10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

☑ Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

For the Quarterly Period Ended April 3, 2022

☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

For the transition period from             to            

Commission File Number 001-35406 

Illumina, Inc.

(Exact name of registrant as specified in its charter)

Delaware	33-0804655
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)

5200 Illumina Way, San Diego, CA 92122

(Address of principal executive offices) (Zip code)

(858) 202-4500

(Registrant’s telephone number, including area code)

N/A

(Former name, former address and former fiscal year, if changed since last report)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Common Stock, $0.01 par value	ILMN	The NASDAQ Stock Market LLC

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes   ☑    No   ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).    Yes   ☑    No  ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer þ Accelerated filer ☐ Non-accelerated filer ☐ Smaller reporting company ☐ Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13a of the Exchange Act. ☐    

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).     Yes  ☐    No   þ

As of April 29, 2022, there were 157.1 million shares of the registrant’s common stock outstanding.

ILLUMINA, INC.

FORM 10-Q

FOR THE FISCAL QUARTER ENDED APRIL 3, 2022

TABLE OF CONTENTS

See “Form 10-Q Cross-Reference Index” within Other Key Information for a cross-reference to the parts and items requirements of the Securities and Exchange Commission Quarterly Report on Form 10-Q.

CONDENSED CONSOLIDATED FINANCIAL STATEMENTS	PAGE
Condensed Consolidated Balance Sheets	5
Condensed Consolidated Statements of Income	6
Condensed Consolidated Statements of Comprehensive Income	7
Condensed Consolidated Statements of Stockholders’ Equity	8
Condensed Consolidated Statements of Cash Flows	10
Notes to Condensed Consolidated Financial Statements	11
1. Organization and Significant Accounting Policies	11
2. Revenue	1
3. Investments and Fair Value Measurements	2
4. Debt	4
5. Stockholders’ Equity	7
6. Supplemental Balance Sheet Details	9
7. Legal Proceedings	10
8. Income Taxes	12
9. Segment Information	12
MANAGEMENT’S DISCUSSION & ANALYSIS
Management’s Overview and Outlook	14
Results of Operations	16
Liquidity and Capital Resources	19
Critical Accounting Policies and Estimates	21
Recent Accounting Pronouncements	21
Quantitative and Qualitative Disclosures About Market Risk	21
OTHER KEY INFORMATION
Controls and Procedures	21
Legal Proceedings	21
Risk Factors	22
Share Repurchases and Sales	22
Exhibits	23
Form 10-Q Cross-Reference Index	24

2

Consideration Regarding Forward-Looking Statements

This Quarterly Report on Form 10-Q contains, and our officers and representatives may from time to time make, “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as: “anticipate,” “intend,” “plan,” “goal,” “seek,” “believe,” “continue,” “project,” “estimate,” “expect,” “strategy,” “future,” “likely,” “may,” “potential,” “predict,” “should,” “will,” or similar words or phrases, or the negatives of these words, may identify forward-looking statements, but the absence of these words does not necessarily mean that a statement is not forward looking. Examples of forward-looking statements include, among others, statements we make regarding:

•our expectations as to our future financial performance, results of operations, or other operational results or metrics;

•our expectations regarding the launch of new products or services;

•the benefits that we expect will result from our business activities and certain transactions we have completed, such as product introductions, increased revenue, decreased expenses, and avoided expenses and expenditures;

•our expectations of the effect on our financial condition of claims, litigation, contingent liabilities, and governmental investigations, proceedings, and regulations;

•our strategies or expectations for product development, market position, financial results, and reserves;

•our expectations regarding the outcome of the legal and regulatory proceedings related to our acquisition of GRAIL, Inc. (GRAIL) and other actions that may be taken or pursued by the European Commission, the Federal Trade Commission and/or other governmental or regulatory authorities in connection with such acquisition;

•the interim measures order imposed by the European Commission, its duration and impact on Illumina and GRAIL, and the appointment of a monitoring trustee to monitor our compliance with such order;

•our expectations regarding the integration of any acquired technologies with our existing technology; and

•other expectations, beliefs, plans, strategies, anticipated developments, and other matters that are not historical facts.

Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations, and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy, and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks, and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following:

•the impact to our business and operating results caused by the COVID-19 pandemic;

•our expectations and beliefs regarding prospects and growth for our business and the markets in which we operate;

•the timing and mix of customer orders among our products and services;

•challenges inherent in developing, manufacturing, and launching new products and services, including expanding manufacturing operations and reliance on third-party suppliers for critical components;

•the impact of recently launched or pre-announced products and services on existing products and services;

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•our ability to develop and commercialize our instruments and consumables, to deploy new products, services, and applications, and to expand the markets for our technology platforms;

•our ability to manufacture robust instrumentation and consumables;

•our ability to identify and acquire technologies and integrate them into our products or businesses successfully;

•risks and uncertainties regarding the legal and regulatory proceedings relating to our acquisition of GRAIL and our ability to achieve the expected benefits of such acquisition and other actions that may be taken or pursued by the European Commission, the Federal Trade Commission and/or other governmental or regulatory authorities in connection with such acquisition;

•the interim measures order imposed by the European Commission, and its duration and impact on Illumina and GRAIL, which impact may include material and adverse effects on synergies and other benefits we expect to achieve as a result of the acquisition of GRAIL, additional costs or liabilities, loss of revenue and other adverse effects on our business, financial condition and results of operations;

•our compliance with the terms of the interim measures order, which is monitored by an appointed monitoring trustee, and which is burdensome to implement and administer, and the risk that the European Commission could impose or seek to impose fines and other penalties for alleged noncompliance with such terms;

•the assumptions underlying our critical accounting policies and estimates;

•our assessments and estimates that determine our effective tax rate;

•our assessments and beliefs regarding the outcome of pending legal proceedings and any liability that we may incur as a result of those proceedings;

•uncertainty, or adverse economic and business conditions, including as a result of slowing or uncertain economic growth in the United States or worldwide; and

•other factors detailed in our filings with the Securities and Exchange Commission (SEC), including the risks, uncertainties, and assumptions described in “Risk Factors” within the Business & Market Information section of our Annual Report on Form 10-K for the fiscal year ended January 2, 2022, or in information disclosed in public conference calls, the date and time of which are released beforehand.

Any forward-looking statement made by us in this Quarterly Report on Form 10-Q is based only on information currently available to us and speaks only as of the date on which it is made. We undertake no obligation, and do not intend, to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, or to review or confirm analysts’ expectations, or to provide interim reports or updates on the progress of any current financial quarter, in each case whether as a result of new information, future developments, or otherwise.

4

CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

ILLUMINA, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

(In millions)    

	April 3, 2022		January 2, 2022
	(Unaudited)
ASSETS
Current assets:
Cash and cash equivalents	$	1,351	$	1,232
Short-term investments	65		107
Accounts receivable, net	614		648
Inventory, net	465		431
Prepaid expenses and other current assets	260		295
Total current assets	2,755		2,713
Property and equipment, net	1,034		1,024
Operating lease right-of-use assets	706		672
Goodwill	7,113		7,113
Intangible assets, net	3,209		3,250
Other assets	457		445
Total assets	$	15,274	$	15,217
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable	$	291	$	332
Accrued liabilities	700		761
Term notes, current portion	499		—
Total current liabilities	1,490		1,093
Operating lease liabilities	803		774
Term notes	495		993
Convertible senior notes	746		702
Other long-term liabilities	845		915
Stockholders’ equity:
Common stock	2		2
Additional paid-in capital	8,957		8,938
Accumulated other comprehensive income	18		17
Retained earnings	5,632		5,485
Treasury stock, at cost	(3,714)		(3,702)
Total stockholders’ equity	10,895		10,740
Total liabilities and stockholders’ equity	$	15,274	$	15,217

See accompanying notes to condensed consolidated financial statements.

5

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF INCOME

(Unaudited)

(In millions, except per share amounts)

	Three Months Ended
	April 3, 2022		April 4, 2021
Revenue:
Product revenue	$	1,070	$	953
Service and other revenue	153		140
Total revenue	1,223		1,093
Cost of revenue:
Cost of product revenue	299		265
Cost of service and other revenue	69		58
Amortization of acquired intangible assets	40		6
Total cost of revenue	408		329
Gross profit	815		764
Operating expense:
Research and development	323		197
Selling, general and administrative	308		374
Total operating expense	631		571
Income from operations	184		193
Other income (expense):
Interest income	—		1
Interest expense	(6)		(19)
Other expense, net	(38)		(6)
Total other expense, net	(44)		(24)
Income before income taxes	140		169
Provision for income taxes	54		22
Net income	$	86	$	147
Earnings per share:
Basic	$	0.55	$	1.01
Diluted	$	0.55	$	1.00
Shares used in computing earnings per share:
Basic	157		146
Diluted	159		147

See accompanying notes to condensed consolidated financial statements.

6

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME

(Unaudited)

(In millions)

	Three Months Ended
	April 3, 2022		April 4, 2021
Net income	$	86	$	147
Unrealized loss on available-for-sale debt securities, net of deferred tax	—		(1)
Unrealized gain on cash flow hedges, net of deferred tax	1		7
Total comprehensive income	$	87	$	153

See accompanying notes to condensed consolidated financial statements.

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ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

(Unaudited)

(In millions)

				Additional		Accumulated Other							Total
	Common Stock			Paid-In		Comprehensive		Retained		Treasury Stock			Stockholders’
	Shares	Amount		Capital		Income		Earnings		Shares	Amount		Equity
Balance as of January 3, 2021	195	$	2	$	3,815	$	2	$	4,723	(49)	$	(3,848)	$	4,694
Net income	—	—		—		—		147		—	—		147
Unrealized loss on available-for-sale debt securities, net of deferred tax	—	—		—		(1)		—		—	—		(1)
Unrealized gain on cash flow hedges, net of deferred tax	—	—		—		7		—		—	—		7
Issuance of common stock, net of repurchases	—	—		31		—		—		—	(24)		7
Share-based compensation	—	—		68		—		—		—	—		68
Balance as of April 4, 2021	195	2		3,914		8		4,870		(49)	(3,872)		4,922
Net income	—	—		—		—		185		—	—		185
Issuance of common stock, net of repurchases	1	—		—		—		—		—	(6)		(6)
Share-based compensation	—	—		79		—		—		—	—		79
Balance as of July 4, 2021	196	2		3,993		8		5,055		(49)	(3,878)		5,180
Net income	—	—		—		—		317		—	—		317
Unrealized gain on cash flow hedges, net of deferred tax	—	—		—		5		—		—	—		5
Issuance of common stock, net of repurchases	—	—		28		—		—		—	(2)		26
GRAIL acquisition	—	—		4,749		—		—		10	237		4,986
Share-based compensation	—	—		79		—		—		—	—		79
Balance as of October 3, 2021	196	2		8,849		13		5,372		(39)	(3,643)		10,593
Net income	—	—		—		—		113		—	—		113
Unrealized gain on cash flow hedges, net of deferred tax	—	—		—		4		—		—	—		4
Issuance of common stock, net of repurchases	1	—		1		—		—		(1)	(59)		(58)
Exchange of GRAIL contingent value rights	—	—		2		—		—		—	—		2
Share-based compensation	—	—		86		—		—		—	—		86
Balance as of January 2, 2022	197	$	2	$	8,938	$	17	$	5,485	(40)	$	(3,702)	$	10,740

See accompanying notes to condensed consolidated financial statements.

8

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

(Unaudited)

(In millions)

				Additional		Accumulated Other							Total
	Common Stock			Paid-In		Comprehensive		Retained		Treasury Stock			Stockholders’
	Shares	Amount		Capital		Income		Earnings		Shares	Amount		Equity
Balance as of January 2, 2022	197	$	2	$	8,938	$	17	$	5,485	(40)	$	(3,702)	$	10,740
Net income	—	—		—		—		86		—	—		86
Unrealized gain on cash flow hedges, net of deferred tax	—	—		—		1		—		—	—		1
Issuance of common stock, net of repurchases	—	—		33		—		—		—	(12)		21
Share-based compensation	—	—		79		—		—		—	—		79
Cumulative-effect adjustment from adoption of ASU 2020-06, net of deferred tax	—	—		(93)		—		61		—	—		(32)
Balance as of April 3, 2022	197	$	2	$	8,957	$	18	$	5,632	(40)	$	(3,714)	$	10,895

See accompanying notes to condensed consolidated financial statements.

9

ILLUMINA, INC.

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(Unaudited)

(In millions)

	Three Months Ended
	April 3, 2022		April 4, 2021
Cash flows from operating activities:
Net income	$	86	$	147
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation expense	50		41
Amortization of intangible assets	41		7
Share-based compensation expense	92		67
Accretion of debt discount on convertible senior notes	—		10
Deferred income taxes	(21)		(79)
Net losses on strategic investments	44		41
Gain on Helix contingent value right	(5)		(10)
Gain on derivative assets related to terminated acquisition	—		(26)
Change in fair value of contingent consideration liability	(49)		—
Other	(1)		22
Changes in operating assets and liabilities:
Accounts receivable	31		(39)
Inventory	(34)		8
Prepaid expenses and other current assets	11		7
Operating lease right-of-use assets and liabilities, net	(3)		(3)
Other assets	6		(4)
Accounts payable	(39)		(8)
Accrued liabilities	(45)		105
Other long-term liabilities	8		(4)
Net cash provided by operating activities	172		282
Cash flows from investing activities:
Maturities of available-for-sale securities	—		331
Purchases of available-for-sale securities	—		(77)
Sales of available-for-sale securities	—		1,031
Cash received for derivative assets related to terminated acquisition	—		52
Purchases of property and equipment	(61)		(42)
Purchases of strategic investments	(13)		(3)
Sales of strategic investments	—		84
Net cash (used in) provided by investing activities	(74)		1,376
Cash flows from financing activities:
Net proceeds from issuance of debt	—		988
Payments on convertible senior notes	—		(27)
Taxes paid related to net share settlement of equity awards	(12)		(24)
Proceeds from issuance of common stock	33		31
Net cash provided by financing activities	21		968
Effect of exchange rate changes on cash and cash equivalents	—		(3)
Net increase in cash and cash equivalents	119		2,623
Cash and cash equivalents at beginning of period	1,232		1,810
Cash and cash equivalents at end of period	$	1,351	$	4,433

See accompanying notes to condensed consolidated financial statements.

10

ILLUMINA, INC.

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

(UNAUDITED)

Unless the context requires otherwise, references in this report to “Illumina,” “we,” “us,” the “Company,” and “our” refer to Illumina, Inc. and its consolidated subsidiaries.

1. ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES

Business Overview

We are a provider of sequencing- and array-based solutions, serving customers in the research, clinical and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture and other emerging segments. Our customers include leading genomic research centers, academic institutions, government laboratories, and hospitals, as well as pharmaceutical, biotechnology, commercial molecular diagnostic laboratories, and consumer genomics companies.

On August 18, 2021, we acquired GRAIL, a healthcare company focused on early detection of multiple cancers. GRAIL’s Galleri blood test detects various types of cancers before they are symptomatic. The acquisition is subject to ongoing legal proceedings and GRAIL is currently being held and operated as a separate company, with oversight provided by an appointed, independent monitoring trustee during the European Commission’s ongoing merger review. Refer to note “7. Legal Proceedings” for additional details. We have included the financial results of GRAIL in our condensed consolidated financial statements from the date of acquisition. There have been no adjustments to the purchase price allocation from those disclosed in our Annual Report on Form 10-K for the fiscal year ended January 2, 2022. We are still finalizing the allocation of the purchase price as additional information is received to complete our analysis and certain tax returns are finalized. In addition, GRAIL is a separate reportable segment. Refer to note “9. Segment Information” for additional details.

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. Interim financial results are not necessarily indicative of results anticipated for the full year. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and footnotes included in the Annual Report on Form 10-K for the fiscal year ended January 2, 2022, from which the prior year balance sheet information herein was derived. The preparation of financial statements requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, and expense, and related disclosure of contingent assets and liabilities. Though the impact of the COVID-19 pandemic to our business and operating results presents additional uncertainty, we continue to use the best information available to form our critical accounting estimates. Actual results could differ from those estimates.

The unaudited condensed consolidated financial statements include our accounts, our wholly-owned subsidiaries, and majority-owned or controlled companies. All intercompany transactions and balances have been eliminated in consolidation. Certain prior period amounts have been reclassified to conform to the current period presentation. In management’s opinion, the accompanying unaudited condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.

Fiscal Year

Our fiscal year is the 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. References to Q1 2022 and Q1 2021 refer to the three months ended April 3, 2022 and April 4, 2021, respectively, which were both 13 weeks.

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Significant Accounting Policies

During Q1 2022, there were no changes to our significant accounting policies as described in our Annual Report on Form 10-K for the fiscal year ended January 2, 2022, except as described in Recently Adopted Accounting Pronouncements below.

Recently Adopted Accounting Pronouncements

In August 2020, the FASB issued ASU 2020-06, Debt - Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging - Contracts in Entity’s Own Equity (Subtopic 815-40). The new standard reduces the number of accounting models for convertible debt instruments, amends the accounting for certain contracts in an entity’s own equity, and modifies how certain convertible instruments and contracts that may be settled in cash or shares impact the calculation of diluted earnings per share. Specifically, the guidance removes certain accounting models that separate the embedded conversion features from the host contract for convertible instruments and requires the use of the if-converted method to calculate diluted earnings per share. We adopted the standard on its effective date in the first quarter of 2022 using a modified retrospective approach by recognizing a cumulative-effect adjustment to retained earnings on January 3, 2022. We did not restate prior periods. As a result of the adoption, we increased our convertible senior notes and retained earnings, on January 3, 2022, by $43 million and $61 million, respectively, and decreased our deferred tax liabilities, included in other long-term liabilities on the condensed consolidated balance sheets, and additional paid-in capital by $11 million and $93 million, respectively. Interest expense recognized in future periods will be reduced as a result of accounting for our convertible senior notes as a single liability measured at amortized cost. In addition, as a result of the adoption, diluted earnings per share decreased by less than $0.01 for Q1 2022. See note “4. Debt” for additional details on the adoption of ASU 2020-06.

Earnings per Share

Basic earnings per share is computed based on the weighted average number of common shares outstanding during the period. Diluted earnings per share is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period.

Potentially dilutive common shares consist of shares issuable under convertible senior notes and equity awards. On January 3, 2022, we adopted ASU 2020-06. As a result, beginning in Q1 2022, we utilize the if-converted method to calculate the impact of convertible senior notes on diluted earnings per share. Prior to the adoption of ASU 2020-06, we applied the treasury stock method when calculating the potential dilutive effect, if any, of convertible senior notes which we intended to settle or have settled in cash the principal outstanding. Under the treasury stock method, convertible senior notes had a dilutive impact when the average market price of our common stock exceeded the applicable conversion price of the respective notes. Potentially dilutive common shares from equity awards are determined using the average share price for each period under the treasury stock method. In addition, proceeds from exercise of equity awards and the average amount of unrecognized compensation expense for equity awards are assumed to be used to repurchase shares. For Q1 2022 and Q1 2021, we did not have any potentially dilutive common shares from equity awards.

The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share:

In millions	Q1 2022	Q1 2021
Weighted average shares outstanding	157	146
Effect of potentially dilutive common shares from:
Convertible senior notes	2	1
Weighted average shares used in calculating diluted earnings per share	159	147

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2. REVENUE

Our revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instruments and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from genotyping and sequencing services, instrument service contracts, development and licensing agreements, and cancer detection testing services related to the GRAIL business.

Revenue by Source

	Q1 2022						Q1 2021
In millions	Sequencing		Microarray		Total		Sequencing		Microarray		Total
Consumables	$	778	$	75	$	853	$	695	$	79	$	774
Instruments	211		6		217		176		3		179
Total product revenue	989		81		1,070		871		82		953
Service and other revenue	120		33		153		108		32		140
Total revenue	$	1,109	$	114	$	1,223	$	979	$	114	$	1,093

Revenue by Geographic Area

Based on region of destination (in millions)	Q1 2022		Q1 2021
Americas	$	648	$	562
Europe, Middle East, and Africa	316		305
Greater China(1)	127		127
Asia-Pacific	132		99
Total revenue	$	1,223	$	1,093

_____________

(1)Region includes revenue from China, Taiwan, and Hong Kong.

Performance Obligations

We regularly enter into contracts with multiple performance obligations. Most performance obligations are generally satisfied within a short time frame, approximately three to six months, after the contract execution date. As of April 3, 2022, the aggregate amount of the transaction price allocated to remaining performance obligations was $1,276 million, of which approximately 91% is expected to be converted to revenue in the next twelve months, approximately 6% in the following twelve months, and the remainder thereafter.

Contract Assets and Liabilities

Contract assets, which consist of revenue recognized and performance obligations satisfied or partially satisfied in advance of customer billing, were $16 million as of April 3, 2022 and January 2, 2022, which were recorded in prepaid expenses and other current assets.

Contract liabilities, which consist of deferred revenue and customer deposits, as of April 3, 2022 and January 2, 2022 were $293 million and $297 million, respectively, of which the short-term portions of $232 million and $234 million, respectively, were recorded in accrued liabilities and the remaining long-term portions were recorded in other long-term liabilities. Revenue recorded in Q1 2022 included $106 million of previously deferred revenue that was included in contract liabilities as of January 2, 2022.

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3. INVESTMENTS AND FAIR VALUE MEASUREMENTS

Strategic Investments

Marketable Equity Securities

Our short-term investments consist of marketable equity securities. As of April 3, 2022 and January 2, 2022, the fair value of our marketable equity securities totaled $65 million and $107 million, respectively.

Net losses recognized in other expense, net on our marketable equity securities were as follows:

In millions	Q1 2022		Q1 2021
Net losses recognized during the period on marketable equity securities	$	(42)	$	(72)
Less: Net losses recognized during the period on marketable equity securities sold during the period	—		14
Net unrealized losses recognized during the period on marketable equity securities still held at the reporting date	$	(42)	$	(58)

Non-Marketable Equity Securities

As of April 3, 2022 and January 2, 2022, the aggregate carrying amounts of our non-marketable equity securities without readily determinable fair values, included in other assets, were $41 million and $40 million, respectively.

Revenue recognized from transactions with our strategic investees was $30 million and $13 million for Q1 2022 and Q1 2021, respectively.

Venture Funds

We invest in two venture capital investment funds (the Funds) with capital commitments of $100 million, callable through April 2026, and up to $150 million, callable through July 2029, respectively, of which $14 million and up to $110 million, respectively, remained callable as of April 3, 2022. Our investments in the Funds are accounted for as equity-method investments. The aggregate carrying amounts of the Funds, included in other assets, were $183 million and $173 million as of April 3, 2022 and January 2, 2022, respectively. We recorded an unrealized loss of $2 million and an unrealized gain of $33 million in Q1 2022 and Q1 2021, respectively, in other expense, net.

Helix Contingent Value Right

In conjunction with the deconsolidation of Helix Holdings I, LLC (Helix) in April 2019, we received a contingent value right with a 7-year term that entitles us to consideration dependent upon the outcome of Helix’s future financing and/or liquidity events. Changes in the fair value of the contingent value right resulted in unrealized gains of $5 million and $10 million in Q1 2022 and Q1 2021, respectively, which were included in other expense, net.

Derivative Assets Related to Terminated Acquisition

Pursuant to the Agreement and Plan of Merger (the PacBio Merger Agreement) to acquire Pacific Biosciences of California, Inc. (PacBio) entered into in November 2018 and amended in September 2019 (Amendment No. 1 to the PacBio Merger Agreement) and the subsequent agreement to terminate the PacBio Merger Agreement (the Termination Agreement) entered into in January 2020, we made cash payments to PacBio of $18 million in Q4 2019 and $34 million in Q1 2020, respectively, collectively referred to as the Continuation Advances. Up to the $52 million of Continuation Advances was repayable, without interest, if, within two years of March 31, 2020, PacBio entered into a Change of Control Transaction or raised at least $100 million in equity or debt financing in a single transaction (with the amount repayable dependent on the amount raised by PacBio). In February 2021, PacBio entered into an investment agreement with SB Northstar LP for the issuance and sale of $900 million in aggregate principal amount of PacBio’s convertible notes. Pursuant to the PacBio Merger Agreement, PacBio repaid to us the $52 million of Continuation Advances and we recorded a gain of $26 million in Q1 2021, which was included in other expense, net.

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Fair Value Measurements

The following table presents the hierarchy for assets and liabilities measured at fair value on a recurring basis:

	April 3, 2022								January 2, 2022
In millions	Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Assets:
Money market funds (cash equivalents)	$	775	$	—	$	—	$	775	$	688	$	—	$	—	$	688
Marketable equity securities	65		—		—		65		107		—		—		107
Helix contingent value right	—		—		70		70		—		—		65		65
Deferred compensation plan assets	—		57		—		57		—		60		—		60
Total assets measured at fair value	$	840	$	57	$	70	$	967	$	795	$	60	$	65	$	920
Liabilities:
Contingent consideration liability	$	—	$	—	$	566	$	566	$	—	$	—	$	615	$	615
Deferred compensation plan liability	—		54		—		54		—		56		—		56
Total liabilities measured at fair value	$	—	$	54	$	566	$	620	$	—	$	56	$	615	$	671

Our marketable equity securities are measured at fair value based on quoted trade prices in active markets. Our deferred compensation plan assets consist primarily of investments in life insurance contracts carried at cash surrender value, which reflects the net asset value of the underlying publicly traded mutual funds. We perform control procedures to corroborate the fair value of our holdings, including comparing valuations obtained from our investment service provider to valuations reported by our asset custodians, validating pricing sources and models, and reviewing key model inputs, if necessary.

We elected the fair value option to measure the contingent value right received from Helix. The fair value of such contingent value right, included in other assets, is derived using a Monte Carlo simulation. Estimates and assumptions used in the Monte Carlo simulation include probabilities related to the timing and outcome of future financing and/or liquidity events, assumptions regarding collectibility and volatility, and an estimated equity value of Helix. These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value.

We reassess the fair value of contingent consideration related to acquisitions on a quarterly basis. The contingent value rights issued as part of the GRAIL acquisition entitle the holders to receive future cash payments on a quarterly basis (Covered Revenue Payments) representing a pro rata portion of certain GRAIL-related revenues (Covered Revenues) each year for a 12-year period. As defined in the Contingent Value Rights Agreement, this will reflect a 2.5% payment right to the first $1 billion of revenue each year for 12 years. Revenue above $1 billion each year will be subject to a 9% contingent payment right during this same period. We use a Monte Carlo simulation to estimate the fair value of contingent consideration related to the GRAIL acquisition. Estimates and assumptions used in the Monte Carlo simulation include forecasted revenues for GRAIL, a revenue risk premium, a revenue volatility, an operational leverage ratio and a counterparty credit spread. These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value. Changes in the fair value of contingent consideration subsequent to the acquisition date are recognized in selling, general and administrative expense in our condensed consolidated statements of income.

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Changes in the estimated fair value of our contingent consideration liability during Q1 2022 were as follows:

In millions
Balance as of January 2, 2022	$	615
Change in estimated fair value	(49)
Balance as of April 3, 2022(1) (2)	$	566

_____________

(1)As of April 3, 2022, $565 million was included in other long-term liabilities, with remaining balance included in accrued liabilities.

(2)Covered Revenues for Q4 2021 were $10 million, driven primarily by sales of GRAIL’s Galleri test. Covered Revenue Payments in Q1 2022 were approximately $97,000; however, pursuant to the Contingent Value Rights Agreement, the Covered Revenue Payments were applied to reimburse us for certain expenses.

4. DEBT

Summary of Term Debt Obligations

In millions	April 3, 2022		January 2, 2022
Principal amount of 2031 Term Notes outstanding	$	500	$	500
Principal amount of 2023 Term Notes outstanding	500		500
Unamortized discounts and debt issuance costs	(6)		(7)
Net carrying amount of term notes	994		993
Less: current portion	(499)		—
Term notes, non-current	$	495	$	993
Fair value of term notes outstanding (Level 2)	$	945	$	996

0.550% Term Notes due 2023 (2023 Term Notes) and 2.550% Term Notes due 2031 (2031 Term Notes)

On March 23, 2021, we issued $500 million aggregate principal amount of term notes due 2023 (2023 Term Notes) and $500 million aggregate principal amount of term notes due 2031 (2031 Term Notes, together the Term Notes). We received net proceeds from the issuance of $992 million, after deducting discounts and debt issuance costs.

The 2023 and 2031 Term Notes accrue interest at a rate of 0.550% and 2.550% per annum, respectively, payable semi-annually. Interest is payable on March 23 and September 23 of each year, beginning on September 23, 2021. The 2023 Term Notes, which were reclassified to short-term as of April 3, 2022, mature on March 23, 2023, and the 2031 Term Notes mature on March 23, 2031.

We may redeem for cash all or any portion of the Term Notes, at our option, at any time prior to maturity. The 2023 Term Notes and, prior to December 23, 2030, the 2031 Term Notes are redeemable at make-whole premium redemption prices as defined in the applicable forms of note. After December 23, 2030, the 2031 Term Notes are redeemable at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid interest up to, but excluding, the redemption date.

Interest expense recognized on the Term Notes was $4 million and $1 million in Q1 2022 and Q1 2021, respectively, which included amortization of debt discounts and issuance costs.

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0% Convertible Senior Notes due 2023 (2023 Convertible Notes)

In millions	April 3, 2022		January 2, 2022
Principal amount outstanding	$	750	$	750
Unamortized debt discount and issuance costs	(4)		(48)
Net carrying amount of liability component, non-current	$	746	$	702
Carrying value of equity component, net of debt issuance costs	$	—	$	126
Fair value of convertible senior notes outstanding (Level 2)	$	836	$	854

In August 2018, we issued $750 million aggregate principal amount of convertible senior notes due 2023 (2023 Convertible Notes). The 2023 Convertible Notes carry no coupon interest and mature on August 15, 2023.

The 2023 Convertible Notes will be convertible into cash, shares of our common stock or a combination of cash and shares of our common stock, at our election, based on an initial conversion rate, subject to adjustment, of 2.1845 shares of common stock per $1,000 principal amount of notes (which represents an initial conversion price of approximately $457.77 per share of common stock), only in the following circumstances: (1) during any calendar quarter commencing after the calendar quarter ending on September 30, 2018 (and only during such calendar quarter), if the last reported sale price of our common stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on, and including, the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price in effect on each applicable trading day; (2) during the five business day period after any 10 consecutive trading day period (the “measurement period”) in which the trading price per $1,000 principal amount of 2023 Convertible Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such trading day; (3) if we call any or all of the notes for redemption, at any time prior to the close of business on the scheduled trading day immediately preceding the redemption date; or (4) upon the occurrence of specified corporate events described in the indenture. Regardless of the foregoing circumstances, the holders may convert their notes on or after May 15, 2023 until August 11, 2023.

We may redeem for cash all or any portion of the 2023 Convertible Notes, at our option, on or after August 20, 2021 if the last reported sale price of our common stock has been at least 130% of the conversion price then in effect (currently $595.10) for at least 20 trading days (whether or not consecutive) during any 30 consecutive trading day period (including the last trading day of such period) ending on, and including, the trading day immediately preceding the date on which we provide notice of redemption at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid special interest to, but excluding, the redemption date.

At the time of issuance, the embedded conversion feature of the 2023 Convertible Notes was required to be bifurcated from the notes and accounted for as an equity instrument classified within stockholders’ equity. As a result, we recognized $126 million in additional paid-in capital in 2018, which was recorded as a debt discount and subsequently amortized to interest expense at an estimated effective rate, assuming no conversion option, of 3.7%. As of January 3, 2022, we adopted ASU 2020-06, which removed the requirement to separate the embedded conversion feature from the notes and requires the notes to be accounted for as a single liability measured at amortized cost. Accordingly, we reclassified the unamortized debt discount from additional paid-in capital to convertible senior notes in the condensed consolidated balance sheets on January 3, 2022. This resulted in an increase to our convertible senior notes and retained earnings of $43 million and $61 million, respectively, and a decrease to our deferred tax liabilities, included in other long-term liabilities, and additional paid-in capital of $11 million and $93 million, respectively.

Interest expense recognized on the 2023 Convertible Notes, which included amortization of debt issuance costs, was $1 million in Q1 2022. Interest expense recognized on the 2023 Convertible Notes in Q1 2021 was $7 million, which included amortization of the original debt discount and debt issuance costs. The 2023 Convertible Notes were not convertible as of April 3, 2022.

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0.5% Convertible Senior Notes due 2021 (2021 Convertible Notes)

In June 2014, we issued $517 million aggregate principal amount of convertible senior notes due 2021 (2021 Convertible Notes). The 2021 Convertible Notes were partially converted in Q1 2021 with the remaining balance converted upon maturity on June 15, 2021. The excess of the conversion value over the principal amount was paid in 0.7 million shares of common stock. Interest expense recognized on the 2021 Convertible Notes, which included amortization of debt discount and issuance costs, was $4 million in Q1 2021. Our adoption of ASU 2020-06 on January 3, 2022 did not impact the accounting for the 2021 Convertible Notes since they were converted and repaid prior to the date of adoption.

Credit Agreement

On March 8, 2021, we entered into a credit agreement (the Credit Agreement), which provides us with a $750 million senior unsecured five-year revolving credit facility, including a $40 million sublimit for swingline borrowings and a $50 million sublimit for letters of credit (the Credit Facility). The proceeds of the loans under the Credit Facility may be used to finance working capital needs and for general corporate purposes.

Any loans under the Credit Facility will have a variable interest rate based on either the eurocurrency rate or the alternate base rate, plus an applicable spread that varies with the Company’s debt rating. The Credit Agreement includes an option for us to elect to increase the commitments under the Credit Facility or to enter into one or more tranches of term loans in the aggregate principal amount of up to $250 million, subject to the consent of the lenders providing the additional commitments or term loans, as applicable, and certain other conditions.

The Credit Agreement contains financial and operating covenants. Pursuant to the Credit Agreement, we are required to maintain a ratio of total debt to annual earnings before interest, taxes, depreciation and amortization (EBITDA), calculated based on the four consecutive fiscal quarters ending with the most recent fiscal quarter, of not greater than 3.50 to 1.00 as of the end of each fiscal quarter. Upon the consummation of any Qualified Acquisition (as defined in the Credit Agreement) and us providing notice to the Administrative Agent, the ratio increases to 4.00 to 1.00 for the fiscal quarter in which the acquisition is consummated and the three consecutive fiscal quarters thereafter. The operating covenants include, among other things, limitations on (i) the incurrence of indebtedness by our subsidiaries, (ii) liens on our and our subsidiaries assets, and (iii) certain fundamental changes and the disposition of assets by us and our subsidiaries. The Credit Agreement contains other customary covenants, representations and warranties, and events of default.

The Credit Facility matures, and all amounts outstanding thereunder become due and payable in full, on March 8, 2026, subject to two one-year extensions at our option, the consent of the extending lenders and certain other conditions. We may prepay amounts borrowed and terminate commitments under the Credit Facility at any time without premium or penalty.

As of April 3, 2022, there were no borrowings outstanding under the Credit Facility, and we were in compliance with all financial and operating covenants.

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5. STOCKHOLDERS’ EQUITY

As of April 3, 2022, approximately 1.9 million shares remained available for future grants under the 2015 Stock and Incentive Compensation Plan.

Restricted Stock

Restricted stock activity was as follows:

	Restricted Stock Units (RSU)	Performance Stock Units (PSU)(1)	Weighted-Average Grant Date Fair Value per Share
Units in thousands			RSU		PSU
Outstanding at January 2, 2022	1,130	328	$	345.66	$	466.42
Awarded	996	194	$	330.98	$	329.57
Vested	(32)	—	$	442.14	$	—
Cancelled	(51)	(7)	$	353.04	$	446.38
Outstanding at April 3, 2022	2,043	515	$	336.77	$	415.16

_____________

(1)The number of units reflect the estimated number of shares to be issued at the end of the performance period. Awarded units are presented net of performance adjustments.

Stock Options

Stock option activity was as follows:

Units in thousands	Options	Weighted-Average Exercise Price		Performance Stock Options(1)	Weighted-Average Exercise Price
Outstanding at January 2, 2022	8	$	66.42	17	$	85.54
Granted	180	$	330.25	—	$	—
Outstanding at April 3, 2022	188	$	318.73	17	$	85.54
Exercisable at April 3, 2022	8	$	66.42	—	$	—

_____________

(1)The number of units reflect awards that have been granted and for which it is assumed to be probable that the underlying performance goals will be achieved.

Liability-Classified Awards

We grant cash-based equity incentive awards to GRAIL employees. The cash to be awarded may subsequently increase or decrease in direct correlation to changes in the enterprise fair value of GRAIL, as defined under the Cash-Based Equity Appreciation Award Plan.

Cash-based equity incentive award activity was as follows:

In millions
Outstanding at January 2, 2022	$	184
Granted	70
Cancelled	(13)
Outstanding at April 3, 2022	$	241
Estimated liability as of April 3, 2022 (included in accrued liabilities)	$	24

We recognized share-based compensation expense of $13 million in Q1 2022. As of April 3, 2022, approximately $217 million of total unrecognized compensation cost related to awards issued to date was expected to be recognized over a weighted-average period of approximately 3.6 years.

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In connection with the acquisition of GRAIL, we assumed a performance-based award for which vesting is based on GRAIL’s future revenues. The award has an aggregate potential value of up to $78 million and expires, to the extent unvested, in August 2030. As of April 3, 2022, it was not probable that the performance conditions associated with the award will be achieved and, therefore, no share-based compensation expense, or corresponding liability, has been recognized in the condensed consolidated financial statements to-date.

Employee Stock Purchase Plan

The price at which common stock is purchased under the Employee Stock Purchase Plan (ESPP) is equal to 85% of the fair market value of the common stock on the first day of the offering period or purchase date, whichever is lower. During Q1 2022, approximately 0.1 million shares were issued under the ESPP. As of April 3, 2022, there were approximately 13.0 million shares available for issuance under the ESPP.

Share Repurchases

We did not repurchase any shares during Q1 2022. As of April 3, 2022, authorizations to repurchase approximately $15 million of our common stock remained available under the $750 million share repurchase program authorized by our Board of Directors on February 5, 2020. The repurchases may be completed under a 10b5-1 plan or at management’s discretion.

Share-Based Compensation

Share-based compensation expense, which includes expense for both equity and liability-classified awards, reported in our condensed consolidated statements of income was as follows:

In millions	Q1 2022		Q1 2021
Cost of product revenue	$	6	$	7
Cost of service and other revenue	1		1
Research and development	36		24
Selling, general and administrative	49		35
Share-based compensation expense before taxes	92		67
Related income tax benefits	(21)		(13)
Share-based compensation expense, net of taxes	$	71	$	54

In February 2021, we modified the metrics and reduced the maximum potential payouts for our performance stock units granted in 2019 and 2020. The PSU granted in 2019 vested on January 2, 2022 and the PSU granted in 2020 vests at the end of the three-year period ending on January 1, 2023. The modifications affected 52 employees with units granted in 2019, which resulted in total incremental share-based compensation expense of approximately $41 million, and 72 employees with units granted in 2020, which resulted in total incremental share-based compensation expense of approximately $65 million.

The assumptions used and the resulting estimate of weighted-average fair value per share for stock purchased under the ESPP during Q1 2022 were as follows:

	Employee Stock Purchase Rights
Risk-free interest rate	0.06% - 0.78%
Expected volatility	37% - 47%
Expected term	0.5 - 1.0 year
Expected dividends	0		%
Weighted-average grant-date fair value per share	$	91.27

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As of April 3, 2022, approximately $782 million of total unrecognized compensation cost related to restricted stock, stock options and ESPP shares issued to date was expected to be recognized over a weighted-average period of approximately 2.6 years.

6. SUPPLEMENTAL BALANCE SHEET DETAILS

Accounts Receivable

In millions	April 3, 2022		January 2, 2022
Trade accounts receivable, gross	$	617	$	651
Allowance for credit losses	(3)		(3)
Total accounts receivable, net	$	614	$	648

Inventory

In millions	April 3, 2022		January 2, 2022
Raw materials	$	170	$	144
Work in process	340		333
Finished goods	32		32
Inventory, gross	542		509
Inventory reserve	(77)		(78)
Total inventory, net	$	465	$	431

Accrued Liabilities

In millions	April 3, 2022		January 2, 2022
Contract liabilities, current portion	$	232	$	234
Accrued compensation expenses	181		241
Accrued taxes payable	91		98
Operating lease liabilities, current portion	72		71
Liability-classified equity incentive awards	24		11
Other, including warranties (a)	100		106
Total accrued liabilities	$	700	$	761

(a) Changes in the reserve for product warranties were as follows:

In millions	Q1 2022		Q1 2021
Balance at beginning of period	$	22	$	13
Additions charged to cost of product revenue	6		8
Repairs and replacements	(7)		(6)
Balance at end of period	$	21	$	15

We generally provide a one-year warranty on instruments. Additionally, we provide a warranty on consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. At the time revenue is recognized, an accrual is established for estimated warranty expenses based on historical experience as well as anticipated product performance. We periodically review the warranty reserve for adequacy and adjust the warranty accrual, if necessary, based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue.

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Derivative Financial Instruments

We are exposed to foreign exchange rate risks in the normal course of business and use derivative financial instruments to partially offset this exposure. We do not use derivative financial instruments for speculative or trading purposes. Foreign exchange contracts are carried at fair value in other current assets, other assets, accrued liabilities, or other long-term liabilities, as appropriate, on the condensed consolidated balance sheets.

We use foreign exchange forward contracts to manage foreign currency risks related to monetary assets and liabilities denominated in currencies other than the U.S. dollar. These derivative financial instruments have terms of one month or less and are not designated as hedging instruments. Changes in fair value of these derivatives are recognized in other expense, net, along with the re-measurement gain or loss on the foreign currency denominated assets or liabilities. As of April 3, 2022, we had foreign exchange forward contracts in place to hedge exposures in the euro, Japanese yen, Australian dollar, Canadian dollar, Singapore dollar, Chinese Yuan Renminbi, and British pound. As of April 3, 2022 and January 2, 2022, the total notional amounts of outstanding forward contracts in place for these foreign currency purchases were $458 million and $462 million, respectively.

We also use foreign currency forward contracts to hedge portions of our foreign currency exposure associated with forecasted revenue transactions. These derivative financial instruments have terms up to 24 months and are designated as cash flow hedges. Changes in fair value of our cash flow hedges are recorded as a component of accumulated other comprehensive income and are reclassified to revenue in the same period the underlying hedged transactions are recorded. We regularly review the effectiveness of our cash flow hedges and consider them to be ineffective if it becomes probable that the forecasted transactions will not occur in the identified period. Changes in fair value of the ineffective portions of our cash flow hedges, if any, will be recognized in other expense, net. As of April 3, 2022, we had foreign currency forward contracts in place to hedge exposures associated with forecasted revenue transactions denominated in the euro, Japanese yen, Australian dollar, and Canadian dollar. As of April 3, 2022 and January 2, 2022, the total notional amounts of outstanding cash flow hedge contracts in place for these foreign currency purchases were $462 million and $450 million, respectively.

7. LEGAL PROCEEDINGS

We are involved in various lawsuits and claims arising in the ordinary course of business, including actions with respect to intellectual property, employment, and contractual matters. In connection with these matters, we assess, on a regular basis, the probability and range of possible loss based on the developments in these matters. A liability is recorded in the condensed consolidated financial statements if it is believed to be probable that a loss has been incurred and the amount of the loss can be reasonably estimated. Because litigation is inherently unpredictable and unfavorable resolutions could occur, assessing contingencies is highly subjective and requires judgments about future events. We regularly review outstanding legal matters to determine the adequacy of the liabilities accrued and related disclosures in consideration of many factors, which include, but are not limited to, past history, scientific and other evidence, and the specifics and status of each matter. We may change our estimates if our assessment of the various factors changes and the amount of ultimate loss may differ from our estimates, resulting in a material effect on our business, financial condition, results of operations, and/or cash flows.

Acquisition of GRAIL

On March 30, 2021, the Federal Trade Commission (the FTC) filed an administrative complaint and a motion for a preliminary injunction in the United States District Court for the District of Columbia. In both actions, the FTC alleged that our acquisition of GRAIL would violate Section 7 of the Clayton Act, as amended, 15 U.S.C. § 18. We filed an answer to the FTC’s complaint in federal district court on April 6, 2021, and in the administrative court on April 13, 2021. On April 20, 2021, the United States District Court for the District of Columbia granted our motion to transfer venue to the United States District Court for the Southern District of California. On May 28, 2021, the district court granted the FTC’s motion to dismiss the complaint without prejudice. The administrative trial commenced on August 24, 2021, and live testimony concluded on September 24, 2021. On April 15, 2022, the parties filed their opening post-trial briefs and proposed findings. Reply briefs are due May 25, 2022. Closing arguments are scheduled for June 8, 2022. A decision by the administrative judge is currently due no later than September 2, 2022. We intend to vigorously defend the FTC action.

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On April 19, 2021, the European Commission accepted a request for a referral of the GRAIL acquisition for European Union merger review, submitted by a Member State of the European Union (France), and joined by several other Member States (Belgium, Greece, Iceland, the Netherlands and Norway), under Article 22(1) of Council Regulation (EC) No 139/2004 (the EU Merger Regulation). On April 29, 2021, we filed an action in the General Court of the European Union (the EU General Court) asking for annulment of the European Commission’s assertion of jurisdiction to review the acquisition under Article 22 of the EU Merger Regulation, as the acquisition does not meet the jurisdictional criteria under the EU Merger Regulation or under the national merger control laws of any Member State of the European Union. On December 16, 2021, the EU General Court held a hearing regarding the European Commission’s assertion of jurisdiction, and we await the court’s judgment. We intend to vigorously challenge the European Commission’s assertion of jurisdiction. Additionally, as a result of our decision to proceed with the completion of the acquisition of GRAIL during the pendency of the European Commission’s review, the European Commission will likely seek to impose a fine on us pursuant to Article 14(2)(b) of the EU Merger Regulation of up to 10% of our consolidated annual revenues.

BGI Genomics Co. Ltd. and its Affiliates

We are involved in lawsuits against BGI Genomics Co. Ltd (BGI) and its affiliates, including Complete Genomics, Inc. (CGI), in the United States and elsewhere.

On June 27, 2019, we filed suit against BGI in the United States District Court for the Northern District of California, alleging that certain BGI sequencing products infringe our U.S. Patent No. 7,566,537 (‘537 patent) and U.S. Patent No. 9,410,200 (‘200 patent). BGI has denied our claims and has counterclaimed that our technology infringes U.S. Patent No. 9,944,984 (‘984 patent). We deny their allegations. On February 27, 2020, we filed a second patent infringement suit against BGI in the United States District Court for the Northern District of California alleging that BGI sequencing products infringed U.S. Patent 7,771,973 (‘973 patent), U.S. Patent 7,541,444 (‘444 patent), and U.S. Patent 10,480,025 (‘025 patent). On June 15, 2020, the Court granted our motions requesting preliminary injunctions against BGI, finding that our patents were likely valid and infringed by BGI’s chemistries. The injunction prohibits the sale of infringing BGI sequencers and sequencing reagents in the U.S. On December 9, 2020, BGI filed a motion to amend its answer to our second suit to include allegations that the ‘444 and ‘973 patents are unenforceable under the doctrine of inequitable conduct; we deny BGI’s allegations. As of April 12, 2021, BGI is seeking approximately $54 million in alleged damages and an ongoing royalty of 3.6% on sales of the accused products by us in the United States until the ‘984 patent expires on June 13, 2026. We deny that we owe any damages or ongoing royalty. On August 27, 2021, and September 9, 2021, the Court issued its decisions on the summary judgment motions: (i) the Court granted our motion for summary judgment that we do not infringe BGI’s ‘984 patent; (ii) the Court granted our motion for summary judgment that our ‘444 and ‘973 patents are not unenforceable; (iii) the Court granted our motion for summary judgment that BGI’s standard MPS products infringe all of our patents-in-suit: (iv) the Court granted our motion for summary judgment that BGI’s “Cool MPS” sequencing products infringe the ‘973 and ‘444 patents, and granted BGI’s motion for summary judgment that BGI’s “Cool MPS” sequencing products do not infringe the ‘025 patent; and (v) the Court denied BGI’s motion for summary judgment that our ‘973 patent is invalid for lack of written description and enablement. Trial began on November 12, 2021, and the jury rendered a verdict on November 30, 2021. The jury found that the ‘537, ‘200, ‘973 patents and claims 9, 27, 31, 33, 34, 42, 47 of the ‘025 patent are valid and were willfully infringed by BGI. The jury also ruled that the claim 4 of the ‘444 patent and claim 1 of the ‘025 patent were invalid as obvious. The jury awarded the Company $8 million in damages. On March 27, 2022, the Court issued a decision on post-trial motions. The Court denied BGI’s motions. The Court (i) upheld the jury’s award of $8 million and granted pre-judgment interest, (ii) upheld the jury’s finding that BGI’s infringement was willful, (iii) granted the Company’s request for a permanent injunction until the relevant patents expire; (iv) granted the Company’s request that claim 1 of the ‘025 patent is not invalid, but denied the request with respect to claim 4 of the ‘444 patent; and (v) denied the Company’s request for enhanced damages. On April 27 2022, BGI appealed the judgment to the United States Court of Appeals for the Federal Circuit. The Company cross-appealed, including with respect to the denial of the Company’s request for enhanced damages.

On January 11, 2021, Complete Genomics, Inc., BGI Americas Corp., and MGI Americas, Inc. also filed a complaint in the United States District Court for the Northern District of California alleging the Company and its subsidiary Illumina Cambridge Ltd. violated federal antitrust and state unfair competition laws. CGI and these affiliates allege that the Company fraudulently withheld a prior art reference that was material to patentability for the ‘444 and ‘973 patents. They also allege that our infringement claims of the ‘025 against BGI’s “Cool MPS” chemistry were objectively baseless. The Company denies the allegations in the complaint. On March 30, 2021, the Court stayed the antitrust case pending resolution of the underlying patent infringement suit taking place in the same court.

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On May 28, 2019, CGI filed suit against us in the United States District Court for the District of Delaware alleging that our two-channel sequencing systems, including the NovaSeq, NextSeq, and MiniSeq systems, infringe certain claims of U.S. Patent No. 9,222,132. We have denied CGI’s allegations and have counterclaimed for infringement by CGI, BGI Americas Corp., and MGI Americas, Inc. of U.S. Patent No. 9,303,290, U.S. Patent No. 9,217,178, and U.S. Patent No. 9,970,055. On August 15, 2019, CGI filed a motion to dismiss our counterclaims. On August 29, 2019, we filed our Opposition to the Motion to Dismiss. The Court denied and granted the motion in part, denying the motion as to our claims for inducing infringement and granting it for contributory infringement. The Court gave us leave to file an amended complaint to attempt to cure the alleged deficiencies as to contributory infringement. On July 1, 2020, CGI amended its complaint to add claims of infringement of U.S. Patent No. 10,662,473 by our two-channel sequencing systems. We deny these allegations. As of April 8, 2022, CGI is seeking $334 million in alleged past damages and an average ongoing royalty of at least 5.5% on sales of the accused two-channel sequencing instruments and chemistry in the U.S. until the patents-in-suit expire on January 28, 2029. We deny that we owe any damages or ongoing royalty. On October 22, 2021, pursuant to the Court’s local rules, the Company sought leave to file a motion for summary judgment of non-infringement of the CGI patents-in-suit. CGI sought leave to file a motion for summary judgment against the Company’s invalidity defense based on prior invention. On January 14, 2022, the Court denied the Company and CGI’s motions for leave to file for summary judgment. Trial began on April 25, 2022.

We will continue to pursue our claims against BGI and CGI, and vigorously defend against BGI’s and CGI’s claims. We currently cannot estimate any possible loss or range of loss that may result from BGI’s and CGI’s claims against us.

8. INCOME TAXES

Our effective tax rate may vary from the U.S. federal statutory tax rate due to the change in the mix of earnings in tax jurisdictions with different statutory rates, benefits related to tax credits, and the tax impact of non-deductible expenses and other permanent differences between income before income taxes and taxable income.

Our effective tax rate was 38.3% in Q1 2022 compared to 13.1% in Q1 2021. In Q1 2022, the variance from the U.S. federal statutory tax rate of 21% was primarily attributable to the $24 million impact of GRAIL pre-acquisition net operating losses on global intangible low-taxed income (GILTI) and the utilization of U.S. foreign tax credits, and the $4 million impact of research and development expense capitalization for tax purposes. This was partially offset by the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom.

9. SEGMENT INFORMATION

We have two reportable segments, Core Illumina and GRAIL. We report segment information based on the management approach, which designates the internal reporting used by the Chief Operating Decision Maker (CODM) for making decisions and assessing performance as the source of our reportable segments. The CODM allocates resources and assesses the performance of each operating segment using information about its revenue and income (loss) from operations. We do not allocate expenses between segments. Core Illumina sells products and provides services to GRAIL, and vice versa, in accordance with contractual agreements between the entities.

Core Illumina:

Core Illumina’s products and services serve customers in the research, clinical and applied markets, and enable the adoption of a variety of genomic solutions. Core Illumina includes all of our operations, excluding the results of GRAIL.

GRAIL:

GRAIL is a healthcare company focused on early detection of multiple cancers. We acquired GRAIL on August 18, 2021. We have included the financial results of GRAIL in our condensed consolidated financial statements from the date of acquisition.

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In millions	Q1 2022		Q1 2021
Revenue:
Core Illumina	$	1,221	$	1,093
GRAIL	10		—
Eliminations	(8)		—
Consolidated revenue	$	1,223	$	1,093
Income (loss) from operations:
Core Illumina	$	362	$	193
GRAIL	(172)		—
Eliminations	(6)		—
Consolidated income from operations	$	184	$	193

Total other expense, net relates primarily to Core Illumina, and we do not allocate income taxes to our segments.

In millions	April 3, 2022		January 2, 2022
Total assets:
Core Illumina	$	5,682	$	5,571
GRAIL	9,600		9,649
Eliminations	(8)		(3)
Consolidated total assets	$	15,274	$	15,217

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MANAGEMENT’S DISCUSSION & ANALYSIS

Our Management’s Discussion and Analysis (MD&A) will help readers understand our results of operations, financial condition, and cash flow. It is provided in addition to the accompanying condensed consolidated financial statements and notes. This MD&A is organized as follows:

•Management’s Overview and Outlook. High level discussion of our operating results and significant known trends that affect our business.

•Results of Operations. Detailed discussion of our revenues and expenses.

•Liquidity and Capital Resources. Discussion of key aspects of our condensed consolidated statements of cash flows, changes in our financial position, and our financial commitments.

•Critical Accounting Policies and Estimates. Discussion of significant changes since our most recent Annual Report on Form 10-K that we believe are important to understanding the assumptions and judgments underlying our condensed consolidated financial statements.

•Recent Accounting Pronouncements. Summary of recent accounting pronouncements applicable to our condensed consolidated financial statements.

•Quantitative and Qualitative Disclosure About Market Risk. Discussion of our financial instruments’ exposure to market risk.

Our discussion of our results of operations, financial condition, and cash flow for Q1 2021 can be found in “Management’s Discussion and Analysis of Financial Condition and Results of Operations” within our filing of Form 10-Q for the fiscal quarter ended April 4, 2021.

This MD&A discussion contains forward-looking statements that involve risks and uncertainties. See “Consideration Regarding Forward-Looking Statements” preceding the Condensed Consolidated Financial Statements section of this report for additional factors relating to such statements. This MD&A should be read in conjunction with our condensed consolidated financial statements and accompanying notes included in this report and our Annual Report on Form 10-K for the fiscal year ended January 2, 2022. Operating results are not necessarily indicative of results that may occur in future periods.

MANAGEMENT’S OVERVIEW AND OUTLOOK

This overview and outlook provide a high-level discussion of our operating results and significant known trends that affect our business. We believe that an understanding of these trends is important to understanding our financial results for the periods being reported herein as well as our future financial performance. This summary is not intended to be exhaustive, nor is it intended to be a substitute for the detailed discussion and analysis provided elsewhere in this report.

About Illumina

Our focus on innovation has established us as the global leader in DNA sequencing and array-based technologies, serving customers in the research, clinical and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture and other emerging segments.

Our customers include leading genomic research centers, academic institutions, government laboratories, and hospitals, as well as pharmaceutical, biotechnology, commercial molecular diagnostic laboratories, and consumer genomics companies.

Our comprehensive line of products addresses the scale of experimentation and breadth of functional analysis to advance disease research, drug development, and the development of molecular tests. This portfolio of leading-edge sequencing and array-based solutions addresses a range of genomic complexity and throughput, enabling researchers and clinical practitioners to select the best solution for their scientific challenge.

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On August 18, 2021, we acquired GRAIL, a healthcare company focused on early detection of multiple cancers. GRAIL’s Galleri blood test detects various types of cancers before they are symptomatic. We believe our acquisition of GRAIL will accelerate the adoption of next-generation sequencing based early multi-cancer detection tests, enhance our position in Clinical Genomics, and increase our directly accessible total addressable market. The acquisition is subject to ongoing legal proceedings and GRAIL is currently being held and operated as a separate company, with oversight provided by an appointed, independent monitoring trustee during the European Commission’s ongoing merger review. See note “7. Legal Proceedings” for further details. We have included the financial results of GRAIL in our condensed consolidated financial statements from the date of acquisition. GRAIL is a separate reportable segment.

Our financial results have been, and will continue to be, impacted by several significant trends, which are described below. While these trends are important to understanding and evaluating our financial results, this discussion should be read in conjunction with our condensed consolidated financial statements and the notes thereto within the Condensed Consolidated Financial Statements section of this report, and the other transactions, events, and trends discussed in “Risk Factors” within the Other Key Information section of this report.

Financial Overview

Beginning in 2020, the COVID-19 pandemic and international efforts to control its spread have significantly curtailed the movement of people, goods, and services worldwide, including in the regions in which we sell our products and services and conduct our business operations. In addition, beginning in 2022, the armed conflict between Russia and Ukraine and the imposed sanctions by the U.S. and other countries may impact our ability to ship products into the regions. Both the COVID-19 pandemic and the armed conflict between Russia and Ukraine could potentially impact our sales and results of operations in 2022, the size and duration of which are significantly uncertain.

Financial highlights for Q1 2022 included the following:

•Revenue increased 12% in Q1 2022 to $1,223 million compared to $1,093 million in Q1 2021 primarily due to growth in sequencing consumables and instruments, as well as in service and other revenue. We expect our revenue to continue to increase in 2022.

•Gross profit as a percentage of revenue (gross margin) was 66.6% in Q1 2022 compared to 69.9% in Q1 2021. The decrease in gross margin was driven primarily by the gross loss incurred by GRAIL in Q1 2022 and higher freight costs. Our gross margin depends on many factors, including: market conditions that may impact our pricing; sales mix changes among consumables, instruments, services, and development and licensing revenue; product mix changes between established products and new products; excess and obsolete inventories; royalties; our cost structure for manufacturing operations relative to volume; freight costs; and product support obligations.

•Income from operations as a percentage of revenue was 15.0% in Q1 2022 compared to 17.7% in Q1 2021. The decrease was primarily due to a decrease in gross margin. We expect our operating expenses to continue to grow on an absolute basis in 2022.

•Our effective tax rate was 38.3% in Q1 2022 compared to 13.1% in Q1 2021. In Q1 2022, the variance from the U.S. federal statutory tax rate of 21% was primarily attributable to the impact of GRAIL pre-acquisition net operating losses on GILTI and the utilization of U.S. foreign tax credits, and the impact of research and development expense capitalization for tax purposes. This was partially offset by the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom.

•We ended Q1 2022 with cash, cash equivalents, and short-term investments totaling $1.4 billion as of April 3, 2022, of which approximately $650 million was held by our foreign subsidiaries.

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RESULTS OF OPERATIONS

To enhance comparability, the following table sets forth unaudited condensed consolidated statement of operations data for the specified reporting periods, stated as a percentage of total revenue(1).

	Q1 2022		Q1 2021
Revenue:
Product revenue	87.5	%	87.2	%
Service and other revenue	12.5		12.8
Total revenue	100.0		100.0
Cost of revenue:
Cost of product revenue	24.5		24.3
Cost of service and other revenue	5.6		5.3
Amortization of acquired intangible assets	3.3		0.5
Total cost of revenue	33.4		30.1
Gross profit	66.6		69.9
Operating expense:
Research and development	26.4		18.0
Selling, general and administrative	25.2		34.2
Total operating expense	51.6		52.2
Income from operations	15.0		17.7
Other income (expense):
Interest income	—		0.1
Interest expense	(0.5)		(1.8)
Other expense, net	(3.1)		(0.5)
Total other expense, net	(3.6)		(2.2)
Income before income taxes	11.4		15.5
Provision for income taxes	4.4		2.0
Net income	7.0	%	13.5	%

_____________

(1)Percentages may not recalculate due to rounding.

Revenue

Dollars in millions	Q1 2022		Q1 2021		Change		% Change
Core Illumina:
Consumables	$	859	$	774	$	85	11	%
Instruments	218		179		39		22
Total product revenue	1,077		953		124		13
Service and other revenue	144		140		4		3
Total Core Illumina revenue	1,221		1,093		128		12
GRAIL:
Service and other revenue	10		—		10		100
Eliminations	(8)		—		(8)		100
Total consolidated revenue	$	1,223	$	1,093	$	130	12	%

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The increase in Core Illumina consumables revenue in Q1 2022 was primarily due to an increase in sequencing consumables revenue of $89 million, driven primarily by growth in the instrument installed base. Core Illumina instruments revenue increased in Q1 2022 primarily due to an increase in sequencing instruments revenue of $36 million, which was driven primarily by increased shipments of our NovaSeq instrument. Core Illumina service and other revenue, which includes revenue generated from genotyping and sequencing services, instrument service contracts, and development and licensing agreements, slightly increased in Q1 2022.

GRAIL service and other revenue for Q1 2022 related primarily to sales of Galleri.

Gross Margin

Dollars in millions	Q1 2022			Q1 2021			Change		% Change
Gross profit (loss):
Core Illumina	$	851		$	764		$	87	11	%
GRAIL	(29)			—			(29)		100
Eliminations	(7)			—			(7)		100
Consolidated gross profit	$	815		$	764		$	51	7	%
Gross margin:
Core Illumina	69.7		%	69.9		%
GRAIL	*			—
Consolidated gross margin	66.6		%	69.9		%

_____________

*Not meaningful.

The slight decrease in Core Illumina gross margin in Q1 2022 was driven primarily by higher freight costs.

GRAIL gross loss for Q1 2022 was primarily due to amortization of intangible assets of $34 million.

Operating Expense

Dollars in millions	Q1 2022		Q1 2021		Change		% Change
Research and development:
Core Illumina	$	238	$	197	$	41	21	%
GRAIL	85		—		85		100
Consolidated research and development	$	323	$	197	$	126	64	%
Selling, general and administrative:
Core Illumina	$	251	$	374	$	(123)	(33)	%
GRAIL	58		—		58		100
Eliminations	(1)		—		(1)		100
Consolidated selling, general and administrative	308		374		(66)		(18)
Total consolidated operating expense	$	631	$	571	$	60	11	%

Core Illumina research and development expense increased by $41 million, or 21%, in Q1 2022 primarily due to increases in headcount, as we continue to invest in the research and development of new products and enhancements to existing products, professional services, and performance-based compensation.

GRAIL research and development expense for Q1 2022 consisted primarily of expenses related to headcount, clinical trials, and performance-based compensation.

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Core Illumina selling, general and administrative expense decreased by $123 million, or 33%, in Q1 2022 primarily due to a decrease in acquisition-related expenses as a result of $105 million in Continuation Payments made to GRAIL in Q1 2021, and a gain of $49 million recorded in Q1 2022 related to the fair value of our contingent consideration liability, partially offset by increases in headcount, professional services, travel expenses, and performance-based compensation in Q1 2022.

GRAIL selling, general and administrative expense for Q1 2022 consisted primarily of expenses related to headcount, professional services, and performance-based compensation.

Other Income (Expense)

Dollars in millions	Q1 2022		Q1 2021		Change		% Change
Interest income	$	—	$	1	$	(1)	(100)	%
Interest expense	(6)		(19)		13		(68)
Other expense, net	(38)		(6)		(32)		533
Total other expense, net	$	(44)	$	(24)	$	(20)	83	%

Total other expense, net relates primarily to the Core Illumina segment.

Interest income decreased in Q1 2022 as a result of selling all of our available-for-sale debt securities in Q1 2021. Interest expense in Q1 2022 consisted primarily of accrued interest on our Term Notes. The decrease in Q1 2022 was primarily due to the recognition of interest expense in Q1 2021 associated with the amortization of debt issuance costs related to the termination of our Bridge Facility in Q1 2021, and the accretion of the original debt discount on our convertible senior notes, prior to the adoption of ASU 2020-06. The fluctuation in other expense, net was primarily due to a $26 million gain recorded on our derivative assets related to the terminated PacBio acquisition in Q1 2021.

Provision for Income Taxes

Dollars in millions	Q1 2022			Q1 2021			Change		% Change
Income before income taxes	$	140		$	169		$	(29)	(17)	%
Provision for income taxes	54			22			32		145
Net income	$	86		$	147		$	(61)	(41)	%
Effective tax rate	38.3		%	13.1		%

Our effective tax rate was 38.3% in Q1 2022 compared to 13.1% in Q1 2021. The variance from the U.S. federal statutory tax rate of 21% in Q1 2022 was primarily attributable to the $24 million impact of GRAIL pre-acquisition net operating losses on GILTI and the utilization of U.S. foreign tax credits, and the $4 million impact of capitalizing research and development expenses for tax purposes beginning in 2022, in accordance with the 2017 Tax Cuts and Jobs Act. If the capitalization requirement is not repealed, modified, or deferred, potentially retroactively to the beginning of 2022, our provision for income taxes will continue to be negatively impacted and our cash tax payments will increase by approximately $103 million in 2022. Our effective tax rate in Q1 2022 was also favorably impacted by the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom.

In Q1 2021, the variance from the U.S. federal statutory tax rate of 21% was primarily attributable to discrete tax benefits related to GRAIL Continuation Payments and the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom. This was partially offset by tax expense on certain foreign subsidiary earnings that are no longer indefinitely reinvested.

Our future effective tax rate may vary from the U.S. federal statutory tax rate due to the mix of earnings in tax jurisdictions with different statutory tax rates and the other factors discussed in the risk factor “We are subject to risks related to taxation in multiple jurisdictions” described in “Risk Factors” within the Business & Market Information section of our Annual Report on Form 10-K for the fiscal year ended January 2, 2022.

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LIQUIDITY AND CAPITAL RESOURCES

At April 3, 2022, we had approximately $1.4 billion in cash and cash equivalents, of which approximately $650 million was held by our foreign subsidiaries. Cash and cash equivalents increased by $119 million from January 2, 2022, due to the factors described in the “Cash Flow Summary” below. Our primary source of liquidity, other than our holdings of cash, cash equivalents, and investments, has been cash flows from operations and, from time to time, issuances of debt. Our ability to generate cash from operations provides us with the financial flexibility we need to meet operating, investing, and financing needs.

Historically, we have liquidated our short-term investments and/or issued debt and equity securities to finance our business needs as a supplement to cash provided by operating activities. As of April 3, 2022, we had $65 million in short-term investments comprised of marketable equity securities.

As of April 3, 2022, the fair value of our contingent consideration liability related to our acquisition of GRAIL was $566 million. The contingent value rights issued as part of the acquisition entitle the holders to receive future cash payments on a quarterly basis (Covered Revenue Payments) representing a pro rata portion of certain GRAIL-related revenues (Covered Revenues) each year for a 12-year period. This will reflect a 2.5% payment right to the first $1 billion of revenue each year for 12 years. Revenue above $1 billion each year will be subject to a 9% contingent payment right during this same period. Covered Revenues for Q4 2021 were $10 million, driven primarily by sales of GRAIL’s Galleri test. Covered Revenue Payments in Q1 2022 were approximately $97,000; however, pursuant to the Contingent Value Rights Agreement, the Covered Revenue Payments were applied to reimburse us for certain expenses.

We continued to grant GRAIL employees cash incentive equity awards in Q1 2022. As of April 3, 2022, the aggregate cash value of awards outstanding and unvested was $241 million, and we accrued an estimated liability of $24 million, included in accrued liabilities. In addition, we have an outstanding performance-based award for which vesting is based on GRAIL’s future revenues. The award has an aggregate potential value of up to $78 million, which is expected to be settled in cash, and expires, to the extent unvested, in August 2030. As of April 3, 2022, it was not probable that the performance conditions associated with the award will be achieved.

On March 23, 2021, we issued term notes due 2023 with an aggregate principal amount of $500 million and term notes due 2031 with an aggregate principal amount of $500 million. The 2023 Term Notes and the 2031 Term Notes accrue interest at a rate of 0.550% and 2.550% per annum, respectively, payable semi-annually on March 23 and September 23 of each year. The 2023 Term Notes, which were reclassified to short-term as of April 3, 2022, mature on March 23, 2023 and the 2031 Term Notes mature on March 23, 2031. We may redeem for cash all or any portion of the Term Notes, at our option, at any time prior to maturity. Our convertible senior notes, with an aggregate principal amount of $750 million, due on August 15, 2023, were not convertible as of April 3, 2022.

On March 8, 2021, we obtained a Credit Facility, which provides us with a $750 million senior unsecured five-year revolving credit facility, including a $40 million sublimit for swingline borrowings and a $50 million sublimit for letters of credit. The Credit Facility matures, and all amounts outstanding thereunder become due and payable in full, on March 8, 2026, subject to two one-year extensions at our option and the consent of the extending lenders and certain other conditions. As of April 3, 2022, there were no borrowings outstanding under the Credit Facility.

We had $14 million and up to $110 million, respectively, remaining in our capital commitments to two venture capital investment funds as of April 3, 2022 that are callable through April 2026 and July 2029, respectively.

Authorizations to repurchase $15 million of our common stock remained available as of April 3, 2022 under the $750 million share repurchase program authorized by our Board of Directors on February 5, 2020. The repurchases may be completed under a 10b5-1 plan or at management’s discretion. We do not intend to make any share repurchases during fiscal year 2022.

We anticipate that our current cash, cash equivalents, and short-term investments, together with cash provided by operating activities and available borrowing capacity under the Credit Facility, are sufficient to fund our near-term capital and operating needs for at least the next 12 months. Operating needs include the planned costs to operate our business, including amounts required to fund working capital and capital expenditures. Our primary short-term needs for capital, which are subject to change, include:

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•support of commercialization efforts related to our current and future products;

•acquisitions of equipment and other fixed assets for use in our current and future manufacturing and research and development facilities;

•the continued advancement of research and development efforts;

•potential strategic acquisitions and investments;

•repayment of debt obligations; and

•the expansion needs of our facilities, including costs of leasing and building out additional facilities.

We expect that our revenue and the resulting operating income, as well as the status of each of our new product development programs, will significantly impact our cash management decisions.

Our future capital requirements and the adequacy of our available funds will depend on many factors, including:

•our ability to successfully commercialize and further develop our technologies and create innovative products in our markets;

•scientific progress in our research and development programs and the magnitude of those programs;

•competing technological and market developments; and

•the need to enter into collaborations with other companies or acquire other companies or technologies to enhance or complement our product and service offerings.

Cash Flow Summary

In millions	Q1 2022		Q1 2021
Net cash provided by operating activities	$	172	$	282
Net cash (used in) provided by investing activities	(74)		1,376
Net cash provided by financing activities	21		968
Effect of exchange rate changes on cash and cash equivalents	—		(3)
Net increase in cash and cash equivalents	$	119	$	2,623

Operating Activities

Net cash provided by operating activities in Q1 2022 primarily consisted of net income of $86 million plus net adjustments of $151 million less net changes in operating assets and liabilities of $65 million. The primary adjustments to net income included share-based compensation expense of $92 million, depreciation and amortization expense of $91 million, and net losses on strategic investments of $44 million, partially offset by a gain recorded on our contingent consideration liability of $49 million, deferred income taxes of $21 million, and a gain on our Helix contingent value right of $5 million. Cash flow impact from changes in net operating assets and liabilities were primarily driven by decreases in accrued liabilities and accounts payable and an increase in inventory, partially offset by a decrease in accounts receivable.

Investing Activities

Net cash used in investing activities totaled $74 million in Q1 2022. We invested $61 million in capital expenditures, primarily associated with our investment in facilities, and $13 million in purchases of strategic investments.

Financing Activities

Net cash provided by financing activities totaled $21 million in Q1 2022. We received $33 million in proceeds from the sale of shares under our employee stock purchase plan, partially offset by $12 million used to pay taxes related to net share settlement of equity awards.

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CRITICAL ACCOUNTING POLICIES AND ESTIMATES

In preparing our condensed consolidated financial statements, we make estimates, assumptions and judgments that can have a significant impact on our net revenue, operating income and net income, as well as on the value of certain assets and liabilities on our balance sheet. We believe that the estimates, assumptions and judgments involved in the accounting policies described in “Critical Accounting Policies and Estimates” within the Management’s Discussion & Analysis section of our Annual Report on Form 10-K for the fiscal year ended January 2, 2022 have the greatest potential impact on our financial statements, so we consider them to be our critical accounting policies and estimates. Though the impact of the COVID-19 pandemic to our business and operating results presents additional uncertainty, we continue to use the best information available to inform our critical accounting estimates. There were no material changes to our critical accounting policies and estimates during Q1 2022.

RECENT ACCOUNTING PRONOUNCEMENTS

For a summary of recent accounting pronouncements applicable to our condensed consolidated financial statements, see note “1. Organization and Significant Accounting Policies” within the Condensed Consolidated Financial Statements section of this report, which is incorporated herein by reference.

QUANTITATIVE AND QUALITATIVE DISCLOSURE ABOUT MARKET RISK

There were no substantial changes to our market risks in Q1 2022, when compared to the disclosures in “Quantitative and Qualitative Disclosures about Market Risk” within the Management’s Discussion & Analysis section of our Annual Report on Form 10-K for the fiscal year ended January 2, 2022.

OTHER KEY INFORMATION

CONTROLS AND PROCEDURES

We design our internal controls to provide reasonable assurance that (1) our transactions are properly authorized; (2) our assets are safeguarded against unauthorized or improper use; and (3) our transactions are properly recorded and reported in conformity with U.S. generally accepted accounting principles. We also maintain internal controls and procedures to ensure that we comply with applicable laws and our established financial policies.

Based on management’s evaluation (under the supervision and with the participation of our chief executive officer (CEO) and chief financial officer (CFO)), as of the end of the period covered by this report, our CEO and CFO concluded that our disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”)), are effective to provide reasonable assurance that information required to be disclosed by us in reports that we file or submit under the Exchange Act is recorded, processed, summarized, and reported within the time periods specified in SEC rules and forms, and is accumulated and communicated to management, including our principal executive officer and principal financial officer, as appropriate, to allow timely decisions regarding required disclosure.

During Q1 2022, we continued to monitor and evaluate the design and operating effectiveness of key controls, including the impact of the COVID-19 pandemic on our internal control environment. There were no changes in our internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) of the Exchange Act) that materially affected or are reasonably likely to materially affect internal control over financial reporting.

LEGAL PROCEEDINGS

See discussion of legal proceedings in note “7. Legal Proceedings” in the Condensed Consolidated Financial Statements section of this report, which is incorporated herein by reference.

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RISK FACTORS

Our business is subject to various risks, including those described in “Risk Factors” within the Business & Market Information Section of our Annual Report on Form 10-K for the fiscal year ended January 2, 2022, which we strongly encourage you to review. In addition to the risk factors disclosed in our Form 10-K, the issues raised in the following risk factor could adversely affect our operating results and stock price:

The armed conflict between Russia and Ukraine and the international sanctions imposed on Russia could negatively affect our business.

As a result of the armed conflict between Russia and Ukraine, doing business in the Ukraine may not be practicable. In addition, the U.S. and other countries have imposed sanctions on Russia, including its major financial institutions and certain other businesses and individuals. Russia may respond in kind, and the continuation of the conflict may result in additional sanctions being enacted by the U.S. or other countries. The impact of these sanctions, along with the spillover effect of ongoing civil, political and economic disturbances on surrounding areas, may affect our ability to ship products into the region, which could reduce our sales. Further, sanctions may restrict our ability to collect or pay liabilities owed by or to certain Russian entities. For the year ended January 2, 2022, total net sales in Russia and Ukraine were approximately $73 million. Although we currently do not expect the conflict to have a material adverse effect on our financial results, the impact of these events on general economic conditions is currently unknown and could in the future have a negative effect on our results of operations, cash flows, financial condition or growth prospects.

SHARE REPURCHASES AND SALES

Purchases of Equity Securities by the Issuer

None during the quarterly period ended April 3, 2022.

Unregistered Sales of Equity Securities

None during the quarterly period ended April 3, 2022.

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EXHIBITS

		Incorporated by Reference
Exhibit Number	Exhibit Description	Form	File Number	Exhibit	Filing Date	Filed Herewith
31.1	Certification of Francis A. deSouza pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.					X
31.2	Certification of Sam A. Samad pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.					X
32.1	Certification of Francis A. deSouza pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.					X
32.2	Certification of Sam A. Samad pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.					X
101.INS	XBRL Instance Document - the instance document does not appear in the Interactive Data File because its XBRL tags are embedded within the Inline XBRL document					X
101.SCH	XBRL Taxonomy Extension Schema					X
101.CAL	XBRL Taxonomy Extension Calculation Linkbase					X
101.LAB	XBRL Taxonomy Extension Label Linkbase					X
101.PRE	XBRL Taxonomy Extension Presentation Linkbase					X
101.DEF	XBRL Taxonomy Extension Definition Linkbase					X
104	Cover Page Interactive Data File - formatted in Inline XBRL and included as Exhibit 101					X

__________________________________

+ Management contract or corporate plan or arrangement

* Certain schedules and exhibits have been omitted pursuant to Item 601(b)(2) of Regulation S-K. A copy of any omitted schedule or exhibit will be furnished supplementally to the SEC upon request.

23

FORM 10-Q CROSS-REFERENCE INDEX

	Page
PART I. FINANCIAL INFORMATION
Item 1. Financial Statements	5
Condensed Consolidated Balance Sheets	5
Condensed Consolidated Statements of Income	6
Condensed Consolidated Statements of Comprehensive Income	7
Condensed Consolidated Statement of Stockholders’ Equity	8
Condensed Consolidated Statements of Cash Flows	10
Notes to Condensed Consolidated Financial Statements	11
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations	14
Item 3. Quantitative and Qualitative Disclosures About Market Risk	21
Item 4. Controls and Procedures	21
PART II. OTHER INFORMATION
Item 1. Legal Proceedings	21
Item 1A. Risk Factors	22
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds	22
Item 3. Defaults Upon Senior Securities	None
Item 4. Mine Safety Disclosures	Not Applicable
Item 5. Other Information	None
Item 6. Exhibits	23
Signatures	25

24

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

		ILLUMINA, INC. (registrant)
Date:	May 5, 2022		/s/ SAM A. SAMAD
			Sam A. Samad Senior Vice President and Chief Financial Officer

25

EX-31.1

Exhibit 31.1

CERTIFICATION OF FRANCIS A. DESOUZA PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Francis A. deSouza, certify that:

1	I have reviewed this Quarterly Report on Form 10-Q of Illumina, Inc.;
2	Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3	Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4	The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
	a)	designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
	b)	designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
	c)	evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
	d)	disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5	The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
	a)	all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
	b)	any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Dated: May 5, 2022

By:	/s/ FRANCIS A. DESOUZA
	Francis A. deSouza
	President and Chief Executive Officer

EX-31.2

Exhibit 31.2

CERTIFICATION OF SAM A. SAMAD PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Sam A. Samad, certify that:

1	I have reviewed this Quarterly Report on Form 10-Q of Illumina, Inc.;
2	Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;
3	Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;
4	The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:
	a)	designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;
	b)	designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;
	c)	evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and
	d)	disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and
5	The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):
	a)	all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and
	b)	any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Dated: May 5, 2022

By:	/s/ SAM A. SAMAD
	Sam A. Samad
	Senior Vice President and Chief Financial Officer

EX-32.1

Exhibit 32.1

CERTIFICATION OF FRANCIS A. DESOUZA PURSUANT TO 18 U.S.C. SECTION

1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-

OXLEY ACT OF 2002

In connection with the Quarterly Report of Illumina, Inc. (the “Company”) on Form 10-Q for the quarter ended April 3, 2022, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Francis A. deSouza, President and Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1)The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Dated: May 5, 2022

By:	/s/ FRANCIS A. DESOUZA
	Francis A. deSouza
	President and Chief Executive Officer

This certification accompanying the Report is not deemed filed with the Securities and Exchange Commission for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities such Section, and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended (whether made before, on or after the date of the Report), irrespective of any general incorporation language contained in such filing.

EX-32.2

Exhibit 32.2

CERTIFICATION OF SAM A. SAMAD PURSUANT TO 18 U.S.C.

SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE

SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Illumina, Inc. (the “Company”) on Form 10-Q for the quarter ended April 3, 2022, as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Sam A. Samad, Senior Vice President and Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1)The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Dated: May 5, 2022

By:	/s/ SAM A. SAMAD
	Sam A. Samad
	Senior Vice President and Chief Financial Officer

This certification accompanying the Report is not deemed filed with the Securities and Exchange Commission for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities such Section, and is not to be incorporated by reference into any filing of the Company under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended (whether made before, on or after the date of the Report), irrespective of any general incorporation language contained in such filing.

XML

Cover Page - shares shares in Millions	3 Months Ended
	Apr. 03, 2022	Apr. 29, 2022
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Apr. 03, 2022
Document Transition Report	false
Entity File Number	001-35406
Entity Registrant Name	Illumina, Inc.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	33-0804655
Entity Address, Address Line One	5200 Illumina Way
Entity Address, City or Town	San Diego
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	92122
City Area Code	858
Local Phone Number	202-4500
Title of 12(b) Security	Common Stock, $0.01 par value
Trading Symbol	ILMN
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Large Accelerated Filer
Entity Small Business	false
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		157.1
Entity Central Index Key	0001110803
Current Fiscal Year End Date	--01-01
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q1
Amendment Flag	false

XML

Condensed Consolidated Balance Sheets - USD ($) $ in Millions	Apr. 03, 2022	Jan. 02, 2022
Current assets:
Cash and cash equivalents	$ 1,351	$ 1,232
Short-term investments	65	107
Accounts receivable, net	614	648
Inventory, net	465	431
Prepaid expenses and other current assets	260	295
Total current assets	2,755	2,713
Property and equipment, net	1,034	1,024
Operating lease right-of-use assets	706	672
Goodwill	7,113	7,113
Intangible assets, net	3,209	3,250
Other assets	457	445
Total assets	15,274	15,217
Current liabilities:
Accounts payable	291	332
Accrued liabilities	700	761
Term notes, current portion	499	0
Total current liabilities	1,490	1,093
Operating lease liabilities	803	774
Term notes	495	993
Convertible senior notes	746	702
Other long-term liabilities	845	915
Stockholders’ equity:
Common stock	2	2
Additional paid-in capital	8,957	8,938
Accumulated other comprehensive income	18	17
Retained earnings	5,632	5,485
Treasury stock, at cost	(3,714)	(3,702)
Total stockholders’ equity	10,895	10,740
Total liabilities and stockholders’ equity	$ 15,274	$ 15,217

XML

Condensed Consolidated Statements of Income - USD ($) shares in Millions, $ in Millions	3 Months Ended
	Apr. 03, 2022	Apr. 04, 2021
Revenue:
Total revenue	$ 1,223	$ 1,093
Cost of revenue:
Amortization of acquired intangible assets	40	6
Total cost of revenue	408	329
Gross profit	815	764
Operating expense:
Research and development	323	197
Selling, general and administrative	308	374
Total operating expense	631	571
Income from operations	184	193
Other income (expense):
Interest income	0	1
Interest expense	(6)	(19)
Other expense, net	(38)	(6)
Total other expense, net	(44)	(24)
Income before income taxes	140	169
Provision for income taxes	54	22
Net income	$ 86	$ 147
Earnings per share:
Basic (in dollars per share)	$ 0.55	$ 1.01
Diluted (in dollars per share)	$ 0.55	$ 1.00
Shares used in computing earnings per share:
Basic (in shares)	157	146
Diluted (in shares)	159	147
Product revenue
Revenue:
Total revenue	$ 1,070	$ 953
Cost of revenue:
Cost of revenue	299	265
Service and other revenue
Revenue:
Total revenue	153	140
Cost of revenue:
Cost of revenue	$ 69	$ 58

XML

Condensed Consolidated Statements of Comprehensive Income - USD ($) $ in Millions	3 Months Ended
	Apr. 03, 2022	Apr. 04, 2021
Statement of Comprehensive Income [Abstract]
Net income	$ 86	$ 147
Unrealized loss on available-for-sale debt securities, net of deferred tax	0	(1)
Unrealized gain on cash flow hedges, net of deferred tax	1	7
Total comprehensive income	$ 87	$ 153

XML

Condensed Consolidated Statements of Stockholders’ Equity - USD ($) shares in Millions, $ in Millions	Total	Cumulative-effect adjustment from adoption of ASU 2016-02, net of deferred tax	Common Stock	Additional Paid-in Capital	Additional Paid-in Capital Cumulative-effect adjustment from adoption of ASU 2016-02, net of deferred tax	Accumulated Other Comprehensive Income	Retained Earnings	Treasury Stock
Beginning balance (in shares) at Jan. 03, 2021			195					49
Beginning balance at Jan. 03, 2021	$ 4,694		$ 2	$ 3,815		$ 2	$ 4,723	$ (3,848)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income	147						147
Unrealized loss on available-for-sale debt securities, net of deferred tax	(1)					(1)
Unrealized gain on cash flow hedges, net of deferred tax	7					7
Issuance of common stock, net of repurchases	7			31				$ (24)
Share-based compensation	68			68
Ending balance (in shares) at Apr. 04, 2021			195					49
Ending balance at Apr. 04, 2021	4,922		$ 2	3,914		8	4,870	$ (3,872)
Beginning balance (in shares) at Jan. 03, 2021			195					49
Beginning balance at Jan. 03, 2021	4,694		$ 2	3,815		2	4,723	$ (3,848)
Ending balance (in shares) at Jan. 02, 2022			197					40
Ending balance at Jan. 02, 2022	$ 10,740	$ (32)	$ 2	8,938	$ (93)	17	5,485	$ (3,702)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Accounting Standards Update [Extensible List]	Accounting Standards Update 2020-06
Beginning balance (in shares) at Apr. 04, 2021			195					49
Beginning balance at Apr. 04, 2021	$ 4,922		$ 2	3,914		8	4,870	$ (3,872)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income	185						185
Issuance of common stock, net of repurchases (in shares)			1
Issuance of common stock, net of repurchases	(6)							$ (6)
Share-based compensation	79			79
Ending balance (in shares) at Jul. 04, 2021			196					49
Ending balance at Jul. 04, 2021	5,180		$ 2	3,993		8	5,055	$ (3,878)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income	317						317
Unrealized gain on cash flow hedges, net of deferred tax	5					5
Issuance of common stock, net of repurchases	26			28				$ (2)
GRAIL acquisition (in shares)								10
GRAIL acquisition	4,986			4,749				$ 237
Share-based compensation	79			79
Ending balance (in shares) at Oct. 03, 2021			196					39
Ending balance at Oct. 03, 2021	10,593		$ 2	8,849		13	5,372	$ (3,643)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income	113						113
Unrealized gain on cash flow hedges, net of deferred tax	4					4
Issuance of common stock, net of repurchases (in shares)			1					(1)
Issuance of common stock, net of repurchases	(58)			1				$ (59)
Share-based compensation	86			86
Exchange of GRAIL contingent value rights	2			2
Ending balance (in shares) at Jan. 02, 2022			197					40
Ending balance at Jan. 02, 2022	10,740	$ (32)	$ 2	8,938	(93)	17	5,485	$ (3,702)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income	86						86
Unrealized loss on available-for-sale debt securities, net of deferred tax	0
Unrealized gain on cash flow hedges, net of deferred tax	1					1
Issuance of common stock, net of repurchases	21			33				$ (12)
Share-based compensation	79			79
Ending balance (in shares) at Apr. 03, 2022			197					40
Ending balance at Apr. 03, 2022	$ 10,895		$ 2	$ 8,957	$ 61	$ 18	$ 5,632	$ (3,714)

XML

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Millions	3 Months Ended
	Apr. 03, 2022	Apr. 04, 2021
Cash flows from operating activities:
Net income	$ 86	$ 147
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation expense	50	41
Amortization of intangible assets	41	7
Share-based compensation expense	92	67
Accretion of debt discount on convertible senior notes	0	10
Deferred income taxes	(21)	(79)
Net losses on strategic investments	44	41
Gain on Helix contingent value right	(5)	(10)
Gain on derivative assets related to terminated acquisition	0	(26)
Change in fair value of contingent consideration liability	(49)	0
Other	(1)	22
Changes in operating assets and liabilities:
Accounts receivable	31	(39)
Inventory	(34)	8
Prepaid expenses and other current assets	11	7
Operating lease right-of-use assets and liabilities, net	(3)	(3)
Other assets	6	(4)
Accounts payable	(39)	(8)
Accrued liabilities	(45)	105
Other long-term liabilities	8	(4)
Net cash provided by operating activities	172	282
Cash flows from investing activities:
Maturities of available-for-sale securities	0	331
Purchases of available-for-sale securities	0	(77)
Sales of available-for-sale securities	0	1,031
Cash received for derivative assets related to terminated acquisition	0	52
Purchases of property and equipment	(61)	(42)
Purchases of strategic investments	(13)	(3)
Sales of strategic investments	0	84
Net cash (used in) provided by investing activities	(74)	1,376
Cash flows from financing activities:
Net proceeds from issuance of debt	0	988
Payments on convertible senior notes	0	(27)
Taxes paid related to net share settlement of equity awards	(12)	(24)
Proceeds from issuance of common stock	33	31
Net cash provided by financing activities	21	968
Effect of exchange rate changes on cash and cash equivalents	0	(3)
Net increase in cash and cash equivalents	119	2,623
Cash and cash equivalents at beginning of period	1,232	1,810
Cash and cash equivalents at end of period	$ 1,351	$ 4,433

XML

Organization and Significant Accounting Policies

3 Months Ended

Apr. 03, 2022

Accounting Policies [Abstract]

Organization and Significant Accounting Policies

1. ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES

Business Overview

We are a provider of sequencing- and array-based solutions, serving customers in the research, clinical and applied markets. Our products are used for applications in the life sciences, oncology, reproductive health, agriculture and other emerging segments. Our customers include leading genomic research centers, academic institutions, government laboratories, and hospitals, as well as pharmaceutical, biotechnology, commercial molecular diagnostic laboratories, and consumer genomics companies.

On August 18, 2021, we acquired GRAIL, a healthcare company focused on early detection of multiple cancers. GRAIL’s Galleri blood test detects various types of cancers before they are symptomatic. The acquisition is subject to ongoing legal proceedings and GRAIL is currently being held and operated as a separate company, with oversight provided by an appointed, independent monitoring trustee during the European Commission’s ongoing merger review. Refer to note “7. Legal Proceedings” for additional details. We have included the financial results of GRAIL in our condensed consolidated financial statements from the date of acquisition. There have been no adjustments to the purchase price allocation from those disclosed in our Annual Report on Form 10-K for the fiscal year ended January 2, 2022. We are still finalizing the allocation of the purchase price as additional information is received to complete our analysis and certain tax returns are finalized. In addition, GRAIL is a separate reportable segment. Refer to note “9. Segment Information” for additional details.

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. Interim financial results are not necessarily indicative of results anticipated for the full year. These unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and footnotes included in the Annual Report on Form 10-K for the fiscal year ended January 2, 2022, from which the prior year balance sheet information herein was derived. The preparation of financial statements requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue, and expense, and related disclosure of contingent assets and liabilities. Though the impact of the COVID-19 pandemic to our business and operating results presents additional uncertainty, we continue to use the best information available to form our critical accounting estimates. Actual results could differ from those estimates.

The unaudited condensed consolidated financial statements include our accounts, our wholly-owned subsidiaries, and majority-owned or controlled companies. All intercompany transactions and balances have been eliminated in consolidation. Certain prior period amounts have been reclassified to conform to the current period presentation. In management’s opinion, the accompanying unaudited condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.

Fiscal Year

Our fiscal year is the 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. References to Q1 2022 and Q1 2021 refer to the three months ended April 3, 2022 and April 4, 2021, respectively, which were both 13 weeks.

Significant Accounting Policies

During Q1 2022, there were no changes to our significant accounting policies as described in our Annual Report on Form 10-K for the fiscal year ended January 2, 2022, except as described in Recently Adopted Accounting Pronouncements below.

Recently Adopted Accounting Pronouncements

In August 2020, the FASB issued ASU 2020-06, Debt - Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging - Contracts in Entity’s Own Equity (Subtopic 815-40). The new standard reduces the number of accounting models for convertible debt instruments, amends the accounting for certain contracts in an entity’s own equity, and modifies how certain convertible instruments and contracts that may be settled in cash or shares impact the calculation of diluted earnings per share. Specifically, the guidance removes certain accounting models that separate the embedded conversion features from the host contract for convertible instruments and requires the use of the if-converted method to calculate diluted earnings per share. We adopted the standard on its effective date in the first quarter of 2022 using a modified retrospective approach by recognizing a cumulative-effect adjustment to retained earnings on January 3, 2022. We did not restate prior periods. As a result of the adoption, we increased our convertible senior notes and retained earnings, on January 3, 2022, by $43 million and $61 million, respectively, and decreased our deferred tax liabilities, included in other long-term liabilities on the condensed consolidated balance sheets, and additional paid-in capital by $11 million and $93 million, respectively. Interest expense recognized in future periods will be reduced as a result of accounting for our convertible senior notes as a single liability measured at amortized cost. In addition, as a result of the adoption, diluted earnings per share decreased by less than $0.01 for Q1 2022. See note “4. Debt” for additional details on the adoption of ASU 2020-06.

Earnings per Share

Basic earnings per share is computed based on the weighted average number of common shares outstanding during the period. Diluted earnings per share is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period.

Potentially dilutive common shares consist of shares issuable under convertible senior notes and equity awards. On January 3, 2022, we adopted ASU 2020-06. As a result, beginning in Q1 2022, we utilize the if-converted method to calculate the impact of convertible senior notes on diluted earnings per share. Prior to the adoption of ASU 2020-06, we applied the treasury stock method when calculating the potential dilutive effect, if any, of convertible senior notes which we intended to settle or have settled in cash the principal outstanding. Under the treasury stock method, convertible senior notes had a dilutive impact when the average market price of our common stock exceeded the applicable conversion price of the respective notes. Potentially dilutive common shares from equity awards are determined using the average share price for each period under the treasury stock method. In addition, proceeds from exercise of equity awards and the average amount of unrecognized compensation expense for equity awards are assumed to be used to repurchase shares. For Q1 2022 and Q1 2021, we did not have any potentially dilutive common shares from equity awards.

The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share:

In millions	Q1 2022	Q1 2021
Weighted average shares outstanding	157	146
Effect of potentially dilutive common shares from:
Convertible senior notes	2	1
Weighted average shares used in calculating diluted earnings per share	159	147

XML

Revenue

3 Months Ended

Apr. 03, 2022

Revenue from Contract with Customer [Abstract]

Revenue

2. REVENUE

Our revenue is generated primarily from the sale of products and services. Product revenue primarily consists of sales of instruments and consumables used in genetic analysis. Service and other revenue primarily consists of revenue generated from genotyping and sequencing services, instrument service contracts, development and licensing agreements, and cancer detection testing services related to the GRAIL business.

Revenue by Source

	Q1 2022						Q1 2021
In millions	Sequencing		Microarray		Total		Sequencing		Microarray		Total
Consumables	$	778	$	75	$	853	$	695	$	79	$	774
Instruments	211		6		217		176		3		179
Total product revenue	989		81		1,070		871		82		953
Service and other revenue	120		33		153		108		32		140
Total revenue	$	1,109	$	114	$	1,223	$	979	$	114	$	1,093

Revenue by Geographic Area

Based on region of destination (in millions)	Q1 2022		Q1 2021
Americas	$	648	$	562
Europe, Middle East, and Africa	316		305
Greater China(1)	127		127
Asia-Pacific	132		99
Total revenue	$	1,223	$	1,093

_____________

(1)Region includes revenue from China, Taiwan, and Hong Kong.

Performance Obligations

We regularly enter into contracts with multiple performance obligations. Most performance obligations are generally satisfied within a short time frame, approximately three to six months, after the contract execution date. As of April 3, 2022, the aggregate amount of the transaction price allocated to remaining performance obligations was $1,276 million, of which approximately 91% is expected to be converted to revenue in the next twelve months, approximately 6% in the following twelve months, and the remainder thereafter.

Contract Assets and Liabilities

Contract assets, which consist of revenue recognized and performance obligations satisfied or partially satisfied in advance of customer billing, were $16 million as of April 3, 2022 and January 2, 2022, which were recorded in prepaid expenses and other current assets.

Contract liabilities, which consist of deferred revenue and customer deposits, as of April 3, 2022 and January 2, 2022 were $293 million and $297 million, respectively, of which the short-term portions of $232 million and $234 million, respectively, were recorded in accrued liabilities and the remaining long-term portions were recorded in other long-term liabilities. Revenue recorded in Q1 2022 included $106 million of previously deferred revenue that was included in contract liabilities as of January 2, 2022.

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Investments and Fair Value Measurements

3 Months Ended

Apr. 03, 2022

Fair Value Disclosures [Abstract]

Investments and Fair Value Measurements

3. INVESTMENTS AND FAIR VALUE MEASUREMENTS

Strategic Investments

Marketable Equity Securities

Our short-term investments consist of marketable equity securities. As of April 3, 2022 and January 2, 2022, the fair value of our marketable equity securities totaled $65 million and $107 million, respectively.

Net losses recognized in other expense, net on our marketable equity securities were as follows:

In millions	Q1 2022		Q1 2021
Net losses recognized during the period on marketable equity securities	$	(42)	$	(72)
Less: Net losses recognized during the period on marketable equity securities sold during the period	—		14
Net unrealized losses recognized during the period on marketable equity securities still held at the reporting date	$	(42)	$	(58)

Non-Marketable Equity Securities

As of April 3, 2022 and January 2, 2022, the aggregate carrying amounts of our non-marketable equity securities without readily determinable fair values, included in other assets, were $41 million and $40 million, respectively.

Revenue recognized from transactions with our strategic investees was $30 million and $13 million for Q1 2022 and Q1 2021, respectively.

Venture Funds

We invest in two venture capital investment funds (the Funds) with capital commitments of $100 million, callable through April 2026, and up to $150 million, callable through July 2029, respectively, of which $14 million and up to $110 million, respectively, remained callable as of April 3, 2022. Our investments in the Funds are accounted for as equity-method investments. The aggregate carrying amounts of the Funds, included in other assets, were $183 million and $173 million as of April 3, 2022 and January 2, 2022, respectively. We recorded an unrealized loss of $2 million and an unrealized gain of $33 million in Q1 2022 and Q1 2021, respectively, in other expense, net.

Helix Contingent Value Right

In conjunction with the deconsolidation of Helix Holdings I, LLC (Helix) in April 2019, we received a contingent value right with a 7-year term that entitles us to consideration dependent upon the outcome of Helix’s future financing and/or liquidity events. Changes in the fair value of the contingent value right resulted in unrealized gains of $5 million and $10 million in Q1 2022 and Q1 2021, respectively, which were included in other expense, net.

Derivative Assets Related to Terminated Acquisition

Pursuant to the Agreement and Plan of Merger (the PacBio Merger Agreement) to acquire Pacific Biosciences of California, Inc. (PacBio) entered into in November 2018 and amended in September 2019 (Amendment No. 1 to the PacBio Merger Agreement) and the subsequent agreement to terminate the PacBio Merger Agreement (the Termination Agreement) entered into in January 2020, we made cash payments to PacBio of $18 million in Q4 2019 and $34 million in Q1 2020, respectively, collectively referred to as the Continuation Advances. Up to the $52 million of Continuation Advances was repayable, without interest, if, within two years of March 31, 2020, PacBio entered into a Change of Control Transaction or raised at least $100 million in equity or debt financing in a single transaction (with the amount repayable dependent on the amount raised by PacBio). In February 2021, PacBio entered into an investment agreement with SB Northstar LP for the issuance and sale of $900 million in aggregate principal amount of PacBio’s convertible notes. Pursuant to the PacBio Merger Agreement, PacBio repaid to us the $52 million of Continuation Advances and we recorded a gain of $26 million in Q1 2021, which was included in other expense, net.

Fair Value Measurements

The following table presents the hierarchy for assets and liabilities measured at fair value on a recurring basis:

	April 3, 2022								January 2, 2022
In millions	Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Assets:
Money market funds (cash equivalents)	$	775	$	—	$	—	$	775	$	688	$	—	$	—	$	688
Marketable equity securities	65		—		—		65		107		—		—		107
Helix contingent value right	—		—		70		70		—		—		65		65
Deferred compensation plan assets	—		57		—		57		—		60		—		60
Total assets measured at fair value	$	840	$	57	$	70	$	967	$	795	$	60	$	65	$	920
Liabilities:
Contingent consideration liability	$	—	$	—	$	566	$	566	$	—	$	—	$	615	$	615
Deferred compensation plan liability	—		54		—		54		—		56		—		56
Total liabilities measured at fair value	$	—	$	54	$	566	$	620	$	—	$	56	$	615	$	671

Our marketable equity securities are measured at fair value based on quoted trade prices in active markets. Our deferred compensation plan assets consist primarily of investments in life insurance contracts carried at cash surrender value, which reflects the net asset value of the underlying publicly traded mutual funds. We perform control procedures to corroborate the fair value of our holdings, including comparing valuations obtained from our investment service provider to valuations reported by our asset custodians, validating pricing sources and models, and reviewing key model inputs, if necessary.

We elected the fair value option to measure the contingent value right received from Helix. The fair value of such contingent value right, included in other assets, is derived using a Monte Carlo simulation. Estimates and assumptions used in the Monte Carlo simulation include probabilities related to the timing and outcome of future financing and/or liquidity events, assumptions regarding collectibility and volatility, and an estimated equity value of Helix. These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value.

We reassess the fair value of contingent consideration related to acquisitions on a quarterly basis. The contingent value rights issued as part of the GRAIL acquisition entitle the holders to receive future cash payments on a quarterly basis (Covered Revenue Payments) representing a pro rata portion of certain GRAIL-related revenues (Covered Revenues) each year for a 12-year period. As defined in the Contingent Value Rights Agreement, this will reflect a 2.5% payment right to the first $1 billion of revenue each year for 12 years. Revenue above $1 billion each year will be subject to a 9% contingent payment right during this same period. We use a Monte Carlo simulation to estimate the fair value of contingent consideration related to the GRAIL acquisition. Estimates and assumptions used in the Monte Carlo simulation include forecasted revenues for GRAIL, a revenue risk premium, a revenue volatility, an operational leverage ratio and a counterparty credit spread. These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect our own assumptions in measuring fair value. Changes in the fair value of contingent consideration subsequent to the acquisition date are recognized in selling, general and administrative expense in our condensed consolidated statements of income.

Changes in the estimated fair value of our contingent consideration liability during Q1 2022 were as follows:

In millions
Balance as of January 2, 2022	$	615
Change in estimated fair value	(49)
Balance as of April 3, 2022(1) (2)	$	566

_____________

(1)As of April 3, 2022, $565 million was included in other long-term liabilities, with remaining balance included in accrued liabilities.

(2)Covered Revenues for Q4 2021 were $10 million, driven primarily by sales of GRAIL’s Galleri test. Covered Revenue Payments in Q1 2022 were approximately $97,000; however, pursuant to the Contingent Value Rights Agreement, the Covered Revenue Payments were applied to reimburse us for certain expenses

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Debt

3 Months Ended

Apr. 03, 2022

Debt Disclosure [Abstract]

Debt

4. DEBT

Summary of Term Debt Obligations

In millions	April 3, 2022		January 2, 2022
Principal amount of 2031 Term Notes outstanding	$	500	$	500
Principal amount of 2023 Term Notes outstanding	500		500
Unamortized discounts and debt issuance costs	(6)		(7)
Net carrying amount of term notes	994		993
Less: current portion	(499)		—
Term notes, non-current	$	495	$	993
Fair value of term notes outstanding (Level 2)	$	945	$	996

0.550% Term Notes due 2023 (2023 Term Notes) and 2.550% Term Notes due 2031 (2031 Term Notes)

On March 23, 2021, we issued $500 million aggregate principal amount of term notes due 2023 (2023 Term Notes) and $500 million aggregate principal amount of term notes due 2031 (2031 Term Notes, together the Term Notes). We received net proceeds from the issuance of $992 million, after deducting discounts and debt issuance costs.

The 2023 and 2031 Term Notes accrue interest at a rate of 0.550% and 2.550% per annum, respectively, payable semi-annually. Interest is payable on March 23 and September 23 of each year, beginning on September 23, 2021. The 2023 Term Notes, which were reclassified to short-term as of April 3, 2022, mature on March 23, 2023, and the 2031 Term Notes mature on March 23, 2031.

We may redeem for cash all or any portion of the Term Notes, at our option, at any time prior to maturity. The 2023 Term Notes and, prior to December 23, 2030, the 2031 Term Notes are redeemable at make-whole premium redemption prices as defined in the applicable forms of note. After December 23, 2030, the 2031 Term Notes are redeemable at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid interest up to, but excluding, the redemption date.

Interest expense recognized on the Term Notes was $4 million and $1 million in Q1 2022 and Q1 2021, respectively, which included amortization of debt discounts and issuance costs.

0% Convertible Senior Notes due 2023 (2023 Convertible Notes)

In millions	April 3, 2022		January 2, 2022
Principal amount outstanding	$	750	$	750
Unamortized debt discount and issuance costs	(4)		(48)
Net carrying amount of liability component, non-current	$	746	$	702
Carrying value of equity component, net of debt issuance costs	$	—	$	126
Fair value of convertible senior notes outstanding (Level 2)	$	836	$	854

In August 2018, we issued $750 million aggregate principal amount of convertible senior notes due 2023 (2023 Convertible Notes). The 2023 Convertible Notes carry no coupon interest and mature on August 15, 2023.

The 2023 Convertible Notes will be convertible into cash, shares of our common stock or a combination of cash and shares of our common stock, at our election, based on an initial conversion rate, subject to adjustment, of 2.1845 shares of common stock per $1,000 principal amount of notes (which represents an initial conversion price of approximately $457.77 per share of common stock), only in the following circumstances: (1) during any calendar quarter commencing after the calendar quarter ending on September 30, 2018 (and only during such calendar quarter), if the last reported sale price of our common stock for at least 20 trading days (whether or not consecutive) during a period of 30 consecutive trading days ending on, and including, the last trading day of the immediately preceding calendar quarter is greater than or equal to 130% of the conversion price in effect on each applicable trading day; (2) during the five business day period after any 10 consecutive trading day period (the “measurement period”) in which the trading price per $1,000 principal amount of 2023 Convertible Notes for each trading day of the measurement period was less than 98% of the product of the last reported sale price of our common stock and the conversion rate on each such trading day; (3) if we call any or all of the notes for redemption, at any time prior to the close of business on the scheduled trading day immediately preceding the redemption date; or (4) upon the occurrence of specified corporate events described in the indenture. Regardless of the foregoing circumstances, the holders may convert their notes on or after May 15, 2023 until August 11, 2023.

We may redeem for cash all or any portion of the 2023 Convertible Notes, at our option, on or after August 20, 2021 if the last reported sale price of our common stock has been at least 130% of the conversion price then in effect (currently $595.10) for at least 20 trading days (whether or not consecutive) during any 30 consecutive trading day period (including the last trading day of such period) ending on, and including, the trading day immediately preceding the date on which we provide notice of redemption at a redemption price equal to 100% of the principal amount of the notes to be redeemed, plus any accrued and unpaid special interest to, but excluding, the redemption date.

At the time of issuance, the embedded conversion feature of the 2023 Convertible Notes was required to be bifurcated from the notes and accounted for as an equity instrument classified within stockholders’ equity. As a result, we recognized $126 million in additional paid-in capital in 2018, which was recorded as a debt discount and subsequently amortized to interest expense at an estimated effective rate, assuming no conversion option, of 3.7%. As of January 3, 2022, we adopted ASU 2020-06, which removed the requirement to separate the embedded conversion feature from the notes and requires the notes to be accounted for as a single liability measured at amortized cost. Accordingly, we reclassified the unamortized debt discount from additional paid-in capital to convertible senior notes in the condensed consolidated balance sheets on January 3, 2022. This resulted in an increase to our convertible senior notes and retained earnings of $43 million and $61 million, respectively, and a decrease to our deferred tax liabilities, included in other long-term liabilities, and additional paid-in capital of $11 million and $93 million, respectively.

Interest expense recognized on the 2023 Convertible Notes, which included amortization of debt issuance costs, was $1 million in Q1 2022. Interest expense recognized on the 2023 Convertible Notes in Q1 2021 was $7 million, which included amortization of the original debt discount and debt issuance costs. The 2023 Convertible Notes were not convertible as of April 3, 2022.

0.5% Convertible Senior Notes due 2021 (2021 Convertible Notes)

In June 2014, we issued $517 million aggregate principal amount of convertible senior notes due 2021 (2021 Convertible Notes). The 2021 Convertible Notes were partially converted in Q1 2021 with the remaining balance converted upon maturity on June 15, 2021. The excess of the conversion value over the principal amount was paid in 0.7 million shares of common stock. Interest expense recognized on the 2021 Convertible Notes, which included amortization of debt discount and issuance costs, was $4 million in Q1 2021. Our adoption of ASU 2020-06 on January 3, 2022 did not impact the accounting for the 2021 Convertible Notes since they were converted and repaid prior to the date of adoption.

Credit Agreement

On March 8, 2021, we entered into a credit agreement (the Credit Agreement), which provides us with a $750 million senior unsecured five-year revolving credit facility, including a $40 million sublimit for swingline borrowings and a $50 million sublimit for letters of credit (the Credit Facility). The proceeds of the loans under the Credit Facility may be used to finance working capital needs and for general corporate purposes.

Any loans under the Credit Facility will have a variable interest rate based on either the eurocurrency rate or the alternate base rate, plus an applicable spread that varies with the Company’s debt rating. The Credit Agreement includes an option for us to elect to increase the commitments under the Credit Facility or to enter into one or more tranches of term loans in the aggregate principal amount of up to $250 million, subject to the consent of the lenders providing the additional commitments or term loans, as applicable, and certain other conditions.

The Credit Agreement contains financial and operating covenants. Pursuant to the Credit Agreement, we are required to maintain a ratio of total debt to annual earnings before interest, taxes, depreciation and amortization (EBITDA), calculated based on the four consecutive fiscal quarters ending with the most recent fiscal quarter, of not greater than 3.50 to 1.00 as of the end of each fiscal quarter. Upon the consummation of any Qualified Acquisition (as defined in the Credit Agreement) and us providing notice to the Administrative Agent, the ratio increases to 4.00 to 1.00 for the fiscal quarter in which the acquisition is consummated and the three consecutive fiscal quarters thereafter. The operating covenants include, among other things, limitations on (i) the incurrence of indebtedness by our subsidiaries, (ii) liens on our and our subsidiaries assets, and (iii) certain fundamental changes and the disposition of assets by us and our subsidiaries. The Credit Agreement contains other customary covenants, representations and warranties, and events of default.

The Credit Facility matures, and all amounts outstanding thereunder become due and payable in full, on March 8, 2026, subject to two one-year extensions at our option, the consent of the extending lenders and certain other conditions. We may prepay amounts borrowed and terminate commitments under the Credit Facility at any time without premium or penalty.

As of April 3, 2022, there were no borrowings outstanding under the Credit Facility, and we were in compliance with all financial and operating covenants.

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Stockholders’ Equity

3 Months Ended

Apr. 03, 2022

Equity [Abstract]

Stockholders’ Equity

5. STOCKHOLDERS’ EQUITY

As of April 3, 2022, approximately 1.9 million shares remained available for future grants under the 2015 Stock and Incentive Compensation Plan.

Restricted Stock

Restricted stock activity was as follows:

	Restricted Stock Units (RSU)	Performance Stock Units (PSU)(1)	Weighted-Average Grant Date Fair Value per Share
Units in thousands			RSU		PSU
Outstanding at January 2, 2022	1,130	328	$	345.66	$	466.42
Awarded	996	194	$	330.98	$	329.57
Vested	(32)	—	$	442.14	$	—
Cancelled	(51)	(7)	$	353.04	$	446.38
Outstanding at April 3, 2022	2,043	515	$	336.77	$	415.16

_____________

(1)The number of units reflect the estimated number of shares to be issued at the end of the performance period. Awarded units are presented net of performance adjustments.

Stock Options

Stock option activity was as follows:

Units in thousands	Options	Weighted-Average Exercise Price		Performance Stock Options(1)	Weighted-Average Exercise Price
Outstanding at January 2, 2022	8	$	66.42	17	$	85.54
Granted	180	$	330.25	—	$	—
Outstanding at April 3, 2022	188	$	318.73	17	$	85.54
Exercisable at April 3, 2022	8	$	66.42	—	$	—

_____________

(1)The number of units reflect awards that have been granted and for which it is assumed to be probable that the underlying performance goals will be achieved.

Liability-Classified Awards

We grant cash-based equity incentive awards to GRAIL employees. The cash to be awarded may subsequently increase or decrease in direct correlation to changes in the enterprise fair value of GRAIL, as defined under the Cash-Based Equity Appreciation Award Plan.

Cash-based equity incentive award activity was as follows:

In millions
Outstanding at January 2, 2022	$	184
Granted	70
Cancelled	(13)
Outstanding at April 3, 2022	$	241
Estimated liability as of April 3, 2022 (included in accrued liabilities)	$	24

We recognized share-based compensation expense of $13 million in Q1 2022. As of April 3, 2022, approximately $217 million of total unrecognized compensation cost related to awards issued to date was expected to be recognized over a weighted-average period of approximately 3.6 years.

In connection with the acquisition of GRAIL, we assumed a performance-based award for which vesting is based on GRAIL’s future revenues. The award has an aggregate potential value of up to $78 million and expires, to the extent unvested, in August 2030. As of April 3, 2022, it was not probable that the performance conditions associated with the award will be achieved and, therefore, no share-based compensation expense, or corresponding liability, has been recognized in the condensed consolidated financial statements to-date.

Employee Stock Purchase Plan

The price at which common stock is purchased under the Employee Stock Purchase Plan (ESPP) is equal to 85% of the fair market value of the common stock on the first day of the offering period or purchase date, whichever is lower. During Q1 2022, approximately 0.1 million shares were issued under the ESPP. As of April 3, 2022, there were approximately 13.0 million shares available for issuance under the ESPP.

Share Repurchases

We did not repurchase any shares during Q1 2022. As of April 3, 2022, authorizations to repurchase approximately $15 million of our common stock remained available under the $750 million share repurchase program authorized by our Board of Directors on February 5, 2020. The repurchases may be completed under a 10b5-1 plan or at management’s discretion.

Share-Based Compensation

Share-based compensation expense, which includes expense for both equity and liability-classified awards, reported in our condensed consolidated statements of income was as follows:

In millions	Q1 2022		Q1 2021
Cost of product revenue	$	6	$	7
Cost of service and other revenue	1		1
Research and development	36		24
Selling, general and administrative	49		35
Share-based compensation expense before taxes	92		67
Related income tax benefits	(21)		(13)
Share-based compensation expense, net of taxes	$	71	$	54

In February 2021, we modified the metrics and reduced the maximum potential payouts for our performance stock units granted in 2019 and 2020. The PSU granted in 2019 vested on January 2, 2022 and the PSU granted in 2020 vests at the end of the three-year period ending on January 1, 2023. The modifications affected 52 employees with units granted in 2019, which resulted in total incremental share-based compensation expense of approximately $41 million, and 72 employees with units granted in 2020, which resulted in total incremental share-based compensation expense of approximately $65 million.

The assumptions used and the resulting estimate of weighted-average fair value per share for stock purchased under the ESPP during Q1 2022 were as follows:

	Employee Stock Purchase Rights
Risk-free interest rate	0.06% - 0.78%
Expected volatility	37% - 47%
Expected term	0.5 - 1.0 year
Expected dividends	0		%
Weighted-average grant-date fair value per share	$	91.27

As of April 3, 2022, approximately $782 million of total unrecognized compensation cost related to restricted stock, stock options and ESPP shares issued to date was expected to be recognized over a weighted-average period of approximately 2.6 years.

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Supplemental Balance Sheet Details

3 Months Ended

Apr. 03, 2022

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Supplemental Balance Sheet Details

6. SUPPLEMENTAL BALANCE SHEET DETAILS

Accounts Receivable

In millions	April 3, 2022		January 2, 2022
Trade accounts receivable, gross	$	617	$	651
Allowance for credit losses	(3)		(3)
Total accounts receivable, net	$	614	$	648

Inventory

In millions	April 3, 2022		January 2, 2022
Raw materials	$	170	$	144
Work in process	340		333
Finished goods	32		32
Inventory, gross	542		509
Inventory reserve	(77)		(78)
Total inventory, net	$	465	$	431

Accrued Liabilities

In millions	April 3, 2022		January 2, 2022
Contract liabilities, current portion	$	232	$	234
Accrued compensation expenses	181		241
Accrued taxes payable	91		98
Operating lease liabilities, current portion	72		71
Liability-classified equity incentive awards	24		11
Other, including warranties (a)	100		106
Total accrued liabilities	$	700	$	761

(a) Changes in the reserve for product warranties were as follows:

In millions	Q1 2022		Q1 2021
Balance at beginning of period	$	22	$	13
Additions charged to cost of product revenue	6		8
Repairs and replacements	(7)		(6)
Balance at end of period	$	21	$	15

We generally provide a one-year warranty on instruments. Additionally, we provide a warranty on consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. At the time revenue is recognized, an accrual is established for estimated warranty expenses based on historical experience as well as anticipated product performance. We periodically review the warranty reserve for adequacy and adjust the warranty accrual, if necessary, based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue.

Derivative Financial Instruments

We are exposed to foreign exchange rate risks in the normal course of business and use derivative financial instruments to partially offset this exposure. We do not use derivative financial instruments for speculative or trading purposes. Foreign exchange contracts are carried at fair value in other current assets, other assets, accrued liabilities, or other long-term liabilities, as appropriate, on the condensed consolidated balance sheets.

We use foreign exchange forward contracts to manage foreign currency risks related to monetary assets and liabilities denominated in currencies other than the U.S. dollar. These derivative financial instruments have terms of one month or less and are not designated as hedging instruments. Changes in fair value of these derivatives are recognized in other expense, net, along with the re-measurement gain or loss on the foreign currency denominated assets or liabilities. As of April 3, 2022, we had foreign exchange forward contracts in place to hedge exposures in the euro, Japanese yen, Australian dollar, Canadian dollar, Singapore dollar, Chinese Yuan Renminbi, and British pound. As of April 3, 2022 and January 2, 2022, the total notional amounts of outstanding forward contracts in place for these foreign currency purchases were $458 million and $462 million, respectively.

We also use foreign currency forward contracts to hedge portions of our foreign currency exposure associated with forecasted revenue transactions. These derivative financial instruments have terms up to 24 months and are designated as cash flow hedges. Changes in fair value of our cash flow hedges are recorded as a component of accumulated other comprehensive income and are reclassified to revenue in the same period the underlying hedged transactions are recorded. We regularly review the effectiveness of our cash flow hedges and consider them to be ineffective if it becomes probable that the forecasted transactions will not occur in the identified period. Changes in fair value of the ineffective portions of our cash flow hedges, if any, will be recognized in other expense, net. As of April 3, 2022, we had foreign currency forward contracts in place to hedge exposures associated with forecasted revenue transactions denominated in the euro, Japanese yen, Australian dollar, and Canadian dollar. As of April 3, 2022 and January 2, 2022, the total notional amounts of outstanding cash flow hedge contracts in place for these foreign currency purchases were $462 million and $450 million, respectively

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Legal Proceedings

3 Months Ended

Apr. 03, 2022

Commitments and Contingencies Disclosure [Abstract]

Legal Proceedings

7. LEGAL PROCEEDINGS

We are involved in various lawsuits and claims arising in the ordinary course of business, including actions with respect to intellectual property, employment, and contractual matters. In connection with these matters, we assess, on a regular basis, the probability and range of possible loss based on the developments in these matters. A liability is recorded in the condensed consolidated financial statements if it is believed to be probable that a loss has been incurred and the amount of the loss can be reasonably estimated. Because litigation is inherently unpredictable and unfavorable resolutions could occur, assessing contingencies is highly subjective and requires judgments about future events. We regularly review outstanding legal matters to determine the adequacy of the liabilities accrued and related disclosures in consideration of many factors, which include, but are not limited to, past history, scientific and other evidence, and the specifics and status of each matter. We may change our estimates if our assessment of the various factors changes and the amount of ultimate loss may differ from our estimates, resulting in a material effect on our business, financial condition, results of operations, and/or cash flows.

Acquisition of GRAIL

On March 30, 2021, the Federal Trade Commission (the FTC) filed an administrative complaint and a motion for a preliminary injunction in the United States District Court for the District of Columbia. In both actions, the FTC alleged that our acquisition of GRAIL would violate Section 7 of the Clayton Act, as amended, 15 U.S.C. § 18. We filed an answer to the FTC’s complaint in federal district court on April 6, 2021, and in the administrative court on April 13, 2021. On April 20, 2021, the United States District Court for the District of Columbia granted our motion to transfer venue to the United States District Court for the Southern District of California. On May 28, 2021, the district court granted the FTC’s motion to dismiss the complaint without prejudice. The administrative trial commenced on August 24, 2021, and live testimony concluded on September 24, 2021. On April 15, 2022, the parties filed their opening post-trial briefs and proposed findings. Reply briefs are due May 25, 2022. Closing arguments are scheduled for June 8, 2022. A decision by the administrative judge is currently due no later than September 2, 2022. We intend to vigorously defend the FTC action.

On April 19, 2021, the European Commission accepted a request for a referral of the GRAIL acquisition for European Union merger review, submitted by a Member State of the European Union (France), and joined by several other Member States (Belgium, Greece, Iceland, the Netherlands and Norway), under Article 22(1) of Council Regulation (EC) No 139/2004 (the EU Merger Regulation). On April 29, 2021, we filed an action in the General Court of the European Union (the EU General Court) asking for annulment of the European Commission’s assertion of jurisdiction to review the acquisition under Article 22 of the EU Merger Regulation, as the acquisition does not meet the jurisdictional criteria under the EU Merger Regulation or under the national merger control laws of any Member State of the European Union. On December 16, 2021, the EU General Court held a hearing regarding the European Commission’s assertion of jurisdiction, and we await the court’s judgment. We intend to vigorously challenge the European Commission’s assertion of jurisdiction. Additionally, as a result of our decision to proceed with the completion of the acquisition of GRAIL during the pendency of the European Commission’s review, the European Commission will likely seek to impose a fine on us pursuant to Article 14(2)(b) of the EU Merger Regulation of up to 10% of our consolidated annual revenues.

BGI Genomics Co. Ltd. and its Affiliates

We are involved in lawsuits against BGI Genomics Co. Ltd (BGI) and its affiliates, including Complete Genomics, Inc. (CGI), in the United States and elsewhere.

On June 27, 2019, we filed suit against BGI in the United States District Court for the Northern District of California, alleging that certain BGI sequencing products infringe our U.S. Patent No. 7,566,537 (‘537 patent) and U.S. Patent No. 9,410,200 (‘200 patent). BGI has denied our claims and has counterclaimed that our technology infringes U.S. Patent No. 9,944,984 (‘984 patent). We deny their allegations. On February 27, 2020, we filed a second patent infringement suit against BGI in the United States District Court for the Northern District of California alleging that BGI sequencing products infringed U.S. Patent 7,771,973 (‘973 patent), U.S. Patent 7,541,444 (‘444 patent), and U.S. Patent 10,480,025 (‘025 patent). On June 15, 2020, the Court granted our motions requesting preliminary injunctions against BGI, finding that our patents were likely valid and infringed by BGI’s chemistries. The injunction prohibits the sale of infringing BGI sequencers and sequencing reagents in the U.S. On December 9, 2020, BGI filed a motion to amend its answer to our second suit to include allegations that the ‘444 and ‘973 patents are unenforceable under the doctrine of inequitable conduct; we deny BGI’s allegations. As of April 12, 2021, BGI is seeking approximately $54 million in alleged damages and an ongoing royalty of 3.6% on sales of the accused products by us in the United States until the ‘984 patent expires on June 13, 2026. We deny that we owe any damages or ongoing royalty. On August 27, 2021, and September 9, 2021, the Court issued its decisions on the summary judgment motions: (i) the Court granted our motion for summary judgment that we do not infringe BGI’s ‘984 patent; (ii) the Court granted our motion for summary judgment that our ‘444 and ‘973 patents are not unenforceable; (iii) the Court granted our motion for summary judgment that BGI’s standard MPS products infringe all of our patents-in-suit: (iv) the Court granted our motion for summary judgment that BGI’s “Cool MPS” sequencing products infringe the ‘973 and ‘444 patents, and granted BGI’s motion for summary judgment that BGI’s “Cool MPS” sequencing products do not infringe the ‘025 patent; and (v) the Court denied BGI’s motion for summary judgment that our ‘973 patent is invalid for lack of written description and enablement. Trial began on November 12, 2021, and the jury rendered a verdict on November 30, 2021. The jury found that the ‘537, ‘200, ‘973 patents and claims 9, 27, 31, 33, 34, 42, 47 of the ‘025 patent are valid and were willfully infringed by BGI. The jury also ruled that the claim 4 of the ‘444 patent and claim 1 of the ‘025 patent were invalid as obvious. The jury awarded the Company $8 million in damages. On March 27, 2022, the Court issued a decision on post-trial motions. The Court denied BGI’s motions. The Court (i) upheld the jury’s award of $8 million and granted pre-judgment interest, (ii) upheld the jury’s finding that BGI’s infringement was willful, (iii) granted the Company’s request for a permanent injunction until the relevant patents expire; (iv) granted the Company’s request that claim 1 of the ‘025 patent is not invalid, but denied the request with respect to claim 4 of the ‘444 patent; and (v) denied the Company’s request for enhanced damages. On April 27 2022, BGI appealed the judgment to the United States Court of Appeals for the Federal Circuit. The Company cross-appealed, including with respect to the denial of the Company’s request for enhanced damages.

On January 11, 2021, Complete Genomics, Inc., BGI Americas Corp., and MGI Americas, Inc. also filed a complaint in the United States District Court for the Northern District of California alleging the Company and its subsidiary Illumina Cambridge Ltd. violated federal antitrust and state unfair competition laws. CGI and these affiliates allege that the Company fraudulently withheld a prior art reference that was material to patentability for the ‘444 and ‘973 patents. They also allege that our infringement claims of the ‘025 against BGI’s “Cool MPS” chemistry were objectively baseless. The Company denies the allegations in the complaint. On March 30, 2021, the Court stayed the antitrust case pending resolution of the underlying patent infringement suit taking place in the same court.

On May 28, 2019, CGI filed suit against us in the United States District Court for the District of Delaware alleging that our two-channel sequencing systems, including the NovaSeq, NextSeq, and MiniSeq systems, infringe certain claims of U.S. Patent No. 9,222,132. We have denied CGI’s allegations and have counterclaimed for infringement by CGI, BGI Americas Corp., and MGI Americas, Inc. of U.S. Patent No. 9,303,290, U.S. Patent No. 9,217,178, and U.S. Patent No. 9,970,055. On August 15, 2019, CGI filed a motion to dismiss our counterclaims. On August 29, 2019, we filed our Opposition to the Motion to Dismiss. The Court denied and granted the motion in part, denying the motion as to our claims for inducing infringement and granting it for contributory infringement. The Court gave us leave to file an amended complaint to attempt to cure the alleged deficiencies as to contributory infringement. On July 1, 2020, CGI amended its complaint to add claims of infringement of U.S. Patent No. 10,662,473 by our two-channel sequencing systems. We deny these allegations. As of April 8, 2022, CGI is seeking $334 million in alleged past damages and an average ongoing royalty of at least 5.5% on sales of the accused two-channel sequencing instruments and chemistry in the U.S. until the patents-in-suit expire on January 28, 2029. We deny that we owe any damages or ongoing royalty. On October 22, 2021, pursuant to the Court’s local rules, the Company sought leave to file a motion for summary judgment of non-infringement of the CGI patents-in-suit. CGI sought leave to file a motion for summary judgment against the Company’s invalidity defense based on prior invention. On January 14, 2022, the Court denied the Company and CGI’s motions for leave to file for summary judgment. Trial began on April 25, 2022.

We will continue to pursue our claims against BGI and CGI, and vigorously defend against BGI’s and CGI’s claims. We currently cannot estimate any possible loss or range of loss that may result from BGI’s and CGI’s claims against us.

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Income Taxes

3 Months Ended

Apr. 03, 2022

Income Tax Disclosure [Abstract]

Income Taxes

8. INCOME TAXES

Our effective tax rate may vary from the U.S. federal statutory tax rate due to the change in the mix of earnings in tax jurisdictions with different statutory rates, benefits related to tax credits, and the tax impact of non-deductible expenses and other permanent differences between income before income taxes and taxable income.

Our effective tax rate was 38.3% in Q1 2022 compared to 13.1% in Q1 2021. In Q1 2022, the variance from the U.S. federal statutory tax rate of 21% was primarily attributable to the $24 million impact of GRAIL pre-acquisition net operating losses on global intangible low-taxed income (GILTI) and the utilization of U.S. foreign tax credits, and the $4 million impact of research and development expense capitalization for tax purposes. This was partially offset by the mix of earnings in jurisdictions with lower statutory tax rates than the U.S. federal statutory tax rate, such as in Singapore and the United Kingdom.

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Segment Information

3 Months Ended

Apr. 03, 2022

Segment Reporting [Abstract]

Segment Information

9. SEGMENT INFORMATION

We have two reportable segments, Core Illumina and GRAIL. We report segment information based on the management approach, which designates the internal reporting used by the Chief Operating Decision Maker (CODM) for making decisions and assessing performance as the source of our reportable segments. The CODM allocates resources and assesses the performance of each operating segment using information about its revenue and income (loss) from operations. We do not allocate expenses between segments. Core Illumina sells products and provides services to GRAIL, and vice versa, in accordance with contractual agreements between the entities.

Core Illumina:

Core Illumina’s products and services serve customers in the research, clinical and applied markets, and enable the adoption of a variety of genomic solutions. Core Illumina includes all of our operations, excluding the results of GRAIL.

GRAIL:

GRAIL is a healthcare company focused on early detection of multiple cancers. We acquired GRAIL on August 18, 2021. We have included the financial results of GRAIL in our condensed consolidated financial statements from the date of acquisition.

In millions	Q1 2022		Q1 2021
Revenue:
Core Illumina	$	1,221	$	1,093
GRAIL	10		—
Eliminations	(8)		—
Consolidated revenue	$	1,223	$	1,093
Income (loss) from operations:
Core Illumina	$	362	$	193
GRAIL	(172)		—
Eliminations	(6)		—
Consolidated income from operations	$	184	$	193

Total other expense, net relates primarily to Core Illumina, and we do not allocate income taxes to our segments.

In millions	April 3, 2022		January 2, 2022
Total assets:
Core Illumina	$	5,682	$	5,571
GRAIL	9,600		9,649
Eliminations	(8)		(3)
Consolidated total assets	$	15,274	$	15,217

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Organization and Significant Accounting Policies (Policies)

3 Months Ended

Apr. 03, 2022

Accounting Policies [Abstract]

Basis of Presentation

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements.

Consolidation

The unaudited condensed consolidated financial statements include our accounts, our wholly-owned subsidiaries, and majority-owned or controlled companies. All intercompany transactions and balances have been eliminated in consolidation. Certain prior period amounts have been reclassified to conform to the current period presentation. In management’s opinion, the accompanying unaudited condensed consolidated financial statements reflect all adjustments, consisting of normal recurring adjustments, considered necessary for a fair presentation of the results for the interim periods presented.

Fiscal Year

Our fiscal year is the 52 or 53 weeks ending the Sunday closest to December 31, with quarters of 13 or 14 weeks ending the Sunday closest to March 31, June 30, September 30, and December 31. References to Q1 2022 and Q1 2021 refer to the three months ended April 3, 2022 and April 4, 2021, respectively, which were both 13 weeks.

Recently Adopted Accounting Pronouncements

Recently Adopted Accounting Pronouncements

In August 2020, the FASB issued ASU 2020-06, Debt - Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging - Contracts in Entity’s Own Equity (Subtopic 815-40). The new standard reduces the number of accounting models for convertible debt instruments, amends the accounting for certain contracts in an entity’s own equity, and modifies how certain convertible instruments and contracts that may be settled in cash or shares impact the calculation of diluted earnings per share. Specifically, the guidance removes certain accounting models that separate the embedded conversion features from the host contract for convertible instruments and requires the use of the if-converted method to calculate diluted earnings per share. We adopted the standard on its effective date in the first quarter of 2022 using a modified retrospective approach by recognizing a cumulative-effect adjustment to retained earnings on January 3, 2022. We did not restate prior periods. As a result of the adoption, we increased our convertible senior notes and retained earnings, on January 3, 2022, by $43 million and $61 million, respectively, and decreased our deferred tax liabilities, included in other long-term liabilities on the condensed consolidated balance sheets, and additional paid-in capital by $11 million and $93 million, respectively. Interest expense recognized in future periods will be reduced as a result of accounting for our convertible senior notes as a single liability measured at amortized cost. In addition, as a result of the adoption, diluted earnings per share decreased by less than $0.01 for Q1 2022. See note “4. Debt” for additional details on the adoption of ASU 2020-06.

Earnings per Share

Basic earnings per share is computed based on the weighted average number of common shares outstanding during the period. Diluted earnings per share is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period.

Potentially dilutive common shares consist of shares issuable under convertible senior notes and equity awards. On January 3, 2022, we adopted ASU 2020-06. As a result, beginning in Q1 2022, we utilize the if-converted method to calculate the impact of convertible senior notes on diluted earnings per share. Prior to the adoption of ASU 2020-06, we applied the treasury stock method when calculating the potential dilutive effect, if any, of convertible senior notes which we intended to settle or have settled in cash the principal outstanding. Under the treasury stock method, convertible senior notes had a dilutive impact when the average market price of our common stock exceeded the applicable conversion price of the respective notes. Potentially dilutive common shares from equity awards are determined using the average share price for each period under the treasury stock method. In addition, proceeds from exercise of equity awards and the average amount of unrecognized compensation expense for equity awards are assumed to be used to repurchase shares. For Q1 2022 and Q1 2021, we did not have any potentially dilutive common shares from equity awards.

Warranties

We generally provide a one-year warranty on instruments. Additionally, we provide a warranty on consumables through the expiration date, which generally ranges from six to twelve months after the manufacture date. At the time revenue is recognized, an accrual is established for estimated warranty expenses based on historical experience as well as anticipated product performance. We periodically review the warranty reserve for adequacy and adjust the warranty accrual, if necessary, based on actual experience and estimated costs to be incurred. Warranty expense is recorded as a component of cost of product revenue.

Derivatives

We are exposed to foreign exchange rate risks in the normal course of business and use derivative financial instruments to partially offset this exposure. We do not use derivative financial instruments for speculative or trading purposes. Foreign exchange contracts are carried at fair value in other current assets, other assets, accrued liabilities, or other long-term liabilities, as appropriate, on the condensed consolidated balance sheets.

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Organization and Significant Accounting Policies (Tables)

3 Months Ended

Apr. 03, 2022

Accounting Policies [Abstract]

Schedule of Calculation of Weighted Average Shares used to Calculate Basic and Diluted Earnings Per Share, Earnings Per Share

The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share:

In millions	Q1 2022	Q1 2021
Weighted average shares outstanding	157	146
Effect of potentially dilutive common shares from:
Convertible senior notes	2	1
Weighted average shares used in calculating diluted earnings per share	159	147

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Revenue (Tables)

3 Months Ended

Apr. 03, 2022

Revenue from Contract with Customer [Abstract]

Schedule of Disaggregation of Revenue

Revenue by Source

	Q1 2022						Q1 2021
In millions	Sequencing		Microarray		Total		Sequencing		Microarray		Total
Consumables	$	778	$	75	$	853	$	695	$	79	$	774
Instruments	211		6		217		176		3		179
Total product revenue	989		81		1,070		871		82		953
Service and other revenue	120		33		153		108		32		140
Total revenue	$	1,109	$	114	$	1,223	$	979	$	114	$	1,093

Revenue by Geographic Area

Based on region of destination (in millions)	Q1 2022		Q1 2021
Americas	$	648	$	562
Europe, Middle East, and Africa	316		305
Greater China(1)	127		127
Asia-Pacific	132		99
Total revenue	$	1,223	$	1,093

_____________

(1)Region includes revenue from China, Taiwan, and Hong Kong.

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Investments and Fair Value Measurements (Tables)

3 Months Ended

Apr. 03, 2022

Fair Value Disclosures [Abstract]

Schedule of Marketable Securities

Net losses recognized in other expense, net on our marketable equity securities were as follows:

In millions	Q1 2022		Q1 2021
Net losses recognized during the period on marketable equity securities	$	(42)	$	(72)
Less: Net losses recognized during the period on marketable equity securities sold during the period	—		14
Net unrealized losses recognized during the period on marketable equity securities still held at the reporting date	$	(42)	$	(58)

Schedule of Hierarchy for Assets and Liabilities Measured at Fair Value on a Recurring Basis

The following table presents the hierarchy for assets and liabilities measured at fair value on a recurring basis:

	April 3, 2022								January 2, 2022
In millions	Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Assets:
Money market funds (cash equivalents)	$	775	$	—	$	—	$	775	$	688	$	—	$	—	$	688
Marketable equity securities	65		—		—		65		107		—		—		107
Helix contingent value right	—		—		70		70		—		—		65		65
Deferred compensation plan assets	—		57		—		57		—		60		—		60
Total assets measured at fair value	$	840	$	57	$	70	$	967	$	795	$	60	$	65	$	920
Liabilities:
Contingent consideration liability	$	—	$	—	$	566	$	566	$	—	$	—	$	615	$	615
Deferred compensation plan liability	—		54		—		54		—		56		—		56
Total liabilities measured at fair value	$	—	$	54	$	566	$	620	$	—	$	56	$	615	$	671

Schedule of Changes in Estimated Fair Value of Acquisition Related Contingent Consideration Liabilities

Changes in the estimated fair value of our contingent consideration liability during Q1 2022 were as follows:

In millions
Balance as of January 2, 2022	$	615
Change in estimated fair value	(49)
Balance as of April 3, 2022(1) (2)	$	566

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(1)As of April 3, 2022, $565 million was included in other long-term liabilities, with remaining balance included in accrued liabilities.

(2)Covered Revenues for Q4 2021 were $10 million, driven primarily by sales of GRAIL’s Galleri test. Covered Revenue Payments in Q1 2022 were approximately $97,000; however, pursuant to the Contingent Value Rights Agreement, the Covered Revenue Payments were applied to reimburse us for certain expenses

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Debt (Tables)

3 Months Ended

Apr. 03, 2022

Debt Disclosure [Abstract]

Schedule of Debt Obligations

Summary of Term Debt Obligations

In millions	April 3, 2022		January 2, 2022
Principal amount of 2031 Term Notes outstanding	$	500	$	500
Principal amount of 2023 Term Notes outstanding	500		500
Unamortized discounts and debt issuance costs	(6)		(7)
Net carrying amount of term notes	994		993
Less: current portion	(499)		—
Term notes, non-current	$	495	$	993
Fair value of term notes outstanding (Level 2)	$	945	$	996

0% Convertible Senior Notes due 2023 (2023 Convertible Notes)

In millions	April 3, 2022		January 2, 2022
Principal amount outstanding	$	750	$	750
Unamortized debt discount and issuance costs	(4)		(48)
Net carrying amount of liability component, non-current	$	746	$	702
Carrying value of equity component, net of debt issuance costs	$	—	$	126
Fair value of convertible senior notes outstanding (Level 2)	$	836	$	854

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Stockholders’ Equity (Tables)

3 Months Ended

Apr. 03, 2022

Equity [Abstract]

Schedule of Restricted Stock Activity and Related Information, Restricted Stock

Restricted stock activity was as follows:

	Restricted Stock Units (RSU)	Performance Stock Units (PSU)(1)	Weighted-Average Grant Date Fair Value per Share
Units in thousands			RSU		PSU
Outstanding at January 2, 2022	1,130	328	$	345.66	$	466.42
Awarded	996	194	$	330.98	$	329.57
Vested	(32)	—	$	442.14	$	—
Cancelled	(51)	(7)	$	353.04	$	446.38
Outstanding at April 3, 2022	2,043	515	$	336.77	$	415.16

_____________

(1)The number of units reflect the estimated number of shares to be issued at the end of the performance period. Awarded units are presented net of performance adjustments.

Schedule of Restricted Stock Activity and Related Information, Performance Units

Restricted stock activity was as follows:

	Restricted Stock Units (RSU)	Performance Stock Units (PSU)(1)	Weighted-Average Grant Date Fair Value per Share
Units in thousands			RSU		PSU
Outstanding at January 2, 2022	1,130	328	$	345.66	$	466.42
Awarded	996	194	$	330.98	$	329.57
Vested	(32)	—	$	442.14	$	—
Cancelled	(51)	(7)	$	353.04	$	446.38
Outstanding at April 3, 2022	2,043	515	$	336.77	$	415.16

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(1)The number of units reflect the estimated number of shares to be issued at the end of the performance period. Awarded units are presented net of performance adjustments.

Schedule of Stock Option Activity Under all Stock Option Plans

Stock option activity was as follows:

Units in thousands	Options	Weighted-Average Exercise Price		Performance Stock Options(1)	Weighted-Average Exercise Price
Outstanding at January 2, 2022	8	$	66.42	17	$	85.54
Granted	180	$	330.25	—	$	—
Outstanding at April 3, 2022	188	$	318.73	17	$	85.54
Exercisable at April 3, 2022	8	$	66.42	—	$	—

_____________

(1)The number of units reflect awards that have been granted and for which it is assumed to be probable that the underlying performance goals will be achieved.

Schedule of Share-based Payment Arrangement, Liability - Classified Awards, Activity

Cash-based equity incentive award activity was as follows:

In millions
Outstanding at January 2, 2022	$	184
Granted	70
Cancelled	(13)
Outstanding at April 3, 2022	$	241
Estimated liability as of April 3, 2022 (included in accrued liabilities)	$	24

Schedule of Share-based Compensation Expense for all Stock Awards

Share-based compensation expense, which includes expense for both equity and liability-classified awards, reported in our condensed consolidated statements of income was as follows:

In millions	Q1 2022		Q1 2021
Cost of product revenue	$	6	$	7
Cost of service and other revenue	1		1
Research and development	36		24
Selling, general and administrative	49		35
Share-based compensation expense before taxes	92		67
Related income tax benefits	(21)		(13)
Share-based compensation expense, net of taxes	$	71	$	54

Schedule of Assumptions used to Estimate the Weighted-Average Fair Value Per Share for Stock Purchase under the Employee Stock Purchase Plan

The assumptions used and the resulting estimate of weighted-average fair value per share for stock purchased under the ESPP during Q1 2022 were as follows:

	Employee Stock Purchase Rights
Risk-free interest rate	0.06% - 0.78%
Expected volatility	37% - 47%
Expected term	0.5 - 1.0 year
Expected dividends	0		%
Weighted-average grant-date fair value per share	$	91.27

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Supplemental Balance Sheet Details (Tables)

3 Months Ended

Apr. 03, 2022

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Schedule of Accounts Receivable

Accounts Receivable

In millions	April 3, 2022		January 2, 2022
Trade accounts receivable, gross	$	617	$	651
Allowance for credit losses	(3)		(3)
Total accounts receivable, net	$	614	$	648

Schedule of Inventory

Inventory

In millions	April 3, 2022		January 2, 2022
Raw materials	$	170	$	144
Work in process	340		333
Finished goods	32		32
Inventory, gross	542		509
Inventory reserve	(77)		(78)
Total inventory, net	$	465	$	431

Schedule of Accrued Liabilities

Accrued Liabilities

In millions	April 3, 2022		January 2, 2022
Contract liabilities, current portion	$	232	$	234
Accrued compensation expenses	181		241
Accrued taxes payable	91		98
Operating lease liabilities, current portion	72		71
Liability-classified equity incentive awards	24		11
Other, including warranties (a)	100		106
Total accrued liabilities	$	700	$	761

(a) Changes in the reserve for product warranties were as follows:

In millions	Q1 2022		Q1 2021
Balance at beginning of period	$	22	$	13
Additions charged to cost of product revenue	6		8
Repairs and replacements	(7)		(6)
Balance at end of period	$	21	$	15

Schedule of Changes in Reserve for Product Warranties

Changes in the reserve for product warranties were as follows:

In millions	Q1 2022		Q1 2021
Balance at beginning of period	$	22	$	13
Additions charged to cost of product revenue	6		8
Repairs and replacements	(7)		(6)
Balance at end of period	$	21	$	15

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Segment Information (Tables)

3 Months Ended

Apr. 03, 2022

Segment Reporting [Abstract]

Schedule of Operating Performance and Assets by Segment

In millions	Q1 2022		Q1 2021
Revenue:
Core Illumina	$	1,221	$	1,093
GRAIL	10		—
Eliminations	(8)		—
Consolidated revenue	$	1,223	$	1,093
Income (loss) from operations:
Core Illumina	$	362	$	193
GRAIL	(172)		—
Eliminations	(6)		—
Consolidated income from operations	$	184	$	193

Total other expense, net relates primarily to Core Illumina, and we do not allocate income taxes to our segments.

In millions	April 3, 2022		January 2, 2022
Total assets:
Core Illumina	$	5,682	$	5,571
GRAIL	9,600		9,649
Eliminations	(8)		(3)
Consolidated total assets	$	15,274	$	15,217

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Organization and Significant Accounting Policies - Narrative - Accounting Pronouncements Adopted in 2022 (Details) - USD ($) $ / shares in Units, $ in Millions	3 Months Ended
	Apr. 03, 2022	Apr. 04, 2021	Jan. 03, 2022	Jan. 02, 2022
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Retained earnings (accumulated deficit)	$ 5,632			$ 5,485
Additional paid-in capital	$ 8,957			$ 8,938
Diluted (in dollars per share)	$ 0.55	$ 1.00
Cumulative-effect adjustment from adoption of ASU 2016-02, net of deferred tax | Accounting Standards Update 2020-06
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Convertible debt			$ 43
Retained earnings (accumulated deficit)			61
Deferred tax liabilities			(11)
Additional paid-in capital			$ (93)
Diluted (in dollars per share)	$ (0.01)

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Organization and Significant Accounting Policies - Summary of Calculation of Weighted Average Shares used to Calculate Basic and Diluted Earnings Per Share (Details) - shares shares in Millions	3 Months Ended
	Apr. 03, 2022	Apr. 04, 2021
Weighted average shares used to calculate basic and diluted earnings per share
Weighted average shares outstanding (in shares)	157	146
Effect of potentially dilutive common shares from:
Convertible senior notes (in shares)	2	1
Weighted average shares used in calculating diluted earnings per share (in shares)	159	147

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Revenue - Disaggregation of Revenue (Details) - USD ($) $ in Millions	3 Months Ended
	Apr. 03, 2022	Apr. 04, 2021
Disaggregation of Revenue [Line Items]
Consolidated revenue	$ 1,223	$ 1,093
Americas
Disaggregation of Revenue [Line Items]
Consolidated revenue	648	562
Europe, Middle East, and Africa
Disaggregation of Revenue [Line Items]
Consolidated revenue	316	305
Greater China
Disaggregation of Revenue [Line Items]
Consolidated revenue	127	127
Asia-Pacific
Disaggregation of Revenue [Line Items]
Consolidated revenue	132	99
Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	1,070	953
Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	853	774
Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	217	179
Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	153	140
Sequencing
Disaggregation of Revenue [Line Items]
Consolidated revenue	1,109	979
Sequencing | Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	989	871
Sequencing | Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	778	695
Sequencing | Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	211	176
Sequencing | Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	120	108
Microarray
Disaggregation of Revenue [Line Items]
Consolidated revenue	114	114
Microarray | Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	81	82
Microarray | Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	75	79
Microarray | Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	6	3
Microarray | Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	$ 33	$ 32

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Revenue - Remaining Performance Obligation (Details) $ in Millions	3 Months Ended
	Apr. 03, 2022 USD ($)
Revenue from Contract with Customer [Abstract]
Remaining performance obligation	$ 1,276
Minimum
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Product or service delivery period	3 years
Maximum
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Product or service delivery period	6 months
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2022-04-04
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Percent of remaining performance obligation	91.00%
Expected timing of remaining performance obligation	12 months
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2023-04-03
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Percent of remaining performance obligation	6.00%
Expected timing of remaining performance obligation	12 months

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Revenue - Narrative (Details) - USD ($) $ in Millions	3 Months Ended
	Apr. 03, 2022	Jan. 02, 2022
Revenue from Contract with Customer [Abstract]
Contract asset	$ 16	$ 16
Contract with customer, liability	293	297
Contract liabilities, current portion	232	$ 234
Revenue recognized	$ 106

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Investments and Fair Value Measurements - Narrative (Details)			3 Months Ended
	Aug. 18, 2021 USD ($)	Apr. 25, 2019	Apr. 03, 2022 USD ($) fund	Apr. 04, 2021 USD ($)	Mar. 31, 2020 USD ($)	Dec. 29, 2019 USD ($)	Jan. 02, 2022 USD ($)	Feb. 28, 2021 USD ($)	Jan. 02, 2020 USD ($)
Schedule of Investments [Line Items]
Marketable equity securities			$ 65,000,000				$ 107,000,000
Strategic equity investments, without readily determinable fair values			41,000,000				40,000,000
Gain on Helix contingent value right			5,000,000	$ 10,000,000
Gain on derivative assets related to terminated acquisition			0	26,000,000
Pacific Biosciences of California, Inc (PacBio)
Schedule of Investments [Line Items]
Cash					$ 34,000,000	$ 18,000,000
Business combination, contingent consideration arrangements, maximum outcome									$ 52,000,000
Equity or debt financing to be raised									$ 100,000,000
GRAIL Inc
Schedule of Investments [Line Items]
Contingent value right, terms	12 years
GRAIL Inc | Payment Rights Of One Billion, Each Twelve Years
Schedule of Investments [Line Items]
Contingent payment rights, percentage	2.50%
Business acquisition, contingent value rights, revenue threshold	$ 1,000,000,000
GRAIL Inc | Payment Rights Of Above One Billion, Each Twelve Years
Schedule of Investments [Line Items]
Business acquisition, contingent value rights, revenue threshold	$ 1,000,000,000
Contingent payment rights, second percentage	9.00%
Helix Holdings I, LLC
Schedule of Investments [Line Items]
Contingent value right, terms		7 years
Gain on Helix contingent value right			$ 5,000,000	10,000,000
Pacific Biosciences of California, Inc (PacBio) | S B Northstar L P
Schedule of Investments [Line Items]
Business combination, contingent consideration arrangements, maximum outcome								$ 52,000,000
Gain on derivative assets related to terminated acquisition				26,000,000
Pacific Biosciences of California, Inc (PacBio) | S B Northstar L P | Convertible Senior Notes
Schedule of Investments [Line Items]
Principal amount of notes outstanding								$ 900,000,000
Venture Capital Investment Fund (the Fund)
Schedule of Investments [Line Items]
Number of venture capital investment funds | fund			2
Equity method investments			$ 183,000,000				$ 173,000,000
Unrealized gain (loss) on investments			(2,000,000)	33,000,000
Venture Capital Investment Fund (the Fund), One
Schedule of Investments [Line Items]
Commitment in new venture capital investment fund			100,000,000
Remaining capital commitment			14,000,000
Venture Capital Investment Fund (the Fund), Two
Schedule of Investments [Line Items]
Commitment in new venture capital investment fund			150,000,000
Remaining capital commitment			110,000,000
Investee
Schedule of Investments [Line Items]
Revenue from transactions with strategic investees			$ 30,000,000	$ 13,000,000

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Investments and Fair Value Measurements - Marketable Equity Securities (Details) - USD ($) $ in Millions	3 Months Ended
	Apr. 03, 2022	Apr. 04, 2021
Fair Value Disclosures [Abstract]
Net losses recognized during the period on marketable equity securities	$ (42)	$ (72)
Less: Net losses recognized during the period on marketable equity securities sold during the period	0	14
Net unrealized losses recognized during the period on marketable equity securities still held at the reporting date	$ (42)	$ (58)

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Investments and Fair Value Measurements - Fair Value Hierarchy of Assets and Liabilities (Details) - USD ($) $ in Millions	Apr. 03, 2022	Jan. 02, 2022
Assets:
Marketable equity securities	$ 65	$ 107
Fair Value, Measurements, Recurring
Assets:
Marketable equity securities	65	107
Helix contingent value right	70	65
Deferred compensation plan assets	57	60
Total assets measured at fair value	967	920
Liabilities:
Contingent consideration liability	566	615
Deferred compensation plan liability	54	56
Total liabilities measured at fair value	620	671
Fair Value, Measurements, Recurring | Money market funds (cash equivalents)
Assets:
Money market funds (cash equivalents)	775	688
Fair Value, Measurements, Recurring | Level 1
Assets:
Marketable equity securities	65	107
Helix contingent value right	0	0
Deferred compensation plan assets	0	0
Total assets measured at fair value	840	795
Liabilities:
Contingent consideration liability	0	0
Deferred compensation plan liability	0	0
Total liabilities measured at fair value	0	0
Fair Value, Measurements, Recurring | Level 1 | Money market funds (cash equivalents)
Assets:
Money market funds (cash equivalents)	775	688
Fair Value, Measurements, Recurring | Level 2
Assets:
Marketable equity securities	0	0
Helix contingent value right	0	0
Deferred compensation plan assets	57	60
Total assets measured at fair value	57	60
Liabilities:
Contingent consideration liability	0	0
Deferred compensation plan liability	54	56
Total liabilities measured at fair value	54	56
Fair Value, Measurements, Recurring | Level 2 | Money market funds (cash equivalents)
Assets:
Money market funds (cash equivalents)	0	0
Fair Value, Measurements, Recurring | Level 3
Assets:
Marketable equity securities	0	0
Helix contingent value right	70	65
Deferred compensation plan assets	0	0
Total assets measured at fair value	70	65
Liabilities:
Contingent consideration liability	566	615
Deferred compensation plan liability	0	0
Total liabilities measured at fair value	566	615
Fair Value, Measurements, Recurring | Level 3 | Money market funds (cash equivalents)
Assets:
Money market funds (cash equivalents)	$ 0	$ 0

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Investments and Fair Value Measurements - Changes in Estimated Fair Value of Acquisition Related Contingent Consideration Liabilities (Details) - USD ($) $ in Thousands	3 Months Ended
	Apr. 03, 2022	Jan. 02, 2022
GRAIL Inc
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Contingent consideration liability	$ 565,000
Covered Revenues of GRAIL, Contingent Consideration Liability		$ 10,000
Payment for contingent consideration	97
Business Combination Contingent Consideration Liability
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Beginning balance	615,000
Change in estimated fair value	(49,000)
Ending balance	$ 566,000	$ 615,000

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Debt - Summary of Term Debt Obligations (Details) - USD ($)	Apr. 03, 2022	Jan. 02, 2022	Mar. 23, 2021
Debt Instrument [Line Items]
Less: current portion	$ (499,000,000)	$ 0
Term Notes
Debt Instrument [Line Items]
Unamortized discounts and debt issuance costs	(6,000,000)	(7,000,000)
Net carrying amount of liability component, non-current	994,000,000	993,000,000
Less: current portion	(499,000,000)	0
Term notes, non-current	495,000,000	993,000,000
Term Notes | Level 2
Debt Instrument [Line Items]
Fair value of term notes outstanding (Level 2)	945,000,000	996,000,000
2031 Term Notes | Term Notes
Debt Instrument [Line Items]
Principal amount of notes outstanding	500,000,000	500,000,000	$ 500,000,000
2023 Term Notes | Term Notes
Debt Instrument [Line Items]
Principal amount of notes outstanding	$ 500,000,000	$ 500,000,000	$ 500,000,000

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Debt - Narrative (Details) $ / shares in Units, shares in Millions				1 Months Ended	3 Months Ended
	Jun. 15, 2021 shares	Mar. 23, 2021 USD ($)	Mar. 08, 2021 USD ($)	Aug. 30, 2018 USD ($) day $ / shares	Apr. 03, 2022 USD ($) renewal	Apr. 04, 2021 USD ($)	Jan. 03, 2022 USD ($)	Jan. 02, 2022 USD ($)	Dec. 30, 2018 USD ($)	Aug. 31, 2018	Aug. 21, 2018	Jun. 30, 2014 USD ($)
Debt Instrument [Line Items]
Additional paid-in capital					$ 8,957,000,000			$ 8,938,000,000
Retained earnings (accumulated deficit)					$ 5,632,000,000			5,485,000,000
Cumulative-effect adjustment from adoption of ASU 2016-02, net of deferred tax | Accounting Standards Update 2020-06
Debt Instrument [Line Items]
Additional paid-in capital							$ (93,000,000)
Convertible debt							43,000,000
Retained earnings (accumulated deficit)							61,000,000
Deferred tax liabilities							$ (11,000,000)
Term Notes
Debt Instrument [Line Items]
Net proceeds		$ 992,000,000
Redemption price, percentage					100.00%
Interest expense recognized					$ 4,000,000	$ 1,000,000
Convertible Senior Notes
Debt Instrument [Line Items]
Interest expense recognized					1,000,000	7,000,000
2023 Term Notes | Term Notes
Debt Instrument [Line Items]
Stated rate		0.55%
Principal amount of notes outstanding		$ 500,000,000			500,000,000			500,000,000
2031 Term Notes | Term Notes
Debt Instrument [Line Items]
Stated rate		2.55%
Principal amount of notes outstanding		$ 500,000,000			500,000,000			500,000,000
2023 Convertible Notes | Convertible Senior Notes
Debt Instrument [Line Items]
Stated rate											0.00%
Principal amount of notes outstanding				$ 750,000,000	$ 750,000,000			$ 750,000,000
Redemption price, percentage				100.00%
Conversion price (in dollars per share) | $ / shares				$ 457.77
Threshold common stock trading days | day				20
Threshold consecutive common stock trading days | day				30
Threshold percentage of common stock price trigger				130.00%
Threshold note trading days | day				5
Threshold consecutive note trading days | day				10
Threshold percentage of note price trigger				98.00%
Convertible stock price trigger (in dollars per share) | $ / shares				$ 595.10
Additional paid-in capital									$ 126,000,000
Effective interest rate used to measure fair value of convertible senior note										3.70%
2021 Convertible Notes
Debt Instrument [Line Items]
Interest expense recognized						$ 4,000,000
Number of shares of common stock issued upon conversion (in shares) | shares	0.7
2021 Convertible Notes | Convertible Senior Notes
Debt Instrument [Line Items]
Stated rate												0.50%
Principal amount of notes outstanding												$ 517,000,000
The Credit Agreement | Line of Credit
Debt Instrument [Line Items]
Debt instrument term, number of renewal | renewal					2
Debt instrument, renewal term					1 year
Borrowings outstanding					$ 0
The Credit Agreement | Line of Credit | Revolving Credit Facility
Debt Instrument [Line Items]
Maximum borrowing capacity			$ 750,000,000
Debt instrument term			5 years
The Credit Agreement | Line of Credit | Swingline Borrowings
Debt Instrument [Line Items]
Maximum borrowing capacity			$ 40,000,000
The Credit Agreement | Line of Credit | Letter of Credit
Debt Instrument [Line Items]
Maximum borrowing capacity			50,000,000
The Credit Agreement | Unsecured Debt
Debt Instrument [Line Items]
Debt instrument, face amount, optional increase in additional borrowings			$ 250,000,000
Debt instrument, covenant, minimum debt to EBITDA ratio			3.50
Debt instrument, covenant, minimum debt to EBITDA ratio upon consummation of acquisition			4.00

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Debt - Summary of Convertible Debt Obligations (Details) - Convertible Senior Notes - USD ($)	Apr. 03, 2022	Jan. 02, 2022	Aug. 30, 2018	Aug. 21, 2018
Debt Instrument [Line Items]
Unamortized debt discount and issuance costs	$ (4,000,000)	$ (48,000,000)
Net carrying amount of liability component, non-current	746,000,000	702,000,000
Carrying value of equity component, net of debt issuance costs	0	126,000,000
Level 2
Debt Instrument [Line Items]
Fair value of convertible senior notes outstanding (Level 2)	836,000,000	854,000,000
2023 Convertible Notes
Debt Instrument [Line Items]
Principal amount of notes outstanding	$ 750,000,000	$ 750,000,000	$ 750,000,000
Stated rate				0.00%

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Stockholders’ Equity - Narrative (Details) shares in Millions	Apr. 03, 2022 shares
2015 Stock Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares available for issuance (in shares)	1.9

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Stockholders’ Equity - Summary of Restricted Stock Activity and Related Information (Details) shares in Thousands	3 Months Ended
	Apr. 03, 2022 $ / shares shares
Restricted Stock Units (RSUs)
Stock Units
Outstanding at period start (in shares) | shares	1,130
Awarded (in shares) | shares	996
Vested (in shares) | shares	(32)
Cancelled (in shares) | shares	(51)
Outstanding at period end (in shares) | shares	2,043
Weighted-Average Grant Date Fair Value per Share
Outstanding at period start (in dollars per share) | $ / shares	$ 345.66
Awarded (in dollars per share) | $ / shares	330.98
Vested (in dollars per share) | $ / shares	442.14
Cancelled (in dollars per share) | $ / shares	353.04
Outstanding at period end (in dollars per share) | $ / shares	$ 336.77
Performance Stock Units (PSU)
Stock Units
Outstanding at period start (in shares) | shares	328
Awarded (in shares) | shares	194
Vested (in shares) | shares	0
Cancelled (in shares) | shares	(7)
Outstanding at period end (in shares) | shares	515
Weighted-Average Grant Date Fair Value per Share
Outstanding at period start (in dollars per share) | $ / shares	$ 466.42
Awarded (in dollars per share) | $ / shares	329.57
Vested (in dollars per share) | $ / shares	0
Cancelled (in dollars per share) | $ / shares	446.38
Outstanding at period end (in dollars per share) | $ / shares	$ 415.16

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Stockholders’ Equity - Summary of Stock Option Activity Under all Stock Option Plans (Details) shares in Thousands	3 Months Ended
	Apr. 03, 2022 $ / shares shares
Options
Options
Outstanding at period start (in shares) | shares	8
Granted (in shares) | shares	180
Outstanding at period end (in shares) | shares	188
Exercisable at period end (in shares) | shares	8
Weighted-Average Exercise Price
Outstanding at period start (in dollars per share) | $ / shares	$ 66.42
Granted (in dollars per share) | $ / shares	330.25
Outstanding at period end (in dollars per share) | $ / shares	318.73
Exercisable at period end (in dollars per share) | $ / shares	$ 66.42
Performance stock options
Options
Outstanding at period start (in shares) | shares	17
Granted (in shares) | shares	0
Outstanding at period end (in shares) | shares	17
Exercisable at period end (in shares) | shares	0
Weighted-Average Exercise Price
Outstanding at period start (in dollars per share) | $ / shares	$ 85.54
Granted (in dollars per share) | $ / shares	0
Outstanding at period end (in dollars per share) | $ / shares	85.54
Exercisable at period end (in dollars per share) | $ / shares	$ 0

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Stockholders’ Equity - Narrative - Liability - Classified Award (Details) - USD ($) $ in Millions	3 Months Ended
	Apr. 03, 2022	Apr. 04, 2021
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes	$ 92	$ 67
Unrecognized compensation cost	$ 782
Weighted-average period of unrecognized compensation cost	2 years 7 months 6 days
Liability-Based Awards
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes	$ 13
Unrecognized compensation cost	$ 217
Weighted-average period of unrecognized compensation cost	3 years 7 months 6 days
Aggregated potential value	$ 78

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Stockholders’ Equity - Liability - Classified Awards (Details) - USD ($) $ in Millions	3 Months Ended
	Apr. 03, 2022	Jan. 02, 2022
Share-Based Compensation Arrangement By Share-Based Payment Award Liability-Classified Awards, Outstanding [Roll Forward]
Liability-classified equity incentive awards	$ 24	$ 11
Liability-Based Awards
Share-Based Compensation Arrangement By Share-Based Payment Award Liability-Classified Awards, Outstanding [Roll Forward]
Outstanding at January 2, 2022	184
Granted	70
Cancelled	(13)
Outstanding at April 3, 2022	241
Liability-classified equity incentive awards	$ 24

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Stockholders’ Equity - Narrative - Employee Stock Purchase Plan (Details) - ESPP - Employee Stock shares in Millions	3 Months Ended
	Apr. 03, 2022 shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Specified percentage of the fair market value of the common stock on the first or last day of the offering period whichever is lower at which stock is purchased	85.00%
Total shares issued under the ESPP (in shares)	0.1
Shares available for issuance (in shares)	13.0

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Stockholders’ Equity - Narrative - Share Repurchases (Details) - Common Stock - USD ($)	3 Months Ended
	Apr. 03, 2022	Feb. 05, 2020
Class of Stock [Line Items]
Repurchased common stock (in shares)	0
Dollar amount remaining in authorized stock repurchase program	$ 15,000,000
Stock repurchase program, authorized amount		$ 750,000,000

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Stockholders’ Equity - Summary of Share-based Compensation Expense for all Stock Awards (Details) $ in Millions	1 Months Ended	3 Months Ended
	Feb. 28, 2021 USD ($) employee	Apr. 03, 2022 USD ($)	Apr. 04, 2021 USD ($)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes		$ 92	$ 67
Related income tax benefits		(21)	(13)
Share-based compensation expense, net of taxes		71	54
Performance Stock Units (PSU)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share based compensation vesting performance period	3 years
Performance Shares, Granted In 2019
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of employees effected by modification | employee	52
Incremental share-based compensation cost	$ 41
Performance Shares, Granted In 2020
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of employees effected by modification | employee	72
Incremental share-based compensation cost	$ 65
Cost of product revenue
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes		6	7
Cost of service and other revenue
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes		1	1
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes		36	24
Selling, general and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation expense before taxes		$ 49	$ 35

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Stockholders’ Equity- Summary of Assumptions Used to Estimate the Weighted Average Fair Value Per Share (Details) $ / shares in Units, $ in Millions	3 Months Ended
	Apr. 03, 2022 USD ($) $ / shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost related to stock options, restricted stock, and ESPP shares granted to date | $	$ 782
Weighted-average period of unrecognized compensation cost related to stock options, restricted stock, and ESPP shares granted to date	2 years 7 months 6 days
Employee Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Risk free interest rate minimum	0.06%
Risk free interest rate maximum	0.78%
Expected volatility, minimum	37.00%
Expected volatility, maximum	47.00%
Expected dividends	0.00%
Weighted-average fair value per share (in dollars per share) | $ / shares	$ 91.27
Minimum | Employee Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected term	6 months
Maximum | Employee Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected term	1 year

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Supplemental Balance Sheet Details - Schedule of Accounts Receivable (Details) - USD ($) $ in Millions	Apr. 03, 2022	Jan. 02, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Trade accounts receivable, gross	$ 617	$ 651
Allowance for credit losses	(3)	(3)
Total accounts receivable, net	$ 614	$ 648

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Supplemental Balance Sheet Details - Summary of Inventory (Details) - USD ($) $ in Millions	Apr. 03, 2022	Jan. 02, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Raw materials	$ 170	$ 144
Work in process	340	333
Finished goods	32	32
Inventory, gross	542	509
Inventory reserve	(77)	(78)
Total inventory, net	$ 465	$ 431

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Supplemental Balance Sheet Details - Summary of Accrued Liabilities (Details) - USD ($) $ in Millions	Apr. 03, 2022	Jan. 02, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Contract liabilities, current portion	$ 232	$ 234
Accrued compensation expenses	181	241
Accrued taxes payable	91	98
Operating lease liabilities, current portion	72	71
Liability-classified equity incentive awards	24	11
Other, including warranties	100	106
Total accrued liabilities	$ 700	$ 761

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Supplemental Balance Sheet Details - Summary of Changes in Reserve for Product Warranties (Details) - USD ($) $ in Millions	3 Months Ended
	Apr. 03, 2022	Apr. 04, 2021
Reserve for product warranties [Roll Forward]
Balance at beginning of period	$ 22	$ 13
Additions charged to cost of product revenue	6	8
Repairs and replacements	(7)	(6)
Balance at end of period	$ 21	$ 15

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Supplemental Balance Sheet Details - Narrative - Warranties (Details)	3 Months Ended
	Apr. 03, 2022
Instruments
Product Warranty Liability [Line Items]
Warranty period	1 year
Consumables | Minimum
Product Warranty Liability [Line Items]
Warranty period	6 months
Consumables | Maximum
Product Warranty Liability [Line Items]
Warranty period	12 months

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Supplemental Balance Sheet Details - Narrative - Derivatives (Details) - Foreign Exchange Forward - USD ($) $ in Millions	3 Months Ended
	Apr. 03, 2022	Jan. 02, 2022
Not Designated as Hedging Instrument
Derivative [Line Items]
Derivative, notional amount	$ 458	$ 462
Derivative, Term of Contract	1 month
Designated as Hedging Instrument
Derivative [Line Items]
Derivative, notional amount	$ 462	$ 450
Derivative, Term of Contract	24 months

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Legal Proceedings (Details) - USD ($) $ in Millions	Apr. 08, 2022	Nov. 30, 2021	Apr. 12, 2021
Commitments and Contingencies Disclosure [Abstract]
Loss contingency, damages sought, value			$ 54
Loss contingency, royalty on sales of accused products, percentage			3.60%
Amount awarded from settlement		$ 8
Subsequent Event [Line Items]
Loss contingency, damages sought, value			$ 54
Loss contingency, royalty on sales of accused products, percentage			3.60%
Subsequent Event
Commitments and Contingencies Disclosure [Abstract]
Loss contingency, damages sought, value	$ 334
Loss contingency, royalty on sales of accused products, percentage	5.50%
Subsequent Event [Line Items]
Loss contingency, damages sought, value	$ 334
Loss contingency, royalty on sales of accused products, percentage	5.50%

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Income Taxes (Details) - USD ($) $ in Millions	3 Months Ended
	Apr. 03, 2022	Apr. 04, 2021
Income Tax Disclosure [Abstract]
Effective tax rate	38.30%	13.10%
Impact on tax rate due to GILTI and U.S. foreign tax credits	$ 24
Impact on tax rate due to capitalization of research and development expenses	$ 4

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Segment Information - Summary of Operating Performance and Assets by Segment (Details) $ in Millions	3 Months Ended
	Apr. 03, 2022 USD ($) segment	Apr. 04, 2021 USD ($)	Jan. 02, 2022 USD ($)
Segment Reporting [Abstract]
Number of reportable segments | segment	2
Segment Reporting Information [Line Items]
Consolidated revenue	$ 1,223	$ 1,093
Consolidated income from operations	184	193
Consolidated total assets	15,274		$ 15,217
Operating Segments | Core Illumina
Segment Reporting Information [Line Items]
Consolidated revenue	1,221	1,093
Consolidated income from operations	362	193
Consolidated total assets	5,682		5,571
Operating Segments | GRAIL
Segment Reporting Information [Line Items]
Consolidated revenue	10	0
Consolidated income from operations	(172)	0
Consolidated total assets	9,600		9,649
Eliminations
Segment Reporting Information [Line Items]
Consolidated revenue	(8)	0
Consolidated income from operations	(6)	$ 0
Consolidated total assets	$ (8)		$ (3)