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Stockholders’ Equity - Summary of Share-based Compensation Expense for all Stock Awards (Details)
$ in Millions
1 Months Ended 3 Months Ended 9 Months Ended
Feb. 28, 2021
USD ($)
employee
Oct. 03, 2021
USD ($)
Sep. 27, 2020
USD ($)
Oct. 03, 2021
USD ($)
Sep. 27, 2020
USD ($)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based compensation expense before taxes   $ 697 $ 61 $ 844 $ 116
Related income tax benefits   (29) (12) (57) (27)
Share-based compensation expense, net of taxes   668 49 787 89
GRAIL Inc          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based payment arrangement, accelerated cost   615      
Replacement Awards | GRAIL Inc          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based compensation expense before taxes   6      
Share-based payment arrangement, accelerated cost   615      
Performance Stock Units (PSU)          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share based compensation vesting performance period 3 years        
Performance Shares, Granted In 2019          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Number of employees effected by modification | employee 52        
Incremental share-based compensation cost $ 41        
Performance Shares, Granted In 2020          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Number of employees effected by modification | employee 72        
Incremental share-based compensation cost $ 65        
Cost of product revenue          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based compensation expense before taxes   7 6 22 13
Cost of service and other revenue          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based compensation expense before taxes   1 1 3 3
Research and development          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based compensation expense before taxes   193 21 243 48
Research and development | Replacement Awards | GRAIL Inc          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based payment arrangement, accelerated cost   167      
Selling, general and administrative          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based compensation expense before taxes   496 $ 33 $ 576 $ 52
Selling, general and administrative | Replacement Awards | GRAIL Inc          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Share-based payment arrangement, accelerated cost   $ 448