Revenue - Disaggregation of Revenue (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Oct. 03, 2021	Sep. 27, 2020	Oct. 03, 2021	Sep. 27, 2020
Disaggregation of Revenue [Line Items]
Consolidated revenue	$ 1,108	$ 794	$ 3,327	$ 2,286
Americas
Disaggregation of Revenue [Line Items]
Consolidated revenue	583	436	1,733	1,248
Europe, Middle East, and Africa
Disaggregation of Revenue [Line Items]
Consolidated revenue	313	213	938	602
Greater China
Disaggregation of Revenue [Line Items]
Consolidated revenue	122	83	382	246
Asia-Pacific
Disaggregation of Revenue [Line Items]
Consolidated revenue	90	62	274	190
Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	794	562	2,347	1,618
Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	184	114	556	286
Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	978	676	2,903	1,904
Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	130	118	424	382
Sequencing
Disaggregation of Revenue [Line Items]
Consolidated revenue	1,015	708	3,015	2,033
Sequencing | Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	723	500	2,123	1,440
Sequencing | Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	180	109	544	276
Sequencing | Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	903	609	2,667	1,716
Sequencing | Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	112	99	348	317
Microarray
Disaggregation of Revenue [Line Items]
Consolidated revenue	93	86	312	253
Microarray | Consumables
Disaggregation of Revenue [Line Items]
Consolidated revenue	71	62	224	178
Microarray | Instruments
Disaggregation of Revenue [Line Items]
Consolidated revenue	4	5	12	10
Microarray | Total product revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	75	67	236	188
Microarray | Service and other revenue
Disaggregation of Revenue [Line Items]
Consolidated revenue	$ 18	$ 19	$ 76	$ 65