Condensed Consolidated Statements of Cash Flows - USD ($) $ in Millions	9 Months Ended
	Oct. 03, 2021	Sep. 27, 2020
Cash flows from operating activities:
Net income	$ 650.0	$ 399.0
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation expense	128.0	114.0
Amortization of intangible assets	34.0	23.0
Share-based compensation expense	656.0	116.0
Accretion of debt discount on convertible senior notes	26.0	29.0
Deferred income taxes	(81.0)	50.0
Gain on previously held investment in GRAIL	(900.0)	0.0
Losses (gains) on equity securities, net	3.0	(128.0)
Gain on Helix contingent value right	(30.0)	(5.0)
(Gain) loss on derivative assets related to terminated acquisition	(26.0)	116.0
Change in fair value of contingent consideration	(7.0)	0.0
Other	(23.0)	(9.0)
Changes in operating assets and liabilities:
Accounts receivable	(125.0)	108.0
Inventory	(27.0)	(56.0)
Prepaid expenses and other current assets	(34.0)	(15.0)
Operating lease right-of-use assets and liabilities, net	(9.0)	(9.0)
Other assets	(35.0)	(25.0)
Accounts payable	(28.0)	(2.0)
Accrued liabilities	81.0	(68.0)
Other long-term liabilities	10.0	36.0
Net cash provided by operating activities	263.0	674.0
Cash flows from investing activities:
Maturities of available-for-sale securities	331.0	327.0
Purchases of available-for-sale securities	(77.0)	(757.0)
Sales of available-for-sale securities	1,031.0	379.0
Cash received (paid for) derivative assets related to terminated acquisition	52.0	(132.0)
Purchases of property and equipment	(138.0)	(127.0)
Purchases of strategic investments	(44.0)	(112.0)
Sales of strategic investments	220.0	0.0
Net cash paid for acquisitions	(2,444.0)	(98.0)
Net cash used in investing activities	(1,069.0)	(520.0)
Cash flows from financing activities:
Net proceeds from issuance of debt	988.0	0.0
Payments on convertible senior notes	(517.0)	0.0
Common stock repurchases	0.0	(455.0)
Taxes paid related to net share settlement of equity awards	(452.0)	(41.0)
Proceeds from issuance of common stock	59.0	61.0
Net cash provided by (used in) financing activities	78.0	(435.0)
Effect of exchange rate changes on cash and cash equivalents	(2.0)	0.0
Net decrease in cash and cash equivalents	(730.0)	(281.0)
Cash and cash equivalents at beginning of period	1,810.0	2,042.0
Cash and cash equivalents at end of period	$ 1,080.0	$ 1,761.0