Revenue - Disaggregation of Revenue (Details) - USD ($) $ in Millions	3 Months Ended
	Apr. 03, 2022	Apr. 04, 2021
Disaggregation of Revenue [Line Items]
Consolidated revenue	$ 1,223	$ 1,093
Americas
Disaggregation of Revenue [Line Items]
Consolidated revenue	648	562
Europe, Middle East, and Africa
Disaggregation of Revenue [Line Items]
Consolidated revenue	316	305
Greater China
Disaggregation of Revenue [Line Items]
Consolidated revenue	127	127
Asia-Pacific
Disaggregation of Revenue [Line Items]
Consolidated revenue	132	99
Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	1,070	953
Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	853	774
Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	217	179
Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	153	140
Sequencing
Disaggregation of Revenue [Line Items]
Consolidated revenue	1,109	979
Sequencing | Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	989	871
Sequencing | Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	778	695
Sequencing | Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	211	176
Sequencing | Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	120	108
Microarray
Disaggregation of Revenue [Line Items]
Consolidated revenue	114	114
Microarray | Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	81	82
Microarray | Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	75	79
Microarray | Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	6	3
Microarray | Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	$ 33	$ 32