Revenue - Disaggregation of Revenue (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Oct. 02, 2022	Oct. 03, 2021	Oct. 02, 2022	Oct. 03, 2021
Disaggregation of Revenue [Line Items]
Consolidated revenue	$ 1,115	$ 1,108	$ 3,501	$ 3,327
Americas
Disaggregation of Revenue [Line Items]
Consolidated revenue	597	583	1,885	1,733
Europe, Middle East, and Africa
Disaggregation of Revenue [Line Items]
Consolidated revenue	290	313	914	938
Greater China
Disaggregation of Revenue [Line Items]
Consolidated revenue	133	122	378	382
Asia-Pacific
Disaggregation of Revenue [Line Items]
Consolidated revenue	95	90	324	274
Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	963	978	3,039	2,903
Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	796	794	2,462	2,347
Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	167	184	577	556
Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	152	130	462	424
Sequencing
Disaggregation of Revenue [Line Items]
Consolidated revenue	1,015	1,015	3,190	3,015
Sequencing | Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	882	903	2,800	2,667
Sequencing | Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	720	723	2,237	2,123
Sequencing | Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	162	180	563	544
Sequencing | Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	133	112	390	348
Microarray
Disaggregation of Revenue [Line Items]
Consolidated revenue	100	93	311	312
Microarray | Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	81	75	239	236
Microarray | Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	76	71	225	224
Microarray | Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	5	4	14	12
Microarray | Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	$ 19	$ 18	$ 72	$ 76