condensed Consolidated Financial Statements	12
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations	29
Item 3. Quantitative and Qualitative Disclosures About Market Risk	39
Item 4. Controls and Procedures	39
PART II. OTHER INFORMATION
Item 1. Legal Proceedings	39
Item 1A. Risk Factors	39
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds	42
Item 3. Defaults Upon Senior Securities	None
Item 4. Mine Safety Disclosures	Not Applicable
Item 5. Other Information	42
Item 6. Exhibits	43
Signatures	45

44

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

		ILLUMINA, INC. (registrant)
Date:	November 9, 2023
		By:	/s/ Joydeep Goswami
		Name:	Joydeep Goswami
		Title:	Chief Financial Officer, Chief Strategy and Corporate Development Officer

45

EX-10.2

SEPARATION AGREEMENT AND GENERAL RELEASE OF ALL CLAIMS

This Separation Agreement and General Release of All Claims (“Agreement”) is made by and between Illumina, Inc. (“Illumina” or “the Company”) and Phil Febbo (“Employee”), collectively (“the Parties”), with respect to the following facts:

A.Employee is employed by Company as its Chief Medical Officer.

B.Employee’s employment ended effective August 7, 2023 (Separation Date).

C.The Company wishes to assist Employee in Employee’s transition to other employment and has offered to provide Employee with a severance payment and benefits as described below.

D.Employee has received all compensation, wages, commissions, equity awards, bonuses, and expense reimbursements owed to Employee by the Company as of the date this Agreement as signed by the Employee.

THEREFORE, in consideration of the promises and mutual agreements hereinafter set forth, it is agreed by and between the undersigned as follows:

1.Severance.

1.1    Severance. The Company agrees to pay Employee a Severance Payment equivalent to 52 weeks of Employee’s normal wages, in the gross amount of Six-Hundred Thousand Dollars and Zero Cents ($600,000.00) less all appropriate federal and state tax withholdings, an amount to which Employee is not otherwise entitled (“Severance Payment”). Employee acknowledges and agrees that this Severance Payment constitutes adequate legal consideration for the promises and representations made by Employee in this Agreement. Subject to the provisions below, the Severance Payment will be made in a lump sum payment within thirty days after all of the following: (1) the Effective Date of this Agreement (as described in paragraph 7.4 below); (2) after signing this Agreement, Employee has returned the Agreement to Illumina at hsotomayor@illumina.com by the deadline described in paragraph 9 below; and (3) Employee has timely returned to Illumina all company property in Employee’s possession, custody, or control (according to paragraph 10).

1.2    The Company agrees to pay the cost of premiums for continued health insurance coverage through the provisions of the Consolidated Omnibus Budget Reconciliation Act (“COBRA”), for an additional period of 12 months following the termination of Employee’s benefits. These sums will be paid directly to Illumina’s carrier provided that the Employee timely and properly completes all required elections to continue coverage under COBRA. Thereafter, Employee may elect to continue such benefits at Employee’s own expense under the provisions of COBRA. The Company will not pay for out-of-pocket medical expenses should the Employee fail to timely and properly elect continuation of coverage through COBRA.

1.3    The Company agrees to pay the cost of Employee's executive physical exam for the 2023 calendar year, provided that Employee has not undergone such physical exam prior to the Effective Date.

2.General Release.

2.1    Employee unconditionally, irrevocably, and absolutely releases and discharges the Company, and any parent and subsidiary corporations, divisions, and other affiliated entities of the Company, past and present, as well as the Company’s employees, officers, directors, agents, attorneys, successors, and assigns of the Company (collectively, “Released Parties”), from all claims related in any way to the transactions or occurrences between them to date to the fullest extent permitted by law including, but not limited to, Employee’s employment with the Company, the termination of Employee’s employment, and all other losses, liabilities, claims, demands, and causes of action, known or unknown, suspected or unsuspected, arising directly or indirectly out of, or in any way connected with, Employee’s employment with the Company. This release is intended to have the broadest possible application and includes, but is not limited to, any claims under any state law, tort, contract, common law, constitutional or other statutory claims;

any claim for unpaid wages, commissions, bonuses or other employment benefits, including claims for unvested stock options or incentive/bonus compensation (including claims for unvested Equity Awards and/or benefits under the Variable Compensation Plans); as well as alleged violations of the California Labor Code or the federal Fair Labor Standards Act; Title VII of the Civil Rights Act of 1964; the Family and Medical Leave Act; the Worker Adjustment and Retraining Notification Act (including any similar state statute); the Sarbanes-Oxley Act of 2002; the California Fair Employment and Housing Act; the Americans with Disabilities Act; the Age Discrimination in Employment Act of 1967, as amended; and all claims for attorneys’ fees, costs, and expenses. However, this release shall not apply to claims for workers’ compensation benefits, unemployment insurance benefits, or any other claims that cannot lawfully be waived, nor to Employee’s rights to indemnification, and advancement of legal fees as may be required, as a former officer of the Company, Employee’s right to enforce the terms of this Agreement, Employee’s rights as a shareholder of the Company and Employee’s rights to any employee benefits accrued for Employee and as to which he has a right following his separation from employment.

2.2    Employee acknowledges that Employee may discover facts or law different from, or in addition to, the facts or law that Employee knows or believes to be true with respect to the claims released in this Agreement and agrees, nonetheless, that this Agreement and the release contained in it shall be and remain effective in all respects notwithstanding such different or additional facts or the discovery of them.

2.3    Employee declares and represents that Employee intends this Agreement to be final and complete and not subject to any claim of mistake. Employee executes this release with the full knowledge that this release covers all possible claims against the Released Parties, to the fullest extent permitted by law.

2.4    Employee expressly waives Employee’s right to recover any type of personal relief from the Company, including monetary damages or reinstatement, in any administrative action or proceeding, whether state or federal, and whether brought by Employee or on Employee’s behalf by an administrative agency, related in any way to the matters released herein. Nothing in this paragraph is intended to prevent or discourage the Employee from communicating with any state or federal governmental agency.

2.5    Employee declares and represents that as of the Effective Date of this Agreement, Employee is not aware of any violations of any applicable rules, regulations and/or laws by Company or any employee of Company; or that if he/she is aware of or is concerned about any such violations, Employee has reported those to the Company.

3.California Civil Code Section 1542 Waiver. Employee expressly acknowledges and agrees that all rights under section 1542 of the California Civil Code are expressly waived. That section provides:

A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS THAT THE CREDITOR OR RELEASING PARTY DOES NOT KNOW OR SUSPECT TO EXIST IN HIS OR HER FAVOR AT THE TIME OF EXECUTING THE RELEASE AND THAT, IF KNOWN BY HIM OR HER, WOULD HAVE MATERIALLY AFFECTED HIS OR HER SETTLEMENT WITH THE DEBTOR OR RELEASED PARTY.

Employee understands that Employee is a “creditor” within the meaning of section 1542.

4.Representation Concerning Filing of Legal Actions. Employee represents that, as of the date of this Agreement, Employee has not filed any lawsuits, complaints, petitions, claims, or other accusatory pleadings against the Company or any of the other Released Parties in any court. Employee further agrees that, to the fullest extent permitted by law, Employee will not prosecute in any court, whether state or federal, any claim or demand of any type related to the matters released above, it being the intention of the parties that with the execution of this release, the Released Parties will be absolutely, unconditionally, and forever discharged of and from all obligations to or on behalf of Employee related in any way to the matters discharged herein. Nothing in this agreement shall prevent the Employee from complying with a lawfully issued subpoena or from communicating with a state or federal governmental agency.

5.No Admissions. By entering into this Agreement, the Released Parties make no admission that they have engaged, or are now engaging, in any unlawful conduct. The parties understand and

acknowledge that this Agreement is not an admission of liability and shall not be used or construed as such in any legal or administrative proceeding.

6.Agreement to Cooperate. Employee agrees that Employee will, in good faith and with due diligence, assist in, facilitate, and cooperate with the Company and provide information as to matters which Employee was personally involved, or has information on, while Employee was an employee of the Company and which become the subject of an action, investigation, proceeding, litigation, or otherwise. Employee agrees to be available, upon reasonable notice, to be interviewed, give sworn testimony and statements, declarations, trial testimony, and other such disclosures. Nothing herein is intended or should be construed as requiring anything other than Employee’s cooperation in providing truthful and accurate information.

7.Older Workers’ Benefit Protection Act. This Agreement is intended to satisfy the requirements of the Older Workers’ Benefit Protection Act, 29 U.S.C. sec. 626(f). The following general provisions, along with the other provisions of this Agreement, are agreed to for this purpose:

7.1    Employee acknowledges and agrees that Employee has read and understands the terms of this Agreement.

7.2    Employee is advised that Employee should consult with an attorney before signing this Agreement, and Employee acknowledges that Employee has obtained and considered any legal advice Employee deems necessary, such that Employee is entering into this Agreement freely, knowingly, and voluntarily.

7.3    Employee acknowledges that Employee has been given at least twenty-one calendar days in which to consider whether or not to enter into this Agreement. Employee understands that, at Employee’s option, Employee may elect not to use the full 21-day period.

7.4    This Agreement shall not become effective or enforceable until the eighth day after Employee signs this Agreement. In other words, Employee may revoke Employee’s acceptance of this Agreement within seven days after the date Employee signs it (“Revocation Period”). Employee's revocation must be in writing and received by Herman Sotomayor of Illumina no later than the conclusion of the Revocation Period in order to be effective. If Employee does not revoke acceptance within the Revocation Period, Employee's acceptance of this Agreement shall become binding and enforceable on the eighth day (“Effective Date”).

7.5    This Agreement does not waive or release any rights or claims that Employee may have under the Age Discrimination in Employment Act that arise after the execution of this Agreement.

8.Severability. In the event any provision of this Agreement shall be found unenforceable by a court of competent jurisdiction, the provision shall be deemed modified to the extent necessary to allow enforceability of the provision as so limited, it being intended that the Released Parties shall receive the benefits contemplated herein to the fullest extent permitted by law. If a deemed modification is not satisfactory in the judgment of such court, the unenforceable provision shall be deemed deleted, and the validity and enforceability of the remaining provisions shall not be affected thereby.

9.Deadline For Agreement Execution. This Agreement constitutes an offer to Employee, which must be accepted by Employee and returned to the Company by no later than the conclusion of the 21-Day Consideration Period described in paragraph 7.3, above, after which date the offer made herein shall lapse and be of no further force or effect.

10.Return of Company Property. Employee understands and agrees that as a condition of receiving the Severance Payment, all Company property still in Employee’s possession, if any, must be immediately returned to the Company. By signing this Agreement, Employee represents and warrants that Employee has or will have returned such Company Property no later than Employee’s Separation Date, including any Company issued or provided credit cards, computers, vehicles, tangible property and equipment, keys, entry cards, identification badges, telephones, PDAs, and all documents, files, folders, correspondence, memoranda, notes, notebooks, drawings, books, records, plans, forecasts, reports, proposals, agreements, financial information, computer-recorded information, as well as all copies thereof, electronic or otherwise.

11.Applicable Law. The validity, interpretation, and performance of this Agreement shall be construed and interpreted according to the laws of the United States of America and the State of California.

12.Binding on Successors; Full Defense. The parties agree that this Agreement shall be binding on, and inure to, the benefit of Employee or Employee’s successors, heirs and/or assigns.

13.Full Defense. This Agreement may be pled as a full and complete defense to, and may be used as a basis for an injunction against, any action, suit, or other proceeding that may be prosecuted, instituted, or attempted by Employee in breach hereof. Employee agrees that in the event an action or proceeding is instituted by the Released Parties in order to enforce the terms or provisions of this Agreement, the Released Parties shall be entitled to an award of reasonable costs and attorneys’ fees incurred in connection with enforcing this Agreement. The terms of this paragraph shall not apply to an action by Employee to challenge the enforceability of Employee’s waiver of rights under the Age Discrimination in Employment Act.

14.Good Faith. The parties agree to do all things necessary and to execute all further documents necessary and appropriate to carry out and effectuate the terms and purposes of this Agreement.

15.Entire Agreement; Integration. This Agreement contains the entire agreement between the Company and the Employee on the subjects addressed in this Agreement and replaces any other prior agreements or representations, whether oral or written, between them, provided, however, that any proprietary information agreement executed by Employee remains in full force and effect and is not superseded by this Agreement.

16.Modification; Counterparts. This Agreement may be amended only by a written instrument executed by all parties hereto. This Agreement may be executed in counterparts and shall be binding on all parties when each has signed either an original or copy of this Agreement.

17.Confidentiality. Employee agrees that the terms and conditions of this Agreement, shall remain confidential as between the parties, and Employee shall not disclose them to any other person, including, but not limited to, any current or former Illumina employee. Employee also agrees Employee will not respond to, participate in, or contribute to any public discussion or other publicity concerning, or in any way relating to, execution of this Agreement or the events (including any negotiations) leading to its execution. Without limiting the foregoing, the Employee may disclose the monetary aspects of this Agreement to Employee’s spouse, attorneys or financial advisors provided Employee informs them of this confidentiality provision and they agree, in writing, to abide by it. Illumina is required by law to disclose the terms of the Settlement and will do so as required. It will not otherwise disclose the terms of the Settlement. A violation of this Confidentiality provision shall be a material breach of this Agreement.

18.Non-Disparagement. Neither Employee, nor anyone subject to Employee’s direction or control, nor the Company, will, and the Company will advise its Board members and Executive officers not to, make any negative, derogatory or disparaging statements, publications or comments, regarding the other party, including as to Employee’s employment with the Company or the business reputation or business practices of the Company and/or the Released Parties, on the one hand, and the Employee, on the other hand, to any person or entity. This section will in no way prevent Employee from testifying truthfully pursuant to an enforceable subpoena or communicating with a governmental agency. Further, nothing in this Agreement is intended to suppress or limit Employee’s right to testify in any administrative, legislative or judicial forum about alleged criminal conduct or sexual harassment, or to prevent the disclosure of factual information related to claims filed in a civil or administrative action regarding sexual assault, sexual harassment or other forms of sex-based workplace harassment, discrimination or retaliation, to the extent such communications are expressly protected under California law.

19.Section 409(A) of the Internal Revenue Code.

19.1    This Agreement is intended to comply with Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”) or an exemption thereunder and shall be construed and administered in accordance with Section 409A of the Code. Any payments under this Agreement that may be excluded from Section 409A of the Code either as separation pay due to an involuntary separation from

service or as a short-term deferral shall be excluded from Section 409A of the Code to the maximum extent possible. For purposes of Section 409A of the Code, each installment payment provided under the Plan shall be treated as a separate payment. Notwithstanding the foregoing, the Company makes no representations that the payments and benefits provided under this Plan comply with Section 409A of the Code and in no event shall the Company be liable for all or any portion of any taxes, penalties, interest, or other expenses that may be incurred by a Participant on account of non-compliance with Section 409A of the Code.

19.2    Notwithstanding anything herein to the contrary, if Employee is a “Specified Employee,” for purposes of Section 409A of the Code, on the date on which Employee incurs a Separation from Service, any payment or benefit provided in this Agreement that provides for the “deferral of compensation” within the meaning of Section 409A of the Code shall not be paid or provided or commence to be paid or provided on any date prior to the first business day after the date that is six months following Employee’s “Separation from Service” (the “409A Suspension Period”); provided, however, that a payment or benefit delayed pursuant to the preceding clause shall commence earlier in the event of Employee’s death prior to the end of the six-month period. Within 14 calendar days after the end of the 409A Suspension Period, Employee shall be paid a lump sum payment in cash equal to any payments delayed because of the preceding sentence. Thereafter, Employee shall receive any remaining benefits as if there had not been an earlier delay. For purposes of this Agreement, “Separation from Service” shall have the meaning set forth in Section 409A(a)(2)(i)(A) of the Internal Revenue Code and shall be determined in accordance with the default rules under Section 409A. “Specified Employee” shall have the meaning set forth in Section 409A(a)(2)(B)(1) of the Internal Revenue Code, as determined in accordance with the uniform methodology and procedures adopted by the Company and then in effect.

THE PARTIES TO THIS AGREEMENT HAVE READ THE FOREGOING AGREEMENT AND FULLY UNDERSTAND EACH AND EVERY PROVISION CONTAINED HEREIN. WHEREFORE, THE PARTIES HAVE EXECUTED THIS AGREEMENT ON THE DATES SHOWN BELOW.

Dated: Sept. 5, 2023 By: /s/ Phil Febbo

Phil Febbo, Employee

Dated: Sept. 5, 2023 By: /s/ Herman Sotomayor

Herman Sotomayor, Sr. Director, HR

Illumina, Inc.

EX-31.1

Exhibit 31.1

CERTIFICATION OF JACOB THAYSEN PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Jacob Thaysen, certify that:

1	I have reviewed this Quarterly Report on Form 10-Q of Illumina, Inc.;
2	Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3	Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4	The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
	a)	designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
	b)	designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
	c)	evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
	d)	disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5	The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
	a)	all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
	b)	any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Dated: November 9, 2023

By:	/s/ JACOB THAYSEN
Name:	Jacob Thaysen
Title:	Chief Executive Officer

EX-31.2

Exhibit 31.2

CERTIFICATION OF JOYDEEP GOSWAMI PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Joydeep Goswami, certify that:

1	I have reviewed this Quarterly Report on Form 10-Q of Illumina, Inc.;
2	Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3	Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4	The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
	a)	designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
	b)	designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
	c)	evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
	d)	disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5	The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
	a)	all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
	b)	any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Dated: November 9, 2023

By:	/s/ JOYDEEP GOSWAMI
Name:	Joydeep Goswami
Title:	Chief Financial Officer, Chief Strategy and Corporate Development Officer

EX-32.1

Exhibit 32.1

CERTIFICATION OF JACOB THAYSEN PURSUANT TO 18 U.S.C. SECTION

1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-

OXLEY ACT OF 2002

In connection with the Quarterly Report of Illumina, Inc. (the “Company”) on Form 10-Q for the quarter ended October 1, 2023, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Jacob Thaysen, Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1)The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Dated: November 9, 2023

By:	/s/ JACOB THAYSEN
Name:	Jacob Thaysen
Title:	Chief Executive Officer

This certification accompanying the Report is not deemed filed with the Securities and Exchange Commission for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of such Section, and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended (whether made before, on or after the date of the Report), irrespective of any general incorporation language contained in such filing.

EX-32.2

Exhibit 32.2

CERTIFICATION OF JOYDEEP GOSWAMI PURSUANT TO 18 U.S.C.

SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE

SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Illumina, Inc. (the “Company”) on Form 10-Q for the quarter ended October 1, 2023, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Joydeep Goswami, Chief Financial Officer, Chief Strategy and Corporate Development Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1)The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Dated: November 9, 2023

By:	/s/ JOYDEEP GOSWAMI
Name:	Joydeep Goswami
Title:	Chief Financial Officer, Chief Strategy and Corporate Development Officer

This certification accompanying the Report is not deemed filed with the Securities and Exchange Commission for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of such Section, and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended (whether made before, on or after the date of the Report), irrespective of any general incorporation language contained in such filing.

XML

Cover Page - shares shares in Millions	9 Months Ended
	Oct. 01, 2023	Nov. 06, 2023
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Oct. 01, 2023
Document Transition Report	false
Entity File Number	001-35406
Entity Registrant Name	Illumina, Inc.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	33-0804655
Entity Address, Address Line One	5200 Illumina Way
Entity Address, City or Town	San Diego
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	92122
City Area Code	858
Local Phone Number	202-4500
Title of 12(b) Security	Common Stock, $0.01 par value
Trading Symbol	ILMN
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Large Accelerated Filer
Entity Small Business	false
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		158.8
Entity Central Index Key	0001110803
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	Q3
Amendment Flag	false

XML

Condensed Consolidated Balance Sheets - USD ($) $ in Millions	Oct. 01, 2023	Jan. 01, 2023
Current assets:
Cash and cash equivalents	$ 927	$ 2,011
Short-term investments	6	26
Accounts receivable, net	690	671
Inventory, net	615	568
Prepaid expenses and other current assets	268	285
Total current assets	2,506	3,561
Property and equipment, net	1,040	1,091
Operating lease right-of-use assets	581	653
Goodwill	2,527	3,239
Intangible assets, net	3,029	3,285
Other assets	439	423
Total assets	10,122	12,252
Current liabilities:
Accounts payable	240	293
Accrued liabilities	1,242	1,232
Term notes, current portion	0	500
Convertible senior notes, current portion	0	748
Total current liabilities	1,482	2,773
Operating lease liabilities	698	744
Term notes	1,489	1,487
Other long-term liabilities	555	649
Stockholders’ equity:
Common stock	2	2
Additional paid-in capital	9,487	9,207
Accumulated other comprehensive income	21	3
Retained earnings	157	1,142
Treasury stock, at cost	(3,769)	(3,755)
Total stockholders’ equity	5,898	6,599
Total liabilities and stockholders’ equity	$ 10,122	$ 12,252

XML

Condensed Consolidated Statements of Operations - USD ($) shares in Millions, $ in Millions	3 Months Ended		9 Months Ended
	Oct. 01, 2023	Oct. 02, 2022	Oct. 01, 2023	Oct. 02, 2022
Revenue:
Total revenue	$ 1,119	$ 1,115	$ 3,382	$ 3,501
Cost of revenue:
Amortization of acquired intangible assets	47	46	143	125
Total cost of revenue	435	398	1,312	1,201
Gross profit	684	717	2,070	2,300
Operating expense:
Research and development	315	325	1,013	975
Selling, general and administrative	303	146	1,127	865
Goodwill and intangible impairment	821	3,914	821	3,914
Legal contingency and settlement	(1)	(11)	14	598
Total operating expense	1,438	4,374	2,975	6,352
Loss from operations	(754)	(3,657)	(905)	(4,052)
Other income (expense):
Interest income	13	3	47	4
Interest expense	(19)	(6)	(59)	(17)
Other expense, net	(22)	(12)	(33)	(103)
Total other expense, net	(28)	(15)	(45)	(116)
Loss before income taxes	(782)	(3,672)	(950)	(4,168)
(Benefit) provision for income taxes	(28)	144	36	97
Net loss	$ (754)	$ (3,816)	$ (986)	$ (4,265)
Loss per share:
Basic (in dollars per share)	$ (4.77)	$ (24.26)	$ (6.23)	$ (27.13)
Diluted (in dollars per share)	$ (4.77)	$ (24.26)	$ (6.23)	$ (27.13)
Shares used in computing loss per share:
Basic (in shares)	158	157	158	157
Diluted (in shares)	158	157	158	157
Product revenue
Revenue:
Total revenue	$ 941	$ 963	$ 2,864	$ 3,039
Cost of revenue:
Cost of revenue	293	280	884	866
Service and other revenue
Revenue:
Total revenue	178	152	518	462
Cost of revenue:
Cost of revenue	$ 95	$ 72	$ 285	$ 210

XML

Condensed Consolidated Statements of Comprehensive Income (Loss) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Oct. 01, 2023	Oct. 02, 2022	Oct. 01, 2023	Oct. 02, 2022
Statement of Comprehensive Income [Abstract]
Net loss	$ (754)	$ (3,816)	$ (986)	$ (4,265)
Unrealized gain on cash flow hedges, net of deferred tax	9	9	18	22
Total comprehensive loss	$ (745)	$ (3,807)	$ (968)	$ (4,243)

XML

Condensed Consolidated Statements of Stockholders’ Equity - USD ($) shares in Millions, $ in Millions	Total	Cumulative-effect adjustment from adoption of ASU 2016-02, net of deferred tax	Common Stock	Additional Paid-in Capital	Additional Paid-in Capital Cumulative-effect adjustment from adoption of ASU 2016-02, net of deferred tax	Accumulated Other Comprehensive Income (Loss)	Retained Earnings	Retained Earnings Cumulative-effect adjustment from adoption of ASU 2016-02, net of deferred tax	Treasury Stock
Beginning Balance (in shares) at Jan. 02, 2022			197
Beginning balance (in shares) at Jan. 02, 2022									(40)
Beginning balance at Jan. 02, 2022	$ 10,740	$ (32)	$ 2	$ 8,938	$ (93)	$ 17	$ 5,485	$ 61	$ (3,702)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	86						86
Unrealized gain (loss) on cash flow hedges, net of deferred tax	1					1
Issuance of common stock, net of repurchases	21			33					$ (12)
Share-based compensation	79			79
Ending Balance (in shares) at Apr. 03, 2022			197
Ending balance (in shares) at Apr. 03, 2022									(40)
Ending balance at Apr. 03, 2022	$ 10,895		$ 2	8,957		18	5,632		$ (3,714)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Accounting Standards Update [Extensible Enumeration]	Accounting Standards Update 2020-06 [Member]
Beginning Balance (in shares) at Jan. 02, 2022			197
Beginning balance (in shares) at Jan. 02, 2022									(40)
Beginning balance at Jan. 02, 2022	$ 10,740	$ (32)	$ 2	8,938	$ (93)	17	5,485	$ 61	$ (3,702)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	(4,265)
Unrealized gain (loss) on cash flow hedges, net of deferred tax	22
Ending Balance (in shares) at Oct. 02, 2022			197
Ending balance (in shares) at Oct. 02, 2022									(40)
Ending balance at Oct. 02, 2022	6,731		$ 2	9,129		39	1,281		$ (3,720)
Beginning Balance (in shares) at Apr. 03, 2022			197
Beginning balance (in shares) at Apr. 03, 2022									(40)
Beginning balance at Apr. 03, 2022	10,895		$ 2	8,957		18	5,632		$ (3,714)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	(535)						(535)
Unrealized gain (loss) on cash flow hedges, net of deferred tax	12					12
Issuance of common stock, net of repurchases	(4)								$ (4)
Share-based compensation	76			76
Ending Balance (in shares) at Jul. 03, 2022			197
Ending balance (in shares) at Jul. 03, 2022									(40)
Ending balance at Jul. 03, 2022	10,444		$ 2	9,033		30	5,097		$ (3,718)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	(3,816)						(3,816)
Unrealized gain (loss) on cash flow hedges, net of deferred tax	9					9
Issuance of common stock, net of repurchases	28			30					$ (2)
Share-based compensation	66			66
Ending Balance (in shares) at Oct. 02, 2022			197
Ending balance (in shares) at Oct. 02, 2022									(40)
Ending balance at Oct. 02, 2022	6,731		$ 2	9,129		39	1,281		$ (3,720)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	(139)						(139)
Unrealized gain (loss) on cash flow hedges, net of deferred tax	(36)					(36)
Issuance of common stock, net of repurchases (in shares)			1
Issuance of common stock, net of repurchases	(35)								$ (35)
Share-based compensation	78			78
Ending Balance (in shares) at Jan. 01, 2023			198
Ending balance (in shares) at Jan. 01, 2023									(40)
Ending balance at Jan. 01, 2023	6,599		$ 2	9,207		3	1,142		$ (3,755)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	3						3
Unrealized gain (loss) on cash flow hedges, net of deferred tax	(4)					(4)
Issuance of common stock, net of repurchases	28			37					$ (9)
Share-based compensation	67			67
Ending Balance (in shares) at Apr. 02, 2023			198
Ending balance (in shares) at Apr. 02, 2023									(40)
Ending balance at Apr. 02, 2023	6,693		$ 2	9,311		(1)	1,145		$ (3,764)
Beginning Balance (in shares) at Jan. 01, 2023			198
Beginning balance (in shares) at Jan. 01, 2023									(40)
Beginning balance at Jan. 01, 2023	6,599		$ 2	9,207		3	1,142		$ (3,755)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	(986)
Unrealized gain (loss) on cash flow hedges, net of deferred tax	18
Ending Balance (in shares) at Oct. 01, 2023			198
Ending balance (in shares) at Oct. 01, 2023									(40)
Ending balance at Oct. 01, 2023	5,898		$ 2	9,487		21	157		$ (3,769)
Beginning Balance (in shares) at Apr. 02, 2023			198
Beginning balance (in shares) at Apr. 02, 2023									(40)
Beginning balance at Apr. 02, 2023	6,693		$ 2	9,311		(1)	1,145		$ (3,764)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	(234)						(234)
Unrealized gain (loss) on cash flow hedges, net of deferred tax	13					13
Issuance of common stock, net of repurchases	(3)			0					$ (3)
Share-based compensation	77			77
Reclassification of liability-classified awards	9			9
Ending Balance (in shares) at Jul. 02, 2023			198
Ending balance (in shares) at Jul. 02, 2023									(40)
Ending balance at Jul. 02, 2023	6,555		$ 2	9,397		12	911		$ (3,767)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	(754)						(754)
Unrealized gain (loss) on cash flow hedges, net of deferred tax	9					9
Issuance of common stock, net of repurchases	28			30					$ (2)
Share-based compensation	60			60
Ending Balance (in shares) at Oct. 01, 2023			198
Ending balance (in shares) at Oct. 01, 2023									(40)
Ending balance at Oct. 01, 2023	$ 5,898		$ 2	$ 9,487		$ 21	$ 157		$ (3,769)

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Condensed Consolidated Statements of Cash Flows - USD ($) $ in Millions	9 Months Ended
	Oct. 01, 2023	Oct. 02, 2022
Cash flows from operating activities:
Net loss	$ (986)	$ (4,265)
Adjustments to reconcile net loss to net cash provided by operating activities:
Depreciation expense	175	158
Amortization of intangible assets	148	130
Share-based compensation expense	286	266
Deferred income taxes	(42)	(40)
Goodwill and intangible (IPR&D) impairment	821	3,914
Property and equipment and right-of-use asset impairment	56	0
Net losses on strategic investments	39	79
(Gain) loss on Helix contingent value right	(8)	8
Payment of accreted debt discount	(15)	0
Change in fair value of contingent consideration liabilities	(82)	(230)
Unrealized loss on foreign exchange translation	21	1
Other	9	6
Changes in operating assets and liabilities:
Accounts receivable	(31)	13
Inventory	(47)	(127)
Prepaid expenses and other current assets	(3)	10
Operating lease right-of-use assets and liabilities, net	(13)	(10)
Other assets	6	17
Accounts payable	(50)	(51)
Accrued liabilities	(25)	388
Other long-term liabilities	(5)	(22)
Net cash provided by operating activities	254	245
Cash flows from investing activities:
Purchases of property and equipment	(144)	(198)
Purchases of strategic investments	(19)	(26)
Sales of strategic investments	18	0
Net cash paid for acquisitions	0	(85)
Cash paid for intangible asset	(1)	(180)
Net cash used in investing activities	(146)	(489)
Cash flows from financing activities:
Debt issuance costs paid for credit facility	(1)	0
Payments on financing obligations	(1,235)	0
Taxes paid related to net share settlement of equity awards	(14)	(19)
Proceeds from issuance of common stock	67	63
Net cash (used in) provided by financing activities	(1,183)	44
Effect of exchange rate changes on cash and cash equivalents	(9)	(32)
Net decrease in cash and cash equivalents	(1,084)	(232)
Cash and cash equivalents at beginning of period	2,011	1,232
Cash and cash equivalents at end of period	$ 927	$ 1,000

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Organization and Significant Accounting Policies

9 Months Ended

Oct. 01, 2023

Accounting Policies [Abstract]

Organization and Significant Accounting Policies

1. ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES

Business Overview

We are a provider of sequencing- and array-based solutions, serving customers in the research, clinical and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture and other emerging segments. Our customers include leading genomic research centers, academic institutions, government laboratories, and hospitals, as well as pharmaceutical, biotechnology, commercial molecular diagnostic laboratories, and consumer genomics companies.

On August 18, 2021, we acquired GRAIL, a healthcare company focused on early detection of multiple cancers. The acquisition is subject to ongoing legal proceedings and, currently, GRAIL must be held and operated separately and independently from Illumina pursuant to the transitional measures ordered by the European Commission in the EC Divestment Decision, following the prohibition of our acquisition of GRAIL on September 6, 2022. Refer to note “7. Legal Proceedings” for additional details. GRAIL is a separate reportable segment.

With respect to GRAIL, we have retained advisors and are preparing for sale and capital markets transaction options in accordance with the European Commission’s divestiture order. In parallel, ongoing appeals preserve flexibility for any divestiture of GRAIL and future transactions.

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. Interim financial results are not necessarily indicative of results anticipated for the full year. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and footnotes included in the Annual Report on Form 10-K for the fiscal year ended January 1, 2023, from which the prior year balance sheet information herein was derived. The preparation of financial statements requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, and expense, and related disclosure of contingent assets and liabilities. Though the COVID-19 pandemic, the armed conflict between Russia and Ukraine, and macroeconomic factors such as inflation, exchange rates and concerns about an economic downturn present additional uncertainty, we continue to use the best information available to form our critical accounting estimates. Actual results could differ from those estimates.

The unaudited condensed consolidated financial statements include our accounts, our wholly-owned subsidiaries, and majority-owned or controlled companies. All intercompany transactions and balances have been eliminated in consolidation. Certain prior period amounts have been reclassified to conform to the current period presentation. In management’s opinion, the accompanying unaudited condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.

Fiscal Year

Our fiscal year is the 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. References to Q3 2023 and Q3 2022 refer to the three months ended October 1, 2023 and October 2, 2022, respectively, which were both 13 weeks, and references to year-to-date (YTD) 2023 and 2022 refer to the nine months ended October 1, 2023 and October 2, 2022, respectively, which were both 39 weeks.

Significant Accounting Policies

During YTD 2023, there were no changes to our significant accounting policies as described in our Annual Report on Form 10-K for the fiscal year ended January 1, 2023, with the exception of the following for income taxes:

Historically, we calculated the provision/(benefit) for income taxes for interim periods utilizing an estimated annual effective tax rate applied to the income/(loss) for the reporting period, except in Q2 2023 when a year-to-date effective tax rate method was utilized. We determined the estimated annual effective tax rate method would provide a more reliable estimate of the provision for income taxes for Q3 2023 and YTD 2023 since minor changes in the estimated income/(loss) before income taxes would not result in significant changes in the estimated annual effective tax rate.

Loss per Share

Basic loss per share is computed based on the weighted average number of common shares outstanding during the period. Diluted loss per share is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period. In loss periods, basic and diluted loss per share are identical since the effect of potentially dilutive common shares is antidilutive and therefore excluded.

Potentially dilutive common shares consist of shares issuable under convertible senior notes and equity awards. We utilize the if-converted method to calculate the impact of convertible senior notes on diluted loss per share. Potentially dilutive common shares from equity awards are determined using the average share price for each period under the treasury stock method. In addition, proceeds from exercise of equity awards and the average amount of unrecognized compensation expense for equity awards are assumed to be used to repurchase shares.

The following table presents the weighted average shares used to calculate basic and diluted loss per share:

In millions	Q3 2023	Q3 2022	YTD 2023	YTD 2022
Weighted average shares used in calculating basic loss per share	158	157	158	157
Weighted average shares used in calculating diluted loss per share	158	157	158	157
Antidilutive shares:
Convertible senior notes	1	2	1	2
Equity awards	3	2	3	2
Potentially dilutive shares excluded from calculation due to antidilutive effect	4	4	4	4

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Revenue

9 Months Ended

Oct. 01, 2023

Revenue from Contract with Customer [Abstract]

Revenue

2. REVENUE

Our revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instruments and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from genotyping and sequencing services, instrument service contracts, development and licensing agreements, and cancer detection testing services related to the GRAIL business.

Revenue by Source

	Q3 2023						Q3 2022
In millions	Sequencing		Microarray		Total		Sequencing		Microarray		Total
Consumables	$	689	$	71	$	760	$	720	$	76	$	796
Instruments	178		3		181		162		5		167
Total product revenue	867		74		941		882		81		963
Service and other revenue	162		16		178		133		19		152
Total revenue	$	1,029	$	90	$	1,119	$	1,015	$	100	$	1,115

	YTD 2023						YTD 2022
In millions	Sequencing		Microarray		Total		Sequencing		Microarray		Total
Consumables	$	2,108	$	219	$	2,327	$	2,237	$	225	$	2,462
Instruments	524		13		537		563		14		577
Total product revenue	2,632		232		2,864		2,800		239		3,039
Service and other revenue	456		62		518		390		72		462
Total revenue	$	3,088	$	294	$	3,382	$	3,190	$	311	$	3,501

Revenue by Geographic Area

Based on region of destination (in millions)	Q3 2023		Q3 2022(1)		YTD 2023		YTD 2022(1)
Americas	$	663	$	597	$	1,920	$	1,885
Europe	260		259		825		819
Greater China(2)	98		133		302		378
Asia-Pacific, Middle East, and Africa(3)	98		126		335		419
Total revenue	$	1,119	$	1,115	$	3,382	$	3,501

_____________

(1)We implemented a new global commercial structure in Q1 2023 to improve operating efficiencies and better align with local markets. We integrated Asia-Pacific and Japan with emerging markets across the Middle East, Africa, Turkey, and Commonwealth of Independent States (CIS). Beginning in Q1 2023, and going forward, we will report regional results for the following regions: Americas, Europe, Greater China, and Asia-Pacific, Middle East and Africa (AMEA). Prior period amounts have been reclassified to conform to this new presentation.

(2)Region includes revenue from China, Taiwan, and Hong Kong.

(3)Region includes revenue from Russia and Turkey.

Performance Obligations

We regularly enter into contracts with multiple performance obligations. These contracts are believed to be firm as of the balance sheet date. However, we may allow customers to make product substitutions as we launch new products. The timing of shipments depends on several factors, including agreed upon shipping schedules, which may span multiple quarters. Most performance obligations are generally satisfied within a short time frame, approximately three to six months, after the contract execution date. As of October 1, 2023, the aggregate amount of the transaction price allocated to remaining performance obligations was $743 million, of which approximately 83% is expected to be converted to revenue in the next twelve months, approximately 10% in the following twelve months, and the remainder thereafter.

Contract Assets and Liabilities

Contract assets, which consist of revenue recognized and performance obligations satisfied or partially satisfied in advance of customer billing, were $19 million and $17 million as of October 1, 2023 and January 1, 2023, respectively, and were recorded in prepaid expenses and other current assets.

Contract liabilities, which consist of deferred revenue and customer deposits, as of October 1, 2023 and January 1, 2023 were $315 million and $308 million, respectively, of which the short-term portions of $242 million and $245 million, respectively, were recorded in accrued liabilities and the remaining long-term portions were recorded in other long-term liabilities. Revenue recorded in Q3 2023 and YTD 2023 included $43 million and $206 million, respectively, of previously deferred revenue that was included in contract liabilities as of January 1, 2023.

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Investments and Fair Value Measurements

9 Months Ended

Oct. 01, 2023

Fair Value Disclosures [Abstract]

Investments and Fair Value Measurements

3. INVESTMENTS AND FAIR VALUE MEASUREMENTS

Strategic Investments

Marketable Equity Securities

Our short-term investments consist of marketable equity securities. As of October 1, 2023 and January 1, 2023, the fair value of our marketable equity securities totaled $6 million and $26 million, respectively.

Gains and losses recognized in other expense, net on our marketable equity securities were as follows:

In millions	Q3 2023		Q3 2022		YTD 2023		YTD 2022
Net gains (losses) recognized during the period on marketable equity securities	$	—	$	3	$	(2)	$	(66)
Less: Net losses recognized during the period on marketable equity securities sold during the period	—		—		(2)		—
Net unrealized gains (losses) recognized during the period on marketable equity securities still held at the reporting date	$	—	$	3	$	—	$	(66)

Non-Marketable Equity Securities

As of October 1, 2023 and January 1, 2023, the aggregate carrying amounts of our non-marketable equity securities without readily determinable fair values, included in other assets, were $28 million.

Revenue recognized from transactions with our strategic investees was $2 million and $68 million for Q3 2023 and YTD 2023, respectively, and $27 million and $83 million for Q3 2022 and YTD 2022, respectively.

Venture Funds

We invest in two venture capital investment funds (the Funds) with capital commitments of $100 million, callable through April 2026, and up to $150 million, callable through July 2029, respectively, of which $5 million and up to $74 million, respectively, remained callable as of October 1, 2023. Our investments in the Funds are accounted for as equity-method investments. The aggregate carrying amounts of the Funds, included in other assets, were $165 million and $183 million as of October 1, 2023 and January 1, 2023, respectively. We recorded unrealized losses of $19 million and $33 million in Q3 2023 and YTD 2023, respectively, and unrealized losses of $5 million and $11 million in Q3 2022 and YTD 2022, respectively, in other expense, net.

Helix Contingent Value Right

In conjunction with the deconsolidation of Helix Holdings I, LLC (Helix) in April 2019, we received a contingent value right with a 7-year term that entitles us to consideration dependent upon the outcome of Helix’s future financing and/or liquidity events. Changes in the fair value of our contingent value right resulted in unrealized gains of $5 million

and $8 million in Q3 2023 and YTD 2023, respectively, and unrealized losses of $5 million and $8 million in Q3 2022 and YTD 2022, respectively, which were included in other expense, net.

Fair Value Measurements

The following table presents the hierarchy for assets and liabilities measured at fair value on a recurring basis:

	October 1, 2023								January 1, 2023
In millions	Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Assets:
Money market funds (cash equivalents)	$	646	$	—	$	—	$	646	$	1,642	$	—	$	—	$	1,642
Marketable equity securities	6		—		—		6		26		—		—		26
Helix contingent value right	—		—		66		66		—		—		58		58
Deferred compensation plan assets	—		57		—		57		—		52		—		52
Total assets measured at fair value	$	652	$	57	$	66	$	775	$	1,668	$	52	$	58	$	1,778
Liabilities:
Contingent consideration liabilities	$	—	$	—	$	330	$	330	$	—	$	—	$	412	$	412
Deferred compensation plan liability	—		54		—		54		—		51		—		51
Total liabilities measured at fair value	$	—	$	54	$	330	$	384	$	—	$	51	$	412	$	463

Our marketable equity securities are measured at fair value based on quoted trade prices in active markets. Our deferred compensation plan assets consist primarily of investments in life insurance contracts carried at cash surrender value, which reflects the net asset value of the underlying publicly traded mutual funds. We perform control procedures to corroborate the fair value of our holdings, including comparing valuations obtained from our investment service provider to valuations reported by our asset custodians, validating pricing sources and models, and reviewing key model inputs, if necessary. We elected the fair value option to measure the contingent value right received from Helix. The fair value of such contingent value right, included in other assets, is derived using a Monte Carlo simulation. Estimates and assumptions used in the Monte Carlo simulation include probabilities related to the timing and outcome of future financing and/or liquidity events, assumptions regarding collectibility and volatility, and an estimated equity value of Helix. These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value.

We reassess the fair value of contingent consideration related to acquisitions on a quarterly basis. Changes in the fair value of contingent consideration subsequent to the acquisition date are recognized in selling, general and administrative expense. The contingent value rights issued as part of the GRAIL acquisition entitle the holders to receive future cash payments on a quarterly basis (Covered Revenue Payments) representing a pro rata portion of certain GRAIL-related revenues (Covered Revenues) each year for a 12-year period. As defined in the Contingent Value Rights Agreement, this will reflect a 2.5% payment right to the first $1 billion of revenue each year for 12 years. Revenue above $1 billion each year will be subject to a 9% contingent payment right during this same period. Covered Revenues for Q4 2022, Q1 2023, and Q2 2023 were $65 million in aggregate and Covered Revenues for Q4 2021, Q1 2022, and Q2 2022 were $32 million in aggregate, driven primarily by sales of GRAIL’s Galleri test. Covered Revenue Payments relating to such periods were approximately $609,000 and $297,000 in YTD 2023 and YTD 2022, respectively. Pursuant to the Contingent Value Rights Agreement, a portion of the Covered Revenue Payments in YTD 2022 were applied to reimburse us for certain expenses. We use a Monte Carlo simulation to estimate the fair value of contingent consideration related to the GRAIL acquisition. Estimates and assumptions used in the Monte Carlo simulation include forecasted revenues for GRAIL, a revenue risk premium, a revenue volatility estimate, an operational leverage ratio and a counterparty credit spread. These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value. The fair value of our contingent consideration liability related to GRAIL was $330 million and $412 million as of October 1, 2023 and January 1, 2023, respectively, of which $329 million and $411 million, respectively, was included in other long-term liabilities, with the remaining balances included in accrued liabilities.

Changes in the estimated fair value of our contingent consideration liabilities during YTD 2023 were as follows:

In millions
Balance as of January 1, 2023	$	412
Change in estimated fair value	(82)
Balance as of October 1, 2023	$	330

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Debt

9 Months Ended

Oct. 01, 2023

Debt Disclosure [Abstract]

Debt

4. DEBT

Summary of Term Debt Obligations

In millions	October 1, 2023		January 1, 2023
Principal amount of 2031 Term Notes outstanding	$	500	$	500
Principal amount of 2027 Term Notes outstanding	500		500
Principal amount of 2025 Term Notes outstanding	500		500
Principal amount of 2023 Term Notes outstanding	—		500
Unamortized discounts and debt issuance costs	(11)		(13)
Net carrying amount of term notes	1,489		1,987
Less: current portion	—		(500)
Term notes, non-current	$	1,489	$	1,487
Fair value of term notes outstanding (Level 2)	$	1,375	$	1,913

Interest expense recognized on our term notes, which included amortization of debt discounts and issuance costs, was $18 million and $55 million in Q3 2023 and YTD 2023, respectively, and $4 million and $13 million in Q3 2022 and YTD 2022, respectively.

0.550% Term Notes due 2023 (2023 Term Notes) and 2.550% Term Notes due 2031 (2031 Term Notes)

In March 2021, we issued $500 million aggregate principal amount of 2023 Term Notes and $500 million aggregate principal amount of 2031 Term Notes. The 2023 Term Notes matured and were repaid in cash on March 23, 2023.

The 2031 Term Notes, which mature on March 23, 2031, accrue interest at a rate of 2.550% per annum, payable semi-annually on March 23 and September 23 of each year. We may redeem for cash all or any portion of the 2031 Term Notes, at our option, at any time prior to maturity. Prior to December 23, 2030, the 2031 Term Notes are redeemable at make-whole premium redemption prices as defined in the applicable forms of note. After December 23, 2030, the notes are redeemable at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid interest up to, but excluding, the redemption date.

5.800% Term Notes due 2025 (2025 Term Notes) and 5.750% Term Notes due 2027 (2027 Term Notes)

In December 2022, we issued $500 million aggregate principal amount of 2025 Term Notes and $500 million aggregate principal amount of 2027 Term Notes. The 2025 Term Notes, which mature on December 12, 2025, and the 2027 Term Notes, which mature on December 13, 2027, accrue interest at a rate of 5.800% and 5.750% per annum, respectively, payable semi-annually. Interest for the 2025 Term Notes is payable on June 12 and December 12 of each year, beginning on June 12, 2023. Interest for the 2027 Term Notes is payable on June 13 and December 13 of each year, beginning on June 13, 2023.

We may redeem for cash all or any portion of the 2025 or 2027 Term Notes, at our option, at any time prior to maturity. Prior to November 12, 2025 for the 2025 Term Notes and prior to November 13, 2027 for the 2027 Term Notes, the notes are redeemable at make-whole premium redemption prices as defined in the applicable forms of note. After November 12, 2025 for the 2025 Term Notes and after November 13, 2027 for the 2027 Term Notes, the notes are redeemable at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid interest up to, but excluding, the redemption date.

0% Convertible Senior Notes due 2023 (2023 Convertible Notes)

In August 2018, we issued $750 million aggregate principal amount of 2023 Convertible Notes. The notes were convertible into cash, shares of common stock, or a combination of cash and shares of common stock, at our election, based on conversion rates as defined in the indenture. The 2023 Convertible Notes matured on August 15, 2023, at which time the principal was repaid in cash. We did not issue any shares of common stock in connection with the 2023 Convertible Notes.

Credit Agreement

On January 4, 2023, we entered into a new credit agreement (the Credit Agreement), which provides us with a $750 million senior unsecured five-year revolving credit facility, including a $40 million sublimit for swingline borrowings and a $50 million sublimit for letters of credit (the Credit Facility). The proceeds of the loans under the Credit Facility may be used to finance working capital needs and for general corporate purposes. The credit agreement dated as of March 8, 2021 and the commitments thereunder were terminated as of January 4, 2023.

The Credit Facility matures, and all amounts outstanding thereunder become due and payable in full, on January 4, 2028, subject to two one-year extensions at our option, the consent of the extending lenders and certain other conditions. We may prepay amounts borrowed and terminate commitments under the Credit Facility at any time without premium or penalty. As of October 1, 2023, there were no borrowings or letters of credit outstanding under the Credit Facility and we were in compliance with all financial and operating covenants.

Any loans under the Credit Facility will have a variable interest rate based on either the term secured overnight financing rate or the alternate base rate, plus an applicable rate that varies with the Company’s debt rating and, in the case of loans bearing interest based on the term secured overnight financing rate, a credit spread adjustment equal to 0.10% per annum. The Credit Agreement includes an option for us to elect to increase the commitments

under the Credit Facility or to enter into one or more tranches of term loans in the aggregate principal amount of up to $250 million, subject to the consent of the lenders providing the additional commitments or term loans, as applicable, and certain other conditions.

The Credit Agreement contains financial and operating covenants. Pursuant to the Credit Agreement, we are required to maintain a ratio of total debt to annual earnings before interest, taxes, depreciation and amortization (EBITDA), calculated based on the four consecutive fiscal quarters ending with the most recent fiscal quarter, of not greater than 3.50 to 1.00 as of the end of each fiscal quarter. Upon the consummation of any Qualified Acquisition (as defined in the Credit Agreement) and us providing notice to the Administrative Agent, the ratio increases to 4.00 to 1.00 for the fiscal quarter in which the acquisition is consummated and the three consecutive fiscal quarters thereafter. The operating covenants include, among other things, limitations on (i) the incurrence of indebtedness by our subsidiaries, (ii) liens on our and our subsidiaries assets, and (iii) certain fundamental changes and the disposition of assets by us and our subsidiaries. The Credit Agreement contains other customary covenants, representations and warranties, and events of default.

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Stockholders’ Equity

9 Months Ended

Oct. 01, 2023

Equity [Abstract]

Stockholders’ Equity

5. STOCKHOLDERS’ EQUITY

In Q2 2023, the Company’s stockholders approved an amended and restated version of the Company’s 2015 Stock Incentive Plan (2015 Stock Plan) and increased the maximum number of shares authorized for issuance by 8.0 million shares. As of October 1, 2023, approximately 8.2 million shares remained available for future grants under the 2015 Stock Plan.

Restricted Stock

Restricted stock activity was as follows:

	Restricted Stock Units (RSU)	Performance Stock Units (PSU)(1)	Weighted-Average Grant Date Fair Value per Share
Units in thousands			RSU		PSU
Outstanding at January 1, 2023	1,611	74	$	311.23	$	446.74
Awarded	2,000	62	$	197.09	$	245.08
Vested	(118)	—	$	296.25	$	—
Cancelled	(411)	(96)	$	255.53	$	300.09
Outstanding at October 1, 2023	3,082	40	$	245.37	$	198.25

_____________

(1)The number of units reflect the estimated number of shares to be issued at the end of the performance period. For market-based PSU, the number of units reflect the estimated number of shares to be issued based on performance as of the current reporting period. Awarded units are presented net of performance adjustments.

Liability-Classified RSU

In Q1 2023, we granted RSU that were to be settled in cash if stockholder approval to increase our share reserve under the amended and restated 2015 Stock Plan was not obtained. In Q2 2023, the Company’s stockholders approved an amended and restated version of the 2015 Stock Plan and increased the maximum number of shares authorized for issuance. Upon such approval, all RSU previously accounted for as liability-classified awards, approximately 557,000 RSU, were reclassified to stockholders’ equity and accounted for prospectively as equity awards. There were no RSU liability-classified awards outstanding as of October 1, 2023.

Market-Based PSU

During YTD 2023, we granted PSU with a market condition that vest based on the Company’s relative total shareholder return (rTSR) as compared to a peer group of companies measured over a three-fiscal year performance period. Depending on the actual performance over the measurement period, an award recipient could receive up to 175% of the granted award. The grant date fair value of such awards is estimated using a Monte Carlo simulation, which includes assumptions for expected volatility, risk-free interest rate and dividend yield. These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value. The compensation expense for the

awards is recognized over the requisite service period regardless of whether the market conditions are achieved. As of October 1, 2023, there were approximately 119,000 PSU with a rTSR market condition granted.

Stock Options

Stock option activity was as follows:

Units in thousands	Options	Weighted-Average Exercise Price		Performance Options(1)	Weighted-Average Exercise Price
Outstanding at January 1, 2023	187	$	319.72	17	$	85.54
Exercised	(8)	$	71.09	(1)	$	16.69
Cancelled	(135)	$	330.25	—	$	—
Outstanding at October 1, 2023	44	$	330.25	16	$	87.74
Exercisable at October 1, 2023	18	$	330.25	—	$	—

_____________

(1)The number of units reflect awards that have been granted and for which it is assumed to be probable that the underlying performance goals will be achieved.

Other Liability-Classified Awards

We grant cash-based equity incentive awards to GRAIL employees. For purposes of valuation and performance measurement of the awards, GRAIL’s stand-alone valuation, as determined by GRAIL using a reasonable calculation and based on advice from independent valuation experts and analyses, is used. The awards generally have terms of four years with equal vesting annually, subject to continued employment through the vesting period.

Cash-based equity incentive award activity was as follows:

In millions
Outstanding at January 1, 2023	$	293
Granted	116
Vested and paid in cash	(65)
Cancelled	(28)
Change in fair value	(8)
Outstanding at October 1, 2023	$	308
Estimated liability as of October 1, 2023 (included in accrued liabilities)	$	42

We recognized share-based compensation expense of $26 million and $72 million in Q3 2023 and YTD 2023, respectively, and $17 million and $46 million in Q3 2022 and YTD 2022, respectively. As of October 1, 2023, approximately $266 million of total unrecognized compensation cost related to awards issued to date was expected to be recognized over a weighted-average period of approximately 2.8 years.

In connection with the acquisition of GRAIL, we assumed a performance-based award for which vesting is based on GRAIL’s future revenues. The award has an aggregate potential value of up to $78 million and expires, to the extent unvested, in August 2030. As of October 1, 2023, it was not probable that the performance conditions associated with the award will be achieved and, therefore, no share-based compensation expense, or corresponding liability, has been recognized in the condensed consolidated financial statements to-date.

Employee Stock Purchase Plan

The price at which common stock is purchased under the Employee Stock Purchase Plan (ESPP) is equal to 85% of the fair market value of the common stock on the first day of the offering period or purchase date, whichever is lower. During YTD 2023, approximately 0.4 million shares were issued under the ESPP. As of October 1, 2023, there were approximately 12.4 million shares available for issuance under the ESPP.

The assumptions used and the resulting estimate of weighted-average fair value per share for stock purchased under the ESPP during YTD 2023 were as follows:

Risk-free interest rate	0.78% - 5.54%
Expected volatility	41% - 51%
Expected term	0.5 - 1.1 year
Expected dividends	0		%
Weighted-average grant-date fair value per share	$	49.87

Share Repurchases

We did not repurchase any shares during YTD 2023. As of October 1, 2023, authorizations to repurchase approximately $15 million of our common stock remained available under the $750 million share repurchase program authorized by our Board of Directors on February 5, 2020. The repurchases may be completed under a 10b5-1 plan or at management’s discretion.

Share-Based Compensation

Share-based compensation expense, which includes expense for both equity and liability-classified awards, reported in our condensed consolidated statements of operations was as follows:

In millions	Q3 2023		Q3 2022		YTD 2023		YTD 2022
Cost of product revenue	$	7	$	7	$	22	$	20
Cost of service and other revenue	2		2		5		4
Research and development	36		37		117		112
Selling, general and administrative	41		37		142		130
Share-based compensation expense, before taxes	86		83		286		266
Related income tax benefits	(19)		(18)		(65)		(60)
Share-based compensation expense, net of taxes	$	67	$	65	$	221	$	206

As of October 1, 2023, approximately $582 million of total unrecognized compensation cost related to restricted stock, including RSU and PSU, stock options, including performance stock options, and ESPP shares issued to date was expected to be recognized over a weighted-average period of approximately 2.4 years.

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Supplemental Balance Sheet Details

9 Months Ended

Oct. 01, 2023

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Supplemental Balance Sheet Details

6. SUPPLEMENTAL BALANCE SHEET DETAILS

Accounts Receivable

In millions	October 1, 2023		January 1, 2023
Trade accounts receivable, gross	$	696	$	675
Allowance for credit losses	(6)		(4)
Total accounts receivable, net	$	690	$	671

Inventory

In millions	October 1, 2023		January 1, 2023
Raw materials	$	278	$	247
Work in process	423		386
Finished goods	35		28
Inventory, gross	736		661
Inventory reserve	(121)		(93)
Total inventory, net	$	615	$	568

Accrued Liabilities

In millions	October 1, 2023		January 1, 2023
Legal contingencies(1)	$	458	$	473
Contract liabilities, current portion	242		245
Accrued compensation expenses	195		188
Accrued taxes payable	65		97
Operating lease liabilities, current portion	85		76
Liability-classified equity incentive awards	42		36
Other, including warranties(2)	155		117
Total accrued liabilities	$	1,242	$	1,232

_____________

(1)See note “7. Legal Proceedings” for additional details.

(2)See table below for changes in the reserve for product warranties.

Changes in the reserve for product warranties were as follows:

In millions	Q3 2023		Q3 2022		YTD 2023		YTD 2022
Balance at beginning of period	$	20	$	21	$	18	$	22
Additions charged to cost of product revenue	10		5		30		17
Repairs and replacements	(11)		(7)		(29)		(20)
Balance at end of period	$	19	$	19	$	19	$	19

We generally provide a one-year warranty on instruments. Additionally, we provide a warranty on consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. At the time revenue is recognized, an accrual is established for estimated warranty expenses based on historical experience as well as anticipated product performance. We periodically review the warranty reserve for adequacy and adjust the warranty accrual, if necessary, based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue.

Restructuring

In Q2 2023, we implemented a cost reduction initiative that included workforce reductions, the consolidation of certain facilities and other actions to reduce expenses, all as part of a plan to realign operating expenses while maintaining focus on our innovation roadmap and sustainable long-term growth. In Q3 2023 and YTD 2023, we recorded restructuring charges primarily consisting of asset impairment charges and employee separation costs.

A summary of the pre-tax restructuring charges are as follows:

In millions	Q3 2023		YTD 2023
Employee separation costs	$	7	$	33
Asset impairment charges (1)	49		56
Other costs	2		2
Total restructuring charges (2)	$	58	$	91

_____________

(1)Primarily related to impairment of right-of-use assets and leasehold improvements for our i3 campus in San Diego, California.

(2)For Q3 2023, $55 million was recorded in SG&A expense, $2 million in R&D expense, with the remainder recorded in cost of revenue.

For YTD 2023 $74 million was recorded in SG&A expense, $13 million in R&D expense, with the remainder recorded in cost of revenue.

We fully exited our i3 campus in San Diego, California in Q3 2023, which resulted in a right-of-use asset impairment of $33 million in Q3 2023 and $38 million in YTD 2023, recognized in selling, general and administrative expense. The impairment was determined by comparing the fair value of the impacted right-of-use asset to the carrying value of the asset as of the impairment measurement date. The fair value of the right-of-use asset was estimated using the discounted future cash flows method, which includes estimates and assumptions for future sublease rental rates that reflect current sublease market conditions, as well as a discount rate. The estimates and assumptions used in our assessment represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value. We also recorded $14 million in Q3 2023 and $16 million in YTD 2023 of leasehold improvement impairment, recognized in selling, general and administrative expense, related to the exit of our i3 campus. We continue to evaluate our options with respect to our campus in Foster City, California. As of October 1, 2023, we had assets, consisting primarily of right-of-use assets and leasehold improvements, related to our Foster City campus of approximately $182 million.

A summary of the restructuring liability is as follows:

In millions	Employee Separation Costs (1)		Other Costs		Total
Expense recorded in YTD 2023	$	33	$	2	$	35
Cash paid during YTD 2023	(30)		(1)		(31)
Amount recorded in accrued liabilities as of October 1, 2023	$	3	$	1	$	4
Estimated total restructuring costs to still be incurred	$	2	$	—	$	2

_____________

(1)It is expected that substantially all of the employee separation related restructuring charges will be incurred and paid by the end of 2023.

Goodwill and Intangible Assets

We test goodwill for impairment annually, as of May, or more frequently if events or circumstances indicate it is more likely than not that the fair value of a reporting unit is less than its carrying amount. We performed our annual impairment test in Q2 2023, as of May 2023. We performed a quantitative assessment for our two reporting units: Core Illumina and GRAIL. No impairment was recorded for either Core Illumina or GRAIL in Q2 2023.

In Q3 2023, we concluded the sustained decrease in the Company’s stock price and overall market capitalization during the quarter was a circumstance indicating the fair value of a reporting unit might be less than its carrying amount that required an interim goodwill and intangible impairment test be performed.

Based on our interim assessment, we concluded that our GRAIL reporting unit’s carrying value exceeded its estimated fair value. As a result, we recorded $712 million of goodwill impairment related to our GRAIL reporting unit in Q3 2023, primarily due to a decrease in the company’s consolidated market capitalization and a higher discount rate selected for the fair value calculation of the GRAIL reporting unit. No impairment was recorded for our Core Illumina reporting unit, noting its fair value exceeded its carrying value by more than $20 billion.

We performed our impairment test using a combination of an income and a market approach to determine the fair value of each reporting unit. The income approach utilized the estimated discounted cash flows for each reporting unit, while the market approach utilized comparable company information. Estimates and assumptions used in the income approach included projected cash flows and a discount rate for each reporting unit. Discount rates were determined using a weighted average cost of capital for risk factors specific to each reporting unit and other market and industry data. For GRAIL, the selected discount rate was 24.0%. The estimates and assumptions used in our assessment represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value. The assumptions used are inherently subject to uncertainty and we note that small changes in these assumptions could have a significant impact on the concluded value. An increase of 50 to 100 basis points to the discount rate used in our assessment for GRAIL would have resulted in additional goodwill impairment of approximately $200 million to $350 million for GRAIL. In order to further validate the reasonableness of the fair values concluded for our reporting units, a reconciliation to market capitalization was performed by estimating a reasonable implied control premium and other market factors.

As a result of the impairment taken in Q3 2023, the carrying value of our GRAIL reporting unit now approximates its fair value. As such, changes in our future operating results, cash flows, share price (our share price has declined approximately 18% during the period October 1, 2023 to November 6, 2023), market capitalization or discount rates, as well as future regulatory decisions related to our acquisition of GRAIL, including the decision adopted by the European Commission on October 12, 2023 requiring us to divest GRAIL (refer to note “7. Legal Proceedings”), used when conducting future goodwill impairment tests could affect the estimated fair values of our reporting units and may result in additional impairment charges in the future. We will continue to monitor events and circumstances which may suggest that interim impairment indicators are present prior to the annual impairment test. As of October 1, 2023, remaining goodwill allocated to GRAIL was $1,466 million.

In conjunction with the interim goodwill impairment test, we also evaluated the in-process research and development (IPR&D) asset assigned to the GRAIL reporting unit for potential impairment. We performed our impairment test by comparing the carrying value of the IPR&D asset to its estimated fair value, which was determined by the income approach, using a discounted cash flow model. Estimates and assumptions used in the income approach, which represent a Level 3 measurement, included projected cash flows and a selected discount rate of 19.0%. Based on our impairment test, the carrying value of the GRAIL IPR&D asset exceeded its estimated fair value and we recorded an impairment of $109 million in Q3 2023, primarily due to a decrease in projected cash flows and a higher discount rate selected for the fair value calculation of the GRAIL IPR&D asset. As of October 1, 2023, the carrying value of the GRAIL IPR&D asset was $561 million. We also performed a recoverability test for the definite-lived intangible assets assigned to the GRAIL reporting unit, which includes developed technology and trade name, noting no impairment. No impairment was noted for Core Illumina definite-lived intangible assets.

Changes to goodwill during YTD 2023 were as follows:

In millions
Balance as of January 1, 2023 (1)	$	3,239
Impairment	(712)
Balance as of October 1, 2023	$	2,527

_____________

(1)The balance as of January 1, 2023 is inclusive of a $3,914 million goodwill impairment related to our GRAIL reporting unit in Q3 2022.

Derivative Financial Instruments

We are exposed to foreign exchange rate risks in the normal course of business and use derivative financial instruments to partially offset this exposure. We do not use derivative financial instruments for speculative or trading purposes. Foreign exchange contracts are carried at fair value in other current assets, other assets, accrued liabilities, or other long-term liabilities, as appropriate, on the condensed consolidated balance sheets.

We use foreign exchange forward contracts to manage foreign currency risks related to monetary assets and liabilities denominated in currencies other than the U.S. dollar. These derivative financial instruments have terms of one month or less and are not designated as hedging instruments. Changes in fair value of these derivatives are recognized in other expense, net, along with the re-measurement gain or loss on the foreign currency denominated assets or liabilities. As of October 1, 2023, we had foreign exchange forward contracts in place to hedge exposures in the euro, Japanese yen, Australian dollar, Canadian dollar, Singapore dollar, Chinese Yuan Renminbi, and British pound. As of October 1, 2023 and January 1, 2023, the total notional amounts of outstanding forward contracts in place for these foreign currency purchases were $912 million and $485 million, respectively. On July 25, 2023, we entered into forward contracts for a total notional amount of €432 million to hedge the foreign currency exposure for the fine imposed by the European Commission on July 12, 2023.

We also use foreign currency forward contracts to hedge portions of our foreign currency exposure associated with forecasted revenue transactions. These derivative financial instruments have terms up to 24 months and are designated as cash flow hedges. Changes in fair value of our cash flow hedges are recorded as a component of accumulated other comprehensive income and are reclassified to revenue in the same period the underlying hedged transactions are recorded. We regularly review the effectiveness of our cash flow hedges and consider them to be ineffective if it becomes probable that the forecasted transactions will not occur in the identified period. Changes in fair value of the ineffective portions of our cash flow hedges, if any, are recognized in other expense, net. As of October 1, 2023, we had foreign currency forward contracts in place to hedge exposures associated with forecasted revenue transactions denominated in the euro, Japanese yen, Australian dollar, Canadian dollar, and Chinese Yuan Renminbi. As of October 1, 2023 and January 1, 2023, the total notional amounts of outstanding cash flow hedge contracts in place for these foreign currency purchases were $663 million and $425 million, respectively. We reclassified $5 million and $9 million to revenue in Q3 2023 and YTD 2023, respectively, and $16 million and $32 million in Q3 2022 and YTD 2022, respectively. As of October 1, 2023, the fair value of the foreign currency forward contracts recorded in total assets and total liabilities was $27 million and $1 million, respectively. As of January 1, 2023, the fair value of the foreign currency forward contracts recorded in total assets and total liabilities was $8 million and $6 million, respectively. The estimated net gains reported in accumulated other comprehensive income that are expected to be reclassified into earnings within the next 12 months are $22 million as of October 1, 2023.

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Legal Proceedings

9 Months Ended

Oct. 01, 2023

Commitments and Contingencies Disclosure [Abstract]

Legal Proceedings

7. LEGAL PROCEEDINGS

We are involved in various lawsuits and claims arising in the ordinary course of business, including actions with respect to intellectual property, employment, and contractual matters. In connection with these matters, we assess, on a regular basis, the probability and range of possible loss based on the developments in these matters. A liability is recorded in the condensed consolidated financial statements if it is believed to be probable that a loss has been incurred and the amount of the loss can be reasonably estimated. Because litigation is inherently unpredictable and unfavorable resolutions could occur, assessing contingencies is highly subjective and requires judgments about future events. We regularly review outstanding legal matters to determine the adequacy of the liabilities accrued and related disclosures in consideration of many factors, which include, but are not limited to, past history, scientific and other evidence, and the specifics and status of each matter. We may change our estimates if our assessment of the various factors changes and the amount of ultimate loss may differ from our estimates, resulting in a material effect on our business, financial condition, results of operations, and/or cash flows.

Acquisition of GRAIL

Our acquisition of GRAIL remains subject to ongoing legal and regulatory proceedings in the United States and in the European Union.

On March 30, 2021, the U.S. Federal Trade Commission (the FTC) filed an administrative complaint and a motion for a preliminary injunction in the United States District Court for the District of Columbia. In both actions, the FTC alleged that our acquisition of GRAIL would violate Section 7 of the Clayton Act, as amended, 15 U.S.C. § 18. We filed an answer to the FTC’s complaint in federal district court on April 6, 2021, and in the administrative court on April 13, 2021. On April 20, 2021, the United States District Court for the District of Columbia granted our motion to transfer venue to the United States District Court for the Southern District of California. On May 28, 2021, the district court granted the FTC’s motion to dismiss the complaint without prejudice. The administrative trial commenced on August 24, 2021. On September 1, 2022, the administrative law judge (the ALJ) ruled in favor of Illumina and found that the acquisition of GRAIL did not violate Section 7 of the Clayton Act. In the decision, the ALJ found that the FTC’s complaint counsel had failed to prove its prima facie case that Illumina’s acquisition of GRAIL would result in harm to competition in a putative market for multi-cancer early detection (MCED) tests. The FTC’s complaint counsel appealed the ALJ’s decision to the full FTC on September 2, 2022. The appeal was fully briefed as of November 10, 2022 and oral argument occurred on December 13, 2022. On March 31, 2023, the FTC issued an opinion and order (the FTC Order) requiring Illumina to divest GRAIL, reversing the ALJ’s ruling. On April 5, 2023, Illumina filed a petition for review of the FTC Order in the U.S. Court of Appeals for the Fifth Circuit. On April 24, 2023, the FTC granted a motion staying in its entirety the FTC Order pending resolution of Illumina’s Fifth Circuit appeal. The appeal was fully briefed as of August 16, 2023 and oral argument occurred on September 12, 2023. We intend to continue to vigorously defend against the FTC action.

On April 19, 2021, the European Commission accepted a request for a referral of the GRAIL acquisition for European Union merger review, submitted by a Member State of the European Union (France), and joined by several other Member States (Belgium, Greece, Iceland, the Netherlands and Norway), under Article 22(1) of Council Regulation (EC) No 139/2004 (the EU Merger Regulation). The European Commission had never solicited referrals to take jurisdiction over an acquisition of a U.S. company that had no revenue in Europe. On April 29, 2021, we filed an action in the General Court of the European Union (the EU General Court) asking for annulment of the European Commission’s assertion of jurisdiction to review the acquisition under Article 22 of the EU Merger Regulation, as the acquisition does not meet the jurisdictional criteria under the EU Merger Regulation or under the national merger control laws of any Member State of the European Union. On December 16, 2021, the EU General Court held a hearing regarding the European Commission’s assertion of jurisdiction. On July 13, 2022, the EU General Court reached a decision in favor of the European Commission, holding that the European Commission has jurisdiction under the EU Merger Regulation to review the acquisition. On September 22, 2022, we filed an appeal in the Court of Justice of the European Union asking for annulment of the EU General Court’s decision.

On October 29, 2021, the European Commission adopted an order imposing interim measures (the Initial Interim Measures Order). As the Initial Interim Measures Order was set to expire on November 3, 2022, the European Commission adopted a new order imposing interim measures (the New Interim Measures Order) on October 28, 2022. On December 1, 2021, we filed an action with the EU General Court asking for annulment of the Initial Interim Measures Order. The hearing of that application has been stayed pending our appeal of the judgment of the EU General Court regarding the European Commission’s assertion of jurisdiction. On January 10, 2023, we filed an action with the EU General Court asking for annulment of the New Interim Measures Order. On January 20, 2023, the European Commission requested that these proceedings be stayed pending our appeal on jurisdiction. We submitted a filing indicating that we had no objections to the European Commission’s request, and the EU General Court stayed the proceedings on February 21, 2023.

On September 6, 2022, the European Commission announced that it had completed its Phase II review of the acquisition of GRAIL and adopted a final decision (the Prohibition Decision), which found that, in its view, our acquisition of GRAIL was incompatible with the internal market in Europe because it results in a significant impediment to effective competition. On November 17, 2022, we filed an action with the EU General Court asking for annulment of the Prohibition Decision.

On October 12, 2023, the European Commission adopted a decision requiring us to (among other things) divest GRAIL, and replacing the interim measures set forth in the New Interim Measures Order with substantially equivalent transitional measures (the EC Divestment Decision). We intend to appeal the EC Divestment Decision.

On July 12, 2023, the European Commission adopted a final decision finding that we breached the EU Merger Regulation by, in its view, acquiring the possibility to exert decisive influence over GRAIL and exerting such influence during the pendency of the European Commission’s review (the Article 14(2)(b) Decision). The European Commission therefore imposed a fine pursuant to Article 14(2)(b) of the EU Merger Regulation of approximately €432 million, representing the maximum fine of 10% of our consolidated annual revenues for fiscal year 2022. We provided guarantees in October 2023 to satisfy the obligation in lieu of cash payment while we appeal the European Commission’s jurisdictional decision and fine decision. The fine is accruing interest at a rate of 5.5% per annum,

beginning in October 2023, while it is outstanding. As of October 1, 2023, we accrued $458 million, including related foreign currency gains (which were recorded in other expense, net), included in accrued liabilities. We appealed the Article 14(2)(b) Decision on September 26, 2023.

SEC Inquiry Letter

In July 2023, we were informed that the staff of the SEC was conducting an investigation relating to Illumina and was requesting documents and communications primarily related to Illumina’s acquisition of GRAIL and certain statements and disclosures concerning GRAIL, its products and its acquisition, and related to the conduct and compensation of certain members of Illumina and GRAIL management, among other things. Illumina is cooperating with the SEC in this investigation.

Derivative and Class Action Complaint

On October 17, 2023, a stockholder derivative and class action complaint captioned Icahn Partners LP, et al. v. deSouza, et al., purportedly brought on behalf of Illumina and public holders of Illumina’s common stock, was filed in the Delaware Court of Chancery against certain current and former directors (including our former Chief Executive Officer). We are named as a nominal defendant in the complaint. The lawsuit alleges the named directors breached their fiduciary duties by knowingly causing Illumina to unlawfully close the GRAIL acquisition, concealing material facts related to the GRAIL acquisition and making inadequate disclosures. Prior to the filing of the complaint, the purported stockholders did not make a demand that our Board of Directors pursue the claims asserted therein. The complaint seeks damages, costs and expenses, including attorney fees, the certification and consolidation of a putative class, the issuance of amended disclosures, the removal of conflicted directors and declaratory and other equitable relief. Since the lawsuit is brought in part on behalf of Illumina as a nominal defendant, the alleged damages were allegedly suffered by us. We deny the allegations in the complaint and intend to vigorously defend the litigation. In light of the fact that the lawsuit is in an early stage, we cannot predict the ultimate outcome of the suit.

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Income Taxes

9 Months Ended

Oct. 01, 2023

Income Tax Disclosure [Abstract]

Income Taxes

8. INCOME TAXES

Our effective tax rate may vary from the U.S. federal statutory tax rate due to the change in the mix of earnings in tax jurisdictions with different statutory rates, benefits related to tax credits, and the tax impact of non-deductible expenses and other permanent differences between income before income taxes and taxable income.

Our effective tax rates for Q3 2023 and YTD 2023 were 3.6% and (3.8)%, respectively, compared to (4.0)% and (2.3)% in Q3 2022 and YTD 2022, respectively. The variance from the U.S. federal statutory tax rate of 21% in Q3 2023 and YTD 2023 was primarily attributable to the $149 million income tax expense impact from the impairment of goodwill, which is nondeductible for tax purposes, the $20 million and $84 million income tax expense impact of research and development expense capitalization for tax purposes, respectively, and the $38 million and $63 million income tax expense impact of GRAIL pre-acquisition net operating losses on global intangible low-taxed income (GILTI) and the utilization of U.S. foreign tax credits, respectively. This was partially offset by the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore.

Historically, we calculated the provision/(benefit) for income taxes for interim periods utilizing an estimated annual effective tax rate applied to the income/(loss) for the reporting period, except in Q2 2023 when a year-to-date effective tax rate method was utilized. We determined the estimated annual effective tax rate method would provide a more reliable estimate of the provision for income taxes for Q3 2023 and YTD 2023, since minor changes in the estimated income/(loss) before income taxes would not result in significant changes in the estimated annual effective tax rate.

As of October 1, 2023 and January 1, 2023, prepaid income taxes, included within prepaid expenses and other current assets on the condensed consolidated balance sheets, were $78 million and $116 million, respectively.

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Segment Information

9 Months Ended

Oct. 01, 2023

Segment Reporting [Abstract]

Segment Information

9. SEGMENT INFORMATION

We have two reportable segments, Core Illumina and GRAIL. We report segment information based on the management approach, which designates the internal reporting used by the Chief Operating Decision Maker (CODM) for making decisions and assessing performance as the source of our reportable segments. The CODM allocates resources and assesses the performance of each operating segment using information about its revenue and income (loss) from operations. Our CODM does not evaluate our operating segments using discrete asset information. We do not allocate expenses between segments. Core Illumina sells products and provides services to GRAIL, and vice versa, in accordance with contractual agreements between the entities.

Core Illumina: Core Illumina’s products and services serve customers in the research, clinical and applied markets, and enable the adoption of a variety of genomic solutions. Core Illumina includes all of our operations, excluding the results of GRAIL.

GRAIL: GRAIL is a healthcare company focused on early detection of multiple cancers.

In millions	Q3 2023		Q3 2022		YTD 2023		YTD 2022
Revenue:
Core Illumina	$	1,106	$	1,110	$	3,341	$	3,487
GRAIL	21		10		62		32
Eliminations	(8)		(5)		(21)		(18)
Consolidated revenue	$	1,119	$	1,115	$	3,382	$	3,501
Income (loss) from operations:
Core Illumina	$	262	$	445	$	519	$	411
GRAIL	(1,015)		(4,101)		(1,424)		(4,460)
Eliminations	(1)		(1)		—		(3)
Consolidated loss from operations	$	(754)	$	(3,657)	$	(905)	$	(4,052)

Total other expense, net primarily relates to Core Illumina and we do not allocate income taxes to our segments.

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Pay vs Performance Disclosure - USD ($) $ in Millions	3 Months Ended							9 Months Ended
	Oct. 01, 2023	Jul. 02, 2023	Apr. 02, 2023	Jan. 01, 2023	Oct. 02, 2022	Jul. 03, 2022	Apr. 03, 2022	Oct. 01, 2023	Oct. 02, 2022
Pay vs Performance Disclosure
Net loss	$ (754)	$ (234)	$ 3	$ (139)	$ (3,816)	$ (535)	$ 86	$ (986)	$ (4,265)

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Insider Trading Arrangements

3 Months Ended

9 Months Ended

Oct. 01, 2023

shares

Oct. 01, 2023

shares

Trading Arrangements, by Individual

Material Terms of Trading Arrangement

ADOPTIONS, MODIFICATIONS OR TERMINATIONS OF TRADING PLANS

During the quarterly period ended October 1, 2023, the following directors and officers adopted, modified or terminated 10b5-1 plans:

•On September 26, 2023, Phil Febbo, our former Chief Medical Officer, terminated a trading arrangement he had previously adopted with respect to the sale of securities of the Company’s common stock (a “Rule 10b5-1 Trading Arrangement”) in connection with his departure from the Company. Mr. Febbo’s Rule 10b5-1 Trading Arrangement was adopted on May 30, 2023, had a termination date of December 31, 2024, and provided for the sale of up to 9,294 shares of common stock pursuant to the terms of the plan.

Rule 10b5-1 Arrangement Adopted

true

Non-Rule 10b5-1 Arrangement Adopted

false

Adoption Date

May 30, 2023

Rule 10b5-1 Arrangement Terminated

false

Non-Rule 10b5-1 Arrangement Terminated

false

Phil Febbo [Member]

Trading Arrangements, by Individual

Name

Phil Febbo

Title

Chief Medical Officer

Arrangement Duration

581 days

Aggregate Available

9,294

9,294

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Organization and Significant Accounting Policies (Policies)	9 Months Ended
	Oct. 01, 2023
Accounting Policies [Abstract]
Basis of Presentation	The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements.
Consolidation	The unaudited condensed consolidated financial statements include our accounts, our wholly-owned subsidiaries, and majority-owned or controlled companies. All intercompany transactions and balances have been eliminated in consolidation. Certain prior period amounts have been reclassified to conform to the current period presentation. In management’s opinion, the accompanying unaudited condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.
Fiscal Year	Our fiscal year is the 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. References to Q3 2023 and Q3 2022 refer to the three months ended October 1, 2023 and October 2, 2022, respectively, which were both 13 weeks, and references to year-to-date (YTD) 2023 and 2022 refer to the nine months ended October 1, 2023 and October 2, 2022, respectively, which were both 39 weeks.
Loss per Share	Basic loss per share is computed based on the weighted average number of common shares outstanding during the period. Diluted loss per share is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period. In loss periods, basic and diluted loss per share are identical since the effect of potentially dilutive common shares is antidilutive and therefore excluded.Potentially dilutive common shares consist of shares issuable under convertible senior notes and equity awards. We utilize the if-converted method to calculate the impact of convertible senior notes on diluted loss per share. Potentially dilutive common shares from equity awards are determined using the average share price for each period under the treasury stock method. In addition, proceeds from exercise of equity awards and the average amount of unrecognized compensation expense for equity awards are assumed to be used to repurchase shares.
Warranties	We generally provide a one-year warranty on instruments. Additionally, we provide a warranty on consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. At the time revenue is recognized, an accrual is established for estimated warranty expenses based on historical experience as well as anticipated product performance. We periodically review the warranty reserve for adequacy and adjust the warranty accrual, if necessary, based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue.
Derivatives	We are exposed to foreign exchange rate risks in the normal course of business and use derivative financial instruments to partially offset this exposure. We do not use derivative financial instruments for speculative or trading purposes. Foreign exchange contracts are carried at fair value in other current assets, other assets, accrued liabilities, or other long-term liabilities, as appropriate, on the condensed consolidated balance sheets.

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Organization and Significant Accounting Policies (Tables)

9 Months Ended

Oct. 01, 2023

Accounting Policies [Abstract]

Schedule of Calculation of Weighted Average Shares Used to Calculate Basic and Diluted Net (Loss) Income Per Share

The following table presents the weighted average shares used to calculate basic and diluted loss per share:

In millions	Q3 2023	Q3 2022	YTD 2023	YTD 2022
Weighted average shares used in calculating basic loss per share	158	157	158	157
Weighted average shares used in calculating diluted loss per share	158	157	158	157
Antidilutive shares:
Convertible senior notes	1	2	1	2
Equity awards	3	2	3	2
Potentially dilutive shares excluded from calculation due to antidilutive effect	4	4	4	4

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Revenue (Tables)

9 Months Ended

Oct. 01, 2023

Revenue from Contract with Customer [Abstract]

Schedule of Disaggregation of Revenue

Revenue by Source

	Q3 2023						Q3 2022
In millions	Sequencing		Microarray		Total		Sequencing		Microarray		Total
Consumables	$	689	$	71	$	760	$	720	$	76	$	796
Instruments	178		3		181		162		5		167
Total product revenue	867		74		941		882		81		963
Service and other revenue	162		16		178		133		19		152
Total revenue	$	1,029	$	90	$	1,119	$	1,015	$	100	$	1,115

	YTD 2023						YTD 2022
In millions	Sequencing		Microarray		Total		Sequencing		Microarray		Total
Consumables	$	2,108	$	219	$	2,327	$	2,237	$	225	$	2,462
Instruments	524		13		537		563		14		577
Total product revenue	2,632		232		2,864		2,800		239		3,039
Service and other revenue	456		62		518		390		72		462
Total revenue	$	3,088	$	294	$	3,382	$	3,190	$	311	$	3,501

Revenue by Geographic Area

Based on region of destination (in millions)	Q3 2023		Q3 2022(1)		YTD 2023		YTD 2022(1)
Americas	$	663	$	597	$	1,920	$	1,885
Europe	260		259		825		819
Greater China(2)	98		133		302		378
Asia-Pacific, Middle East, and Africa(3)	98		126		335		419
Total revenue	$	1,119	$	1,115	$	3,382	$	3,501

_____________

(1)We implemented a new global commercial structure in Q1 2023 to improve operating efficiencies and better align with local markets. We integrated Asia-Pacific and Japan with emerging markets across the Middle East, Africa, Turkey, and Commonwealth of Independent States (CIS). Beginning in Q1 2023, and going forward, we will report regional results for the following regions: Americas, Europe, Greater China, and Asia-Pacific, Middle East and Africa (AMEA). Prior period amounts have been reclassified to conform to this new presentation.

(2)Region includes revenue from China, Taiwan, and Hong Kong.

(3)Region includes revenue from Russia and Turkey.

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Investments and Fair Value Measurements (Tables)

9 Months Ended

Oct. 01, 2023

Fair Value Disclosures [Abstract]

Schedule of Marketable Securities

Gains and losses recognized in other expense, net on our marketable equity securities were as follows:

In millions	Q3 2023		Q3 2022		YTD 2023		YTD 2022
Net gains (losses) recognized during the period on marketable equity securities	$	—	$	3	$	(2)	$	(66)
Less: Net losses recognized during the period on marketable equity securities sold during the period	—		—		(2)		—
Net unrealized gains (losses) recognized during the period on marketable equity securities still held at the reporting date	$	—	$	3	$	—	$	(66)

Schedule of Hierarchy for Assets and Liabilities Measured at Fair Value on a Recurring Basis

The following table presents the hierarchy for assets and liabilities measured at fair value on a recurring basis:

	October 1, 2023								January 1, 2023
In millions	Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Assets:
Money market funds (cash equivalents)	$	646	$	—	$	—	$	646	$	1,642	$	—	$	—	$	1,642
Marketable equity securities	6		—		—		6		26		—		—		26
Helix contingent value right	—		—		66		66		—		—		58		58
Deferred compensation plan assets	—		57		—		57		—		52		—		52
Total assets measured at fair value	$	652	$	57	$	66	$	775	$	1,668	$	52	$	58	$	1,778
Liabilities:
Contingent consideration liabilities	$	—	$	—	$	330	$	330	$	—	$	—	$	412	$	412
Deferred compensation plan liability	—		54		—		54		—		51		—		51
Total liabilities measured at fair value	$	—	$	54	$	330	$	384	$	—	$	51	$	412	$	463

Schedule of Changes in Estimated Fair Value of Acquisition Related Contingent Consideration Liabilities

Changes in the estimated fair value of our contingent consideration liabilities during YTD 2023 were as follows:

In millions
Balance as of January 1, 2023	$	412
Change in estimated fair value	(82)
Balance as of October 1, 2023	$	330

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Debt (Tables)

9 Months Ended

Oct. 01, 2023

Debt Disclosure [Abstract]

Schedule of Debt Obligations

Summary of Term Debt Obligations

In millions	October 1, 2023		January 1, 2023
Principal amount of 2031 Term Notes outstanding	$	500	$	500
Principal amount of 2027 Term Notes outstanding	500		500
Principal amount of 2025 Term Notes outstanding	500		500
Principal amount of 2023 Term Notes outstanding	—		500
Unamortized discounts and debt issuance costs	(11)		(13)
Net carrying amount of term notes	1,489		1,987
Less: current portion	—		(500)
Term notes, non-current	$	1,489	$	1,487
Fair value of term notes outstanding (Level 2)	$	1,375	$	1,913

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Stockholders’ Equity (Tables)

9 Months Ended

Oct. 01, 2023

Equity [Abstract]

Schedule of Restricted Stock Activity and Related Information, Restricted Stock

Restricted stock activity was as follows:

	Restricted Stock Units (RSU)	Performance Stock Units (PSU)(1)	Weighted-Average Grant Date Fair Value per Share
Units in thousands			RSU		PSU
Outstanding at January 1, 2023	1,611	74	$	311.23	$	446.74
Awarded	2,000	62	$	197.09	$	245.08
Vested	(118)	—	$	296.25	$	—
Cancelled	(411)	(96)	$	255.53	$	300.09
Outstanding at October 1, 2023	3,082	40	$	245.37	$	198.25

_____________

(1)The number of units reflect the estimated number of shares to be issued at the end of the performance period. For market-based PSU, the number of units reflect the estimated number of shares to be issued based on performance as of the current reporting period. Awarded units are presented net of performance adjustments.

Schedule of Restricted Stock Activity and Related Information, Performance Units

Restricted stock activity was as follows:

	Restricted Stock Units (RSU)	Performance Stock Units (PSU)(1)	Weighted-Average Grant Date Fair Value per Share
Units in thousands			RSU		PSU
Outstanding at January 1, 2023	1,611	74	$	311.23	$	446.74
Awarded	2,000	62	$	197.09	$	245.08
Vested	(118)	—	$	296.25	$	—
Cancelled	(411)	(96)	$	255.53	$	300.09
Outstanding at October 1, 2023	3,082	40	$	245.37	$	198.25

_____________

(1)The number of units reflect the estimated number of shares to be issued at the end of the performance period. For market-based PSU, the number of units reflect the estimated number of shares to be issued based on performance as of the current reporting period. Awarded units are presented net of performance adjustments.

Schedule of Stock Option Activity Under all Stock Option Plans

Stock option activity was as follows:

Units in thousands	Options	Weighted-Average Exercise Price		Performance Options(1)	Weighted-Average Exercise Price
Outstanding at January 1, 2023	187	$	319.72	17	$	85.54
Exercised	(8)	$	71.09	(1)	$	16.69
Cancelled	(135)	$	330.25	—	$	—
Outstanding at October 1, 2023	44	$	330.25	16	$	87.74
Exercisable at October 1, 2023	18	$	330.25	—	$	—

_____________

(1)The number of units reflect awards that have been granted and for which it is assumed to be probable that the underlying performance goals will be achieved.

Schedule of Share-based Payment Arrangement, Liability - Classified Awards, Activity

Cash-based equity incentive award activity was as follows:

In millions
Outstanding at January 1, 2023	$	293
Granted	116
Vested and paid in cash	(65)
Cancelled	(28)
Change in fair value	(8)
Outstanding at October 1, 2023	$	308
Estimated liability as of October 1, 2023 (included in accrued liabilities)	$	42

Schedule of Assumptions used to Estimate the Weighted-Average Fair Value Per Share for Stock Purchase under the Employee Stock Purchase Plan

The assumptions used and the resulting estimate of weighted-average fair value per share for stock purchased under the ESPP during YTD 2023 were as follows:

Risk-free interest rate	0.78% - 5.54%
Expected volatility	41% - 51%
Expected term	0.5 - 1.1 year
Expected dividends	0		%
Weighted-average grant-date fair value per share	$	49.87

Schedule of Share-based Compensation Expense for all Stock Awards

Share-based compensation expense, which includes expense for both equity and liability-classified awards, reported in our condensed consolidated statements of operations was as follows:

In millions	Q3 2023		Q3 2022		YTD 2023		YTD 2022
Cost of product revenue	$	7	$	7	$	22	$	20
Cost of service and other revenue	2		2		5		4
Research and development	36		37		117		112
Selling, general and administrative	41		37		142		130
Share-based compensation expense, before taxes	86		83		286		266
Related income tax benefits	(19)		(18)		(65)		(60)
Share-based compensation expense, net of taxes	$	67	$	65	$	221	$	206

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Supplemental Balance Sheet Details (Tables)

9 Months Ended

Oct. 01, 2023

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Schedule of Accounts Receivable

Accounts Receivable

In millions	October 1, 2023		January 1, 2023
Trade accounts receivable, gross	$	696	$	675
Allowance for credit losses	(6)		(4)
Total accounts receivable, net	$	690	$	671

Schedule of Inventory

Inventory

In millions	October 1, 2023		January 1, 2023
Raw materials	$	278	$	247
Work in process	423		386
Finished goods	35		28
Inventory, gross	736		661
Inventory reserve	(121)		(93)
Total inventory, net	$	615	$	568

Schedule of Accrued Liabilities

Accrued Liabilities

In millions	October 1, 2023		January 1, 2023
Legal contingencies(1)	$	458	$	473
Contract liabilities, current portion	242		245
Accrued compensation expenses	195		188
Accrued taxes payable	65		97
Operating lease liabilities, current portion	85		76
Liability-classified equity incentive awards	42		36
Other, including warranties(2)	155		117
Total accrued liabilities	$	1,242	$	1,232

_____________

(1)See note “7. Legal Proceedings” for additional details.

(2)See table below for changes in the reserve for product warranties.

Schedule of Changes in Reserve for Product Warranties

Changes in the reserve for product warranties were as follows:

In millions	Q3 2023		Q3 2022		YTD 2023		YTD 2022
Balance at beginning of period	$	20	$	21	$	18	$	22
Additions charged to cost of product revenue	10		5		30		17
Repairs and replacements	(11)		(7)		(29)		(20)
Balance at end of period	$	19	$	19	$	19	$	19

Schedule Of Restructuring and Related Costs

A summary of the pre-tax restructuring charges are as follows:

In millions	Q3 2023		YTD 2023
Employee separation costs	$	7	$	33
Asset impairment charges (1)	49		56
Other costs	2		2
Total restructuring charges (2)	$	58	$	91

_____________

(1)Primarily related to impairment of right-of-use assets and leasehold improvements for our i3 campus in San Diego, California.

(2)For Q3 2023, $55 million was recorded in SG&A expense, $2 million in R&D expense, with the remainder recorded in cost of revenue.

For YTD 2023 $74 million was recorded in SG&A expense, $13 million in R&D expense, with the remainder recorded in cost of revenue.

A summary of the restructuring liability is as follows:

In millions	Employee Separation Costs (1)		Other Costs		Total
Expense recorded in YTD 2023	$	33	$	2	$	35
Cash paid during YTD 2023	(30)		(1)		(31)
Amount recorded in accrued liabilities as of October 1, 2023	$	3	$	1	$	4
Estimated total restructuring costs to still be incurred	$	2	$	—	$	2

_____________

(1)It is expected that substantially all of the employee separation related restructuring charges will be incurred and paid by the end of 2023.

Schedule of Goodwill and Intangible Assets

Changes to goodwill during YTD 2023 were as follows:

In millions
Balance as of January 1, 2023 (1)	$	3,239
Impairment	(712)
Balance as of October 1, 2023	$	2,527

_____________

(1)The balance as of January 1, 2023 is inclusive of a $3,914 million goodwill impairment related to our GRAIL reporting unit in Q3 2022.

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Segment Information (Tables)

9 Months Ended

Oct. 01, 2023

Segment Reporting [Abstract]

Schedule of Operating Performance and Assets by Segment

In millions	Q3 2023		Q3 2022		YTD 2023		YTD 2022
Revenue:
Core Illumina	$	1,106	$	1,110	$	3,341	$	3,487
GRAIL	21		10		62		32
Eliminations	(8)		(5)		(21)		(18)
Consolidated revenue	$	1,119	$	1,115	$	3,382	$	3,501
Income (loss) from operations:
Core Illumina	$	262	$	445	$	519	$	411
GRAIL	(1,015)		(4,101)		(1,424)		(4,460)
Eliminations	(1)		(1)		—		(3)
Consolidated loss from operations	$	(754)	$	(3,657)	$	(905)	$	(4,052)

Total other expense, net primarily relates to Core Illumina and we do not allocate income taxes to our segments.

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Organization and Significant Accounting Policies - Summary of Calculation of Weighted Average Shares used to Calculate Basic and Diluted Earnings Per Share (Details) - shares shares in Millions	3 Months Ended		9 Months Ended
	Oct. 01, 2023	Oct. 02, 2022	Oct. 01, 2023	Oct. 02, 2022
Weighted average shares used to calculate basic and diluted earnings per share
Weighted average shares used in calculating basic loss per share (in shares)	158	157	158	157
Weighted average shares used in calculating diluted loss per share (in shares)	158	157	158	157
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive shares excluded from calculation due to antidilutive effect (in shares)	4	4	4	4
Convertible senior notes
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive shares excluded from calculation due to antidilutive effect (in shares)	1	2	1	2
Equity awards
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive shares excluded from calculation due to antidilutive effect (in shares)	3	2	3	2

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Revenue - Disaggregation of Revenue (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Oct. 01, 2023	Oct. 02, 2022	Oct. 01, 2023	Oct. 02, 2022
Disaggregation of Revenue [Line Items]
Consolidated revenue	$ 1,119	$ 1,115	$ 3,382	$ 3,501
Americas
Disaggregation of Revenue [Line Items]
Consolidated revenue	663	597	1,920	1,885
Europe
Disaggregation of Revenue [Line Items]
Consolidated revenue	260	259	825	819
Greater China
Disaggregation of Revenue [Line Items]
Consolidated revenue	98	133	302	378
Asia-Pacific, Middle East, and Africa
Disaggregation of Revenue [Line Items]
Consolidated revenue	98	126	335	419
Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	941	963	2,864	3,039
Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	760	796	2,327	2,462
Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	181	167	537	577
Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	178	152	518	462
Sequencing
Disaggregation of Revenue [Line Items]
Consolidated revenue	1,029	1,015	3,088	3,190
Sequencing | Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	867	882	2,632	2,800
Sequencing | Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	689	720	2,108	2,237
Sequencing | Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	178	162	524	563
Sequencing | Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	162	133	456	390
Microarray
Disaggregation of Revenue [Line Items]
Consolidated revenue	90	100	294	311
Microarray | Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	74	81	232	239
Microarray | Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	71	76	219	225
Microarray | Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	3	5	13	14
Microarray | Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	$ 16	$ 19	$ 62	$ 72

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Revenue - Performance Obligation (Details) $ in Millions	9 Months Ended
	Oct. 01, 2023 USD ($)
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Remaining performance obligation	$ 743
Minimum
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Product or service delivery period (in months)	3 months
Maximum
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Product or service delivery period (in months)	6 months
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2023-10-02
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Percent of remaining performance obligation (as a percent)	83.00%
Expected timing of remaining performance obligation (in months)	12 months
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2024-10-01
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Percent of remaining performance obligation (as a percent)	10.00%
Expected timing of remaining performance obligation (in months)	12 months

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Revenue - Narrative (Details) - USD ($) $ in Millions	3 Months Ended	9 Months Ended
	Oct. 01, 2023	Oct. 01, 2023	Jan. 01, 2023
Revenue from Contract with Customer [Abstract]
Contract asset	$ 19	$ 19	$ 17
Contract with customer, liability	315	315	308
Contract liabilities, current portion	242	242	$ 245
Revenue recognized	$ 43	$ 206

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Investments and Fair Value Measurements - Narrative (Details) $ in Thousands		1 Months Ended	3 Months Ended								9 Months Ended
	Aug. 18, 2021 USD ($)	Apr. 30, 2019	Oct. 01, 2023 USD ($)	Jul. 02, 2023 USD ($)	Apr. 02, 2023 USD ($)	Jan. 01, 2023 USD ($)	Oct. 02, 2022 USD ($)	Jul. 03, 2022 USD ($)	Apr. 03, 2022 USD ($)	Jan. 02, 2022 USD ($)	Oct. 01, 2023 USD ($) fund	Oct. 02, 2022 USD ($)
Schedule of Investments [Line Items]
Marketable equity securities			$ 6,000			$ 26,000					$ 6,000
Strategic equity investments, without readily determinable fair values			28,000			28,000					28,000
Total revenue			1,119,000				$ 1,115,000				3,382,000	$ 3,501,000
(Gain) loss on Helix contingent value right											8,000	(8,000)
Accumulated other comprehensive income			21,000			3,000					21,000
GRAIL Inc
Schedule of Investments [Line Items]
Contingent value right, terms (in years)	12 years
Covered revenues of GRAIL, contingent consideration liability				$ 65,000	$ 65,000	65,000		$ 32,000	$ 32,000	$ 32,000
Payment for contingent consideration											609	297
Contingent consideration liabilities			330,000			412,000					330,000
Contingent consideration, noncurrent			329,000			411,000					329,000
GRAIL Inc | Payment Rights Of One Billion, Each Twelve Years
Schedule of Investments [Line Items]
Contingent payment rights (as a percent)	2.50%
Business acquisition, contingent value rights, revenue threshold	$ 1,000,000
GRAIL Inc | Payment Rights Of Above One Billion, Each Twelve Years
Schedule of Investments [Line Items]
Business acquisition, contingent value rights, revenue threshold	$ 1,000,000
Contingent payment rights, second percentage (as a percent)	9.00%
Helix Holdings I, LLC
Schedule of Investments [Line Items]
Contingent value right, terms (in years)		7 years
(Gain) loss on Helix contingent value right			(5,000)				(5,000)				$ 8,000	(8,000)
Venture Capital Investment Fund (the Fund)
Schedule of Investments [Line Items]
Number of venture capital investment funds | fund											2
Equity method investments			165,000			$ 183,000					$ 165,000
Unrealized (loss) gain on investments			(19,000)				(5,000)				(33,000)	(11,000)
Venture Capital Investment Fund (the Fund), One
Schedule of Investments [Line Items]
Commitment in new venture capital investment fund			100,000								100,000
Remaining capital commitment			5,000								5,000
Venture Capital Investment Fund (the Fund), Two
Schedule of Investments [Line Items]
Commitment in new venture capital investment fund			150,000								150,000
Remaining capital commitment			74,000								74,000
Investee
Schedule of Investments [Line Items]
Total revenue			$ 2,000				$ 27,000				$ 68,000	$ 83,000

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Investments and Fair Value Measurements - Schedule of Marketable Equity Securities (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Oct. 01, 2023	Oct. 02, 2022	Oct. 01, 2023	Oct. 02, 2022
Fair Value Disclosures [Abstract]
Net gains (losses) recognized during the period on marketable equity securities	$ 0	$ 3	$ (2)	$ (66)
Less: Net losses recognized during the period on marketable equity securities sold during the period	0	0	(2)	0
Net unrealized gains (losses) recognized during the period on marketable equity securities still held at the reporting date	$ 0	$ 3	$ 0	$ (66)

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Investments and Fair Value Measurements - Fair Value Hierarchy of Assets and Liabilities (Details) - USD ($) $ in Millions	Oct. 01, 2023	Jan. 01, 2023
Assets:
Marketable equity securities	$ 6	$ 26
Fair Value, Measurements, Recurring
Assets:
Money market funds (cash equivalents)	646	1,642
Marketable equity securities	6	26
Helix contingent value right	66	58
Deferred compensation plan assets	57	52
Total assets measured at fair value	775	1,778
Liabilities:
Contingent consideration liabilities	330	412
Deferred compensation plan liability	54	51
Total liabilities measured at fair value	384	463
Fair Value, Measurements, Recurring | Level 1
Assets:
Money market funds (cash equivalents)	646	1,642
Marketable equity securities	6	26
Helix contingent value right	0	0
Deferred compensation plan assets	0	0
Total assets measured at fair value	652	1,668
Liabilities:
Contingent consideration liabilities	0	0
Deferred compensation plan liability	0	0
Total liabilities measured at fair value	0	0
Fair Value, Measurements, Recurring | Level 2
Assets:
Money market funds (cash equivalents)	0	0
Marketable equity securities	0	0
Helix contingent value right	0	0
Deferred compensation plan assets	57	52
Total assets measured at fair value	57	52
Liabilities:
Contingent consideration liabilities	0	0
Deferred compensation plan liability	54	51
Total liabilities measured at fair value	54	51
Fair Value, Measurements, Recurring | Level 3
Assets:
Money market funds (cash equivalents)	0	0
Marketable equity securities	0	0
Helix contingent value right	66	58
Deferred compensation plan assets	0	0
Total assets measured at fair value	66	58
Liabilities:
Contingent consideration liabilities	330	412
Deferred compensation plan liability	0	0
Total liabilities measured at fair value	$ 330	$ 412

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Investments and Fair Value Measurements - Changes in Estimated Fair Value of Acquisition Related Contingent Consideration Liabilities (Details) - Business Combination Contingent Consideration Liability $ in Millions	9 Months Ended
	Oct. 01, 2023 USD ($)
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Beginning balance	$ 412
Change in estimated fair value	(82)
Ending balance	$ 330

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Debt - Summary of Term Debt Obligations (Details) - Term Notes - USD ($)	Oct. 01, 2023	Jan. 01, 2023	Dec. 13, 2022	Mar. 23, 2021
Debt Instrument [Line Items]
Unamortized discounts and debt issuance costs	$ (11,000,000)	$ (13,000,000)
Net carrying amount of term notes	1,489,000,000	1,987,000,000
Less: current portion	0	(500,000,000)
Term notes, non-current	1,489,000,000	1,487,000,000
Level 2
Debt Instrument [Line Items]
Fair value of term notes outstanding (Level 2)	1,375,000,000	1,913,000,000
2031 Term Notes
Debt Instrument [Line Items]
Principal amount outstanding	500,000,000	500,000,000		$ 500,000,000
2027 Term Notes
Debt Instrument [Line Items]
Principal amount outstanding	500,000,000	500,000,000	$ 500,000,000
2025 Term Notes
Debt Instrument [Line Items]
Principal amount outstanding	500,000,000	500,000,000	$ 500,000,000
2023 Term Notes
Debt Instrument [Line Items]
Principal amount outstanding	$ 0	$ 500,000,000		$ 500,000,000

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Debt - Narrative (Details)		1 Months Ended	3 Months Ended		9 Months Ended
	Jan. 04, 2023 USD ($) consecutive_fiscal_quarter one_year_extension	Aug. 31, 2018 USD ($)	Oct. 01, 2023 USD ($)	Oct. 02, 2022 USD ($)	Oct. 01, 2023 USD ($)	Oct. 02, 2022 USD ($)	Jan. 01, 2023 USD ($)	Dec. 13, 2022 USD ($)	Mar. 23, 2021 USD ($)
Term Notes
Debt Instrument [Line Items]
Interest expense recognized			$ 18,000,000	$ 4,000,000	$ 55,000,000	$ 13,000,000
Redemption price (as a percent)					100.00%
2023 Term Notes | Term Notes
Debt Instrument [Line Items]
Stated rate (as a percent)									0.55%
Principal amount outstanding			0		$ 0		$ 500,000,000		$ 500,000,000
2031 Term Notes | Term Notes
Debt Instrument [Line Items]
Stated rate (as a percent)									2.55%
Principal amount outstanding			500,000,000		500,000,000		500,000,000		$ 500,000,000
2025 Term Notes | Term Notes
Debt Instrument [Line Items]
Stated rate (as a percent)								5.80%
Principal amount outstanding			500,000,000		500,000,000		500,000,000	$ 500,000,000
2027 Term Notes | Term Notes
Debt Instrument [Line Items]
Stated rate (as a percent)								5.75%
Principal amount outstanding			$ 500,000,000		$ 500,000,000		$ 500,000,000	$ 500,000,000
2023 Convertible Notes | Convertible Senior Notes
Debt Instrument [Line Items]
Stated rate (as a percent)			0.00%		0.00%
Principal amount outstanding		$ 750,000,000
Debt conversion ratio		0.0021845
The Credit Agreement | Line of Credit | Revolving Credit Facility
Debt Instrument [Line Items]
Maximum borrowing capacity	$ 750,000,000
The Credit Agreement | Line of Credit | Swingline Borrowings
Debt Instrument [Line Items]
Maximum borrowing capacity	$ 40,000,000
Number of one year extension, credit facility | one_year_extension	2
One year extension, credit facility	1 year
Debt instrument term (in years)	5 years
The Credit Agreement | Line of Credit | Letter of Credit
Debt Instrument [Line Items]
Maximum borrowing capacity	$ 50,000,000
The Credit Agreement | Unsecured Debt
Debt Instrument [Line Items]
Debt instrument, face amount, optional increase in additional borrowings	$ 250,000,000
Number of consecutive fiscal quarters, minimum debt to EBITDA ratio | consecutive_fiscal_quarter	4
Debt instrument, covenant, minimum debt to EBITDA ratio	3.50
Debt instrument, covenant, minimum debt to EBITDA ratio upon consummation of acquisition	4.00
Number of consecutive fiscal quarters, minimum debt to EBITDA ratio upon consummation of acquisition | consecutive_fiscal_quarter	3
The Credit Agreement | Unsecured Debt | Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate
Debt Instrument [Line Items]
Credit spread adjustment rate (as a percent)	0.10%

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Debt - Summary of Convertible Debt Obligations (Details) - 2023 Convertible Notes - Convertible Senior Notes - USD ($)	Oct. 01, 2023	Aug. 31, 2018
Debt Instrument [Line Items]
Stated rate (as a percent)	0.00%
Principal amount outstanding		$ 750,000,000

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Stockholders’ Equity - Narrative (Details) shares in Thousands	9 Months Ended
	Oct. 01, 2023 shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Additional shares authorized	8,000
Liability-Classified RSU
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares outstanding	557,000
Market-Based PSU
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share based compensation vesting performance period (in years)	3 years
Granted award (as a percent)	175.00%
Granted (in shares)	119
2015 Stock Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares available for issuance (in shares)	8,200

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Stockholders’ Equity - Summary of Restricted Stock Activity and Related Information (Details) shares in Thousands	9 Months Ended
	Oct. 01, 2023 $ / shares shares
Restricted Stock Units (RSUs)
Stock Units
Outstanding at period start (in shares) | shares	1,611,000
Awarded (in shares) | shares	2,000,000
Vested (in shares) | shares	(118,000)
Cancelled (in shares) | shares	(411,000)
Outstanding at period end (in shares) | shares	3,082,000
Weighted-Average Grant Date Fair Value per Share
Outstanding at period start (in dollars per share) | $ / shares	$ 311.23
Awarded (in dollars per share) | $ / shares	197.09
Vested (in dollars per share) | $ / shares	296.25
Cancelled (in dollars per share) | $ / shares	255.53
Outstanding at period end (in dollars per share) | $ / shares	$ 245.37
Performance Stock Units (PSU)
Stock Units
Outstanding at period start (in shares) | shares	74
Awarded (in shares) | shares	62
Vested (in shares) | shares	0
Cancelled (in shares) | shares	(96)
Outstanding at period end (in shares) | shares	40
Weighted-Average Grant Date Fair Value per Share
Outstanding at period start (in dollars per share) | $ / shares	$ 446.74
Awarded (in dollars per share) | $ / shares	245.08
Vested (in dollars per share) | $ / shares	0
Cancelled (in dollars per share) | $ / shares	300.09
Outstanding at period end (in dollars per share) | $ / shares	$ 198.25

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Stockholders’ Equity - Summary of Stock Option Activity Under all Stock Option Plans (Details) shares in Thousands	9 Months Ended
	Oct. 01, 2023 $ / shares shares
Options
Options
Outstanding at period start (in shares) | shares	187
Exercised (in shares) | shares	(8)
Cancelled (in shares) | shares	(135)
Outstanding at period end (in shares) | shares	44
Exercisable at period end (in shares) | shares	18
Weighted-Average Exercise Price
Outstanding at period start (in dollars per share) | $ / shares	$ 319.72
Exercised (in dollars per share) | $ / shares	71.09
Cancelled (in dollars per share) | $ / shares	330.25
Outstanding at period end (in dollars per share) | $ / shares	330.25
Exercisable at period end (in dollars per share) | $ / shares	$ 330.25
Performance stock options
Options
Outstanding at period start (in shares) | shares	17
Exercised (in shares) | shares	(1)
Cancelled (in shares) | shares	0
Outstanding at period end (in shares) | shares	16
Exercisable at period end (in shares) | shares	0
Weighted-Average Exercise Price
Outstanding at period start (in dollars per share) | $ / shares	$ 85.54
Exercised (in dollars per share) | $ / shares	16.69
Cancelled (in dollars per share) | $ / shares	0
Outstanding at period end (in dollars per share) | $ / shares	87.74
Exercisable at period end (in dollars per share) | $ / shares	$ 0

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Stockholders’ Equity - Narrative - Other Liability - Classified Awards (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Oct. 01, 2023	Oct. 02, 2022	Oct. 01, 2023	Oct. 02, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes	$ 86	$ 83	$ 286	$ 266
Unrecognized compensation cost	582		$ 582
Weighted-average period of unrecognized compensation cost (in years)			2 years 4 months 24 days
Liability-Based Awards
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share based compensation vesting performance period (in years)			4 years
Share-based compensation expense before taxes	26	$ 17	$ 72	$ 46
Unrecognized compensation cost	266		$ 266
Weighted-average period of unrecognized compensation cost (in years)			2 years 9 months 18 days
Aggregated potential value	$ 78		$ 78

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Stockholders’ Equity - Other Liability - Classified Awards (Details) - USD ($) $ in Millions	9 Months Ended
	Oct. 01, 2023	Jan. 01, 2023
Share-Based Compensation Arrangement By Share-Based Payment Award Liability-Classified Awards, Outstanding [Roll Forward]
Liability-classified equity incentive awards	$ 42	$ 36
Liability-Based Awards
Share-Based Compensation Arrangement By Share-Based Payment Award Liability-Classified Awards, Outstanding [Roll Forward]
Estimated liability, Beginning balance	293
Granted	116
Vested and paid in cash	(65)
Cancelled	(28)
Change in fair value	(8)
Estimated liability, Ending balance	308
Liability-classified equity incentive awards	$ 42

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Stockholders’ Equity - Narrative - Employee Stock Purchase Plan (Details) - ESPP - Employee Stock shares in Millions	9 Months Ended
	Oct. 01, 2023 shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Specified percentage of the fair market value of the common stock on the first or last day of the offering period whichever is lower at which stock is purchased (as a percent)	85.00%
Total shares issued under the ESPP (in shares)	0.4
Shares available for issuance (in shares)	12.4

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Stockholders’ Equity- Summary of Assumptions Used to Estimate the Weighted Average Fair Value Per Share (Details) - Employee Stock	9 Months Ended
	Oct. 01, 2023 $ / shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Risk free interest rate minimum (as a percent)	0.78%
Risk free interest rate maximum (as a percent)	5.54%
Expected volatility, minimum (as a percent)	41.00%
Expected volatility, maximum (as a percent)	51.00%
Expected dividends	0.00%
Weighted-average fair value per share (in dollars per share)	$ 49.87
Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected term (in years)	6 months
Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected term (in years)	1 year 1 month 6 days

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Stockholders’ Equity - Narrative - Share Repurchases (Details) - Common Stock - USD ($)	9 Months Ended
	Oct. 01, 2023	Feb. 05, 2020
Class of Stock [Line Items]
Repurchased common stock (in shares)	0
Dollar amount remaining in authorized stock repurchase program	$ 15,000,000
Stock repurchase program, authorized amount		$ 750,000,000

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Stockholders’ Equity - Summary of Share-based Compensation Expense for all Stock Awards (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Oct. 01, 2023	Oct. 02, 2022	Oct. 01, 2023	Oct. 02, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes	$ 86	$ 83	$ 286	$ 266
Related income tax benefits	(19)	(18)	(65)	(60)
Share-based compensation expense, net of taxes	67	65	221	206
Cost of product revenue
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes	7	7	22	20
Cost of service and other revenue
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes	2	2	5	4
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes	36	37	117	112
Selling, general and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes	$ 41	$ 37	$ 142	$ 130

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Supplemental Balance Sheet Details - Schedule of Accounts Receivable (Details) - USD ($) $ in Millions	Oct. 01, 2023	Jan. 01, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Trade accounts receivable, gross	$ 696	$ 675
Allowance for credit losses	(6)	(4)
Total accounts receivable, net	$ 690	$ 671

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Supplemental Balance Sheet Details - Summary of Inventory (Details) - USD ($) $ in Millions	Oct. 01, 2023	Jan. 01, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Raw materials	$ 278	$ 247
Work in process	423	386
Finished goods	35	28
Inventory, gross	736	661
Inventory reserve	(121)	(93)
Total inventory, net	$ 615	$ 568

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Supplemental Balance Sheet Details - Summary of Accrued Liabilities (Details) - USD ($) $ in Millions	Oct. 01, 2023	Jan. 01, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Legal contingencies	$ 458	$ 473
Contract liabilities, current portion	242	245
Accrued compensation expenses	195	188
Accrued taxes payable	65	97
Operating lease liabilities, current portion	85	76
Liability-classified equity incentive awards	42	36
Other, including warranties	155	117
Total accrued liabilities	$ 1,242	$ 1,232

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Supplemental Balance Sheet Details - Summary of Changes in Reserve for Product Warranties (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Oct. 01, 2023	Oct. 02, 2022	Oct. 01, 2023	Oct. 02, 2022
Reserve for product warranties [Roll Forward]
Balance at beginning of period	$ 20	$ 21	$ 18	$ 22
Additions charged to cost of product revenue	10	5	30	17
Repairs and replacements	(11)	(7)	(29)	(20)
Balance at end of period	$ 19	$ 19	$ 19	$ 19

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Supplemental Balance Sheet Details - Pre-Tax Restructuring Charge (Details) - USD ($) $ in Millions	3 Months Ended	9 Months Ended
	Oct. 01, 2023	Oct. 01, 2023
Restructuring Cost and Reserve [Line Items]
Total restructuring charges	$ 58	$ 91
Selling, general and administrative
Restructuring Cost and Reserve [Line Items]
Total restructuring charges	55	74
Research and development
Restructuring Cost and Reserve [Line Items]
Total restructuring charges	2	13
Employee separation costs
Restructuring Cost and Reserve [Line Items]
Total restructuring charges	7	33
Asset impairment charges
Restructuring Cost and Reserve [Line Items]
Total restructuring charges	49	56
Other Costs
Restructuring Cost and Reserve [Line Items]
Total restructuring charges	$ 2	$ 2

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Supplemental Balance Sheet Details - Narrative - Restructuring (Details) $ in Millions	3 Months Ended	9 Months Ended
	Oct. 01, 2023 USD ($)	Oct. 01, 2023 USD ($)
Restructuring Cost and Reserve [Line Items]
Right-of-use asset impairment	$ 33	$ 38
CALIFORNIA
Restructuring Cost and Reserve [Line Items]
Right-of-use assets and leasehold improvements	182	182
Leasehold improvements
Restructuring Cost and Reserve [Line Items]
Right-of-use asset impairment	$ 14	$ 16

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Supplemental Balance Sheet Details - Pre-Tax Charges and Total Costs (Details) $ in Millions	9 Months Ended
	Oct. 01, 2023 USD ($)
Restructuring Cost and Reserve [Line Items]
Expense recorded in YTD 2023	$ 35
Cash paid during YTD 2023	(31)
Amount recorded in accrued liabilities as of October 1, 2023	4
Estimated total restructuring costs to still be incurred	2
Employee separation costs
Restructuring Cost and Reserve [Line Items]
Expense recorded in YTD 2023	33
Cash paid during YTD 2023	(30)
Amount recorded in accrued liabilities as of October 1, 2023	3
Estimated total restructuring costs to still be incurred	2
Other Costs
Restructuring Cost and Reserve [Line Items]
Expense recorded in YTD 2023	2
Cash paid during YTD 2023	(1)
Amount recorded in accrued liabilities as of October 1, 2023	1
Estimated total restructuring costs to still be incurred	$ 0

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Supplemental Balance Sheet Details - Narrative - Warranties (Details)	9 Months Ended
	Oct. 01, 2023
Instruments
Product Warranty Liability [Line Items]
Warranty period (in months)	1 year
Consumables | Minimum
Product Warranty Liability [Line Items]
Warranty period (in months)	6 months
Consumables | Maximum
Product Warranty Liability [Line Items]
Warranty period (in months)	12 months

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Supplemental Balance Sheet Details - Narrative - Goodwill and Intangible Assets (Details) $ in Millions	1 Months Ended	3 Months Ended			9 Months Ended
	Nov. 06, 2023	Oct. 01, 2023 USD ($)	Jul. 02, 2023 unit	Oct. 02, 2022 USD ($)	Oct. 01, 2023 USD ($)	Oct. 02, 2022 USD ($)	Jan. 01, 2023 USD ($)
Indefinite-lived Intangible Assets [Line Items]
Number of reporting units | unit			2
Impairment		$ (821)		$ (3,914)	$ (821)	$ (3,914)
Goodwill		2,527			$ 2,527		$ 3,239
Subsequent Event
Indefinite-lived Intangible Assets [Line Items]
Decline in share price (in percent)	0.18
In-process research and development (IPR&D)
Indefinite-lived Intangible Assets [Line Items]
Fair value of discount rate (as a percent)					19.00%
Goodwill fair value recorded impairment		109
Goodwill carrying value		561			$ 561
Core Illumina
Indefinite-lived Intangible Assets [Line Items]
Fair value in excess of carrying amount (more than)		20,000			20,000
GRAIL
Indefinite-lived Intangible Assets [Line Items]
Impairment				$ (3,914)	$ (712)
Fair value of discount rate (as a percent)					24.00%
Goodwill		$ 1,466			$ 1,466
GRAIL | Minimum
Indefinite-lived Intangible Assets [Line Items]
Fair value of discount rate (as a percent)					0.50%
Goodwill impairment loss upon increase in discount rate					$ 200
GRAIL | Maximum
Indefinite-lived Intangible Assets [Line Items]
Fair value of discount rate (as a percent)					1.00%
Goodwill impairment loss upon increase in discount rate					$ 350

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Supplemental Balance Sheet Details - Changes to Goodwill (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Oct. 01, 2023	Oct. 02, 2022	Oct. 01, 2023	Oct. 02, 2022
Indefinite-lived Intangible Assets [Line Items]
Goodwill and intangible impairment	$ 821	$ 3,914	$ 821	$ 3,914
Goodwill [Roll Forward]
Goodwill, beginning balance			3,239
Impairment	(821)	(3,914)	(821)	$ (3,914)
Goodwill, ending balance	2,527		2,527
GRAIL
Indefinite-lived Intangible Assets [Line Items]
Goodwill and intangible impairment		3,914	712
Goodwill [Roll Forward]
Impairment		$ (3,914)	(712)
Goodwill, ending balance	$ 1,466		$ 1,466

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Supplemental Balance Sheet Details - Narrative - Derivatives (Details) € in Millions, $ in Millions	3 Months Ended		9 Months Ended
	Oct. 01, 2023 USD ($)	Oct. 02, 2022 USD ($)	Oct. 01, 2023 USD ($)	Oct. 02, 2022 USD ($)	Jul. 12, 2023 EUR (€)	Jan. 01, 2023 USD ($)
Derivative [Line Items]
Reclassification to revenue	$ 5	$ 16	$ 9	$ 32
Estimated net gains reported in accumulated other comprehensive income	22		22
GRAIL
Derivative [Line Items]
Loss contingency accrual | €					€ 432
Foreign Exchange Forward
Derivative [Line Items]
Foreign currency forward contracts assets	27		27
Foreign currency forward contracts liabilities	1		$ 1
Derivative asset, current amount						$ 8
Derivative liability, current amount						6
Foreign Exchange Forward | Not Designated as Hedging Instrument
Derivative [Line Items]
Derivative, term of contract (in months)			1 month
Derivative, notional amount	912		$ 912			485
Foreign Exchange Forward | Designated as Hedging Instrument
Derivative [Line Items]
Derivative, term of contract (in months)			24 months
Derivative, notional amount	$ 663		$ 663			$ 425

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Legal Proceedings (Details) € in Millions, $ in Millions	12 Months Ended
	Jan. 01, 2023 USD ($)	Oct. 01, 2023 USD ($)	Jul. 12, 2023 EUR (€)
Loss Contingencies [Line Items]
Legal contingencies | $	$ 473	$ 458
GRAIL
Loss Contingencies [Line Items]
Loss contingency accrual | €			€ 432
Potential fine as a percent of consolidated annual revenues	0.10
Long-term debt, fine percentage rate		0.055

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Income Taxes (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Oct. 01, 2023	Oct. 02, 2022	Oct. 01, 2023	Oct. 02, 2022	Jan. 01, 2023
Income Tax Examination [Line Items]
Effective tax rate (as a percent)	3.60%	(4.00%)	(3.80%)	(2.30%)
Income tax expense			$ 149
Impact on tax rate due to capitalization of research and development expenses	$ 20		84
Impact on tax rate due to GILTI and U.S. foreign tax credits	38
Foreign income tax expense (benefit)			63
Income tax receivable	$ 78		$ 78		$ 116
US
Income Tax Examination [Line Items]
Effective tax rate (as a percent)	21.00%		21.00%

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Segment Information - Summary of Operating Performance and Assets by Segment (Details) $ in Millions	3 Months Ended		9 Months Ended
	Oct. 01, 2023 USD ($)	Oct. 02, 2022 USD ($)	Oct. 01, 2023 USD ($) segment	Oct. 02, 2022 USD ($)
Segment Reporting [Abstract]
Number of reportable segments | segment			2
Segment Reporting Information [Line Items]
Consolidated revenue	$ 1,119	$ 1,115	$ 3,382	$ 3,501
Consolidated loss from operations	(754)	(3,657)	(905)	(4,052)
Operating Segments | Core Illumina
Segment Reporting Information [Line Items]
Consolidated revenue	1,106	1,110	3,341	3,487
Consolidated loss from operations	262	445	519	411
Operating Segments | GRAIL
Segment Reporting Information [Line Items]
Consolidated revenue	21	10	62	32
Consolidated loss from operations	(1,015)	(4,101)	(1,424)	(4,460)
Eliminations
Segment Reporting Information [Line Items]
Consolidated revenue	(8)	(5)	(21)	(18)
Consolidated loss from operations	$ (1)	$ (1)	$ 0	$ (3)